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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2022-16-19-114-121</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7172</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ СЛУЧАЙ/ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE/PRACTICE</subject></subj-group></article-categories><title-group><article-title>Клинический случай осложненного течения инфекционного эндокардита у подростка</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of complicated course of infectious endocarditis in a teenager</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8390-343X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дакуко</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dakuko</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дакуко Анастасия Николаевна, к.м.н., доцент кафедры госпитальной педиатрии с курсом дополнительного профессионального образования</p><p>644099, Россия, Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Anastasia N. Dakuko, Cand. Sci. (Med.), Associate Professor of the Department of Hospital Pediatrics with the Additional Professional Education Course</p><p>12, Lenin St., Omsk, 644099, Russia </p></bio><email xlink:type="simple">doc-man85@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8994-4857</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Завалина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavalina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Завалина Наталья Васильевна, клинический ординатор кафедры госпитальной педиатрии с курсом дополнительного профессионального образования</p><p>644099, Россия, Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Natalia V. Zavalina, Clinical Resident of the Department of Hospital Pediatrics with the Additional Professional Education Course</p><p>12, Lenin St., Omsk, 644099, Russia </p></bio><email xlink:type="simple">z.natali.v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8300-1348</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цеханович</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsekhanovich</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цеханович Валерий Николаевич, д.м.н., профессор, заведующий кардиохирургическим отделением</p><p>644111, Россия, Омск, ул. Березовая, д. 3</p></bio><bio xml:lang="en"><p>Valery N. Tsekhanovich, Dr. Sci. (Med.), Professor, Head of the Cardiac Surgery Department</p><p>3, Berezovaya St., Omsk, 644111, Russia </p></bio><email xlink:type="simple">cvn50omsk@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5975-2624</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батаева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bataeva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Батаева Татьяна Владимировна, детский кардиолог кардиохирургического отделения</p><p>644111, Россия, Омск, ул. Березовая, д. 3</p></bio><bio xml:lang="en"><p>Tatiana V. Bataeva, Pediatric Cardiologist at the Cardiac Surgery Department</p><p>3, Berezovaya St., Omsk, 644111, Russia </p></bio><email xlink:type="simple">bat1707@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0025-8656</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кунгурцева</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kungurtseva</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кунгурцева Анна Геннадьевна, заведующая педиатрическим отделением</p><p>644001, Россия, Омск, ул. Куйбышева, д. 77 </p></bio><bio xml:lang="en"><p>Anna G. Kungurtseva, Head of the Pediatric Department</p><p>77, Kuibyshev St., Omsk, 644001, Russia</p></bio><email xlink:type="simple">anna.omck@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8290-6380</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каук</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kauk</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каук Алена Викторовна, детский кардиолог педиатрического отделения </p><p>644001, Россия, Омск, ул. Куйбышева, д. 77 </p></bio><bio xml:lang="en"><p>Alena V. Kauk, Pediatric Cardiologist of the Pediatric Department </p><p>77, Kuibyshev St., Omsk, 644001, Russia</p></bio><email xlink:type="simple">patrik1111@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Омский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Областная детская клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Children’s Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>14</day><month>11</month><year>2022</year></pub-date><volume>0</volume><issue>19</issue><fpage>114</fpage><lpage>121</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дакуко А.Н., Завалина Н.В., Цеханович В.Н., Батаева Т.В., Кунгурцева А.Г., Каук А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Дакуко А.Н., Завалина Н.В., Цеханович В.Н., Батаева Т.В., Кунгурцева А.Г., Каук А.В.</copyright-holder><copyright-holder xml:lang="en">Dakuko A.N., Zavalina N.V., Tsekhanovich V.N., Bataeva T.V., Kungurtseva A.G., Kauk A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7172">https://www.med-sovet.pro/jour/article/view/7172</self-uri><abstract><p>Инфекционный эндокардит (ИЭ) – заболевание сердца инфекционной природы с первичным поражением эндокарда, клапанов сердца, связочного аппарата с последующей диссеминацией процесса в различные органы. ИЭ до настоящего времени остается заболеванием, сложным для диагностики и непредсказуемым по исходам и регистрируется во всех странах мира. Несмотря на все достижения медицины, это крайне опасное заболевание, летальность от которого составляет 10–30%. Наиболее распространенными причинами летального исхода ИЭ являются множественные осложнения: эмболии различной локализации, в том числе мозговых артерий, аневризмы, токсические поражения селезенки, миокардит и перикардит, острая почечная недостаточность. В настоящее время в детской кардиологической практике возросла частота первичного ИЭ, протекающего с изменением клинической картины и атипичными вариантами. Осведомленность врачей всех специальностей о данной проблеме, правильная и своевременная диагностика заболевания позволяют раньше назначать адекватную терапию и тем самым улучшить прогноз. В работе описано клиническое наблюдение подростка с атипичным началом первичного ИЭ, протекающего под маской острого нарушения мозгового кровообращения. Особенность данного случая заключалась в первичной диагностике у пациента наследственной тромбофилии и возможного дебюта демиелинизирующего заболевания центральной нервной системы в процессе обследования, что, безусловно, затрудняло диагностический поиск и повлияло на исход ИЭ. Значимость предшествующих заболеванию стоматологических манипуляций у ребенка, к сожалению, не была оценена родителями должным образом, но именно воспалительный процесс в ротовой полости стоит рассматривать как ключевой этиологический фактор развития ИЭ в данном случае.</p></abstract><trans-abstract xml:lang="en"><p>Infective endocarditis (IE) is a heart disease of an infectious nature with a primary lesion of the endocardium, heart valves, ligaments, followed by dissemination of the process to various organs. Infective endocarditis still remains a disease that is difficult to diagnose and unpredictable in terms of outcomes; it is registered in all countries of the world. Despite all the advances in medicine, infective endocarditis remains an extremely dangerous disease, with a mortality rate of 10–30%. The most common causes of lethal outcome of IE are multiple complications: embolisms of various localization, including cerebral arteries, aneurysms, toxic lesions of the spleen, myocarditis and pericarditis, acute renal failure. Currently, in pediatric cardiology practice, the frequency of primary infective endocarditis, which occurs with a change in the clinical picture, its atypical variants, has increased. The awareness of doctors of all specialties about this problem, the correct and timely diagnosis of the disease allows prescribing adequate therapy earlier and thereby improves the prognosis. The aim of our work was to familiarize physicians with the clinical observation of a teenager with an atypical onset of primary infective endocarditis, occurring under the “mask” of acute cerebrovascular accident. Also, the peculiarity of this case was the primary diagnosis of hereditary thrombophilia in the patient and the possible debut of a demyelinating disease of the central nervous system during the examination, which certainly complicated the diagnostic search and affected the outcome of infective endocarditis. The significance of dental procedures preceding the disease in a child, unfortunately, was not properly appreciated by the parents, but it is the inflammatory process in the oral cavity that should be considered as a key etiological factor in the development of infective endocarditis in this case.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>дети</kwd><kwd>диагностика</kwd><kwd>нарушение мозгового кровообращения</kwd><kwd>ротовая полость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infective endocarditis</kwd><kwd>children</kwd><kwd>diagnostics</kwd><kwd>cerebrovascular accident</kwd><kwd>oral cavity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Царегородцев А.Д., Белозеров Ю.М., Брегель Л.В. Кардиология детского возраста. 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