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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2022-16-5-61-68</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6793</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Репродуктивное здоровье и ВРТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reproductive health and ART</subject></subj-group></article-categories><title-group><article-title>Состояние биоценоза влагалища у беременных женщин, проживающих в Ханты-Мансийском автономном округе – Югре</article-title><trans-title-group xml:lang="en"><trans-title>Status of biocenosis of vagina in pregnant women living in the Khanty-Mansi Autonomous Okrug–Yugra</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6711-1563</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyeva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьева Алина Викторовна, д.м.н., доцент кафедры акушерства и гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Alina V. Solovyeva, Dr. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology with the Course of Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">av_soloveva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9698-8038</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чегус</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chegus</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чегус Лариса Алексеевна, к.м.н., доцент кафедры акушерства и гинекологии</p><p>628011, Ханты-Мансийский автономный округ – Югра, Ханты-Мансийск, ул. Мира, д. 40</p></bio><bio xml:lang="en"><p>Larisa A. Chegus, Cand. Sci. (Med.), Associate Professor</p><p>40, Mira St., Khanty-Mansiysk, Khanty-Mansiysk Autonomous Okrug – Ugra, 628011</p></bio><email xlink:type="simple">lchegus@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4870-2282</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovev</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьев Владимир Георгиевич, д.м.н., профессор, заведующий кафедрой медицинской и биологической химии</p><p>628011, Ханты-Мансийский автономный округ – Югра, Ханты-Мансийск, ул. Мира, д. 40</p></bio><bio xml:lang="en"><p>Vladimir G. Solovev, Dr. Sci. (Med.), Professor, Department of  Medical and Biological Chemistry</p><p>40, Mira St., Khanty-Mansiysk, Khanty-Mansiysk Autonomous Okrug – Ugra, 628011</p></bio><email xlink:type="simple">vg.solovyev@hmgma.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4408-1378</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермоленко</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yermolenko</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ермоленко Кристина Станиславовна, к.м.н., ассистент кафедры акушерства и гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Kristina S. Yermolenko, Cand. Sci. (Med.), Assistant of the Obstetrics and Gynecology Department with a Course in Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">z.kristinast@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7093-877X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Ольга Алексеевна, к.м.н., доцент кафедры акушерства и гинекологии с курсом перинатологии</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Olga A. Kuznetsova, Cand. Sci. (Med.), Associate Professor of the Obstetrics and Gynecology Department with a Course in Perinatology</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">koa.15@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Ханты-Мансийская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Khanty-Mansiysk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>5</issue><fpage>61</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соловьева А.В., Чегус Л.А., Соловьев В.Г., Ермоленко К.С., Кузнецова О.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Соловьева А.В., Чегус Л.А., Соловьев В.Г., Ермоленко К.С., Кузнецова О.А.</copyright-holder><copyright-holder xml:lang="en">Solovyeva A.V., Chegus L.A., Solovev V.G., Yermolenko K.S., Kuznetsova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6793">https://www.med-sovet.pro/jour/article/view/6793</self-uri><abstract><sec><title> </title><p> </p></sec><sec><title>Введение</title><p>Введение. Интенсивное развитие добывающей промышленности привело к стремительному росту численности населения, масштабным миграционным процессам в города, строительству многочисленных индустриальных объектов, что сопровождалось изменением экологических, социально-экономических и  культурных устоев местного коренного населения (ханты и манси). Это, в свою очередь, вызвало нарушение привычного ритма жизни, существующего здесь веками.</p></sec><sec><title>Цель</title><p>Цель. Изучить массо-ростовые показатели, состояние биоценоза влагалища и желудочно-кишечного тракта у беременных женщин, проживающих в селе и в городе в Ханты-Мансийском автономном округе – Югре, и возможность коррекции нарушений метронидазолом и миконазолом.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен проспективный анализ жалоб, анамнестических, антропометрических, а также оценка состояния биоценоза влагалища и  кишечника у  пациенток, отобранных методом сплошной выборки. Обследованы женщины из числа коренных малочисленных народностей Севера – ханты и манси. В группе сравнения были женщины из числа пришлого населения (русские), проживающие в Ханты-Мансийске.</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования. Было выявлено, что наибольшее количество нарушений биоценоза влагалища и кишечника было у беременных женщин, проживающих в городе, как из числа КМНС, так и у пришлого населения. У половины беременных женщин был выявлен нормоценоз. У каждой второй были выявлены воспалительные изменения – неспецифический вагинит встречался у 9,1%, вульвовагинальный кандидоз – у 13,6% и смешанная патогенная флора (бактериальный вагиноз и вульвовагинальный кандидоз)  – у  31,8% женщин. Контроль состояния биоценоза влагалища был проведен через 4—5  нед., и по окончании послеродового периода (40–44-е сут.) был определен нормобиоценоз. Рецидивов как до родов, так и после в течение 42 дней у данного контингента не наблюдалось.</p></sec><sec><title>Выводы</title><p>Выводы. Применение метронидазола и миконазола интравагинально является эффективным средством лечения бактериального вагиноза в сочетании с вульвовагинальным кандидозом с быстрым купированием симптомов и отсутствием побочных эффектов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The intensive development of the mining industry led to a rapid growth in the population, large-scale migration processes to cities, the construction of numerous industrial facilities, which was accompanied by changes in the ecological, socioeconomic and cultural foundations of the local indigenous population (Khanty and Mansi) caused by the disruption of the usual rhythm of life that exists here. over the centuries</p></sec><sec><title>Aim</title><p>Aim. The study of mass and growth parameters, the state of the biocenosis of the vagina and gastrointestinal tract in pregnant women living in the village and in the city in the Khanty-Mansi Autonomous Okrug-Yugra and correction of violations with metronidazole and miconazole.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A prospective analysis of complaints, anamnestic, anthropometric, as well as an assessment of the state of the biocenosis of the vagina and intestines in patients selected by the method of continuous sampling was carried out. We examined women from among the  indigenous small-numbered peoples of  the north (indigenous peoples of  the North)  – the Khanty and Mansi, living in the urban-type settlement. Berezovo, in camps and in the city of Khanty-Mansiysk. The comparison group included women from the migrant population (Russians) living in the city of Khanty-Mansiysk.</p></sec><sec><title>Results</title><p>Results. It was found that the greatest number of violations of the biocenosis of the vagina and intestines was in pregnant women living in the city, both from the indigenous minorities and the migrant population. Half of pregnant women, 50% of women, had normocenosis. Every second had inflammatory changes  – nonspecific vaginitis occurred in  9.1%, vulvovaginal candidiasis in 13.6% and mixed pathogenic flora (bacterial vaginosis and vulvovaginal candidiasis) were in 31.8% of women. Monitoring of the state of the vaginal biocenosis was carried out after 4–5 weeks and at the end of the postpartum period (40–44 days), normobiocenosis was determined. Relapses both before and after childbirth within 42 days were not observed in this contingent.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of metronidazole and miconazole intravaginally is an effective trea for bacterial vaginosis in combination with vulvovaginal candidiasis with rapid relief of symptoms and no side effects.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>микробиота влагалища и кишечника</kwd><kwd>метронидазол</kwd><kwd>миконазол</kwd><kwd>бактериальный вагиноз</kwd><kwd>вульвовагинальный кандидоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>vaginal and gut microbiota</kwd><kwd>metronidazole</kwd><kwd>miconazole</kwd><kwd>bacterial vaginosis</kwd><kwd>vulvovaginal candidiasis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Харамзин Т.Г., Хайруллина Н.Г. Экологическое здоровье обских угров. Ханты-Мансийск: ИИЦ ЮГУ; 2010. С. 4–5. 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