medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2022-002medsovet-7278Research ArticleПЕДИАТРИЯPEDIATRICSРанние и отдаленные последствия для новорожденных при синдроме задержки роста плода: данные ретроспективного исследования за 2019–2021 годыEarly and long-term consequences for newborns with fetus growth retardation. Retrospective study data for 2019–2021https://orcid.org/0000-0002-2882-8163ГасанбековаА. П.GasanbekovaA. P.

Гасанбекова Аида Пирмагомедовна, аспирант акушерского отделения 

117997, Москва, ул. Академика Опарина, д. 4

Aida P. Gasanbekova, Graduate Student of the Institute of Obstetrics 

4, Academician Oparin St., Moscow, 117997

aidoxxa21@mail.ruhttps://orcid.org/0000-0002-6090-586XЛомоваН. А.LomovaN. A.

Ломова Наталья Анатольевна, к.м.н., старший научный сотрудник акушерского отделения 

117997, Москва, ул. Академика Опарина, д. 4

Natalia A. Lomova, Cand. Sci. (Med.), Senior Research Associate of the Institute of Obstetrics 

4, Academician Oparin St., Moscow, 117997

natasha-lomova@yandex.ruhttps://orcid.org/0000-0003-2572-9028ДолгополоваЕ. Л.DolgopolovaE. L.

Долгополова Елена Леонидовна, аспирант акушерского отделения 

117997, Москва, ул. Академика Опарина, д. 4

Elena L. Dolgopolova, Graduate Student of the Institute of Obstetrics 

4, Academician Oparin St., Moscow, 117997

dolgopolovae93@mail.ruhttps://orcid.org/0000-0003-2001-8761ТитоваЕ. В.TitovaE. V.

Титова Елена Витальевна, младший научный отделения патологии новорожденных и недоношенных детей 

117997, Москва, ул. Академика Опарина, д. 4

Elena V. Titova, Junior Researcher of the Department of Pathology of Newborns and Premature Babies 

4, Academician Oparin St., Moscow, 117997

e_titova@oparina4.ruhttps://orcid.org/0000-0003-0025-3182КарапетянТ. Э.KarapetyanT. Eh.

Карапетян Тамара Эдуардовна, д.м.н., старший научный сотрудник акушерского отделения 

117997, Москва, ул. Академика Опарина, д. 4

Tamara Eh. Karapetyan, Dr. Sci. (Med.), Senior Research Associate of the Institute of Obstetrics 

4, Academician Oparin St., Moscow, 117997

tomamed02@mail.ruhttps://orcid.org/0000-0003-1831-887XРюминаИ. И.RyuminaI. I.

Рюмина Ирина Ивановна, д.м.н., профессор, заведующая отделением патологии новорожденных и недоношенных детей 

117997, Москва, ул. Академика Опарина, д. 4

Irina I. Ryumina, Dr. Sci. (Med.), Professor, Head of Department of Pathology of Newborns and Premature Babies 

4, Academician Oparin St., Moscow, 117997

i_ryumina@oparina4.ruНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian Federation20232712202206172179Copyright © Гасанбекова А.П., Ломова Н.А., Долгополова Е.Л., Титова Е.В., Карапетян Т.Э., Рюмина И.И., 20232023Гасанбекова А.П., Ломова Н.А., Долгополова Е.Л., Титова Е.В., Карапетян Т.Э., Рюмина И.И.Gasanbekova A.P., Lomova N.A., Dolgopolova E.L., Titova E.V., Karapetyan T.E., Ryumina I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7278

Введение. Актуальность проблемы задержки роста плода не вызывает сомнений. На сегодняшний день установлено, что ЗРП осложняет 15% всех беременностей в  мире, увеличиваясь до  25% при отягощенном акушерско-гинекологическом анамнезе и осложненной беременности. По данным ряда исследований известно, что ЗРП приводит в более позднем возрасте к развитию таких заболеваний, как метаболический синдром, ожирение, ишемическая болезнь сердца, гипертония, сахарный диабет 2-го типа. Цель. Выявить клинико-анамнестические факторы риска развития формирования ЗРП и оценить ранние неонатальные исходы здоровья новорожденных при различных формах ЗРП (ранняя и поздняя). Материалы и методы. Работа была построена на ретроспективном обзоре карт, включающем 2 000 историй родов женщин, родоразрешенных в  центре с  2019  по  2021  г. Было отобрано 145  историй родов с  ЗРП согласно критериям включения и исключения и 66 историй родов с нормально протекающей беременностью. Краткосрочные итоги ЗРП были проанализированы на основе данных медицинских карт новорожденных, долгосрочные исходы ЗРП были определены после последующего изучения 64 случаев детей за 12 мес., наблюдающихся на территории детской поликлиники центра. Результаты. К значимым клиническим факторам риска реализации ЗРП следует относить: ИМТ матери, вызванную беременностью гипертензию/преэклампсию, гестационный сахарный диабет на  фоне нормальных массо-ростовых показателей матери и маловодие. Среди младенцев с ЗРП отмечено увеличение таких осложнений, как дыхательная недостаточность, гипертрофия миокарда, недостаточность кровообращения и диссеминированное внутрисосудистое свертывание крови, они ассоциированы с повышением риска перинатальной смертности и увеличением младенческой смертности. Выводы. Задержка роста плода имеет значительное неблагоприятное воздействие на здоровье плода и новорожденного и его отдаленные прогнозы. Новорожденные с задержкой роста имеют более высокую заболеваемость и смертность, требуют более длительного пребывания в стационаре и, соответственно, больших больничных расходов. 

Introduction. The urgency of the problem of fetal growth retardation is beyond doubt. To date, it has been established that IUGR complicates 15% of all pregnancies in the world, increasing to 25% with a burdened obstetric and gynecological history and complicated pregnancy. According to a number of studies, it is known that FGR leads at a later age to the development of diseases such as metabolic syndrome, obesity, coronary heart disease, hypertension, and type 2 diabetes. Objective. To identify clinical and anamnestic risk factors for the development of IUGR and assess early neonatal health outcomes for newborns with various forms of IUGR (early and late).Materials and methods. The work was based on a retrospective review of maps, including 2000 birth histories of women who gave birth at the Center from 2019 to 2021. We selected 145 birth histories with IUGR, according to the inclusion and exclusion criteria and 66 birth histories with a normal pregnancy. Short-term outcomes of IUGR were analyzed on the basis of data from medical records of newborns, long-term outcomes of IUGR were determined after a subsequent study of 64 cases of children at 12 months old, observed on the territory of the Center’s children’s polyclinic Results. Significant clinical risk factors for the implementation of IGR should include: maternal BMI, pregnancy-induced hypertension/preeclampsia, gestational diabetes mellitus against the background of normal maternal weight and height, and oligohydramnios. Among infants with IGR, an increase in complications such as respiratory failure, myocardial hypertrophy, circulatory failure and disseminated intravascular coagulation is associated with an increased risk of perinatal mortality and an increase in infant mortality. Conclusions. IGR has a significant adverse effect on the health of the fetus and newborn and its long-term prognosis. Newborns with growth retardation have higher morbidity and mortality, require longer hospital stays, and consequently require higher hospital costs

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The authors declare that there are no conflicts of interest present.