medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-3-63-68medsovet-6741Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESФакторы экспосома в патогенезе акнеExposome factors in the acne pathogenesishttps://orcid.org/0000-0001-8584-615XСмирноваИ. О.SmirnovaI. O.

д.м.н., доцент, профессор кафедры инфекционных болезней, эпидемиологии и дерматовенерологии; врач-дерматовенеролог Городского центра дерматологии и венерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9;

192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Dr. Sci. (Med.), Associate Professor, Professor of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034;

3, Volkovka river Emb., St Petersburg, 192102

driosmirnova@yandex.ruhttps://orcid.org/0000-0002-8007-8945ЖелонкинаА. О.ZhelonkinaA. O.

аспирант кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9;

192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Postgraduate Student of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034;

3, Volkovka river Emb., St Petersburg, 192102

lina.zhelonkina@gmail.comhttps://orcid.org/0000-0001-9013-3197ЖелонкинА. Р.ZhelonkinA. R.

аспирант кафедры инфекционных болезней, эпидемиологии и дерматовенерологии; врач-дерматовенеролог

199034, Санкт-Петербург, Университетская наб., д. 7/9;

192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Postgraduate Student of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034;

3, Volkovka river Emb., St Petersburg, 192102

good.tony@yandex.ruhttps://orcid.org/0000-0002-6489-4555ПетуноваЯ. Г.PetunovaY. G.

к.м.н., доцент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии; врач-дерматовенеролог Городского центра дерматологии и венерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9;

192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Cand. Sci. (Med.), Associate Professor of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034;

3, Volkovka river Emb., St Petersburg, 192102

yaninapetunova@yandex.ruhttps://orcid.org/0000-0002-8138-1639ШинН. В.ShinN. V.

к.м.н., доцент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9

Cand. Sci. (Med.), Associate Professor of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034

shinataly@mail.ruhttps://orcid.org/0000-0003-1744-7610БессаловаА. Ю.BessalovaA. Y.

к.м.н., врач-дерматовенеролог, врач-патологоанатом

191015, Санкт-Петербург, ул. Кирочная, д. 41

Cand. Sci. (Med.), Dermatovenerologist, Рathologist

41, Kirochnaya St., St Petersburg, 191015

doctor.bessalova@gmail.comhttps://orcid.org/0000-0002-6592-1914КуликоваЕ. А.KulikovaE. A.

к.м.н., врач-дерматовенеролог, косметолог, ассистент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9

Cand. Sci. (Med.), Dermatovenerologist, Сosmetologist, Аssistant of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034

dr.e.kulikova@yandex.ruhttps://orcid.org/0000-0002-1551-8115НовиковаН. Е.NovikovaN. E.

ординатор кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург, Университетская наб., д. 7/9

Resident of the Department of Infectious Diseases, Epidemiology and Dermatovenerology

7/9, Universitetskaya Еmb., St Petersburg, 199034

nadyalekseev@yandex.ruhttps://orcid.org/0000-0003-4699-1746ПташниковаП. Д.PtashnikovaP. D.

студент медицинского факультета

199034, Санкт-Петербург, Университетская наб., д. 7/9

 

Student of the Faculty of Medicine

7/9, Universitetskaya Еmb., St Petersburg, 199034

enternita7@yandex.ruСанкт-Петербургский государственный университет; Городской кожно-венерологический диспансерРоссияSt Petersburg State University; City Dermatovenerological DispensaryRussian FederationСанкт-Петербургский государственный университетРоссияSt Petersburg State UniversityRussian FederationСеверо-Западный государственный медицинский университет имени И.И. МечниковаРоссияNorth-Western State Medical University named after I.I. MechnikovRussian Federation202212032022036368Copyright © Смирнова И.О., Желонкина А.О., Желонкин А.Р., Петунова Я.Г., Шин Н.В., Бессалова А.Ю., Куликова Е.А., Новикова Н.Е., Пташникова П.Д., 20222022Смирнова И.О., Желонкина А.О., Желонкин А.Р., Петунова Я.Г., Шин Н.В., Бессалова А.Ю., Куликова Е.А., Новикова Н.Е., Пташникова П.Д.Smirnova I.O., Zhelonkina A.O., Zhelonkin A.R., Petunova Y.G., Shin N.V., Bessalova A.Y., Kulikova E.A., Novikova N.E., Ptashnikova P.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6741

Концепция экспосома, сформулированная более пятнадцати лет назад, все чаще обсуждается в современной научной литературе. Под термином «экспосом» понимают совокупную меру воздействия факторов окружающей среды на человека на протяжении всей его жизни (от пренатального периода до смерти) и связанной с ним биологической реакции. Сумма этих факторов оказывает существенное влияние на возникновение, характер течения и эффективность терапии мультифакториальных заболеваний. Кожа представляет собой пограничный орган и постоянно подвергается воздействиям окружающей среды, т. е. является мишенью для экспосома. Влияние компонентов последнего описано при старении кожи, атопическом дерматите, злокачественных новообразованиях кожи. Акне является одним из наиболее распространенных хронических воспалительных дерматозов. В последнее десятилетие отметается рост заболеваемости акне во всем мире, его раннее начало и затяжное течение с поражением взрослых мужчин и женщин. В обзоре представлен анализ данных об эффектах компонентов экспосома – характера питания, приема лекарственных препаратов, стресса, поллютантов – на характер течения акне. Особое внимание уделено немногочисленным данным о характере взаимодействия между компонентами экспосома и микробиома кожи, который, с одной стороны, участвует в патогенезе дерматозов, в т. ч. акне, а с другой – изменяется под влиянием факторов экспосома, выступая посредником между окружающей средой и организмом человека. Поиск факторов окружающей среды имеет под собой, по крайней мере, две цели: обнаружение потенциальных патогенетических звеньев, силы их взаимосвязи с клиническими проявлениями заболевания для разработки новых методов терапии, нацеленных на новые мишени, а также создание и рекомендация охранительного режима в отношении факторов с доказанным действием на течение заболевания пациентам, страдающим акне.

The concept of the exposome, formulated more than fifteen years ago, is increasingly discussed in the modern scientific literature. The term “exposome” is understood as a cumulative measure of the impact of environmental factors on an individual throughout his or her life (from the prenatal period to death) and the biological response associated with it. The sum of these factors has a significant impact on the occurrence, course, and treatment efficacy of multifactorial diseases. The skin is a border organ and is constantly exposed to environmental influences, i.e., it is a target for the exposome. The influence of the latter components has been described in skin aging, atopic dermatitis, and malignant skin neoplasms. Acne is one of the most common chronic inflammatory dermatoses. Over the past decade, the worldwide increase in the incidence of acne, its early onset and a prolonged course, affecting adult men and women, has been noted. The review presents an analysis of the data on the effects of the components of the exposome – diet, medications, stress, and pollutants - on the course of acne. Particular attention is paid to the few data on the nature of interaction between the components of the exposome and the skin microbiome, which, on the one hand, is involved in the pathogenesis of dermatoses, including acne, and, on the other hand, is changed under the influence of exposome factors, acting as an intermediary between the environment and the human body. The search for environmental factors has at least two objectives: the discovery of potential pathogenetic links, the strength of their relationship with the clinical manifestations of the disease to develop new therapies aimed at new targets; and the creation and recommendation of a protective regime for factors with a proven effect on the course of the disease, for patients suffering from acne.

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The authors declare that there are no conflicts of interest present.