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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2022-16-3-32-36</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ КОЖИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Экзема кистей: возможные риски и выбор терапии</article-title><trans-title-group xml:lang="en"><trans-title>Hand eczema: possible risks and choice of therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2027-5987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сакания</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sakaniya</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-дерматовенеролог, младший научный сотрудник; врач-дерматовенеролог, косметолог, трихолог</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p><p>127473, Москва, ул. Селезневская, д. 20</p></bio><bio xml:lang="en"><p>Dermatovenerologist, Junior Researcher; Dermatovenerologist, Cosmetologist, Trichologist</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029;</p><p>20, Seleznevskaya St., Moscow, 127473</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3235-6461</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смолкина</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Smolkina</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник; врач-дерматовенеролог</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30;</p><p>117513, Москва, ул. Островитянова, д. 6</p></bio><bio xml:lang="en"><p>Junior Researcher; Dermatovenerologist</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029; </p><p>6, Ostrovityanov St., Moscow, 117513</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-0318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корсунская</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korsunskaya</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая лабораторией</p><p>127473, Россия, Москва, ул. Селезневская, д. 20;</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p><p> </p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Head of the Laboratory</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029;</p><p>20, Seleznevskaya St., Moscow, 127473</p></bio><email xlink:type="simple">marykor@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Центр теоретических проблем физико-химической фармакологии Российской академии наук; Московский научно-практический центр дерматовенерологии и косметологии<country>Россия</country></aff><aff xml:lang="en">Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences; Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Центр теоретических проблем физико-химической&#13;
фармакологии Российской академии наук; Научно-клинический&#13;
консультативный центр аллергологии и иммунологии<country>Россия</country></aff><aff xml:lang="en">Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences; Scientific and Clinical Consulting Center of Allergology and Immunology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Центр теоретических проблем физико-химической&#13;
фармакологии Российской академии наук; Московский научно-практический центр дерматовенерологии и косметологии<country>Россия</country></aff><aff xml:lang="en">Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences; Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>11</day><month>03</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>32</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сакания Л.Р., Смолкина О.Ю., Корсунская И.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Сакания Л.Р., Смолкина О.Ю., Корсунская И.М.</copyright-holder><copyright-holder xml:lang="en">Sakaniya L.R., Smolkina O.Y., Korsunskaya I.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6732">https://www.med-sovet.pro/jour/article/view/6732</self-uri><abstract><p>Экзема рук довольно часто встречаемое заболевание – до 5% в общей популяции. Кроме того, экзема тесно связана с атопией и, как и атопический дерматит, с мутацией в гене FLG. Помимо генетических факторов, причиной экземы являются внешние раздражители и токсические вещества. Экзема часто возникает в семьях с атопическими заболеваниями, в т. ч. астмой, аллергическим ринитом/сенной лихорадкой (и пищевой аллергией) и атопическим дерматитом. Эти заболевания имеют общий патогенез и часто встречаются вместе у одного человека и/или представителей одной семьи. Экзематозные высыпания нередко сопровождаются зудом. Этот симптом может привести не только к нарушениям сна, но и к присоединению вторичной инфекции. По некоторым данным, частота возникновения инфекций при экземе может достигать более 70%. В подобных случаях препаратами выбора становятся комбинированные глюкокортикостероиды (ГКС), в чьем составе помимо ГКС есть антимикотик и антибиотик. Наш практический опыт показывает высокую эффективность комбинации беклометазона дипропионата, гентамицина и клотримазола не только в случаях экземы, осложненной вторичной инфекцией, но и у пациентов с другими инфицированными хроническими дерматозами. В статье рассмотрены эти и другие практические аспекты и проблемы терапии экземы кистей, этиологические факторы, приводящие к развитию заболевания, приведены актуальные данные из клинических рекомендаций и руководств по лечению экземы.</p></abstract><trans-abstract xml:lang="en"><p>Hand eczema is a common disease – up to 5% in the general population. In addition, eczema is closely related to atopy and, like atopic dermatitis, to a mutation in the FLG gene. In addition to genetic factors, eczema is caused by external irritants and toxic substances. Eczema often occurs in families with atopic diseases, including asthma, allergic rhinitis/hay fever (and food allergies), and atopic dermatitis. These diseases share a common pathogenesis and often occur together in the same person and/or family. Eczematous rashes are often accompanied by itching. This symptom can lead not only to sleep disturbances but also to secondary infections. According to some data, the rate of infections in eczema can be more than 70%. In such cases, the drugs of choice are combined glucocorticosteroids (GC), which in addition to GC contain an antimycotic and an antibiotic. Our practical experience shows the high effectiveness of the combination of beclomethasone dipropionate, gentamicin, and clotrimazole not only in cases of eczema complicated by secondary infection but also in patients with other infected chronic dermatoses. This article reviews these and other practical aspects and problems in the treatment of hand eczema, discusses the etiological factors that lead to the development of the disease, and presents current data from clinical recommendations and guidelines for the treatment of eczema.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>экзема</kwd><kwd>вторичная инфекция</kwd><kwd>беклометазон дипропионат</kwd><kwd>клотримазол</kwd><kwd>гентамицин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>eczema</kwd><kwd>secondary infection</kwd><kwd>beclomethasone dipropionate</kwd><kwd>clotrimazole</kwd><kwd>gentamicin</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>статья подготовлена при поддержке компании «Гленмарк».</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>the article was prepared with support from Glenmark.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Stone K.D. 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