medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-16-151-159medsovet-7103Research ArticleИНФЕКЦИИINFECTIONSПрименение ресвератрола и индол-3-карбинола в качестве антипролиферативного метода профилактики ВПЧ-ассоциированных заболеванийAntiproliferative effects of resveratrol and indole-3-carbinol in HPV-associated diseases preventionhttps://orcid.org/0000-0003-3895-8225ГусаковК. И.GusakovK. I.

Кирилл Ильич Гусаков, к. м. н., научный сотрудник

научно-поликлиническое отделение

117997

ул. Академика Опарина, д. 4

Москва

Kirill I. Gusakov, Cand. Sci. (Med.), Research Associate

Research Polyclinic Department

117997

4, Academician Oparin St.

Moscow

kigusakov@gmail.comhttps://orcid.org/0000-0001-9499-7654НазароваН. М.NazarovaN. M.

Нисо Мирзоевна Назарова, д. м. н., ведущий научный сотрудник

научно-поликлиническое отделение

117997

ул. Академика Опарина, д. 4

Москва

Niso M. Nazarova, Dr. Sci. (Med.), Lead Research Associate

Research Polyclinic Department

117997

4, Academician Oparin St.

Moscow

grab2@yandex.ruhttps://orcid.org/0000-0002-8243-5272АбакароваП. Р.AbakarovaP. R.

Патимат Рапиевна Абакарова, к. м. н., научный сотрудник

научно-поликлиническое отделение

117997

ул. Академика Опарина, д. 4

Москва

Patimat R. Abakarova, Cand. Sci. (Med.), Research Associate

Research Polyclinic Department

117997

4, Academician Oparin St.

Moscow

p_abakarova@oparina4.ruhttps://orcid.org/0000-0002-5548-3295ТарарыковаА. А.TararykovaA. A.

Анастасия Алексеевна Тарарыкова, к. м. н., врач-онколог

Научно-исследовательский институт клинической онкологии имени акад. Н. Н. Трапезникова

отдел общей онкологии

онкологическое отделение хирургических методов лечения № 1

115478

Каширское шоссе, д. 24

Москва

Anastasia A. Tararykova, Cand. Sci. (Med.), Oncologist

Research Institute of Clinical Oncology named after N. N. Trapeznikov

General Oncology Department 

Oncology Department of Surgical Methods of Treatment No. 1

115478

24, Kashirskoye Shosse

Moscow

anastasiatararykova@gmail.comhttps://orcid.org/0000-0003-0751-7566ИвановИ. А.IvanovI. A.

Илья Андреевич Иванов, к. м. н., научный сотрудник

отделение гинекологической эндокринологии

117997

ул. Академика Опарина, д. 4

Москва

Ilya A. Ivanov, Cand. Sci. (Med.), Research Associate

Department of Gynecological Endocrinology

117997

4, Academician Oparin St.

Moscow

doctor.i.ivanov@yandex.ruНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В. И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationНациональный медицинский исследовательский центр онкологии имени Н. Н. БлохинаРоссияBlokhin National Medical Research Center of OncologyRussian Federation202210102022016151159Copyright © Гусаков К.И., Назарова Н.М., Абакарова П.Р., Тарарыкова А.А., Иванов И.А., 20222022Гусаков К.И., Назарова Н.М., Абакарова П.Р., Тарарыкова А.А., Иванов И.А.Gusakov K.I., Nazarova N.M., Abakarova P.R., Tararykova A.A., Ivanov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7103

   Влияние персистирующей папиллома-вирусной инфекции (ПВИ) на здоровье женщины может не только повышать риск развития рака шейки матки (РШМ), остающегося одним из наиболее распространенных видов злокачественных новообразований, но и приводить к формированию аногенитальных кондилом. Ввиду того, что этиотропного лечения вируса папилломы человека (ВПЧ) до сих пор не существует, внимание исследователей сфокусировано на разработке принципиально новых терапевтических платформ и лекарственных средств, нацеленных на предупреждение рецидивов ВПЧ-ассоциированных заболеваний, в т. ч. после хирургического лечения. Существенное антипролиферативное действие ресвератрола было продемонстрировано при различных видах рака, включая рак молочной железы, кожи, легких, поджелудочной железы и желудка. В клетках РШМ ресвератрол стимулирует апоптоз опухолевых клеток, снижает экспрессию белков Е6 и Е7 и повышает экспрессию белка супрессора опухоли p53. Ресвератрол оказывает супрессивное влияние на миграцию и инвазию клеток РШМ путем ингибирования транскрипционного фактора NF-κB и AP-1-опосредованной экспрессии ММР9. Ресвератрол демонстрирует целый спектр противовоспалительных эффектов, начиная от подавления экспрессии провоспалительных цитокинов IL-1α, IL-1β, IL-6, IL-17 и медиаторов воспаления простагландина E2 и заканчивая подавлением образования АФК и NO. И3К обладает доказанной противоопухолевой эффективностью, основанной на молекулярных механизмах патологической клеточной пролиферации и опухолевой трансформации в гормонозависимых тканях, в т. ч. в клетках цервикального эпителия. Ресвератрол и индол-3-карбинол (И3К) обладают широким спектром изученных положительных терапевтических эффектов, способных значительно снизить вероятность развития и прогрессирования ВПЧ-ассоциированных заболеваний аногенитальной области.

   The burden of persistent papillomavirus infection on public healthcare is not limited to cervical cancer (CC). At present, cervical cancer continues to be one of the most common types of cancer worldwide, although HPV also causes anogenital warts. As there is no HPV treatment available, nowadays researchers focus on the search for new therapeutic platforms, new agents for HPV-associated diseases relapse prevention after surgical treatment. Significant anticancer effects of resveratrol have been demonstrated in a variety of cancers, including breast cancer, skin cancer, lung cancer, pancreatic cancer, and stomach cancer. In CC cells, resveratrol stimulates apoptosis of cancer cells, increases expression of HPV E6 and E7, and the expression of p53 tumor suppressor protein. Protective effects on CC cells migration and invasion is achieved by inhibiting NF-κB transcription and AP-1 mediated MMP9 expression. Resveratrol demonstrates a whole range of anti-inflammatory effects, ranging from the suppression of the pro-inflammatory cytokines IL-1α, IL-1β, IL-6, IL-17 expression and inflammatory mediator prostaglandin E2, to the suppression of the formation of ROS and NO. I3K has a proven antitumor efficacy based on the molecular mechanisms of pathological cell proliferation and tumor transformation in hormone- dependent tissues, including cervical epithelial cells. Resveratrol and I3K have a wide range of studied positive therapeutic effects that can significantly reduce the likelihood of development and progression of HPV-associated lesions.

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The authors declare that there are no conflicts of interest present.