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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-029</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7396</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АЛЛЕРГОДЕРМАТОЗЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ALLERGODERMATOSES</subject></subj-group></article-categories><title-group><article-title>Топические глюкокортикостероиды в лечении атопического дерматита у детей: результаты собственных наблюдений</article-title><trans-title-group xml:lang="en"><trans-title>Atopic dermatitis management with topical corticosteroids in children: own observations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5793-5753</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скороходкина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skorokhodkina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скороходкина Олеся Валерьевна, д.м.н., профессор, заведующий кафедрой клинической иммунологии с аллергологией </p><p>420012, Россия, Казань, ул. Бутлерова, д. 49 </p></bio><bio xml:lang="en"><p>Olesya V. Skorokhodkina, Dr. Sci. (Med.), professor, the Head of the Department of Clinical Immunology and Allergology</p><p>49, Butlerov St., Kazan, 420012, Russia </p></bio><email xlink:type="simple">olesya-27@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3573-244X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайнетдинова</surname><given-names>Г. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaynetdinova</surname><given-names>G. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зайнетдинова Гульнара Мукарьямовна, к.м.н., заведующий аллергологическим отделением, врач аллерголог-иммунолог </p><p>420138, Россия, Казань, ул. Оренбургский Тракт, д. 140 </p></bio><bio xml:lang="en"><p> Gulnara M. Zaynetdinova, Cand. Sci. (Med.), Head of the Department of Allergology </p><p>140, Orenburgskiy Tract, Kazan, 420138, Russia </p></bio><email xlink:type="simple">gulnara-z@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0754-9605</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хакимова</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Khakimova</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хакимова Резеда Фидаиловна, д.м.н., профессор кафедры клинической иммунологии с аллергологией </p><p>420012, Россия, Казань, ул. Бутлерова, д. 49 </p></bio><bio xml:lang="en"><p>Rezeda F. Khakimova, Dr. Sci. (Med.), Professor of the Department of Clinical Immunology and Allergology</p><p>49, Butlerov St., Kazan, 420012, Russia </p></bio><email xlink:type="simple">khakimova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Казанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Детская республиканская клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Children’s Republican Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>16</day><month>03</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>114</fpage><lpage>120</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Скороходкина О.В., Зайнетдинова Г.М., Хакимова Р.Ф., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Скороходкина О.В., Зайнетдинова Г.М., Хакимова Р.Ф.</copyright-holder><copyright-holder xml:lang="en">Skorokhodkina O.V., Zaynetdinova G.M., Khakimova R.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7396">https://www.med-sovet.pro/jour/article/view/7396</self-uri><abstract><p>Атопический дерматит является наиболее распространенным хроническим воспалительным заболеванием кожи у детей, которое значительно влияет на качество жизни ребенка и семьи в целом. Атопический дерматит рассматривается как заболевание, клинические проявления которого генетически детерминированы и обусловлены дефектом барьерных функций кожи и развитием иммунных реакций. Особенностью атопического дерматита является раннее начало, склонность к рецидивированию, формированию резистентных к терапии форм. Поэтому назначение лечения, позволяющего достичь контроля над симптомами заболевания, снизить риск тяжелого течения заболевания, является важным при ведении пациентов. Наружная терапия атопического дерматита предполагает назначение топических глюкокортикостероидов, роль которых трудно переоценить. Тем не менее длительная история применения препаратов данной группы показала возможность развития побочных реакций. В связи с этим правильный выбор препарата для лечения атопического дерматита у детей, обладающего высокой эффективностью и профилем безопасности, является основой для достижения ремиссии заболевания и преодоления кортикостероидофобии. Препаратом, соответствующим требованиям, предъявляемым к наружным топическим глюкокортикостероидам, обладающим высокой терапевтической эффективностью и безопасностью, является метилпреднизолона ацепонат, который рекомендован для лечения пациентов с атопическим дерматитом с 4-месячного возраста. В работе представлены современные данные, подтверждающие оптимизированный профиль эффективности / безопасности метилпреднизолона ацепоната с минимальными местными или системными побочными эффектами. Как показывают исследования, новые отечественные препараты метилпреднизолона ацепоната (Комфодерм К) хорошо зарекомендовали себя в клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Atopic dermatitis is the most common chronic inflammatory skin disease in children, that significantly affects quality of life. Clinical manifestations are genetically determined and caused by skin barrier dysfunction and development of immune reactions. Atopic dermatitis is characterized by early onset, recurrence, and presence of treatment resistant forms. It is important to prescribe treatment that controls the symptoms and reduces the risk of severe forms of this disease. Topical corticosteroids are the mainstay of atopic dermatitis management, although the prolonged treatment can lead to development of side effects. The treatment option, that has high efficacy and high profile of safety, is the basis for disease remission and overcoming corticosteroid phobia. Methylprednisolone aceponate meets all criteria for topical corticosteroids and has high efficacy and high profile of safety. It can be recommended for patients with atopic dermatitis from the age of 4 months. This paper shows up-to-date data on methylprednisolone aceponate, that confirm the optimized efficacy/safety profile and minimal local or systemic adverse effects. Recent studies demonstrated the efficacy of new Russian product – methylprednisolone aceponate (Komfoderm K).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>атопический дерматит</kwd><kwd>дети</kwd><kwd>топические глюкокортикостероиды</kwd><kwd>метилпреднизолона ацепонат</kwd><kwd>эпидермальный барьер</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atopic dermatitis</kwd><kwd>children</kwd><kwd>topical corticosteroids</kwd><kwd>methylprednisolone aceponate</kwd><kwd>epidermal barrier</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кубанов А.А., Намазова-Баранова Л.С., Хаитов Р.М., Ильина Н.И., Алексеева Е.А., Амбарчян Э.Т. Клинические рекомендации. Атопический дерматит. 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