medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-039medsovet-7388Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESФоточувствительные дерматозы в детской практикеPhotosensitive dermatoses in paediatric practicehttps://orcid.org/0000-0003-3261-6718ТамразоваО. Б.TamrazovaO. B.

Тамразова Ольга Борисовна, д.м.н., профессор  кафедры дерматовенерологии с курсом  косметологии факультета непрерывного  медицинского образования Медицинского института; руководитель центра аллергодерматозов 

 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6 

 125373, Россия, Москва, ул. Героев Панфиловцев, д. 28 

 Olga В. Tamrazova, Dr. Sci. (Med.), Рrofessor of the Department of Dermatovenerology with the course of Cosmetology of the Faculty of Continuing Medical Education of the Medical Institute; Head of the Allergodermatosis Center

6, Miklukho-Maklai St., Moscow, 117198, Russia

28, Geroev Panfilovtsev St., Moscow, 125373, Russia 

anait_tamrazova@mail.ruhttps://orcid.org/0000-0003-3420-4442СтадниковаА. С.StadnikovaA. S.

Стадникова Антонина Сергеевна, к.м.н., ассистент кафедры дерматовенерологии с курсом косметологии факультета непрерывного медицинского образования Медицинского института; врач-дерматовенеролог 

117198, Россия, Москва, ул. Миклухо-Маклая, д. 6

125373, Россия, Москва, ул. Героев Панфиловцев, д. 28 

Antonina S. Stadnikova, Cand. Sci. (Med.), Аssistant of the Department of Dermatovenerology with the course of Cosmetology of the Facultyof Continuing Medical Education of the Medical Institute; Dermatovenerologist

6, Miklukho-Maklai St., Moscow, 117198, Russia;

28, Geroev Panfilovtsev St., Moscow, 125373, Russia 

tonya-st@yandex.ruhttps://orcid.org/0000-0002-7571-5460НовикГ. А.NovikG. A.

Новик Геннадий Айзикович, д.м.н., профессор, заведующий кафедрой педиатрии имени профессора И.М. Воронцова 

194100, Россия, Санкт-Петербург, ул. Литовская, д. 2 

Gennady А. Novik, Dr. Sci. (Med.), Professor, Head of the Department of Pediatrics named after Professor I.M. Vorontsov

2, Litovskaya St., St Petersburg, 194100, Russia 

ga_novik@mail.ruhttps://orcid.org/0000-0003-4615-7356БаграмоваГ. Э.BagramovaG. E.

Баграмова Гаянэ Эрнстовна, д.м.н., профессор кафедры дерматовенерологии с курсом косметологии факультета непрерывного медицинского образования Медицинского института 

 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6 

Gayane Е. Bagramova, Dr. Sci. (Med.), Рrofessor of the Department of Dermatovenerology with the course of Cosmetology of the Faculty of Continuing Medical Education of the Medical Institute

6, Miklukho-Maklai St., Moscow, 117198, Russia 

bagramovaga@mail.ruРоссийский университет дружбы народов; Детская городская клиническая больница имени З.А. БашляевойРоссияPeoples’ Friendship University of Russia; Bashlyaeva City Children’s Clinical HospitalRussian FederationРоссийский университет дружбы народов; Детская городская клиническая больница имени З.А. БашляевойРоссияPeoples’ Friendship University of Russia; Bashlyaeva City Children’s Clinical HospitalRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSt Petersburg State Pediatric Medical UniversityRussian FederationРоссийский университет дружбы народовРоссияPeoples’ Friendship University of RussiaRussian Federation202315032023025461Copyright © Тамразова О.Б., Стадникова А.С., Новик Г.А., Баграмова Г.Э., 20232023Тамразова О.Б., Стадникова А.С., Новик Г.А., Баграмова Г.Э.Tamrazova O.B., Stadnikova A.S., Novik G.A., Bagramova G.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7388

Фотодерматозы – это гетерогенная группа заболеваний, которая характеризуется развитием патологической реакции кожи на солнечное излучение. Отличительной чертой всех фоточувствительных фотодерматозов является развитие или усиление воспалительной реакции в коже после облучения ультрафиолетовым или видимым электромагнитным спектром света. Несмотря на то что фотодерматозы в детском возрасте встречаются реже, чем во взрослом, они зачастую связаны с генетическими или врожденными метаболическими нарушениями, а также могут указывать на диффузные заболевания соединительной ткани. По данным эпидемиологических исследований, распространенность фотодерматозов в мире, диагностированных с помощью фотопатч-тестов, составляет от 5,7%. Авторы представили современную классификацию фоточувствительных дерматозов по этиологическому фактору. В статье приведены современные сведения о фоточувствительных дерматозах, включая статистические эпидемиологические данные, особенности патогенеза, а также сделаны акценты на проблемах качества жизни детей и их родителей. Авторы описали клинические проявления наиболее распространенных фоточувствительных дерматозов у детей и основные принципы их терапии. Из топических глюкокортикостероидов в лечении фотодерматозов у детей хорошо зарекомендовал себя метилпреднизолона ацепонат, т. к. он обладает не только выраженным противовоспалительным действием, но и удобен в применении. Своевременная диагностика фоточувствительности в детском возрасте позволит свести к минимуму развитие осложнений, связанных с несвоевременным лечением и недостаточной профилактикой (фотозащитой).

Photodermatoses represent a heterogeneous group of disorders characterized by the development of pathological skin reaction to solar radiation. The development or intensification of inflammatory skin reaction after exposure to ultraviolet or electromagnetic spectrum that is visible to the human eye is a distinctive feature of all photosensitive photodermatoses. Although photodermatoses are less common in children than in adults, they are often associated with genetic or congenital metabolic disorders, and may also point to diffuse connective tissue diseases. Paediatric photodermatoses are often the result of genetic or congenital metabolic disorders, and may also indicate diffuse connective tissue diseases. The epidemiological studies have showed that the global prevalence of photodermatoses diagnosed with photopatch tests is above or equal to 5.7%. The authors presented a modern classification of photosensitive dermatoses according to the etiological factor. The article provides up-to-date information about photosensitive dermatoses, including statistical epidemiological data, pathogenesis features, and also emphasis is placed on the issues of the quality of life of children and their parents. The authors described the clinical presentations of the most common paediatric photosensitive dermatoses and the basic principles of their therapy. Among topical glucocorticosteroids, methylprednisolone aceponate has proven itself in the treatment of paediatric photodermatoses as it has not only a pronounced anti-inflammatory effect, but also is easy-to-use. The timely diagnosis of paediatric photosensitivity will help to minimize the development of complications associated with delayed treatment and insufficient prevention (photoprotection).

фотодерматозыфотозащитаглюкокортикостероидыультрафиолетметилпреднизолона ацепонатphotodermatosesphotoprotectionglucocorticosteroidsultravioletmethylprednisolone aceponateReferencesMateeva V., Angelova-Fischer I. Irritant Contact Dermatitis: Clinical Aspects. In: Maibach H., Honari G. (eds.). Applied Dermatotoxicology. Boston: Academic Press; 2014. 150 p.Mateeva V., Angelova-Fischer I. Irritant Contact Dermatitis: Clinical Aspects. In: Maibach H., Honari G. (eds.). Applied Dermatotoxicology. Boston: Academic Press; 2014. 150 p.Epstein J.H. Phototoxicity and photoallergy in man. J Am Acad Dermatol. 1983;8(2):141–147. https://doi.org/10.1016/s0190-9622(83)70016-2.Epstein J.H. Phototoxicity and photoallergy in man. J Am Acad Dermatol. 1983;8(2):141–147. https://doi.org/10.1016/s0190-9622(83)70016-2.Бакстон П.К. Дерматология. М.; 2005. 173 с.Buxton P.K. ABC of dermatology. London: BMJ; 1999. 124 р.Вульф К., Джонсон К., Сюрмонд К. (ред.). Дерматология по Томасу Фицпатрику. М.: Практика; 2007. 1248 с. Wolf K., Johnson K., Suurmond K. (eds.). Clinical Dermatology: Fitzpatrick’s Color Atlas and Synopsis. 5th ed. New York: McGraw-Hill Medical Pub. Division; 2005. 1085 р.Wolf K., Johnson K., Suurmond K. (eds.). Clinical Dermatology: Fitzpatrick’s Color Atlas and Synopsis. 5th ed. New York: McGraw-Hill Medical Pub. Division; 2005. 1085 р.Gaspari A.A. Mechanisms of resolution of allergic contact dermatitis. Am J Contact Dermat. 1996;7(4):212–219. Available at: https://pubmed.ncbi.nlm.nih.gov/8955483.Gaspari A.A. Mechanisms of resolution of allergic contact dermatitis. Am J Contact Dermat. 1996;7(4):212–219. Available at: https://pubmed.ncbi. nlm.nih.gov/8955483.Jansen C.T. Photosensitivity in childhood. Acta Derm Venereol Suppl (Stockh). 1981;95:54–57. Available at: https://pubmed.ncbi.nlm.nih.gov/6953715.Jansen C.T. Photosensitivity in childhood. Acta Derm Venereol Suppl (Stockh). 1981;95:54–57. Available at: https://pubmed.ncbi.nlm.nih.gov/6953715.Greenspoon J., Ahluwalia R., Juma N., Rosen C.F. Allergic and photoallergic contact dermatitis: a 10-year experience. Dermatitis. 2013;24(1):29–32. https://doi.org/10.1097/DER.0b013e31827edc8b.Greenspoon J., Ahluwalia R., Juma N., Rosen C.F. Allergic and photoallergic contact dermatitis: a 10-year experience. Dermatitis. 2013;24(1):29–32. https://doi.org/10.1097/DER.0b013e31827edc8b.Gao L., Hu Y., Ni C., Xu Y., Ma L., Yan S., Dou X. Retrospective study of PhotoPatch testing in a Chinese population during a 7-year period. Dermatitis. 2014;25(1):22–26. https://doi.org/10.1097/DER.0000000000000008.Gao L., Hu Y., Ni C., Xu Y., Ma L., Yan S., Dou X. Retrospective study of PhotoPatch testing in a Chinese population during a 7-year period. Dermatitis. 2014;25(1):22–26. https://doi.org/10.1097/DER.0000000000000008.Rodrı´guez E., Valbuena M.C., Rey M., Porras de Quintana L. Causal agents of photoallergic contact dermatitis diagnosed in the National Institute of Dermatology of Colombia. Photodermatol Photoimmunol Photomed. 2006;22(4):189–192. https://doi.org/10.1111/j.1600-0781.2006.00212.x.Rodrı´guez E., Valbuena M.C., Rey M., Porras de Quintana L. Causal agents of photoallergic contact dermatitis diagnosed in the National Institute of Dermatology of Colombia. Photodermatol Photoimmunol Photomed. 2006;22(4):189–192. https://doi.org/10.1111/j.1600-0781.2006.00212.x.The European Multicentre Photopatch Test Study (EMCPPTS) Taskforce. A European multicentre photopatch test study: European photopatch test study. Br J Dermatol. 2012;166(5):1002–1009. https://doi.org/10.1111/j.1365-2133.2012.10857.x.The European Multicentre Photopatch Test Study (EMCPPTS) Taskforce. A European multicentre photopatch test study: European photopatch test study. Br J Dermatol. 2012;166(5):1002–1009. https://doi.org/10.1111/j.1365-2133.2012.10857.x.Katsarou A., Makris M., Zarafonitis G., Lagogianni E., Gregoriou S., Kalogeromitros D. Photoallergic contact dermatitis: the 15-year experience of a tertiary reference center in a sunny Mediterranean city. Int J Immunopathol Pharmacol. 2008;21(3):725–727. https://doi.org/10.1177/039463200802100327.Katsarou A., Makris M., Zarafonitis G., Lagogianni E., Gregoriou S., Kalogeromitros D. Photoallergic contact dermatitis: the 15-year experience of a tertiary reference center in a sunny Mediterranean city. Int J Immunopathol Pharmacol. 2008;21(3):725–727. https://doi.org/10.1177/039463200802100327.Pigatto P.D., Guzzi G., Schena D., Guarrera M., Foti C., Francalanci S. et al. Photopatch tests: an Italian multicenter study from 2004 to 2006. Contact Dermatitis. 2008;59(2):103–108. https://doi.org/10.1111/j.1600-0536.2008.01374.x.Pigatto P.D., Guzzi G., Schena D., Guarrera M., Foti C., Francalanci S. et al. Photopatch tests: an Italian multicenter study from 2004 to 2006. Contact Dermatitis. 2008;59(2):103–108. https://doi.org/10.1111/j.1600-0536.2008.01374.x.Bryden A.M., Moseley H., Ibbotson S.H., Chowdhury M.M., Beck M.H., Bourke J. et al. Photopatch testing of 1155 patients: results of the U.K. multicentre photopatch study group. Br J Dermatol. 2006;155(4):737–747. https://doi.org/10.1111/j.1365-2133.2006.07458.x.Bryden A.M., Moseley H., Ibbotson S.H., Chowdhury M.M., Beck M.H., Bourke J. et al. Photopatch testing of 1155 patients: results of the U.K. multicentre photopatch study group. Br J Dermatol. 2006;155(4):737–747. https://doi.org/10.1111/j.1365-2133.2006.07458.x.Scalf L.A., Davis M.D.P., Rohlinger A.L., Connolly S.M. Photopatch testing of 182 patients: a 6 year experience at the Mayo Clinic. Dermatitis. 2009;20(1):44–45. Available at: https://pubmed.ncbi.nlm.nih.gov/19321120.Scalf L.A., Davis M.D.P., Rohlinger A.L., Connolly S.M. Photopatch testing of 182 patients: a 6 year experience at the Mayo Clinic. Dermatitis. 2009;20(1):44–45. Available at: https://pubmed.ncbi.nlm.nih.gov/19321120.Gill L., Lim H.W. Drug-induced photosensitivity. In: Hall J.C., Hall B.J. (eds.). Cutaneous Drug Eruptions: Diagnosis, Histopathology and Therapy. London: Springer-Verlag; 2015.Gill L., Lim H.W. Drug-induced photosensitivity. In: Hall J.C., Hall B.J. (eds.). Cutaneous Drug Eruptions: Diagnosis, Histopathology and Therapy. London: Springer-Verlag; 2015.Grossberg A.L. Pediatric photosensitivity. Photodermatol Photoimmunol Photomed. 2012;28(4):174–180. https://doi.org/10.1111/j.1600-0781.2012.00670.x.Grossberg A.L. Pediatric photosensitivity. Photodermatol Photoimmunol Photomed. 2012;28(4):174–180. https://doi.org/10.1111/j.1600-0781.2012.00670.x.Rizwan M., Haylett A.K., Richards H.L., Ling T.C., Rhodes L.E. Impact of photosensitivity disorders on the life quality of children. Photodermatol Photoimmunol Photomed. 2012;28(6):290–292. https://doi.org/10.1111/j.1600-0781.2012.00691.x.Rizwan M., Haylett A.K., Richards H.L., Ling T.C., Rhodes L.E. Impact of photosensitivity disorders on the life quality of children. Photodermatol Photoimmunol Photomed. 2012;28(6):290–292. https://doi.org/10.1111/j.1600-0781.2012.00691.x.Hongbo Y., Thomas C.L., Harrison M.A., Salek M.S., Finlay A.Y. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol. 2005;125(4):659–664. https://doi.org/10.1111/j.0022-202X.2005.23621.x.Hongbo Y., Thomas C.L., Harrison M.A., Salek M.S., Finlay A.Y. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol. 2005;125(4):659–664. https://doi.org/10.1111/j.0022-202X.2005.23621.x.Lewis-Jones M.S., Finlay A.Y. The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132(6):942–949. https://doi.org/10.1111/j.1365-2133.1995.tb16953.x.Lewis-Jones M.S., Finlay A.Y. The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132(6):942–949. https://doi.org/10.1111/j.1365-2133.1995.tb16953.x.Beattie P.E., Lewis-Jones M.S. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol. 2006;155(1):145–151. https://doi.org/10.1111/j.1365-2133.2006.07185.x.Beattie P.E., Lewis-Jones M.S. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol. 2006;155(1):145–151. https://doi.org/10.1111/j.1365-2133.2006.07185.x.Cavallo J., DeLeo V.A. Sunburn. Dermatol Clin. 1986;4(2):181–187. Available at: https://pubmed.ncbi.nlm.nih.gov/3955890.Cavallo J., DeLeo V.A. Sunburn. Dermatol Clin. 1986;4(2):181–187. Available at: https://pubmed.ncbi.nlm.nih.gov/3955890.Lopes D.M., McMahon S.B. Ultraviolet Radiation on the Skin: A Painful Experience? CNS Neurosci Ther. 2016;22(2):118–126. https://doi.org/10.1111/cns.12444.Lopes D.M., McMahon S.B. Ultraviolet Radiation on the Skin: A Painful Experience? CNS Neurosci Ther. 2016;22(2):118–126. https://doi.org/10.1111/cns.12444.Dawes J.M., Calvo M., Perkins J.R., Paterson K.J., Kiesewetter H., Hobbs C. et al. CXCL5 mediates UVB irradiation-induced pain. Sci Transl Med. 2011;3(90):90ra60. https://doi.org/10.1126/scitranslmed.3002193.Dawes J.M., Calvo M., Perkins J.R., Paterson K.J., Kiesewetter H., Hobbs C. et al. CXCL5 mediates UVB irradiation-induced pain. Sci Transl Med. 2011;3(90):90ra60. https://doi.org/10.1126/scitranslmed.3002193.Bishop T., Marchand F., Young A.R., Lewin G.R., McMahon S.B. Ultraviolet-Binduced mechanical hyperalgesia: A role for peripheral sensitisation. Pain. 2010;150(1):141–152. https://doi.org/10.1016/j.pain.2010.04.018.Bishop T., Marchand F., Young A.R., Lewin G.R., McMahon S.B. Ultraviolet-Binduced mechanical hyperalgesia: A role for peripheral sensitisation. Pain. 2010;150(1):141–152. https://doi.org/10.1016/j.pain.2010.04.018.Epstein J.H. Phototoxicity and photoallergy. Semin Cutan Med Surg. 1999;18(4):274–284. https://doi.org/10.1016/s1085-5629(99)80026-1.Epstein J.H. Phototoxicity and photoallergy. Semin Cutan Med Surg. 1999;18(4):274–284. https://doi.org/10.1016/s1085-5629(99)80026-1.Levine G.M., Harber L.C. The effect of humidity on the phototoxic response to 8-methoxypsoralen in guinea pigs. Acta Derm Venereol. 1969;49(1):82–86. Available at: https://pubmed.ncbi.nlm.nih.gov/4182099.Levine G.M., Harber L.C. The effect of humidity on the phototoxic response to 8-methoxypsoralen in guinea pigs. Acta Derm Venereol. 1969;49(1):82–86. Available at: https://pubmed.ncbi.nlm.nih.gov/4182099.Owens D.W., Knox J.M. Influence of heat, wind, and humidity on ultraviolet radiation injury. Natl Cancer Inst Monogr. 1978;(50):161–167. Available at: https://pubmed.ncbi.nlm.nih.gov/753972.Owens D.W., Knox J.M. Influence of heat, wind, and humidity on ultraviolet radiation injury. Natl Cancer Inst Monogr. 1978;(50):161–167. Available at: https://pubmed.ncbi.nlm.nih.gov/753972.Abramowitz A.I., Resnik K.S., Cohen K.R. Margarita photodermatitis. N Engl J Med. 1993;328(12):891. https://doi.org/10.1056/NEJM199303253281220.Abramowitz A.I., Resnik K.S., Cohen K.R. Margarita photodermatitis. N Engl J Med. 1993;328(12):891. https://doi.org/10.1056/NEJM199303253281220.Harshman J., Quan Y., Hsiang D. Phytophotodermatitis: Rash with many faces. Can Fam Physician. 2017;63(12):938–940. Available at: https://pubmed.ncbi.nlm.nih.gov/29237634.Harshman J., Quan Y., Hsiang D. Phytophotodermatitis: Rash with many faces. Can Fam Physician. 2017;63(12):938–940. Available at: https://pubmed.ncbi.nlm.nih.gov/29237634.Tokura Y. Drug photoallergy. J Cutan Immunol Allergy. 2018;1:48–57.Tokura Y. Drug photoallergy. J Cutan Immunol Allergy. 2018;1:48–57.Wahie S., Lloyd J.J., Farr P.M. Positive photocontact responses are not elicited to sunscreen ingredients exposed to UVA prior to application onto the skin. Contact Dermatitis. 2007;57(4):273–275. https://doi.org/10.1111/j.1600-0536.2007.01217.x.Wahie S., Lloyd J.J., Farr P.M. Positive photocontact responses are not elicited to sunscreen ingredients exposed to UVA prior to application onto the skin. Contact Dermatitis. 2007;57(4):273–275. https://doi.org/10.1111/j.1600-0536.2007.01217.x.DeLeo V.A., Suarez S.M., Maso M.J. Photoallergic contact dermatitis. Results of photopatch testing in New York, 1985 to 1990. Arch Dermatol. 1992;128(11):1513–1518. https://doi.org/10.1001/archderm.128.11.1513.DeLeo V.A., Suarez S.M., Maso M.J. Photoallergic contact dermatitis. Results of photopatch testing in New York, 1985 to 1990. Arch Dermatol. 1992;128(11):1513–1518. https://doi.org/10.1001/archderm.128.11.1513.Fotiades J., Soter N.A., Lim H.W. Results of evaluation of 203 patients for photosensitivity in a 7.3-year period. J Am Acad Dermatol. 1995;33(4):597–602. https://doi.org/10.1016/0190-9622(95)91277-0.Fotiades J., Soter N.A., Lim H.W. Results of evaluation of 203 patients for photosensitivity in a 7.3-year period. J Am Acad Dermatol. 1995;33(4):597–602. https://doi.org/10.1016/0190-9622(95)91277-0.Акимов В.Г. Фотодерматозы. В: Скрипкин Ю.К., Бутов Ю.С., Иванов О.Л. (ред.). Дерматовенерология. М.: ГЭОТАР-Медиа; 2011. 1021 с.Akimov V.G. Photodermatoses. In: Skripkin Yu.K., Butov Yu.S., Ivanov O.L. (eds.). Dermatovenerology. Moscow: GEOTAR-Media; 2011. 1021 р. (In Russ.)Kecskés A., Heger-Mahn D., Kuhlmann R.K., Lange L. Comparison of the local and systemic side effects of methylprednisolone aceponate and mometasone furoate applied as ointments with equal anti-inflammatory activity. J Am Acad Dermatol. 1993;29(4):576–580. https://doi.org/10.1016/0190-9622(93)70224-h.Kecskés A., Heger-Mahn D., Kuhlmann R.K., Lange L. Comparison of the local and systemic side effects of methylprednisolone aceponate and mometasone furoate applied as ointments with equal anti-inflammatory activity. J Am Acad Dermatol. 1993;29(4):576–580. https://doi.org/10.1016/0190-9622(93)70224-h.Eberlein-König B., Placzek M., Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alphatocopherol (vitamin E). J Am Acad Dermatol. 1998;38(1):45–48. https://doi.org/10.1016/s0190-9622(98)70537-7.Eberlein-König B., Placzek M., Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alphatocopherol (vitamin E). J Am Acad Dermatol. 1998;38(1):45–48. https://doi.org/10.1016/s0190-9622(98)70537-7.Stahl W., Sies H. Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight. Mol Biotechnol. 2007;37(1):26–30. https://doi.org/10.1007/s12033-007-0051-z.Stahl W., Sies H. Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight. Mol Biotechnol. 2007;37(1):26–30. https://doi.org/10.1007/s12033-007-0051-z.Schagen S.K., Zampeli V.A., Makrantonaki E., Zouboulis C.C. Discovering the link between nutrition and skin aging. Dermatoеndocrinol. 2012;4(3):298–307. https://doi.org/10.4161/derm.22876.Schagen S.K., Zampeli V.A., Makrantonaki E., Zouboulis C.C. Discovering the link between nutrition and skin aging. Dermatoеndocrinol. 2012;4(3):298–307. https://doi.org/10.4161/derm.22876.Stein K.R., Scheinfeld N.S. Drug-induced photoallergic and phototoxic reactions. Expert Opin Drug Saf. 2007;6(4):431–443. https://doi.org/10.1517/14740338.6.4.431.Stein K.R., Scheinfeld N.S. Drug-induced photoallergic and phototoxic reactions. Expert Opin Drug Saf. 2007;6(4):431–443. https://doi.org/10.1517/14740338.6.4.431.Luger T. Balancing efficacy and safety in the management of atopic dermatitis: the role of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011;25(3):251–258. https://doi.org/10.1111/j.1468-3083.2010.03789.x.Luger T. Balancing efficacy and safety in the management of atopic dermatitis: the role of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011;25(3):251–258. https://doi.org/10.1111/j.1468-3083.2010.03789.x.Смирнов К.В. Эмульсия адвантана в лечении фотодерматитов. Российский журнал кожных и венерических болезней. 2003;(2):33–35.Smirnov K.V. Advantan emulsion in the treatment of photodermatitis. Russian Journal of Skin and Venereal Diseases. 2003;(2):33–35. (In Russ.)Hölzle E., Lehmann P., Neumann N. Phototoxic and photoallergic reactions. J Dtsch Dermatol Ges. 2009;7(7):643–648. https://doi.org/10.1111/j.1610-0387.2009.07094.x.Hölzle E., Lehmann P., Neumann N. Phototoxic and photoallergic reactions. J Dtsch Dermatol Ges. 2009;7(7):643–648. https://doi.org/10.1111/j.1610-0387.2009.07094.x.Horio T. Photosensitivity Diseases. In: Krieg T., Bickers D.R., Miyachi Y. (eds.). Therapy of Skin Diseases. A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis. Dordrecht, London, New York: Springer-Verlag Berlin Heidelberg; 2010.Horio T. Photosensitivity Diseases. In: Krieg T., Bickers D.R., Miyachi Y. (eds.). Therapy of Skin Diseases. A Worldwide Perspective on Therapeutic Approaches and Their Molecular Basis. Dordrecht, London, New York: Springer-Verlag Berlin Heidelberg; 2010.Drucker A.M., Rosen C.F. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf. 2011;34(10):821–837. https://doi.org/10.2165/11592780-000000000-00000.Drucker A.M., Rosen C.F. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf. 2011;34(10):821–837. https://doi.org/10.2165/11592780-000000000-00000.Morison W.L. Photosensitivity. N Engl J Med. 2004;350(11):1111–1117. https://doi.org/10.1056/NEJMcp022558.Morison W.L. Photosensitivity. N Engl J Med. 2004;350(11):1111–1117. https://doi.org/10.1056/NEJMcp022558.

The authors declare that there are no conflicts of interest present.