medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-14-145-153medsovet-7032Research ArticleРЕВМАТОЛОГИЯRHEUMATOLOGYЗначение неденатурированного коллагена для нормализации функции хрящевой ткани суставовThe value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the jointshttps://orcid.org/0000-0002-2985-8831ДыдыкинаИ. С.DydykinaI. S.

Дыдыкина Ирина Степановна, кандидат медицинских наук, ведущий научный сотрудник лаборатории эволюции ревматоидного артрита

115522, Москва, Каширское шоссе, д. 34А

Irina S. Dydykina, Cand. Sci. (Med.), Leading Research Fellow of Laboratory of Rheumatoid Arthritis Evolution

34a, Kashirskoe Shosse, Moscow, 115522

dydykina_is@mail.ruhttps://orcid.org/0000-0002-6076-4374КоваленкоП. С.KovalenkoP. S.

Коваленко Полина Сергеевна, кандидат медицинских наук, младший научный сотрудник лаборатории мониторинга безопасности антиревматических препаратов

115522, Москва, Каширское шоссе, д. 34А

Polina S. Kovalenko, Cand. Sci. (Med.), Junior Researcher of Laboratory of Antirheumatic Drug Safety Monitoring

34a, Kashirskoe Shosse, Moscow, 115522

polina_dydykina@mail.ruhttps://orcid.org/0000-0002-3333-0220КоваленкоА. А.KovalenkoA. A.

Коваленко Алексей Анатольевич, кандидат медицинских наук, врач Университетской клинической больницы №5

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Alexey A. Kovalenko, Cand. Sci. (Med.), Doctor of the University Clinical Hospital No. 5

8, Bldg. 2, Trubetskaya St., Moscow, 119991

alexey-kovalenko@yandex.ruАболешинаА. В.AboleshinaA. V.

Аболешина Александра Вадимовна, клинический ординатор

115522, Москва, Каширское шоссе, д. 34А

Aleksandra V. Aboleshina, Resident Doctor

34a, Kashirskoe Shosse, Moscow, 115522

Научно-исследовательский институт ревматологии имени В.А. НасоновойРоссияNasonova Research Institute of RheumatologyRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation202212082022014145153Copyright © Дыдыкина И.С., Коваленко П.С., Коваленко А.А., Аболешина А.В., 20222022Дыдыкина И.С., Коваленко П.С., Коваленко А.А., Аболешина А.В.Dydykina I.S., Kovalenko P.S., Kovalenko A.A., Aboleshina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7032

Среди белков организма человека на долю коллагена приходится не менее 25–45%. Коллаген является обязательным структурным компонентом скелетных тканей, соединительной ткани внутренних органов (сердца, кишечника, легких печени, почек), а также кровеносных сосудов. Многообразие типов коллагена обусловлено их ролью и функцией. В статье представлены сведения о строении и синтезе коллагена, высокой концентрации глицина, пролина и гидроксипролина в составе альфа-цепей спирали коллагена. Обращается внимание на то, что поперечные связи и ориентация волокон коллагена в направлении вектора действия внешних сил и нагрузок обеспечивают защиту тканям и органам. Клиническое значение коллагена II типа рассмотрено на примере хрящевой ткани суставов и сухожилий. Подчеркивается, что дисбаланс в структуре питания, генетические мутации, дисфункция эндокринной и иммунной системы, особенно в пожилом возрасте, ассоциируются с возникновением одного из наиболее распространенных заболеваний суставов – остеоартрита (ОА). Установлено, что деградация или уменьшение коллагена II типа в матриксе хряща сопровождается прогрессированием этого заболевания. В связи с увеличением распространенности ОА, признаков метаболических нарушений и посттравматических повреждений суставов растет интерес к нефармакологическим и фармакологическим вмешательствам с целью профилактики и лечения остеоартрита. В последние годы появились убедительные доказательства успешного применения препаратов (биологически активных добавок к пище) коллагена при остеоартрите. В статье представлены результаты экспериментальных и клинических исследований, метаанализа и систематического обзора, подтверждающие возможность применения этих препаратов (продуктов) в составе комплексной терапии ОА. Возможность использования композиций на основе неденатурированного (нативного) коллагена II типа с включением аскорбиновой кислоты, витамина D, метилсульфонилметана и босвеллиевых кислот способствует синергизму этих веществ, замедлению скорости разрушения хряща, уменьшению проявления боли и воспаления в суставах, улучшению функционального состояния суставов и позвоночника, синтезу эндогенного коллагена.

Among the proteins of the human body, collagen accounts for at least 25–45% collagen; it is an essential structural component of skeletal tissues, connective tissue of internal organs (heart, intestines, lungs, liver, kidneys), as well as blood vessels. The variety of types of collagen is due to their role and function. The article presents information about the structure and synthesis of collagen, a high concentration of glycine, proline and hydroxyproline in the alpha chains of the collagen helix. Attention is drawn to the fact that cross-links and orientation of collagen fibers in the direction of the vector of external forces and loads provide protection to tissues and organs. The clinical significance of type II collagen is considered on the example of the cartilaginous tissue of the joints and tendons. It is emphasized that an imbalance in the structure of nutrition, genetic mutations, dysfunction of the endocrine and immune systems, especially in old age, are associated with the occurrence of one of the most common joint diseases – osteoarthritis (ОА). It has been established that the degradation or reduction of type II collagen in the cartilage matrix is accompanied by the progression of this disease. Due to the increasing prevalence of OA, signs of metabolic disorders and post-traumatic joint injuries, there is a growing interest in non-pharmacological and pharmacological interventions for the prevention and treatment of osteoarthritis. In recent years, convincing evidence has emerged of the successful use of drugs (biologically active food supplements) of collagen in osteoarthritis. The article presents the results of experimental and clinical studies, meta-analysis and systematic review, confirming the possibility of using these drugs (products) as part of the complex treatment of OA. The possibility of using compositions based on undenatured (native) collagen type II, with the inclusion of ascorbic acid, vitamin D, methylsulfonylmethane and boswellic acids promotes the synergy of these substances, slows down the rate of cartilage destruction, reduces the manifestation of pain and inflammation in the joints, improves functional joint and spinal conditions, promotes the synthesis of endogenous collagen.

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The authors declare that there are no conflicts of interest present.