medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-1-134-141medsovet-6695Research ArticleНЕФРОЛОГИЯ / УРОЛОГИЯNEPHROLOGY / UROLOGYПандемия COVID-19 и поражение почек у детей: обзор литературы и собственные региональные наблюденияCOVID-19 pandemic and kidney disease in children: literature review and own regional observationshttps://orcid.org/0000-0003-1430-6708БорисоваО. В.BorisovaO. V.

 д.м.н., профессор, заведующая кафедрой детских инфекций 

 443099, Россия, Самара, ул. Чапаевская, д. 89 

Dr. Sci. (Med.), Professor, Head of the Department of Children’s Infections

89, Chapaevskaya St., Samara, 443099, Russia 

kaf_di@samsmu.ruhttps://orcid.org/0000-0003-3934-8699МаковецкаяГ. А.MakovetskayaG. A.

 д.м.н., профессор, профессор кафедры госпитальной педиатрии  

 443099, Россия, Самара, ул. Чапаевская, д. 89 

 Dr. Sci. (Med.), Professor, Honored Scientist of Russia, Professor at the Department of Hospital Pediatrics 

89, Chapaevskaya St., Samara, 443099, Russia 

kaf_gped@samsmu.ruhttps://orcid.org/0000-0002-4373-0703МазурЛ. И.MazurL. I.

 д.м.н., профессор, заведующая кафедрой госпитальной педиатрии

 443099, Россия, Самара, ул. Чапаевская, д. 89 

 Dr. Sci. (Med.), Professor, Head of the Department of Hospital Pediatrics 

89, Chapaevskaya St., Samara, 443099, Russia 

https://orcid.org/0000-0002-4603-3209БочкареваН. М.BochkarevaN. M.

 к.м.н., доцент кафедры детских инфекций

 443099, Россия, Самара, ул. Чапаевская, д. 89 

 Cand. Sci. (Med.), Associate Professor of the Department of Children’s Infections,

89, Chapaevskaya St., Samara, 443099, Russia 

https://orcid.org/0000-0003-4994-2608БариновВ. Н.BarinovV. N.

 к.м.н., заведующий нефрологическим отделением

 443095, Россия, Самара, ул. Ташкентская, д. 159

Cand. Sci. (Med.), Head of the Nephrology Department

159, Tashkentskaya St., Samara, 443095, Russia 

ЯшкинаО. Н.YashkinaO. N.

 аспирант кафедры детских инфекций 

 443099, Россия, Самара, ул. Чапаевская, д. 89 

 Postgraduate Student of the Department of Children’s Infections

89, Chapaevskaya St., Samara, 443099, Russia 

КолесниковС. А.KolesnikovS. A.

 старший лаборант кафедры детских инфекций 

 443099, Россия, Самара, ул. Чапаевская, д. 89 

 Senior Laboratory Assistant of the Department of Children’s Infections 

89, Chapaevskaya St., Samara, 443099, Russia 

РешетоваС. Н.ReshetovaS. N.

 старший лаборант кафедры госпитальной педиатрии 

 443099, Россия, Самара, ул. Чапаевская, д. 89 

Senior Laboratory Assistant of the Department of Hospital Pediatrics 

89, Chapaevskaya St., Samara, 443099, Russia 

Самарский государственный медицинский университетРоссияSamara State Medical UniversityRussian FederationСамарская областная клиническая больница имени В.Д. СередавинаРоссияSeredavin Samara Regional Clinical HospitalRussian Federation20220103202201134141Copyright © Борисова О.В., Маковецкая Г.А., Мазур Л.И., Бочкарева Н.М., Баринов В.Н., Яшкина О.Н., Колесников С.А., Решетова С.Н., 20222022Борисова О.В., Маковецкая Г.А., Мазур Л.И., Бочкарева Н.М., Баринов В.Н., Яшкина О.Н., Колесников С.А., Решетова С.Н.Borisova O.V., Makovetskaya G.A., Mazur L.I., Bochkareva N.M., Barinov V.N., Yashkina O.N., Kolesnikov S.A., Reshetova S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6695

Введение. В настоящее время во всем мире продолжается пандемия коронавирусной инфекции, вызванная вирусом SARS-CoV-2. Данные исследований отечественных и зарубежных авторов свидетельствуют, что почки являются таргетным органом для новой инфекции, поражения которых варьируются от протеинурии и гематурии до острого повреждения почек.Цель исследования – определить частоту и характер поражения почек у детей с подтвержденной коронавирусной инфекцией.Материалы и методы. Проведен ретроспективный и проспективный анализ случаев подтвержденной инфекции COVID-19 у детей (n = 441), госпитализированных в Самарскую областную детскую инфекционную больницу с марта 2020 г. по июль 2021 г. У всех пациентов обнаружена РНК SARS-CoV-2 методом одностадийной реакции обратной транскриптации, совмещенной с полимеразной цепной реакцией. Изучены изменения со стороны почек, возникшие у 57 детей. Результаты исследования обработаны с применением программы Statistica 7.0 (StatSoft, США).Результаты. Вовлечение почек в инфекционный процесс выявлено у каждого 8-го ребенка с COVID-19 (12,9%) чаще в виде изолированного мочевого синдрома, частота выявления которого коррелировала с тяжестью течения коронавирусной инфекции: при тяжелом течении протеинурия определена у 31,6% пациентов, гематурия – у 21%, острое повреждение почек – у 10,5%, диабетическая нефропатия – у 5,3%. Повреждение почек сочеталось с поражением респираторного и желудочно-кишечного трактов, характеризовалось быстрым восстановлением диуреза и показателей азотемии без проведения специальной почечной терапии. Описан клинический случай дебюта нефротического синдрома, развившегося через 2 нед. после перенесенной коронавирусной инфекции.Выводы. Дети с COVID-19 требуют проведения мониторинга функции почек для раннего выявления нарушений и их коррекции при необходимости. Пациенты с изолированным мочевым синдромом в острый период нуждаются в длительном наблюдении с целью выявления скрытой почечной патологии.

Introduction. Currently, the coronavirus infection pandemic caused by the SARS-CoV-2 virus continues around the world. Research data from domestic and foreign authors indicate that the kidneys are a target organ for a new infection, lesions vary from proteinuria and hematuria to acute kidney injury.Aim of the study – to determine the frequency and nature of kidney damage in children with confirmed coronavirus infection.Materials and methods. A retrospective and prospective analysis of cases of confirmed COVID-19 infection in children (n = 441) admitted to the Samara Regional Children’s Infectious Diseases Hospital from March 2020 to July 2021 was carried out. SARSCoV-2 RNA was detected in all patients by a one-step reverse transcription reaction combined with a polymerase chain reaction. The changes in the kidneys that occurred in 57 children were studied. The research results were processed using the Statistica 7.0 software (StatSoft, USA).Results. The involvement of the kidneys in the infectious process was detected in every 8 children with COVID-19 (12.9%), more often in the form of isolated urinary syndrome, the detection rate of which correlated with the severity of the course of coronavirus infection: in severe cases, proteinuria was detected in 31.6% of patients, hematuria – in 21%, acute kidney injury – in 10.5%, diabetic nephropathy – in 5.3%. Kidney damage was combined with damage to the respiratory and gastrointestinal tract, characterized by rapid recovery of urine output and azotemia parameters without special renal therapy. A clinical case of the onset of nephrotic syndrome that developed 2 weeks after suffering a coronavirus infection is described.Conclusions. Children with COVID-19 require kidney function monitoring for early detection and correction in case of impairment. Patients with isolated urinary syndrome in the acute period require long-term observation in order to detect latent renal pathology.

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The authors declare that there are no conflicts of interest present.