medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2022-16-23-310-318medsovet-7311Research ArticleCOVID-19Факторы, ассоциированные с тяжелым течением новой коронавирусной инфекцииProspects for studying the role of some essential and toxic trace elements in the pathogenesis of COVID-19https://orcid.org/0000-0003-0059-4980ЯнушевичО. О.YanushevichO. O.

Янушевич Олег Олегович - академик РАН, доктор медицинских наук, профессор, ректор.

127473, Москва, ул. Делегатская, д. 20, стр. 1

Oleg O. Yanushevich - Acad. RAS, Dr. Sci. (Med.), Professor, Rector, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

mail@msmsu.ruhttps://orcid.org/0000-0002-5085-4587РомановА. О.RomanovA. O.

Романов Алексей Олегович - преподаватель кафедры ЮНЕСКО «Здоровый образ жизни – залог успешного развития».

127473, Москва, ул. Делегатская, д. 20, стр. 1

Alexeу O. Romanov - Lecturer of the UNESCO Department “Healthy Lifestyle is the Key to Successful Development”, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

alexseu23ru@gmail.comhttps://orcid.org/0000-0001-5261-3552ИвкинаМ. В.IvkinaM. V.

Ивкина Мария Валентиновна - кандидат медицинских наук, старший преподаватель кафедры нормальной физиологии и медицинской физики.

127473, Москва, ул. Делегатская, д. 20, стр. 1

Mariia V. Ivkina - Cand. Sci. (Med.), Senior Lecturer, Department of Normal Physiology and Medical Physics, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

terekhova_m@mail.ruhttps://orcid.org/0000-0002-0792-6194АрхангельскаяА. Н.ArkhangelskaiaA. N.

Архангельская Анна Николаевна - кандидат медицинских наук, доцент кафедры ЮНЕСКО «Здоровый образ жизни – залог успешного развития».

127473, Москва, ул. Делегатская, д. 20, стр. 1

Anna N. Arkhangelskaia - Cand. Sci. (Med.), Associate Professor of the UNESCO Department “Healthy Lifestyle is the Key to Successful Development”, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

cattiva@list.ruhttps://orcid.org/0000-0001-7452-1122ШариповаМ. М.SharipovaM. M.

Шарипова Майсият Магомедовна - кандидат медицинских наук, ассистент кафедры нервных болезней.

127473, Москва, ул. Делегатская, д. 20, стр. 1

Maisiyat M. Sharipova - Cand. Sci. (Med.), Assistant of the Department of Nervous Diseases, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

maisiyat@bk.ruhttps://orcid.org/0000-0002-9709-8299ЯковлеваМ. В.YakovlevaM. V.

Яковлева Мария Владимировна - кандидат биологических наук, ведущий научный сотрудник научно-исследовательского отдела биоиндикации, заведующий лабораторией элементного анализа.

194044, Санкт-Петербург, ул. Академика Лебедева, д. 4/2

Maria V. Yakovleva - Cand. Sci. (Biol.), Leading Researcher of the Research Department of Bioindication, Head of the Laboratory of Elemental Analysis, Nikiforov Russian Center of Emergency and Radiation Medicine.

4/2, Akademik Lebedev St., St Petersburg, 194044

iakorobok@mail.ruhttps://orcid.org/0000-0003-1840-5770ШантырьИ. И.ShantyrI. I.

Шантырь Игорь Игнатьевич - доктор медицинских наук, профессор, главный научный сотрудник, заведующий научно-исследовательским отделом биоиндикации.

194044, Санкт-Петербург, ул. Академика Лебедева, д. 4/2

Igor I. Shantyr - Dr. Sci. (Med.), Professor, Chief Researcher, Head of the Research Department of Bioindication, Nikiforov Russian Center of Emergency and Radiation Medicine.

4/2, Akademik Lebedev St., St Petersburg, 194044

shantyr@arcerm.spb.ruhttps://orcid.org/0000-0003-2836-6891ВласенкоМ. А.VlasenkoM. A.

Власенко Мария Александровна - кандидат биологических наук, старший научный сотрудник научно-исследовательского отдела биоиндикации.

194044, Санкт-Петербург, ул. Академика Лебедева, д. 4/2

Maria A. Vlasenko - Cand. Sci. (Biol.), Senior Researcher, Research Department of Bioindication, Nikiforov Russian Center of Emergency and Radiation Medicine.

4/2, Akademik Lebedev St., St Petersburg, 194044

vlasenkomaria@gmail.comhttps://orcid.org/0000-0002-7603-6064ГуревичК. Г.GurevichK. G.

Гуревич Константин Георгиевич - доктор медицинских наук, профессор РАН, заведующий кафедрой ЮНЕСКО «Здоровый образ жизни – залог успешного развития».

127473, Москва, ул. Делегатская, д. 20, стр. 1

Konstantin G. Gurevich - Dr. Sci. (Med.), Professor RAS, Head of the UNESCO Department “Healthy Lifestyle is the Key to Successful Development”, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

kgurevich@mail.ruhttps://orcid.org/0000-0003-0857-9398ЛевченкоО. В.LevchenkoO. V.

Левченко Олег Валерьевич - доктор медицинских наук, профессор, проректор по лечебной работе, профессор кафедры нейрохирургии и нейрореанимации.

127473, Москва, ул. Делегатская, д. 20, стр. 1

Oleg V. Levchenko - Dr. Sci. (Med.), Professor, Vice-Rector for General Medicine, Professor of the Department of Neurosurgery and Neuroreanimation, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

prorektor-04@msmsu.ruhttps://orcid.org/0000-0001-6114-564XМаевИ. В.MaevI. V.

Маев Игорь Вениаминович - академик РАН, доктор медицинских наук, профессор, проректор по учебной работе – первый проректор, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии лечебного факультета.

127473, Москва, ул. Делегатская, д. 20, стр. 1

Igor V. Maev - Acad. RAS, Dr. Sci. (Med.), Professor, Vice-Rector for Academic Affairs – First Vice-Rector, Head of the Department of Propaedeutics of Internal Diseases and Gastroenterology of the Faculty of Medicine, Yevdokimov Moscow State University of Medicine and Dentistry.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

ProRekt-02@msmsu.ruМосковский государственный медико-стоматологический университет имени А.И. ЕвдокимоваРоссияYevdokimov Moscow State University of Medicine and DentistryRussian FederationВсероссийский центр экстренной и радиационной медицины имени А.М. НикифороваРоссияNikiforov Russian Center of Emergency and Radiation MedicineRussian Federation202218012023023310318Copyright © Янушевич О.О., Романов А.О., Ивкина М.В., Архангельская А.Н., Шарипова М.М., Яковлева М.В., Шантырь И.И., Власенко М.А., Гуревич К.Г., Левченко О.В., Маев И.В., 20232023Янушевич О.О., Романов А.О., Ивкина М.В., Архангельская А.Н., Шарипова М.М., Яковлева М.В., Шантырь И.И., Власенко М.А., Гуревич К.Г., Левченко О.В., Маев И.В.Yanushevich O.O., Romanov A.O., Ivkina M.V., Arkhangelskaia A.N., Sharipova M.M., Yakovleva M.V., Shantyr I.I., Vlasenko M.A., Gurevich K.G., Levchenko O.V., Maev I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7311Введение

Введение. Факторы, влияющие на тяжесть течения новой коронавирусной инфекции, остаются до конца не изученными.

Цель

Цель. Исследовать факторы, ассоциированные с переходом COVID-19 из средней в тяжелую форму, у пациентов, находящихся на стационарном лечении.

Материалы и методы

Материалы и методы. Диагноз ассоциированной с COVID-19 пневмонии выставлялся врачом-клиницистом на основании данных ПЦР-теста и актуального КТ-исследования органов грудной клетки. Всего было обследовано 195 последовательно набранных пациентов. Средний возраст обследованных составил 54 (12,1) года.

Результаты

Результаты. Значимо большее число пациентов с тяжелым течением коронавирусной инфекции на момент госпитализации были активными курильщиками (33 (29,73%) против 67 (79,6%); p < 0,002) и имели ИМТ, соответствующий предожирению/ ожирению (42 (37,84%) против 44 (52,38%); p = 0,027). У пациентов с тяжелым течением COVID-19 в общем анализе крови отмечалось значимо большее содержание лейкоцитов (6,054 (2,813) против 7,307 (4,707); p = 0,021). Также группы достоверно отличались по содержанию микро- и макроэлементов. Выявленный в нашем исследовании дисбаланс минеральных веществ публикуется впервые, так как содержание Al, B, Li, Co, Sr и Si у пациентов с COVID-19 не изучалось.

Заключение

Заключение. Выявленные изменения микроэлементного статуса требуют дальнейшего изучения для подтверждения их значения в развитии тяжелой формы новой коронавирусной инфекции у пациентов.

Introduction

Introduction. Factors affecting the severity of the course of a new coronavirus infection remain unexplored to the end

Aim

Aim. To study the factors associated with the transition of COVID-19 from moderate to severe form of the disease in patients undergoing inpatient treatment

Materials and methods

Materials and methods. The diagnosis of COVID-19-associated pneumonia was made by a clinician on the basis of PCR test data and an up-to-date chest CT scan. A total of 195 consecutively recruited patients were examined. The average age of the surveyed was 54 (12.1) years.

Results

Results. Significantly more patients with severe coronavirus infection at the time of hospitalization were active tobacco smokers (33 (29.73%) vs 67 (79.6%); p < 0.002) and had a BMI consistent with pre-obesity/obesity (42 (37.84%) vs 44 (52.38%); p = 0.027). In patients with severe COVID-19, a significantly higher content of leukocytes was noted in the complete blood count (6.054 (2.813) vs 7.307 (4.707); p = 0.021). The groups also differed significantly in the content of micro- and macroelements. The imbalance of minerals revealed in our study is published for the first time, because. The study of the content of Al, B, Li, Co, Sr and Si in patients with COVID-19 was not carried out.

Conclusion

Conclusion. The revealed changes in the microelement status require further study to confirm their significance in the development of a severe form of a new coronavirus infection in patients.

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The authors declare that there are no conflicts of interest present.