<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-12-25-32</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-683</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTERIAL HYPERTENSION</subject></subj-group></article-categories><title-group><article-title>Клиническая фармакология и клиническая эффективность амлодипина. Данные доказательной медицины</article-title><trans-title-group xml:lang="en"><trans-title>Clinical pharmacology and clinical efficacy of amlodipine. Evidence-based data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Leonova</surname><given-names>MV</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University, Russia’s Ministry of Health, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>12</issue><fpage>25</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Леонова М.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Леонова М.В.</copyright-holder><copyright-holder xml:lang="en">Leonova M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/683">https://www.med-sovet.pro/jour/article/view/683</self-uri><abstract><p>Сердечно-сосудистые заболевания остаются наиболее распространенными в мире, фармакотерапия которых представляется актуальной для большинства больных в течение длительного периода времени, порой пожизненно. Главной целью фармакотерапии сердечно-сосудистых заболеваний является предотвращение развития осложнений и смертности. Поэтому кардиоваскулярные препараты должны иметь высокую и доказанную эффективность и безопасность в достижении долгосрочного прогноза.</p></abstract><trans-abstract xml:lang="en"><p>Cardiovascular diseases remain the most common pathology worldwide, the pharmacotherapy of which remains relevant for the majority of patients over a long period of time, sometimes for life. The main purpose of pharmacotherapy of cardiovascular diseases is prevention of complications and mortality. Cardiovascular drugs must have high proven efficacy and safety in achieving the long-term prognosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>клиническая фармакология</kwd><kwd>амлодипин</kwd><kwd>Норваск</kwd><kwd>cardiovascular disease</kwd><kwd>clinical pharmacology</kwd><kwd>amlodipine</kwd><kwd>Norvasc</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nayler WG. Amlodipine. Berlin: Springer-Verlag, 1993.</mixed-citation><mixed-citation xml:lang="en">Nayler WG. Amlodipine. Berlin: Springer-Verlag, 1993.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Donelly R, Meredith PA, Miller SHK et al. Pharmacodynamic modeling of the antihypertensive response to amlodipine. Clin. Pharmacol. Ther., 1993, 54: 303-10.</mixed-citation><mixed-citation xml:lang="en">Donelly R, Meredith PA, Miller SHK et al. Pharmacodynamic modeling of the antihypertensive response to amlodipine. Clin. Pharmacol. Ther., 1993, 54: 303-10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bainbridge AD, Herlihy PA, Meredith PA, Elliott HL. A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic in incites. Eur.J. Clin. Pharmacol., 1993, 45: 425-30.</mixed-citation><mixed-citation xml:lang="en">Bainbridge AD, Herlihy PA, Meredith PA, Elliott HL. A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic in incites. Eur.J. Clin. Pharmacol., 1993, 45: 425-30.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mason RP, Marche P, Hintze TH. Novel Vascular Biology of Third-Generation L-Type Calcium Channel Antagonists: Ancillary Actions of Amlodipine. Arterioscler Thromb Vasc Biol., 2003, 23: 2155-63.</mixed-citation><mixed-citation xml:lang="en">Mason RP, Marche P, Hintze TH. Novel Vascular Biology of Third-Generation L-Type Calcium Channel Antagonists: Ancillary Actions of Amlodipine. Arterioscler Thromb Vasc Biol., 2003, 23: 2155-63.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez RH, Armas-Hernarndez MJ, Zafar HI, Armas-Padilla MC. Calcium antagonists and atherosclerosis protection in hypertension. Am. J. Therap., 2003, 10: 409-14.</mixed-citation><mixed-citation xml:lang="en">Hernandez RH, Armas-Hernarndez MJ, Zafar HI, Armas-Padilla MC. Calcium antagonists and atherosclerosis protection in hypertension. Am. J. Therap., 2003, 10: 409-14.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips JE, Mason RP. Inhibition of oxidized LDL aggregation with a charged calcium antagonist amlodipine: role of electrostatic interactions. Atherosclerosis, 2003, 168: 239-44.</mixed-citation><mixed-citation xml:lang="en">Phillips JE, Mason RP. Inhibition of oxidized LDL aggregation with a charged calcium antagonist amlodipine: role of electrostatic interactions. Atherosclerosis, 2003, 168: 239-44.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mason RP, Walter MF, Trumbore MW et al. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J. Mol. Cell Cardiol., 1999, 31: 275-81.</mixed-citation><mixed-citation xml:lang="en">Mason RP, Walter MF, Trumbore MW et al. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J. Mol. Cell Cardiol., 1999, 31: 275-81.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Batova S, DeWever J, Godfraind T et al. The calcium channel blocker amlodipine promotes the unclamping of eNOS from caveolin in endothelial cells. Cardiovascular Research, 2006, 71: 478-85.</mixed-citation><mixed-citation xml:lang="en">Batova S, DeWever J, Godfraind T et al. The calcium channel blocker amlodipine promotes the unclamping of eNOS from caveolin in endothelial cells. Cardiovascular Research, 2006, 71: 478-85.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang X-P, Xu X, Nasjletti A, Hintze TH. Amlodipine enhances NO production induced by an ACE inhibitor through a kinin-mediated mechanism in canine coronary microvessels.J. Cardiovasc Pharmacol., 2000, 35: 195-202.</mixed-citation><mixed-citation xml:lang="en">Zhang X-P, Xu X, Nasjletti A, Hintze TH. Amlodipine enhances NO production induced by an ACE inhibitor through a kinin-mediated mechanism in canine coronary microvessels.J. Cardiovasc Pharmacol., 2000, 35: 195-202.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
