medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-21-78-87medsovet-7207Research ArticleГОЛОВНАЯ БОЛЬ И ГОЛОВОКРУЖЕНИЕHEADACHE AND VERTIGOКлинико-психологические характеристики пациентов с мигреньюClinical and psychological characteristics of migraine patientshttps://orcid.org/0000-0002-2752-4109ГоловачеваВ. А.GolovachevaV. А.

Головачева Вероника Александровна, к.м.н., доцент кафедры нервных болезней и нейрохирургии 

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Veronika A. Golovacheva, Cand. Sci. (Med.), Associate Professor of the Department of Nervous Diseases and Neurosurgery 

8, Bldg. 2, Trubetskaya St., Moscow, 119991

xoxo.veronicka@gmail.comhttps://orcid.org/0000-0002-2845-7323ГоловачеваА. А.GolovachevaА. А.

Головачева Анжелика Александровна, клинический ординатор кафедры нервных болезней и нейрохирургии 

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Anzhelika А. Golovacheva, Clinical Resident of the Department of Nervous Diseases and Neurosurgery 

8, Bldg. 2, Trubetskaya St., Moscow, 119991

angelika.golovacheva@gmail.comhttps://orcid.org/0000-0001-9879-0036ВолодарскаяЕ. А.VolodarskayaЕ. А.

Володарская Елена Александровна, д.п.н., доцент, ведущий научный сотрудник отдела науковедения 

125315, Москва, ул. Балтийская, д. 14

Elena А. Volodarskaya, Dr. Sci. (Ped.), Associate Professor, Lead Researcher of the Department of Scientific Studies 

14, Baltiyskaya St., Moscow, 125315

eavolod@gmail.comhttps://orcid.org/0000-0001-9282-3319БахтадзеМ. А.BakhtadzeМ. А.

Бахтадзе Максим Альбертович, к.м.н., ведущий научный сотрудник лаборатории фундаментальных и прикладных проблем боли; ассистент кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета; врач-невролог, врач мануальной терапии

125315, Москва, ул. Балтийская, д. 8

117997, Москва, ул. Островитянова, д. 1

109004, Москва, Большой Дровяной переулок, д. 14, стр. 3

Maxim А. Bakhtadze, Cand. Sci. (Med.), Leading Researcher of the Laboratory of Fundamental and Applied Problems of Pain; Assistant of the Department of Neurology, Neurosurgery and Medical Genetics; Neurologist, Manual Therapist

8, Baltiyskaya St., Moscow, 125315

1, Ostrovityanov St., Moscow, 117997

14, Bldg. 3, Bolshoi Drovyanoy Lane, Moscow, 109004

bmaksb@gmail.comПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian FederationИнститут истории естествознания и техники имени С.И. Вавилова РАНРоссияInstitute of the History of Natural History and Technology named after S.I. Vavilov, RASRussian FederationНаучно-исследовательский институт общей патологии и патофизиологии; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова; Клиника восстановительной медицины «Качество жизни»РоссияInstitute of General Pathology and Pathophysiology; Pirogov Russian National Research Medical University; Restorative Medicine Clinic “Quality of Life”Russian Federation2022191120220217887Copyright © Головачева В.А., Головачева А.А., Володарская Е.А., Бахтадзе М.А., 20222022Головачева В.А., Головачева А.А., Володарская Е.А., Бахтадзе М.А.Golovacheva V.А., Golovacheva А.А., Volodarskaya Е.А., Bakhtadze М.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7207

Введение. Понимание клинико-психологических характеристик пациентов с мигренью необходимо для разработки эффективного междисциплинарного лечения, включающего психологические методы. Личностные особенности пациентов с мигренью продолжают изучаться и обсуждаться. Актуально исследование индивидуально-психологических характеристик личности у пациентов с мигренью различной частоты.Цель. Оценить клинико-психологические характеристики у пациентов с различной частотой мигрени.Материалы и методы. В исследование включено 60 пациентов с мигренью, средний возраст 32,92 ± 6,23 года. В зависимости от частоты мигрени все участники исследования распределялись в 1 из 3 групп: 1-я группа – пациенты с редкой эпизодической мигренью; 2-я группа – пациенты с частой эпизодической мигренью; 3-я группа – пациенты с хронической мигренью. Со всеми пациентами проводилась беседа и тестирование.Результаты и обсуждение. Достоверных различий между группами по средним показателям нейротизма, психотизма, экстраверсии, интроверсии не получено. В каждой группе у большинства пациентов была средняя выраженность нейротизма, а у всех остальных – ярко выраженный нейротизм; большинство пациентов были амбивалентны, т. е. имели черты и интроверта, и экстраверта, а остальные пациенты были чистыми экстравертами или чистыми интровертами. Ни у кого из пациентов не было ярко выраженного психотизма (склонности к неадекватным эмоциональным реакциям). В каждой группе преобладали пациенты с нормальным типом темперамента и темпераментами меланхолического спектра.Заключение. При хронической и частой эпизодической мигрени чаще встречаются депрессивные и тревожные расстройства, чем при редкой эпизодической мигрени. Нейротизм, психотизм, экстраверсия/интроверсия встречаются вне зависимости от частоты приступов мигрени.

Introduction. Understanding the clinical and psychological characteristics of migraine patients is essential for developing effective multidisciplinary treatment that includes psychological methods. The personality characteristics of migraine patients continue to be studied and discussed. The study of individual-psychological characteristics of personality in patients with migraine of different frequency is topical.Aim. To assess clinical and psychological characteristics in patients with varying frequency of migraine.Materials and Methods. Sixty migraine patients, mean age 32.92 ± 6.23 years, were included in the study. Depending on the frequency of migraine, all study participants were allocated to 1 of 3 groups: Group 1 – patients with rare episodic migraine; Group 2 – patients with frequent episodic migraine; Group 3 – patients with chronic migraine. All patients were interviewed and tested.Results and discussion. There were no significant differences between the groups in terms of the mean values of neuroticism, psychoticism, extraversion or introversion. Most patients in each group were moderately neurotic and all others were highly neurotic; most patients were ambivalent, i.e., shared both introvert and extrovert personality traits, with the rest being either pure extrovert or pure introvert. None of the patients were psychotic (prone to inappropriate emotional reactions). In each group, patients with a normal temperament type and melancholic spectrum temperaments predominated.Conclusion. Depressive and anxiety disorders are more common in chronic and frequent episodic migraine than in rare episodic migraine. Neuroticism, psychoticism and extraversion/introversion were found regardless of the frequency of migraine attacks.

качество жизнитревогадепрессиянейротизмтемпераментэкстраверсияинтроверсияпсихологические особенностиличностные характеристикиquality of lifeanxietydepressionneuroticismtemperamentextraversionintroversionpsychological characteristicspersonality traitsReferencesФилатова Е.Г., Осипова В.В., Табеева Г.Р., Парфенов В.А., Екушева Е.В., Азимова Ю.Э. и др. Диагностика и лечение мигрени: рекомендации российских экспертов. Неврология, нейропсихиатрия, психосоматика. 2020;12(4):4–14. https://doi.org/10.14412/2074-2711-2020-4-4-14. Filatova E.G., Osipova V.V., Tabeeva G.R., Parfenov V.A., Ekusheva E.V., Azimova Yu.E. et al. Diagnosis and treatment of migraine: Russian experts’ recommendations. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):4–14. (In Russ.) https://doi.org/10.14412/2074-2711-2020-4-4-14.Филатова Е.Г., Осипова В.В., Табеева Г.Р., Парфенов В.А., Екушева Е.В., Азимова Ю.Э. и др. Диагностика и лечение мигрени: рекомендации российских экспертов. Неврология, нейропсихиатрия, психосоматика. 2020;12(4):4–14. https://doi.org/10.14412/2074-2711-2020-4-4-14. Filatova E.G., Osipova V.V., Tabeeva G.R., Parfenov V.A., Ekusheva E.V., Azimova Yu.E. et al. Diagnosis and treatment of migraine: Russian experts’ recommendations. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):4–14. (In Russ.) https://doi.org/10.14412/2074-2711-2020-4-4-14.Ayzenberg I., Katsarava Z., Sborowski A., Chernysh M., Osipova V., Tabeeva G. et al. The prevalence of primary headache disorders in Russia: a countrywide survey. Cephalalgia. 2012;32(5):373–381. https://doi.org/10.1177/0333102412438977.Ayzenberg I., Katsarava Z., Sborowski A., Chernysh M., Osipova V., Tabeeva G. et al. The prevalence of primary headache disorders in Russia: a countrywide survey. Cephalalgia. 2012;32(5):373–381. https://doi.org/10.1177/0333102412438977.Sacco S., Lampl C., Maassen van den Brink A., Caponnetto V., Braschinsky M., Ducros A. et al. Burden and Attitude to Resistant and Refractory (BARR) Study Group. Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance. J Headache Pain. 2021;22(1):39. https://doi.org/10.1186/s10194-021-01252-4.Sacco S., Lampl C., Maassen van den Brink A., Caponnetto V., Braschinsky M., Ducros A. et al. Burden and Attitude to Resistant and Refractory (BARR) Study Group. Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance. J Headache Pain. 2021;22(1):39. https://doi.org/10.1186/s10194-021-01252-4.Safiri S., Pourfathi H., Eagan A., Mansournia M.A., Khodayari M.T., Sullman M.J.M. et al. Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019. Pain. 2022;163(2):e293–e309. https://doi.org/10.1097/j.pain.0000000000002275.Safiri S., Pourfathi H., Eagan A., Mansournia M.A., Khodayari M.T., Sullman M.J.M. et al. Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019. Pain. 2022;163(2):e293–e309. https://doi.org/10.1097/j.pain.0000000000002275.Agostoni E.C., Barbanti P., Calabresi P., Colombo B., Cortelli P., Frediani F. et al. Current and emerging evidence-based treatment options in chronic migraine: a narrative review. J Headache Pain. 2019;20(1):92. https://doi.org/10.1186/s10194-019-1038-4.Agostoni E.C., Barbanti P., Calabresi P., Colombo B., Cortelli P., Frediani F. et al. Current and emerging evidence-based treatment options in chronic migraine: a narrative review. J Headache Pain. 2019;20(1):92. https://doi.org/10.1186/s10194-019-1038-4.Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018;17(2):174–182. https://doi.org/10.1016/S1474-4422(17)30435-0.Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018;17(2):174–182. https://doi.org/10.1016/S1474-4422(17)30435-0.Головачева В.А., Головачева А.А., Парфенов В.А. Терапия при хронической мигрени: междисциплинарный подход. Клиническое наблюдение. Терапевтический архив. 2021;93(12):1528–1532. https://doi.org/10.26442/00403660.2021.12.201247. Golovacheva V.A., Golovacheva A.A., Parfenov V.A. Chronic migraine treatment: multidisciplinary approach. Case report. Terapevticheskii Arkhiv. 2021;93(12): 1528–1532. (In Russ.) https://doi.org/10.26442/00403660.2021.12.201247.Головачева В.А., Головачева А.А., Парфенов В.А. Терапия при хронической мигрени: междисциплинарный подход. Клиническое наблюдение. Терапевтический архив. 2021;93(12):1528–1532. https://doi.org/10.26442/00403660.2021.12.201247. Golovacheva V.A., Golovacheva A.A., Parfenov V.A. Chronic migraine treatment: multidisciplinary approach. Case report. Terapevticheskii Arkhiv. 2021;93(12): 1528–1532. (In Russ.) https://doi.org/10.26442/00403660.2021.12.201247.Olesen J., Bolay H., Charles A., Evers S., First M., Hershey A. et al. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. https://doi.org/10.1177/0333102417738202.Olesen J., Bolay H., Charles A., Evers S., First M., Hershey A. et al. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. https://doi.org/10.1177/0333102417738202.Modarresi S., Lukacs M.J., Ghodrati M., Salim S., MacDermid J.C., Walton D.M. A Systematic Review and Synthesis of Psychometric Properties of the Numeric Pain Rating Scale and the Visual Analog Scale for Use in People With Neck Pain. Clin J Pain. 2021;38(2):132–148. https://doi.org/10.1097/AJP.0000000000000999.Modarresi S., Lukacs M.J., Ghodrati M., Salim S., MacDermid J.C., Walton D.M. A Systematic Review and Synthesis of Psychometric Properties of the Numeric Pain Rating Scale and the Visual Analog Scale for Use in People With Neck Pain. Clin J Pain. 2021;38(2):132–148. https://doi.org/10.1097/AJP.0000000000000999.Stewart W.F., Lipton R.B., Dowson A.J., Sawyer J. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology. 2001;56(6 Suppl. 1):S20–28. https://doi.org/10.1212/wnl.56.suppl_1.s20.Stewart W.F., Lipton R.B., Dowson A.J., Sawyer J. Development and testing of the Migraine Disability Assessment (MIDAS) Questionnaire to assess headache-related disability. Neurology. 2001;56(6 Suppl. 1):S20–28. https://doi.org/10.1212/wnl.56.suppl_1.s20.Wei Y., Li H., Wang H., Zhang S., Sun Y. Psychological Status of Volunteers in a Phase I Clinical Trial Assessed by Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ). Med Sci Monit. 2018;(24):4968–4973. https://doi.org/10.12659/MSM.909524.Wei Y., Li H., Wang H., Zhang S., Sun Y. Psychological Status of Volunteers in a Phase I Clinical Trial Assessed by Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ). Med Sci Monit. 2018;(24):4968–4973. https://doi.org/10.12659/MSM.909524.Bados A., Gómez-Benito J., Balaguer G. The state-trait anxiety inventory, trait version: does it really measure anxiety? J Pers Assess. 2010;92(6):560–567. https://doi.org/10.1080/00223891.2010.513295.Bados A., Gómez-Benito J., Balaguer G. The state-trait anxiety inventory, trait version: does it really measure anxiety? J Pers Assess. 2010;92(6):560–567. https://doi.org/10.1080/00223891.2010.513295.Henry S.K., Grant M.M., Cropsey K.L. Determining the optimal clinical cutoff on the CES-D for depression in a community corrections sample. J Affect Disord. 2018;(234):270–275. https://doi.org/10.1016/j.jad.2018.02.071.Henry S.K., Grant M.M., Cropsey K.L. Determining the optimal clinical cutoff on the CES-D for depression in a community corrections sample. J Affect Disord. 2018;(234):270–275. https://doi.org/10.1016/j.jad.2018.02.071.Silberstein S.D., Stauffer V.L., Day K.A., Lipsius S., Wilson M.C. Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2). J Headache Pain. 2019;20(1):75. https://doi.org/10.1186/s10194-019-1024-x.Silberstein S.D., Stauffer V.L., Day K.A., Lipsius S., Wilson M.C. Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2). J Headache Pain. 2019;20(1):75. https://doi.org/10.1186/s10194-019-1024-x.Katsarava Z., Buse D.C., Manack A.N., Lipton R.B. Defining the differences between episodic migraine and chronic migraine. Curr Pain Headache Rep. 2012;16(1):86–92. https://doi.org/10.1007/s11916-011-0233-z.Katsarava Z., Buse D.C., Manack A.N., Lipton R.B. Defining the differences between episodic migraine and chronic migraine. Curr Pain Headache Rep. 2012;16(1):86–92. https://doi.org/10.1007/s11916-011-0233-z.Burch R.C., Buse D.C., Lipton R.B. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37(4):631–649. https://doi.org/10.1016/j.ncl.2019.06.001.Burch R.C., Buse D.C., Lipton R.B. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37(4):631–649. https://doi.org/10.1016/j.ncl.2019.06.001.Buse D.C., Reed M.L., Fanning K.M., Bostic R., Dodick D.W., Schwedt T.J. et al. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study. J Headache Pain. 2020;21(1):23. https://doi.org/10.1186/s10194-020-1084-y.Buse D.C., Reed M.L., Fanning K.M., Bostic R., Dodick D.W., Schwedt T.J. et al. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study. J Headache Pain. 2020;21(1):23. https://doi.org/10.1186/s10194-020-1084-y.Peres M.F.P., Mercante J.P.P., Tobo P.R., Kamei H., Bigal M.E. Anxiety and depression symptoms and migraine: a symptom-based approach research. J Headache Pain. 2017;18(1):37. https://doi.org/10.1186/s10194-017-0742-1.Peres M.F.P., Mercante J.P.P., Tobo P.R., Kamei H., Bigal M.E. Anxiety and depression symptoms and migraine: a symptom-based approach research. J Headache Pain. 2017;18(1):37. https://doi.org/10.1186/s10194-017-0742-1.Davis R.E., Smitherman T.A., Baskin S.M. Personality traits, personality disorders, and migraine: a review. Neurol Sci. 2013;34(1):S7–10. https://doi.org/10.1007/s10072-013-1379-8.Davis R.E., Smitherman T.A., Baskin S.M. Personality traits, personality disorders, and migraine: a review. Neurol Sci. 2013;34(1):S7–10. https://doi.org/10.1007/s10072-013-1379-8.Mongini F., Fassino S., Rota E., Deregibus A., Levi M., Monticone D., Abbate-Daga G. The temperament and character inventory in women with migraine. J Headache Pain. 2005;6(4):247–249. https://doi.org/10.1007/s10194-005-0198-6.Mongini F., Fassino S., Rota E., Deregibus A., Levi M., Monticone D., Abbate-Daga G. The temperament and character inventory in women with migraine. J Headache Pain. 2005;6(4):247–249. https://doi.org/10.1007/s10194-005-0198-6.Hamedi V., Ameri V., Azamameri A. Comparison of Anxiety, Depression, Stress and Anger in Migraine, Diabetic and Cardiac Patients and Healthy People. Procedia – Social and Behavioral Sciences. 2013;(84):1885–1888. https://doi.org/10.1016/j.sbspro.2013.07.053.Hamedi V., Ameri V., Azamameri A. Comparison of Anxiety, Depression, Stress and Anger in Migraine, Diabetic and Cardiac Patients and Healthy People. Procedia – Social and Behavioral Sciences. 2013;(84):1885–1888. https://doi.org/10.1016/j.sbspro.2013.07.053.Huber D., Henrich G. Personality traits and stress sensitivity in migraine patients. Behav Med. 2003;29(1):4–13. https://doi.org/10.1080/08964280309596169.Huber D., Henrich G. Personality traits and stress sensitivity in migraine patients. Behav Med. 2003;29(1):4–13. https://doi.org/10.1080/08964280309596169.Hedborg K., Anderberg U.M., Muhr C. Stress in migraine: personalitydependent vulnerability, life events, and gender are of significance. Ups J Med Sci. 2011;116(3):187–199. https://doi.org/10.3109/03009734.2011.573883.Hedborg K., Anderberg U.M., Muhr C. Stress in migraine: personalitydependent vulnerability, life events, and gender are of significance. Ups J Med Sci. 2011;116(3):187–199. https://doi.org/10.3109/03009734.2011.573883.Garramone F., Baiano C., Russo A., D’Iorio A., Tedeschi G., Trojano L., Santangelo G. Personality profile and depression in migraine: a meta-analysis. Neurol Sci. 2020;41(3):543–554. https://doi.org/10.1007/s10072-019-04174-x.Garramone F., Baiano C., Russo A., D’Iorio A., Tedeschi G., Trojano L., Santangelo G. Personality profile and depression in migraine: a meta-analysis. Neurol Sci. 2020;41(3):543–554. https://doi.org/10.1007/s10072-019-04174-x.Schäfer M.L. Typus melancholicus as a personality characteristic of migraine patients. Eur Arch Psychiatry Clin Neurosci. 1994;243(6):328–339. https://doi.org/10.1007/BF02195727.Schäfer M.L. Typus melancholicus as a personality characteristic of migraine patients. Eur Arch Psychiatry Clin Neurosci. 1994;243(6):328–339. https://doi.org/10.1007/BF02195727.Caspar F. Studying Effects and Process in Psychotherapy for Personality Disorders. Psychopathology. 2018;51(2):141–148. https://doi.org/10.1159/000487895.Caspar F. Studying Effects and Process in Psychotherapy for Personality Disorders. Psychopathology. 2018;51(2):141–148. https://doi.org/10.1159/000487895.Paris J., Black D.W. Psychotherapy for personality disorders is underfunded. Ann Clin Psychiatry. 2021;33(4):217–218. https://doi.org/10.12788/acp.0043.Paris J., Black D.W. Psychotherapy for personality disorders is underfunded. Ann Clin Psychiatry. 2021;33(4):217–218. https://doi.org/10.12788/acp.0043.Green M.W., Muskin P.R. The neuropsychiatry of headache. UK: Cambridge University Press, 2013; 181 p. https://doi.org/10.1017/CBO9781139206952.013.Green M.W., Muskin P.R. The neuropsychiatry of headache. UK: Cambridge University Press, 2013; 181 p. https://doi.org/10.1017/CBO9781139206952.013.Rothrock J., Lopez I., Zweilfer R., Andress-Rothrock D., Drinkard R., Walters N. Borderline personality disorder and migraine. Headache. 2007;47(1):22–26. https://doi.org/10.1111/j.1526-4610.2007.00649.x.Rothrock J., Lopez I., Zweilfer R., Andress-Rothrock D., Drinkard R., Walters N. Borderline personality disorder and migraine. Headache. 2007;47(1):22–26. https://doi.org/10.1111/j.1526-4610.2007.00649.x.

The authors declare that there are no conflicts of interest present.