medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-1-115-120medsovet-6692Research ArticleГАСТРОЭНТЕРОЛОГИЯGASTROENTEROLOGYМладенческие колики: от теории к практикеInfant colic: from theory to practicehttps://orcid.org/0000-0003-3204-1846КаннерЕ. В.KannerE. V.

 д.м.н., старший научный сотрудник клинического отдела инфекционной патологии 

111123, Россия, Москва, ул. Новогиреевская, д. 3А

 Dr. Sci. (Med.), Senior Researcher of the Clinical Department of Infectious Pathology

3А, Novogireevskaya St., Moscow, 111123, Russia 

ekanner@mail.ruhttps://orcid.org/0000-0002-8979-8084МаксимовМ. Л.MaksimovM. L.

 д.м.н., главный внештатный специалист – клинический фармаколог Министерства здравоохранения Республики Татарстан, заведующий кафедрой клинической фармакологии и фармакотерапии; профессор кафедры фармакологии педиатрического факультета 

420012, Россия, Казань, ул. Бутлерова, д. 36

117997, Россия, Москва, ул. Островитянова, д. 1

 Dr. Sci. (Med.), Chief Freelance Specialist – Clinical Pharmacologist of the Ministry of Health of the Republic of Tatarstan, Head of the Department of Clinical Pharmacology and Pharmacotherapy; Pofessor of the Department of Pharmacology of the Pediatric Faculty

36, Butlerov St., Kazan, 420012, Russia

1, Ostrovityanov St., Moscow, 117997, Russia 

maksim_maksimov@mail.ruhttps://orcid.org/0000-0003-4632-0547КаннерИ. Д.KannerI. D.

 студент 4-го курса 

119991, Россия, Москва, Ленинские горы, д. 1 

 4th Year Student

1, Leninskie Gory, Moscow, 119991, Russia 

dwilya4@mail.ruhttps://orcid.org/0000-0001-6078-9240ЛапкинН. М.LapkinN. M.

 студент 6-го курса 

150000, Россия, Ярославль, ул. Революционная, д. 5 

6th Year Student

5, Revolyutsionnaya St., Yaroslavl, 150000, Russia 

nikita.n98@yandex.ruhttps://orcid.org/0000-0001-9257-0171ГореловА. В.GorelovA. V.

 чл.-корр. РАН, д.м.н., профессор, заместитель директора по научной работе; профессор кафедры детских болезней 

111123, Россия, Москва, ул. Новогиреевская, д. 3А 

119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2 

 Сorr. Member RAS, Dr. Sci. (Med.), Professor, Deputy Director for Scientific Work; Professor of the Department of Children’s Diseases

3А, Novogireevskaya St., Moscow, 111123, Russia

8, Bld. 2, Trubetskaya St., Moscow, 119991, Russia 

crie@pcr.ruЦентральный научно-исследовательский институт эпидемиологииРоссияCentral Research Institute of EpidemiologyRussian FederationКазанская государственная медицинская академия – филиал Российской медицинской академии непрерывного профессионального образования; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияKasan State Medical Academy – Branch of the Russian Medical Academy of Continuous Professional Education; Pirogov Russian National Research Medical UniversityRussian FederationМосковский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian FederationЯрославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian FederationЦентральный научно-исследовательский институт эпидемиологии; Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияCentral Research Institute of Epidemiology; Sechenov First Moscow State Medical University (Sechenov University)Russian Federation20220103202201115120Copyright © Каннер Е.В., Максимов М.Л., Каннер И.Д., Лапкин Н.М., Горелов А.В., 20222022Каннер Е.В., Максимов М.Л., Каннер И.Д., Лапкин Н.М., Горелов А.В.Kanner E.V., Maksimov M.L., Kanner I.D., Lapkin N.M., Gorelov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6692

Младенческие колики относятся к числу наиболее частых, но при этом наименее изученных функциональных расстройств желудочно-кишечного тракта. До сегодняшнего дня нет определенности как в понимании сущности данного состояния, так и в подходах к его коррекции. В то же время младенческий плач вызывает тревогу у родителей, заставляя их обращаться за профессиональной помощью и нести значительные расходы на медицинское обслуживание, а врача, порой необоснованно, прибегать к диетической и медикаментозной коррекции. В статье на основе анализа современной литературы представлена информация об этиологии, патогенезе и коррекции младенческих колик с точки зрения доказательной медицины. Детально анализируются различные предпосылки возникновения и развития младенческих колик, ни одна из которых не может затронуть все случаи возникновения. Приведены данные о доказанной эффективности включения Lactobacillus reuteri в терапию кишечных колик у младенцев. Воздействие на микробиом желудочно-кишечного тракта могут принести несомненную пользу. Lactobacillus reuteri являются одними из наиболее изученных и научно задокументированных пробиотиков. 203 завершенных клинических испытания с участием 17 200 человек, в том числе 67 исследований в возрасте от 0 до 3 лет с участием 8 200 человек. Многочисленные плацебо-контролируемые исследования показали, что прием Lactobacillus reuteri DSM 17938 может значительно сократить время плача у младенцев с коликами, и в таких исследованиях показатели снижения времени плача на 50% и более были в 2,3 раза выше по сравнению с контролем.

Infant colic is one of the most common, yet least studied, functional disorders of the gastrointestinal tract. Until now, there is no certainty both in the understanding of the nature of this condition and in the approaches to its correction. At the same time, infant crying is of concern to parents, forcing them to seek professional help and incur considerable medical expenses and to resort, sometimes unreasonably, to dietary and medical corrections. This article provides information on the etiology, pathogenesis and management of infantile colic from an evidence-based perspective, based on a review of the current literature. Various preconditions for the occurrence and development of infantile colic are analysed in detail, none of which can affect all occurrences. Evidence for the proven efficacy of including Lactobacillus reuteri in the treatment of intestinal colic in infants is presented. Effects on the gastrointestinal tract microbiome can be of undeniable benefit. Lactobacillus reuteri is one of the most studied and scientifically documented probiotics. 203 completed clinical trials involving 17,200 participants, including 67 trials involving 8,200 participants between 0 and 3 years of age. Numerous placebo-controlled studies have shown that taking Lactobacillus reuteri DSM 17938 can significantly reduce crying time in infants with colic, and in these studies, rates of 50% or more reduction in crying time were 2.3 times higher compared to controls.

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The authors declare that there are no conflicts of interest present.