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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2022-16-6-44-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6810</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>COVID-19</subject></subj-group></article-categories><title-group><article-title>Особенности течения COVID-19 у пациентов с коморбидной патологией</article-title><trans-title-group xml:lang="en"><trans-title>Features of the course of COVID-19 in patients with comorbid pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7452-1122</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарипова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharipova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент кафедры нервных болезней,</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Аssistant of the Department of Nervous Diseases, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">maisiyat@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5261-3552</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивкина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivkina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший преподаватель кафедры нормальной физиологии и медицинской физики, </p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Senior Teacher of the Department of Normal Physiology and Medical Physics, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">terekhova_m@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0792-6194</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архангельская</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Arkhangelskaia</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры ЮНЕСКО «Здоровый образ жизни – залог успешного развития», </p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Аssociate Рrofessor of the UNESCO Department “Healthy Lifestyle – the Key to Successful Development”, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">cattiva@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7603-6064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>К. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>K. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор РАН, заведующий кафедрой ЮНЕСКО «Здоровый образ жизни – залог успешного развития»,</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Рrofessor of the Russian Academy of Sciences, Head of the UNESCO Department “Healthy Lifestyle – the Key to Successful Development”, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">kgurevich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6114-564X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН, проректор по учебной работе, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии, </p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Рrofessor, Academician of the Russian Academy of Sciences, Prorector for Academic Affairs, Head of the Department of Internal Diseases Propaedeutics and Gastroenterology, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">ProRekt-02@msmsu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет имени А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>21</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>6</issue><fpage>44</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарипова М.М., Ивкина М.В., Архангельская А.Н., Гуревич К.Г., Маев И.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шарипова М.М., Ивкина М.В., Архангельская А.Н., Гуревич К.Г., Маев И.В.</copyright-holder><copyright-holder xml:lang="en">Sharipova M.M., Ivkina M.V., Arkhangelskaia A.N., Gurevich K.G., Maev I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6810">https://www.med-sovet.pro/jour/article/view/6810</self-uri><abstract><p>Коморбидность является важной проблемой современной медицины, изучение которой представляет приоритетную задачу здравоохранения. Согласно литературным данным, по распространенности коморбидность в некоторых странах охватывает треть населения, при этом отмечена тенденция к росту числа таких пациентов во всех возрастных группах. В контексте пандемии COVID-19 наличие сопутствующей патологии у пациентов является значимым фактором риска, влияющим на течение и прогноз новой коронавирусной инфекции, при этом именно коморбидные пациенты относятся к наиболее уязвимой группе. В  обзоре представлены данные, свидетельствующие о  значимом влиянии коморбидных патологий на увеличение числа осложнений и летальности; проанализированы наиболее часто встречающиеся сочетания заболеваний у пациентов с новой коронавирусной инфекцией. Отмечается рост распространенности коморбидности во всех возрастных группах, что диктует необходимость разработки комплексного междисциплинарного подхода для таких пациентов. Преобладающее большинство клинических рекомендаций по  лечению сопутствующей патологии при COVID-19 в основном сфокусированы на отдельных заболеваниях, что ограничивает использование этих алгоритмов у коморбидных пациентов. В связи с высоким риском заражения вирусной инфекцией, а также частым развитием осложнений и смертностью у коморбидных пациентов профилактические мероприятия должны быть сосредоточены одновременно на мерах, направленных на предотвращение заражения COVID-19, и компенсации коморбидной патологии. В случае инфицирования SARS-CoV-2 необходимо тщательное наблюдение таких пациентов, чаще всего в условиях стационара, с целью предотвращения осложнений и неблагоприятных исходов. </p></abstract><trans-abstract xml:lang="en"><p>Comorbidity is an important problem of modern medicine, the study of which is a priority for public health. According to  the literature, the prevalence of comorbidity reaches a third of the population in some countries, while there is a tendency for an increase in the number of such patients in all age groups. In the context of the COVID-19 pandemic, the presence of   comorbidity in patients is a significant risk factor affecting the course and prognosis of a new coronavirus infection; at the same time, it is comorbid patients who belong to the most vulnerable group. The review presents data indicating a significant impact of comorbid pathologies on an increase in the number of complications and mortality; the most common combinations of diseases in patients with a new coronavirus infection were analyzed. There is an increase in the prevalence of comorbidity in all age groups, which dictates the need to develop an integrated interdisciplinary approach for such patients. The vast majority of clinical guidelines for the  treatment of comorbidities in COVID-19 are mainly focused on individual diseases, which limits the use of these algorithms in comorbid patients. Due to the high risk of contracting a viral infection, as  well as the frequent development of   complications and mortality in comorbid patients, preventive measures should be  focused simultaneously on two tasks: measures aimed at preventing infection with COVID-19 and compensating for  comorbid pathology. In the case of SARS-CoV-2 infection, careful monitoring of such patients, most often in a hospital setting, is necessary in order to prevent complications and adverse outcomes. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>коморбидность</kwd><kwd>фактор риска</kwd><kwd>осложнения</kwd><kwd>летальность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>comorbidity</kwd><kwd>risk factor</kwd><kwd>complications</kwd><kwd>mortality</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Нагорных А.М., Тюменцев А.И., Тюменцева М.А., Акимкин В.Г. SARS, снова SARS и MERS. Обзор животных моделей респираторных синдромов человека, вызываемых коронавирусными инфекциями. 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