medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-15-90-97medsovet-7078Research ArticleЗАБОЛЕВАНИЯ КИШЕЧНИКАBOWEL DISEASESМесалазин в индукции клинико-эндоскопической ремиссии легких и среднетяжелых форм язвенного колитаMesalazine in the induction of clinical and endoscopic remission of mild and moderate ulcerative colitishttps://orcid.org/0000-0003-1172-6221ШапинаМ. В.ShapinaM. V.

Шапина Марина Владимировна, к.м.н., руководитель отдела функциональных и воспалительных заболеваний кишечника 

123423, Москва, ул. Саляма Адиля, д. 2 

Marina V. Shapina, Cand. Sci. (Med.), Head of the Department of Functional and Inflammatory Bowel Diseases 

2, Salyam Adil St., Moscow, 123423

shapina.mv@yandex.ruНациональный медицинский исследовательский центр колопроктологии имени А.Н. РыжихРоссияRyzhikh State Scientific Center of ColoproctologyRussian Federation2022061020220159097Copyright © Шапина М.В., 20222022Шапина М.В.Shapina M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7078

Введение. Лечение язвенного колита (ЯК) необходимо проводить для индукции ремиссии и в последующем для ее поддержания. С учетом хорошей переносимости, безопасности и эффективности месалазин рассматривают в качестве терапии первой линии для пациентов с легкими и среднетяжелыми формами ЯК.Цель – оценить эффективность индукции клинико-эндоскопической ремиссии у пациентов с легкой и среднетяжелой формой ЯК на фоне терапии месалазином в течение 8 нед. в клинической практике.Материалы и методы. В исследование включены 40 пациентов от 18 до 75 лет с легкой и среднетяжелой атакой ЯК, которые получали терапию в течение 8 нед. Оценка эффективности проводилась через 2 и 8 нед. Динамика качества жизни пациентов оценивалась на основании данных опросника IBS-QOL, удовлетворенность терапией – по шкале Лайкерта.Результаты. На фоне терапии индекс Мейо значимо снижался, составив 4,95 ± 1,74 против 4,08 ± 1,58 и 2,53 ± 1,45 для визитов 1, 2 и 3 соответственно (р < 0,05). Среднее значение уровня кальпротектина снизилось в 2,5 раза за 8 нед. терапии (р < 0,05). Через 8 нед. наблюдения отмечалось отсутствие эндоскопических признаков воспаления у 10 пациентов (25%), у 3 пациентов (7,5%) эндоскопическая активность соответствовала умеренной, а у оставшихся 27 обследуемых (67,5%) соответствовала минимальной. Средний балл IBS-QOL снизился с 84,25 ± 19,67 до 69,80 ± 17,96 через 8 нед. применения препарата (р < 0,05). Удовлетворенность лечением по шкале Лайкерта составила 4,13 ± 0,79 балла, что соответствует высокой степени удовлетворенности. Нежелательных явлений в течение всего периода наблюдения зарегистрировано не было.Заключение. Анализ данных продемонстрировал эффективность индукции клинико-эндоскопической ремиссии легких и среднетяжелых форм левостороннего и тотального ЯК при достоверном положительном влиянии на качество жизни и хорошей переносимости препарата.

Introduction. Treatment of ulcerative colitis (UC) is necessary to induce remission and subsequently to maintain it. Given the good tolerability, safety and efficacy of mesalazine, it is considered as a first-line therapy for patients with mild to moderate forms.Aim of the study. To evaluate the effectiveness of induction of clinical and endoscopic remission in patients with mild and moderate UC during 8 weeks therapy with mesalazine in routine clinical practice.Materials and methods. The study included 40 patients aged 18 to 75 years with mild to moderate attacks of UC who received therapy for 8 weeks. Efficacy was evaluated after 2 and 8 weeks. The dynamics of the quality of life of patients was assessed on the basis of the IBS-QOL questionnaire, satisfaction with therapy was assessed using the Likert scale.Results. During therapy, the Mayo index significantly decreased, amounting to 4.95 ± 1.74 vs 4.08 ± 1.58 vs 2.53 ± 1.45 for visits 1, 2 and 3, respectively (p < 0.05). The mean value of the level of calprotectin decreased by 2.5 times during 8 weeks of therapy (p < 0.05). After 8 weeks of observation, there were no endoscopic signs of inflammation in 10 patients (25%), in 3 patients (7.5%) endoscopic activity was moderate, and in the remaining 27 subjects (67.5%) it was minimal. The mean IBS-QOL score decreased from 84.25 ± 19.67 to 69.80 ± 17.96 after 8 weeks of therapy (p < 0.05). Satisfaction with treatment according to the Likert scale was 4.13 ± 0.79 points, which corresponds to a high degree of satisfaction. No adverse events were recorded during the entire observation period.Conclusion. Data analysis demonstrated the effectiveness of induction of clinical and endoscopic remission of mild to moderate forms of left-sided UC and pancolitis with a significant positive effect on the quality of life and good tolerability of the drug.

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The authors declare that there are no conflicts of interest present.