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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-12-92-99</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-694</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТРОМБОЭМБОЛИЯ ЛЕГОЧНОЙ АРТЕРИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PULMONARY EMBOLISM</subject></subj-group></article-categories><title-group><article-title>Тромбоэмболия легочной артерии: лечение в стационаре и на амбулаторном этапе</article-title><trans-title-group xml:lang="en"><trans-title>Pulmonary embolism: inpatient and outpatient treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гендлин</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Gendlin</surname><given-names>GE</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелехов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Melekhov</surname><given-names>AV</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сторожаков</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Storozhakov</surname><given-names>GI</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рязанцева</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryazantseva</surname><given-names>EE</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>the Pirogov Russian National Research Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>12</issue><fpage>92</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гендлин Г.Е., Мелехов А.В., Сторожаков Г.И., Рязанцева Е.Е., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Гендлин Г.Е., Мелехов А.В., Сторожаков Г.И., Рязанцева Е.Е.</copyright-holder><copyright-holder xml:lang="en">Gendlin G., Мелехов А.В., Storozhakov G., Ryazantseva E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/694">https://www.med-sovet.pro/jour/article/view/694</self-uri><abstract><p>Тромбоэмболия легочной артерии (ТЭЛА) представляет собой достаточно частую неотложную ситуацию. Окклюзия легочных артерий различного калибра может приводить к общему тяжелому состоянию, шоку, внезапной смерти, а у ряда больных, переживших тромбоэмболию, - к отдаленным последствиям различной тяжести: хронической посттромбоэмболической легочной гипертензии, изменениям биомеханики дыхания и дыхательной недостаточности и т. д. В абсолютном большинстве случаев источником тромбов, попадающих в легочные артерии (до 90% случаев), является венозная система нижних конечностей, таза, почек и, крайне редко, правые отделы сердца и венозная система верхних конечностей [<xref ref-type="bibr" rid="cit1">1</xref>].</p></abstract><trans-abstract xml:lang="en"><p>Pulmonary embolism (PE) is a rather common emergency situation. Occlusion of pulmonary arteries of different calibre may result in critical condition, shock, sudden death, while in a number of patients who survived thromboembolism it may lead to long-term complications of varying severity: post-thromboembolic chronic pulmonary hypertension, changes in respiratory biomechanics and respiratory failure, and so on. In most cases blood clots enter the pulmonary arterial tree (up to 90% of cases) from the venous system of the lower extremities, pelvis, kidney, and quite rarely from the right side of the heart and the venous system of the upper extremities [<xref ref-type="bibr" rid="cit1">1</xref>].</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбоэмболия легочной артерии</kwd><kwd>тромбоз глубоких вен</kwd><kwd>венозные тромбоэмболические осложнения</kwd><kwd>антикоагулянты</kwd><kwd>варфарин</kwd><kwd>дабигатрана этексилат</kwd><kwd>ривароксабан</kwd><kwd>pulmonary embolism</kwd><kwd>deep vein thrombosis</kwd><kwd>venous thromboembolic complications</kwd><kwd>anticoagulants</kwd><kwd>warfarin</kwd><kwd>dabigatran etexilate</kwd><kwd>rivaroxaban</kwd><kwd>apixaban</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений. Флебология, 2010, 4, 2(1): 1-37.</mixed-citation><mixed-citation xml:lang="en">Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений. Флебология, 2010, 4, 2(1): 1-37.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal, 2008, 29: 2276-2315.</mixed-citation><mixed-citation xml:lang="en">Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal, 2008, 29: 2276-2315.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Spirk D, Husmann M, Hayoz D, Baldi T et al. Predictors of in-hospital mortality in elderly patients with acute venous thrombo-embolism: the SWIss Venous ThromboEmbolism Registry (SWIVTER). European Heart Journal, 2012, 33: 921-926.</mixed-citation><mixed-citation xml:lang="en">Spirk D, Husmann M, Hayoz D, Baldi T et al. Predictors of in-hospital mortality in elderly patients with acute venous thrombo-embolism: the SWIss Venous ThromboEmbolism Registry (SWIVTER). European Heart Journal, 2012, 33: 921-926.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous Thromboembolism. A Public Health Concern. Am J Prev Med, 2010, 38(4S): 495-501.</mixed-citation><mixed-citation xml:lang="en">Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous Thromboembolism. A Public Health Concern. Am J Prev Med, 2010, 38(4S): 495-501.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Spencer FA, Lessard D, Emery C, Reed G et al. Venous Thromboembolism in the Outpatient Setting. Arch Intern Med, 2007, 23, 167(14): 1471-1475.</mixed-citation><mixed-citation xml:lang="en">Spencer FA, Lessard D, Emery C, Reed G et al. Venous Thromboembolism in the Outpatient Setting. Arch Intern Med, 2007, 23, 167(14): 1471-1475.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sweetland S, Green J, Liu B, de Gonzalez AB et al. Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ, 2009, 3, 339: b4583.</mixed-citation><mixed-citation xml:lang="en">Sweetland S, Green J, Liu B, de Gonzalez AB et al. Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ, 2009, 3, 339: b4583.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева Н.А., Пономарева И.А. Венозный тромбоэмболизм - мифы и реальность. Трудный пациент, 2009, 6-7: 29-36.</mixed-citation><mixed-citation xml:lang="en">Воробьева Н.А., Пономарева И.А. Венозный тромбоэмболизм - мифы и реальность. Трудный пациент, 2009, 6-7: 29-36.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Le Cal, Righini M, Roy PM, Sanches O et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med, 2006, 7, 144 (3): 165-171.</mixed-citation><mixed-citation xml:lang="en">Le Cal, Righini M, Roy PM, Sanches O et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med, 2006, 7, 144 (3): 165-171.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Багрова И.В., Кухарчик Г.А., Серебрякова В.И., Константинова И.В., Капутин М.Ю. Современные подходы к диагностике тромбоэмболии легочной артерии. Флебология, 2012, 4: 35-42.</mixed-citation><mixed-citation xml:lang="en">Багрова И.В., Кухарчик Г.А., Серебрякова В.И., Константинова И.В., Капутин М.Ю. Современные подходы к диагностике тромбоэмболии легочной артерии. Флебология, 2012, 4: 35-42.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Valid U, Singer E, Marhefka GD, Kraft WK et al. Poor Positive Predictive Value of McConnells Sign on Transthoracic Echocardiography for the Diagnosis of Acute Pulmonary Embolism. Hospital Practice, 2013, 41, 3: 2154-8331.</mixed-citation><mixed-citation xml:lang="en">Valid U, Singer E, Marhefka GD, Kraft WK et al. Poor Positive Predictive Value of McConnells Sign on Transthoracic Echocardiography for the Diagnosis of Acute Pulmonary Embolism. Hospital Practice, 2013, 41, 3: 2154-8331.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Powell BP, Simes D. Levosimendan in acute pulmonary embolism. Anaesth Intensive Care, 2007, 35(5): 771-772.</mixed-citation><mixed-citation xml:lang="en">Powell BP, Simes D. Levosimendan in acute pulmonary embolism. Anaesth Intensive Care, 2007, 35(5): 771-772.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Turpie AG. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Thromb. Vasc. Biol. 2007, 27: 1238-1247.</mixed-citation><mixed-citation xml:lang="en">Turpie AG. Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Thromb. Vasc. Biol. 2007, 27: 1238-1247.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bauersachs R et al. Oral Rivaroxaban for Symptomatic Venous Thromboembolism. N Engl J Med., 2010, 23, 363(26): 2499-2510.</mixed-citation><mixed-citation xml:lang="en">Bauersachs R et al. Oral Rivaroxaban for Symptomatic Venous Thromboembolism. N Engl J Med., 2010, 23, 363(26): 2499-2510.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Buller HR, Prins MH, Lensing AWA, Decousus H et al. Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism. N Engl J Med, 2012, 366: 1287-1297.</mixed-citation><mixed-citation xml:lang="en">Buller HR, Prins MH, Lensing AWA, Decousus H et al. Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism. N Engl J Med, 2012, 366: 1287-1297.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Agnelli G, Gallus A, Goldhaber SZ, Haas S et al. Treatment of Proximal Deep-Vein Thrombosis With the Oral Direct Factor Xa Inhibitor Rivaroxaban (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) Study. Circulation July 10, 2007, 116: 180-187.</mixed-citation><mixed-citation xml:lang="en">Agnelli G, Gallus A, Goldhaber SZ, Haas S et al. Treatment of Proximal Deep-Vein Thrombosis With the Oral Direct Factor Xa Inhibitor Rivaroxaban (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) Study. Circulation July 10, 2007, 116: 180-187.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Prins MH, Lensing A, Bauersachs R, van Bellen B et al. Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies. Thrombosis Journal, 2013, 11, 21. http://wwwthrombosisjournal. com/content/11/1/21.</mixed-citation><mixed-citation xml:lang="en">Prins MH, Lensing A, Bauersachs R, van Bellen B et al. Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies. Thrombosis Journal, 2013, 11, 21. http://wwwthrombosisjournal. com/content/11/1/21.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Van Es J, Douma RA, Kamphuisen PW, Gerdes VE et al. Clot resolution after 3 weeks of anticoagulant treatment for pulmonary embolism: comparison of computed tomography and perfusion scintigraphy J Thromb Haemost., 2013, 11: 679-685.</mixed-citation><mixed-citation xml:lang="en">Van Es J, Douma RA, Kamphuisen PW, Gerdes VE et al. Clot resolution after 3 weeks of anticoagulant treatment for pulmonary embolism: comparison of computed tomography and perfusion scintigraphy J Thromb Haemost., 2013, 11: 679-685.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
