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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-18-172-177</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6568</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ШКОЛА ОТОРИНОЛАРИНГОЛОГА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>THE SCHOOL’S OF OTORHINOLARYNGOLOGIST</subject></subj-group></article-categories><title-group><article-title>Системная антибактериальная терапия пациентов с острым бактериальным риносинуситом с учетом резистентности</article-title><trans-title-group xml:lang="en"><trans-title>Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7165-1308</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старостина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Starostina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старостина Светлана Викторовна - доктор медицинских наук, доцент, профессор кафедры болезней уха, горла и носа.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2.</p></bio><bio xml:lang="en"><p>Svetlana V. Starostina - Dr. Sci. (Med.), Associate Professor, Professor of the Department of Ear, Throat and Nose Diseases, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991.</p></bio><email xlink:type="simple">starostina_sv@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7341-1167</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивохин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivokhin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сивохин Дмитрий Алексеевич - клинический ординатор кафедры болезней уха, горла и носа.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2.</p></bio><bio xml:lang="en"><p>Dmitrii A. Sivokhin - Clinical Resident of the Department of Ear, Throat and Nose Diseases, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991.</p></bio><email xlink:type="simple">dr.sivokhin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2021</year></pub-date><volume>0</volume><issue>18</issue><fpage>172</fpage><lpage>177</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Старостина С.В., Сивохин Д.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Старостина С.В., Сивохин Д.А.</copyright-holder><copyright-holder xml:lang="en">Starostina S.V., Sivokhin D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6568">https://www.med-sovet.pro/jour/article/view/6568</self-uri><abstract><p>Острый риносинусит - одно из самых частых заболеваний в мире. По данным статистики, в России ежегодно регистрируется около 10 млн случаев. Острый бактериальный риносинусит в большинстве случаев развивается в исходе острого респираторного вирусного заболевания, протекает легко и не требует назначения антибактериальной терапии. Однако значительно снижается качество жизни пациента при средней и тяжелой степени ОБРС, а при отсутствии своевременного лечения может привести к внутричерепным (менингит, энцефалит, внутричерепные абсцессы и др.) и орбитальным (реактивный отек века, флегмона орбиты, периорбитальные абсцессы и др.) осложнениям. Во избежание осложнений при отягощенном течении риносинусита необходимо правильно выбрать антибактериальную терапию с учетом резистентности микроорганизмов, вызвавших заболевание.</p><p>В статье описываются принципы дифференциальной диагностики бактериального риносинусита согласно последним рекомендациям и исследованиям в этой области; приводятся наиболее частые антибиотикорезистентные возбудители, встречающиеся в практике лор-врача, рассматривается вопрос о выборе правильной системной антибактериальной терапии для лечения пациентов со среднетяжелым и тяжелым течением острого бактериального риносинусита согласно современным данным о чувствительности бактериальных патогенов к назначаемым в практике врача-оториноларинголога антибактериальным препаратам. Приводятся данные о новом универсальном цефалоспорине 3-го поколения, действующим веществом которого является цефдиторен, в качестве препарата второй и третьей линии в связи с его высокой активностью к большинству возбудителей острого бактериального риносинусита, и клиническое наблюдение с использованием вышеприведенного антибактериального средства в рамках рассматриваемой темы.</p></abstract><trans-abstract xml:lang="en"><p>Acute rhinosinusitis is one of the most common diseases in the world. According to statistics, about 10 million cases are registered in Russia every year.</p><p>Acute bacterial rhinosinusitis (ABRS) in most cases develops as a result of an acute respiratory viral disease, proceeds easily and it does not require antibiotic therapy. However, it significantly reduces the patient's quality of life in cases of moderate and severe disease, and in the absence of timely treatment, can lead to intracranial complications (meningitis, encephalitis, intracranial abscesses, etc.) and orbital (reactive edema of the eyelid, phlegmon of the orbit, periorbital abscesses, etc.). To avoid complications, with exacerbation of rhinosinusitis, it is necessary to choose the right antibiotic therapy, taking into account the resistance of the microorganisms that caused the disease.</p><p>The article describes the differential diagnosticprinciples of bacterial rhinosinusitis according to the latest recommendations and research in this area, the most common antibiotic-resistant pathogens in the practice of an ENT doctor are presented, the issue of choosing the correct systemic antibiotic therapy for the treatment of patients with moderate and severe acute bacterial rhinosinusitis is considered according to modern data on the sensitivity of bacterial pathogens to antibacterial drugs prescribed in the otorhinolaryngologist's practice. The article presents data on a new universal cephalosporin of the 3rd generation (the active ingredient is cefditoren), as a second- and third-line drug, due to its high activity against most causative agents of acute bacterial rhinosinusitis, and clinical observation using the above antibacterial agent within the framework of the considered topics.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бактериальный синусит</kwd><kwd>резистентные микроорганизмы</kwd><kwd>антибиотики</kwd><kwd>цефалоспорины</kwd><kwd>цефдиторен</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bacterial rhinosinusitis</kwd><kwd>antibiotics</kwd><kwd>resistant microorganisms</kwd><kwd>cephalosporins</kwd><kwd>cefditoren</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenfeld R.M., Piccirillo J.F., Chandrasekhar S.S., Brook I., Ashok Kumar K., Kramper M. et al. Clinical practice guideline (update): Adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl.):S1-S39. https://doi.org/10.1177/0194599815572097.</mixed-citation><mixed-citation xml:lang="en">Rosenfeld R.M., Piccirillo J.F., Chandrasekhar S.S., Brook I., Ashok Kumar K., Kramper M. et al. Clinical practice guideline (update): Adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl.):S1-S39. https://doi.org/10.1177/0194599815572097.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Esposito S., Marchisio P., Tenconi R., Tagliaferri L., Albertario G., Patria M.F., Principi N. Diagnosis of acute rhinosinusitis. Pediatr Allergy Immunol. 2012;23(22 Suppl.):17-19. https://doi.org/10.1111/j.1399-3038.2 012.01319.x.</mixed-citation><mixed-citation xml:lang="en">Esposito S., Marchisio P., Tenconi R., Tagliaferri L., Albertario G., Patria M.F., Principi N. Diagnosis of acute rhinosinusitis. Pediatr Allergy Immunol. 2012;23 (22 Suppl.):17-19. https://doi.org/10.1111/j.1399-3038.2012.01319.x.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Дербенева М.Л., Гусева А.Л. Острый риносинусит: диагностика и лечение. Consilium Medicum. 2018;20(3):58-60. Режим доступа: https://cyberleninka.ru/article/n/ostryy-rinosinusit-diagnostika-i-lechenie.</mixed-citation><mixed-citation xml:lang="en">Derbeneva M.L., Guseva A.L. Acute rhinosinusitis: diagnosis and treatment. Consilium Medicum. 2018;20(3):58-60. (In Russ.) Available at: https://cyberleninka.ru/article/n/ostryy-rinosinusit-diagnostika-i-lechenie.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Smith S.S., Ference E.H., Evans C.T., Tan B.K., Kern R.C., Chandra R.K. The prevalence of bacterial infection in acute rhinosinusitis: A systematic review and meta-analysis. Laryngoscope. 2015;125(1):57-69. https://doi.org/10.1002/lary.24709.</mixed-citation><mixed-citation xml:lang="en">Smith S.S., Ference E.H., Evans C.T., Tan B.K., Kern R.C., Chandra R.K. The prevalence of bacterial infection in acute rhinosinusitis: A systematic review and meta-analysis. Laryngoscope. 2015;125(1):57-69. https://doi.org/10.1002/lary.24709.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Loftus P.A., Lin J., Tabaee A. Anatomic variants of the paranasal sinuses in patients with recurrent acute rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(3):328-333. https://doi.org/10.1002/alr.21658.</mixed-citation><mixed-citation xml:lang="en">Loftus P.A., Lin J., Tabaee A. Anatomic variants of the paranasal sinuses in patients with recurrent acute rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(3):328-333. https://doi.org/10.1002/alr.21658.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fokkens W.J., Lund V.J., Hopkins C., Hellings P.W., Kern R., Reitsma S. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;(29 Suppl.):1-464. https://doi.org/10.4193/Rhin20.600.</mixed-citation><mixed-citation xml:lang="en">Fokkens W.J., Lund V.J., Hopkins C., Hellings P.W., Kern R., Reitsma S. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;(29 Suppl.):1-464. https://doi.org/10.4193/Rhin20.600.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lemiengre M.B., van Driel M.L., Merenstein D., Liira H., Makela M., De Sutter A.I.M. Antibiotics for acute rhinosinusitis in adults. Cochrane Database Syst Rev. 2012;10:CD006089. Available at: https://pubmed.ncbi.nlm.nih.gov/23076918.</mixed-citation><mixed-citation xml:lang="en">Lemiengre M.B., van Driel M.L., Merenstein D., Liira H., Makela M., De Sutter A.I.M. Antibiotics for acute rhinosinusitis in adults. Cochrane Database Syst Rev. 2012;10:CD006089. Available at: https://pubmed.ncbi.nlm.nih.gov/23076918.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Еремин С.А., Рязанцев С.В., Коноплев О.И. Рациональный выбор антибактериального препарата для терапии ЛОР-органов в амбулаторной практике. Медицинский совет. 2018;(20):8-12. https://doi.org/10.21518/2079-701X-2018-20-8-12.</mixed-citation><mixed-citation xml:lang="en">Eremin S.A., Ryazantsev S.V., Konoplev O.I. Rational choice of antibacterial drug for the treatment of ent organs in outpatient practice. Meditsinskiy sovet = Medical Council. 2018;(20):8-12. (In Russ.) https://doi.org/10.21518/2079-701X-2018-20-8-12.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кочетков П.А., Фатьянова Е.И. Острый риносинусит: современные подходы к диагностике и лечению. Медицинский совет. 2017;(8):130-136. https://doi.org/10.21518/2079-701X-2017-8-130-136.</mixed-citation><mixed-citation xml:lang="en">Kochetkov P.A., Fatyanova E.I. Acute Rhinosinusitis: actual approaches to diagnosis and treatment. Meditsinskiy sovet = Medical Council. 2017;(8):130-136. (In Russ.) https://doi.org/10.21518/2079-701X-2017-8-130-136.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Desrosiers M. Diagnosis and management of acute rhinosinusitis. Postgrad Med. 2009;121(3):83-89. https://doi.org/10.3810/pgm.2009.05.2006.</mixed-citation><mixed-citation xml:lang="en">Desrosiers M. Diagnosis and management of acute rhinosinusitis. Postgrad Med. 2009;121(3):83-89. https://doi.org/10.3810/pgm.2009.05.2006.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Berg O., Carenfelt C. Analysis of symptoms and clinical signs in the maxillary sinus empyema. Acta Otolaryngol. 1988;105(3-4):343-349. https://doi.org/10.3109/00016488809097017.</mixed-citation><mixed-citation xml:lang="en">Berg O., Carenfelt C. Analysis of symptoms and clinical signs in the maxillary sinus empyema. Acta Otolaryngol. 1988;105(3-4):343-349. https://doi.org/10.3109/00016488809097017.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen J.G., Hojbjerg T., Rosborg J. Symptoms and signs in culture-proven acute maxillary sinusitis in a general practice population. APMIS. 2009;117(10): 724-729. https://doi.org/10.1111/j.1600-0463.2009.02526.x.</mixed-citation><mixed-citation xml:lang="en">Hansen J.G., Hojbjerg T., Rosborg J. Symptoms and signs in culture-proven acute maxillary sinusitis in a general practice population. APMIS. 2009;117(10): 724-729. https://doi.org/10.1111/j.1600-0463.2009.02526.x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Autio T.J., Koskenkorva T., Leino T.K., Koivunen P., Alho O.P. Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis. Laryngoscope. 2017;127(2):55-61. https://doi.org/10.1002/lary.26344.</mixed-citation><mixed-citation xml:lang="en">Autio T.J., Koskenkorva T., Leino T.K., Koivunen P., Alho O.P. Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis. Laryngoscope. 2017;127(2):55-61. https://doi.org/10.1002/lary.26344.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ebell M.H., McKay B., Dale A., Guilbault R., Ermias Y. Accuracy of signs and symptoms for the diagnosis of acute rhinosinusitis and acute bacterial rhinosinusitis. Ann Fam Med. 2019;17(2):164-172. https://doi.org/10.1370/afm.2354.</mixed-citation><mixed-citation xml:lang="en">Ebell M.H., McKay B., Dale A., Guilbault R., Ermias Y. Accuracy of signs and symptoms for the diagnosis of acute rhinosinusitis and acute bacterial rhinosinusitis. Ann Fam Med. 2019;17(2):164-172. https://doi.org/10.1370/afm.2354.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Franck N., Zehtabchi S. Antibiotics for acute rhinosinusitis in adults. Am Fam Physician. 2019;100(7):402A-402B. Available at: https://pubmed.ncbi.nlm.nih.gov/31573155.</mixed-citation><mixed-citation xml:lang="en">Franck N., Zehtabchi S. Antibiotics for acute rhinosinusitis in adults. Am Fam Physician. 2019;100(7):402A-402B. Available at: https://pubmed.ncbi.nlm.nih.gov/31573155.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Piltcher O.B., Kosugi E.M., Sakano E., Mion O., Testa J.R.G, Romano F.R. et al. How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel. Braz J Otorhinolaryngol. 2018;84(3):265-279. https://doi.org/10.1016/j.bjorl.2018.02.001.</mixed-citation><mixed-citation xml:lang="en">Piltcher O.B., Kosugi E.M., Sakano E., Mion O., Testa J.R.G, Romano F.R. et al. How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel. Braz J Otorhinolaryngol. 2018;84(3):265-279. https://doi.org/10.1016/j.bjorl.2018.02.001.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Кривопалов А.А. Риносинусит: классификация, эпидемиология, этиология и лечение. Медицинский совет. 2016;(6):22-25. https://doi.org/10.21518/2079-701X-2016-6-22-25.</mixed-citation><mixed-citation xml:lang="en">Krivopalov A.A. Rhinosinusitis: classification, epidemiology, etiology and treatment. Meditsinskiy sovet = Medical Council. 2016;(6):22-25. (In Russ.) https://doi.org/10.21518/2079-701X-2016-6-22-25.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Кривопалов А.А. Осложненные формы острого бактериального риносинусита у взрослых: этиология, патогенетические принципы и организация лечения. Медицинский совет. 2015;(4):20-25. Режим доступа: https://med-sovet.pro/jour/article/view/148.</mixed-citation><mixed-citation xml:lang="en">Krivopalov A.A. Complicated forms of acute bacterial rhinosinusitis in adults: etiology, pathogenetic principles and management. Meditsinskiy sovet = Medical Council. 2015;(4):20-25. (In Russ.) Available at: https://med-sovet.pro/jour/article/view/148.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Carr T.F. Complications of sinusitis. Am J Rhinol Allergy. 2016;30(4):241-245. https://doi.org/10.2500/ajra.2016.30.4322.</mixed-citation><mixed-citation xml:lang="en">Carr T.F. Complications of sinusitis. Am J Rhinol Allergy. 2016;30(4):241-245. https://doi.org/10.2500/ajra.2016.30.4322.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jaume F., Valls-Mateus M., Mullol J. Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020. Curr Allergy Asthma Rep. 2020;20(7):28. https://doi.org/10.1007/s11882-020-00917-5.</mixed-citation><mixed-citation xml:lang="en">Jaume F., Valls-Mateus M., Mullol J. Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020. Curr Allergy Asthma Rep. 2020;20(7):28. https://doi.org/10.1007/s11882-020-00917-5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Кривопалов А.А., Смирнов А.П. Применение рокситромицина в терапии острых бактериальных риносинуситов. Медицинский совет. 2018;(21): 61-65. https://doi.org/10.21518/2079-701X-2018-21-61-65.</mixed-citation><mixed-citation xml:lang="en">Krivopalov A.A., Smirnov A.P The use of roxithromycin in the treatment of acute bacterial rhinosinusitis. Meditsinskiy sovet = Medical Council. 2018;(21):61-65. (In Russ.) https://doi.org/10.21518/2079-701X-2018-21-61-65.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Рязанцев С.В., Хамгушкеева Н.Н., Еремин С.А. Антибактериальная терапия острого риносинусита препаратом Цефдиторен. Медицинский совет. 2017;(8):50-52. https://doi.org/10.21518/2079-701X-2017-8-50-52.</mixed-citation><mixed-citation xml:lang="en">Ryazantsev S.V., Khamgushkeeva N.N., Eremin S.A. Antibacterial therapy of acute rinosinusitis by cefditoren. Meditsinskiy sovet = Medical Council. 2017;(8):50-52. (In Russ.) https://doi.org/10.21518/2079-701X-2017-8-50-52.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Felmingham D., Reinert R.R., Hirakata Y., Rodloff A. Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and comparative in vitro activity of the ketolide, telithromycin. J Antimicrob Chemother. 2002;(50 Suppl.): 25-37. https://doi.org/10.1093/jac/dkf808.</mixed-citation><mixed-citation xml:lang="en">Felmingham D., Reinert R.R., Hirakata Y., Rodloff A. Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and comparative in vitro activity of the ketolide, telithromycin. J Antimicrob Chemother. 2002;(50 Suppl.): 25-37. https://doi.org/10.1093/jac/dkf808.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hadley J.A., Pfaller M.A. Oral b-lactams in the treatment of acute bacterial rhinosinusitis. Diagn Microbiol Infect Dis. 2007;57(3):47-54. https://doi.org/10.1016/j.diagmicrobio.2006.11.018.</mixed-citation><mixed-citation xml:lang="en">Hadley J.A., Pfaller M.A. Oral b-lactams in the treatment of acute bacterial rhinosinusitis. Diagn Microbiol Infect Dis. 2007;57(3):47-54. https://doi.org/10.1016/j.diagmicrobio.2006.11.018.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sahm D.F., Benninger M.S., Evangelista A.T., Yee Y.C., Thornsberry C., Brown N.P. Antimicrobial resistance trends among sinus isolates of Streptococcus pneumoniae in the United States (2001-2005). Otolaryngol Head Neck Surg. 2007;136(3):385-389. https://doi.org/10.1016/j.otohns.2006.09.016.</mixed-citation><mixed-citation xml:lang="en">Sahm D.F., Benninger M.S., Evangelista A.T., Yee Y.C., Thornsberry C., Brown N.P. Antimicrobial resistance trends among sinus isolates of Streptococcus pneumoniae in the United States (2001-2005). Otolaryngol Head Neck Surg. 2007;136(3):385-389. https://doi.org/10.1016/j.otohns.2006.09.016.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Fenoll A., Granizo JJ., Aguilar L., Gimenez MJ., Aragoneses-Fenoll L., Hanquet G. et al. Temporal trends of invasive streptococcus pneumoniae serotypes and antimicrobial resistance patterns in Spain from 1979 to 2007. J Clin Microbiol. 2009;47(4):1012-1020. https://doi.org/10.1128/JCM.01454-08.</mixed-citation><mixed-citation xml:lang="en">Fenoll A., Granizo J.J., Aguilar L., Gimenez M.J., Aragoneses-Fenoll L., Hanquet G. et al. Temporal trends of invasive streptococcus pneumoniae serotypes and antimicrobial resistance patterns in Spain from 1979 to 2007. J Clin Microbiol. 2009;47(4):1012-1020. https://doi.org/10.1128/JCM.01454-08.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Fenoll A., Aguilar L., Vicioso M.D., Gimenez M.J., Robledo O., Granizo J.J. Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997—2009. BMC Infect Dis. 2011;11:239. https://doi.org/10.1186/1471-2334-11-239.</mixed-citation><mixed-citation xml:lang="en">Fenoll A., Aguilar L., Vicioso M.D., Gimenez M.J., Robledo O., Granizo J.J. Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997—2009. BMC Infect Dis. 2011;11:239. https://doi.org/10.1186/1471-2334-11-239.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Калиногорская О.С., Беланов С.С., Волкова М.О., Гостев В.В., Сидоренко С.В. Антибиотикорезистентность и серотиповый состав Streptococcus pneumoniae, выделенных у детей в Санкт-Петербурге в 2010-2013 гг. Антибиотики и химиотерапия. 2015;60(1-2):10-18. Режим доступа: https://antibiotics-chemotherapy.ru/jour/article/view/582.</mixed-citation><mixed-citation xml:lang="en">Kalinogorskaya O.S., Belanov S.S., Volkova M.O., Gostev V.V., Sidorenko S.V. Antibiotic Resistance and Serotype Pattern of Streptococcus pneumoniae Isolated from Children in St. Petersburg in 2010—2013. Antibiotiki i Khimioterapiya = Antibiotics and Chemotherapy. 2015;60(1-2):10-18. (In Russ.) Available at: https://antibiotics-chemotherapy.ru/jour/article/view/582.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999-2009 гг. Клиническая микробиология и антимикробная химиотерапия. 2010;12(4):329-341. Режим доступа: https://antibiotic-save.ru/files/pdf/antibiotic-resistance-streptococcus-pneumoniae.pdf.</mixed-citation><mixed-citation xml:lang="en">Kozlov R.S., Sivaya O.V., Kretchikova O.I., Ivanchik N.V. Antimicrobial Resistance of Streptococcus pneumoniae in Russia over the 1999-2009: Results of Multicenter Prospective Study PEHASus. Klinicheskaya Mikrobiologiya i Antim ikrobnaya Khimioterapiya = Clinical Microbiology and Antimicrobial Chemotherapy. 2010;12(4):329-341. (In Russ.) Available at: https://antibiotic-save.ru/files/pdf/antibiotic-resistance-streptococcus-pneumoniae.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Chow A.W., Benninger M.S., Brook I., Brozek J.L., Goldstein E.J.C., Hicks L.A. et al. Executive Summary: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults. Clin Infect Dis. 2012;54(8):1041-1045. https://doi.org/10.1093/cid/cir1043.</mixed-citation><mixed-citation xml:lang="en">Chow A.W., Benninger M.S., Brook I., Brozek J.L., Goldstein E.J.C., Hicks L.A. et al. Executive Summary: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults. Clin Infect Dis. 2012;54(8):1041-1045. https://doi.org/10.1093/cid/cir1043.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Gotoh K., Qin L., Watanabe K., Anh D.D., Huong P.L.T., Anh N.T.H. et al. Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam. J Infect Chemother. 2008;14(5):349-353. https://doi.org/10.1007/s10156-008-0632-1.</mixed-citation><mixed-citation xml:lang="en">Gotoh K., Qin L., Watanabe K., Anh D.D., Huong P.L.T., Anh N.T.H. et al. Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam. J Infect Chemother. 2008;14(5):349-353. https://doi.org/10.1007/s10156-008-0632-1.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bae S., Lee J., Lee J., Kim E., Lee S., Yu J., Kang Y. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: Results of a nationwide acute respiratory infections surveillance. Antimicrob Agents Chemother. 2010;54(1):65-71. https//doi.org/10.1128/AAC.00966-09.</mixed-citation><mixed-citation xml:lang="en">Bae S., Lee J., Lee J., Kim E., Lee S., Yu J., Kang Y. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: Results of a nationwide acute respiratory infections surveillance. Antimicrob Agents Chemother. 2010;54(1):65-71. https://doi.org/10.1128/AAC.00966-09.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs M.R., Bajaksouzian S., Zilles A., Lin G., Pankuch G.A., Appelbaum PC. Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. surveillance study. Antimicrob Agents Chemother. 1999;43(8):1901-1908. https//doi.org/10.1128/aac.43.8.1901.</mixed-citation><mixed-citation xml:lang="en">Jacobs M.R., Bajaksouzian S., Zilles A., Lin G., Pankuch G.A., Appelbaum PC. Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. surveillance study. Antimicrob Agents Chemother. 1999;43(8):1901-1908. https://doi.org/10.1128/aac.43.8.1901.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Белобородов В.Б. Клинические перспективы применения цефдиторена пивоксила - нового цефалоспорина 3-й генерации для приема внутрь. Эпидемиология и инфекционные болезни. 2016;21(4):219-225. https//doi.org/10.17816/EID40921.</mixed-citation><mixed-citation xml:lang="en">Beloborodov V.B. Clinical perspectives of Cefditoren pivoxil - new oral third generation cephalosporin. Ehpidemiologiya i infektsionnye bolezni = Epidemiol Infect Desease. 2016;21(4):219-225. (In Russ.) https://doi.org/10.17816/EID40921.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wang L.-M., Qiao X.-L., Ai L., Zhai J.-J., Wang X.-X. Isolation of antimicrobial resistant bacteria in upper respiratory tract infections of patients. 3 Biotech. 2016;6(2):166. https://doi.org/10.1007/s13205-016-0473-z.</mixed-citation><mixed-citation xml:lang="en">Wang L.-M., Qiao X.-L., Ai L., Zhai J.-J., Wang X.-X. Isolation of antimicrobial resistant bacteria in upper respiratory tract infections of patients. 3 Biotech. 2016;6(2):166. https://doi.org/10.1007/s13205-016-0473-z.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов Р.С., Дехнич А.В. Цефдиторен пивоксил: клинико-фармакологическая и микробиологическая характеристика. Клиническая микробиология и антимикробная химиотерапия. 2014;16(2):111-129. Режим доступа: https://cyberleninka.ru/article/n/tsefditoren-pivoksil-kliniko-farmakologicheskaya-i-mikrobiologicheskaya-harakteristika.</mixed-citation><mixed-citation xml:lang="en">Kozlov R.S., Dekhnich A.V. Cefditoren Pivoxil: Clinical, Pharmacological, and Microbiological Aspects. Klinicheskaya Mikrobiologiya i Antimikrobnaya Khimioterapiya = Clinical Microbiology and Antimicrobial Chemotherapy. 2014;16(2):111-129. (In Russ.) Available at: https://cyberleninka.ru/article/n/tsefditoren-pivoksil-kliniko-farmakologicheskaya-i-mikrobiologicheskaya-harakteristika.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wellington K., Curran M.P. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 2004;64(22):2597-2618. https://doi.org/10.2165/00003495-200464220-00009.</mixed-citation><mixed-citation xml:lang="en">Wellington K., Curran M.P. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 2004;64(22):2597-2618. https://doi.org/10.2165/00003495-200464220-00009.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Barberan J., Aguilar L., Gimenez MJ. Update on the clinical utility and optimal use of cefditoren. Int J Gen Med. 2012;5:455-464. https://doi.org/10.2147/IJGM.S25989.</mixed-citation><mixed-citation xml:lang="en">Barberan J., Aguilar L., Gimenez MJ. Update on the clinical utility and optimal use of cefditoren. Int J Gen Med. 2012;5:455-464. https://doi.org/10.2147/IJGM.S25989.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Jose Granizo J., Gimenez M.J., Barberdn J., Coronel P., Gimeno M., Aguilar L. The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: A pooled analysis of seven clinical trials. Clin Ther. 2006;28(12):2061-2069. https://doi.org/10.1016/j.clinthera.2006.12.010.</mixed-citation><mixed-citation xml:lang="en">Jose Granizo J., Gimenez M.J., Barberdn J., Coronel P., Gimeno M., Aguilar L. The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: A pooled analysis of seven clinical trials. Clin Ther. 2006;28(12):2061-2069. https://doi.org/10.1016/j.clinthera.2006.12.010.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Poachanukoon O., Kitcharoensakkul M. Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: A randomized, investigator-blinded, controlled trial. Clin Ther. 2008;30(10):1870-1879. https://doi. org/10.1016/j.clinthera.2008.10.001.</mixed-citation><mixed-citation xml:lang="en">Poachanukoon O., Kitcharoensakkul M. Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: A randomized, investigator-blinded, controlled trial. Clin Ther. 2008;30(10):1870-1879. https://doi.org/10.1016/j.clinthera.2008.10.001.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Савлевич Е.Л., Козлов В.С., Жарких М.А. Изучение эффективности и безопасности нового цефалоспоринового антибиотика при лечении острого бактериального риносинусита. Вестник оториноларингологии. 2016;6:73-77. https://doi.org/10.17116/otorino201681673-77.</mixed-citation><mixed-citation xml:lang="en">Savlevich E.L., Kozlov V.S., Zharkykh М.А. A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis. Vestnik otorinolaringologii = Bulletin of Otorhinolaryngology. 2016;6:73-77. (In Russ.) https://doi.org/10.17116/otorino201681673-77.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Garda-de-Lomas J., Lerma M., Cebrian L., Juan-Banon J.L., Coronel P., Gimenez MJ., Aguilar L. Influence of Haemophilus influenzae в-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins. Int J Antimicrob Agents. 2007;30(2):190-192. https://doi.org/10.1016/j.ijantimicag.2007.02.014.</mixed-citation><mixed-citation xml:lang="en">Garda-de-Lomas J., Lerma M., Cebrian L., Juan-Banon J.L., Coronel P., Gimenez MJ., Aguilar L. Influence of Haemophilus influenzae в-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins. Int J Antimicrob Agents. 2007;30(2):190-192. https://doi.org/10.1016/j.ijantimicag.2007.02.014.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez Artola B., Barberan J. Cefditoreno: una realidad para el tratamien-to de las infecciones comunitarias [Cefditoren: a reality for the treatment of community infections]. Rev Esp Quimioter. 2017;30(6):407-412. (Spanish). Available at: https://pubmed.ncbi.nlm.nih.gov/29199418/.</mixed-citation><mixed-citation xml:lang="en">Sanchez Artola B., Barberan J. Cefditoreno: una realidad para el tratamien-to de las infecciones comunitarias [Cefditoren: a reality for the treatment of community infections]. Rev Esp Quimioter. 2017;30(6):407-412. (Spanish). Available at: https://pubmed.ncbi.nlm.nih.gov/29199418/.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Gracia M., D^az C., Coronel P., Gimeno M., Garda-Rodas R., Rodnguez-Cerrato V. et al. Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program. Diagn Microbiol Infect Dis. 2009;64(1):52-56. https://doi.org/10.1016/j.diagmicrobio.2008.12.018.</mixed-citation><mixed-citation xml:lang="en">Gracia M., D^az C., Coronel P., Gimeno M., Garda-Rodas R., Rodriguez-Cerrato V. et al. Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program. Diagn Microbiol Infect Dis. 2009;64(1):52-56. https://doi.org/10.1016/j.diagmicrobio.2008.12.018.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Yang Q., Xu Y., Chen M., Wang H., Sun H., Hu Y. et al. In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae , and Moraxella catarrhalis causing community-acquired respiratory tract infections in China. Diagn Microbiol Infect Dis. 2012;73(2):187-191. https://doi.org/10.1016/j.diagmicrobio.2012.03.005.</mixed-citation><mixed-citation xml:lang="en">Yang Q., Xu Y., Chen M., Wang H., Sun H., Hu Y. et al. In vitro activity of cefditor-en and other comparators against Streptococcus pneumoniae, Haemophilus influenzae , and Moraxella catarrhalis causing community-acquired respiratory tract infections in China. Diagn Microbiol Infect Dis. 2012;73(2):187-191. https://doi.org/10.1016/j.diagmicrobio.2012.03.005.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Gimenez M., Aguilar L., Granizo J.J. Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults. Multidiscip Respir Med. 2018;13:40. https://doi.org/10.1186/s40248-018-0152-5.</mixed-citation><mixed-citation xml:lang="en">Gimenez M., Aguilar L., Granizo J.J. Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults. Multidiscip Respir Med. 2018;13:40. https://doi.org/10.1186/s40248-018-0152-5.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Soriano F., Gimenez M.-J., Aguilar L. Cefditoren in upper and lower community-acquired respiratory tract infections. Drug Des Devel Ther. 2011;5:85-94. https://doi.org/10.2147/DDDT.S9499.</mixed-citation><mixed-citation xml:lang="en">Soriano F., Gimenez M.-J., Aguilar L. Cefditoren in upper and lower community-acquired respiratory tract infections. Drug Des Devel Ther. 2011;5:85-94. https://doi.org/10.2147/DDDT.S9499.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada M., Watanabe T., Miyara T., Baba N., Saito J., Takeuchi Y., Ohsawa F. Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: Structural basis for its high antimicrobial activity. Antimicrob Agents Chemother. 2007;51(11):3902-3907. https://doi.org/10.1128/AAC.00743-07.</mixed-citation><mixed-citation xml:lang="en">Yamada M., Watanabe T., Miyara T., Baba N., Saito J., Takeuchi Y., Ohsawa F. Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: Structural basis for its high antimicrobial activity. Antimicrob Agents Chemother. 2007;51(11):3902-3907. https://doi.org/10.1128/AAC.00743-07.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Alou L., Gimenez MJ., Sevillano D., Aguilar L., Gonzalez N., Echeverna O. et al. Are в-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view? J Antimicrob Chemother. 2007;59(4):652-657. https://doi.org/10.1093/jac/dkm015.</mixed-citation><mixed-citation xml:lang="en">Alou L., Gimenez MJ., Sevillano D., Aguilar L., Gonzalez N., Echeverna O. et al. Are в-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view? J Antimicrob Chemother. 2007;59(4):652-657. https://doi.org/10.1093/jac/dkm015.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Brogard J.M., Comte F. Pharmacokinetics of the new cephalosporins. Antibiot Chemother. 1981;31:145-210. https://doi.org/10.1159/000400133.</mixed-citation><mixed-citation xml:lang="en">Brogard J.M., Comte F. Pharmacokinetics of the new cephalosporins. Antibiot Chemother. 1981;31:145-210. https://doi.org/10.1159/000400133.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Biedenbach D.J., Jones R.N. Update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations. Diagn Microbiol Infect Dis. 2009;64(2):202-212. https://doi.org/10.1016/j.diagmicrobio.2009.01.017.</mixed-citation><mixed-citation xml:lang="en">Biedenbach D.J., Jones R.N. Update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations. Diagn Microbiol Infect Dis. 2009;64(2):202-212. https://doi.org/10.1016/j.diagmicrobio.2009.01.017.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
