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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2022-028</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7412</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕРАПИЯ БОЛИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PAIN THERAPY</subject></subj-group></article-categories><title-group><article-title>Влияние преморбидных психосоциальных стрессоров на клинические характеристики хронических локализованных болевых синдромов (обсервационное исследование)</article-title><trans-title-group xml:lang="en"><trans-title>Influence of premorbid psychosocial stressors on chronic localized pain syndromes clinical characteristics (observational study)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3324-5472</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герцог</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gertsog</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Герцог Анна Алексеевна - ассистент кафедры общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Anna A. Gertsog - Assistant of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">gertsog.aa@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5070-926X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorob’eva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьева Ольга Владимировна - доктор медицинских наук, профессор кафедры общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Olga V. Vorob’eva - Dr. Sci. (Med.), Professor of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">ovvorobeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3748-8180</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>T. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Татьяна Евгеньевна - доктор медицинских наук, профессор, заведующий кафедрой общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Tatiana E. Morozova - Dr. Sci. (Med.), Professor, Head of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">temorozova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2337-7420</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резе</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Reze</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Резе Андрей Геннадьевич - кандидат медицинских наук, доцент кафедры общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Andrey G. Reze - Cand. Sci. (Med.), Associate Professor of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">andrey.reze@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5148-1551</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заугольникова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaugolnikova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заугольникова Татьяна Васильевна - кандидат медицинских наук, доцент кафедры общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Tatiana V. Zaugolnikova - Cand. Sci. (Med.), Associate Professor of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">tzaugol@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6550-2915</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самохина</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Samokhina</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самохина Елена Олеговна - кандидат медицинских наук, доцент кафедры общей врачебной практики Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Elena O. Samokhina - Cand. Sci. (Med.), Associate Professor of the Department of General Medical Practice, Institute of Post-Graduate Education.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">elenasamokhina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>11</day><month>04</month><year>2023</year></pub-date><volume>0</volume><issue>3</issue><fpage>52</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Герцог А.А., Воробьева О.В., Морозова Т.Е., Резе А.Г., Заугольникова Т.В., Самохина Е.О., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Герцог А.А., Воробьева О.В., Морозова Т.Е., Резе А.Г., Заугольникова Т.В., Самохина Е.О.</copyright-holder><copyright-holder xml:lang="en">Gertsog A.A., Vorob’eva O.V., Morozova T.E., Reze A.G., Zaugolnikova T.V., Samokhina E.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7412">https://www.med-sovet.pro/jour/article/view/7412</self-uri><abstract><sec><title>Введение</title><p>Введение. В настоящее время признано, что в возникновении и обострении хронических болевых синдромов немаловажная роль отводится стрессу. Стресс оказывает модуляторное воздействие на структуры нервной системы в зависимости от характера, продолжительности и интенсивности стрессора, что отражается в клинической картине боли.</p></sec><sec><title>Цель</title><p>Цель. Изучить особенности клинического течения хронических локализованных болевых синдромов в зависимости от наличия психосоциальных стрессоров в дебюте боли.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включено 118 пациентов с хроническими локализованными болевыми синдромами – 38 мужчин (32,2%) и 80 женщин (67,8%) в возрасте от 19 до 66 лет (средний возраст 41 ± 11 лет). В зависимости от наличия преморбидных психосоциальных стрессоров в дебюте боли пациенты были разделены на 2 группы – группа I (основная), группа II (контрольная). Методы исследования включали общеклиническую оценку характеристик болевого синдрома, оценку эмоционального состояния, психосоциальных показателей и качества жизни с использованием специальных шкал и тестов. Статистический анализ проводился с помощью программы StatTech v. 2.6.1.</p></sec><sec><title>Результаты</title><p>Результаты. Пациенты I группы испытывают более 4–6 эпизодов обострений в год, длительность которых составляет от 8 до 28 дней, затрагивающих в среднем 4 (3; 6) локализации, большей интенсивности (7 (5; 8) баллов по ЧРШБ, используют больше дескрипторов при описании боли (p &lt; 0,001, p = 0,013, p = 0,014, p = 0,017, p = 0,002 соответственно), чаще страдают головными болями и цервикалгией (p = 0,004 и p &lt; 0,001 соответственно), используют в среднем 4 (2; 5) группы лекарственных средств по поводу боли (p = 0,004). Среди пациентов с преморбидными психосоциальными стрессорами доля женщин выше в 6,5 раза (р &lt; 0,001). Выявлено достоверно большее количество пациентов с нарушениями сна, наличием тревоги в I группе (p &lt; 0,001, p = 0,009 соответственно), общая сумма баллов при оценке усталости составила 24 (19; 39) балла, что соответствует усталости средней степени (p = 0,009). Средний стрессовый балл по шкале Холмса–Рея составил 80 (53; 102) (p &lt; 0,001), основными стрессовыми событиями являются проблемы, связанные с работой. Установлены прямые статистически значимые взаимосвязи уровня стресса с характеристиками болевого синдрома – количеством болевых локализаций, интенсивностью боли, количеством дескрипторов (p &lt; 0,001, p &lt; 0,001, p &lt; 0,001). Индекс качества жизни составил 2 (2; 4) балла по опроснику EQ-5D-3L, что свидетельствует о снижении качества жизни (p &lt; 0,001) в I группе. Отмечено, что шансы стресс-дебюта боли при ведении активного образа жизни ниже в 3,4 раза (p = 0,012).</p></sec><sec><title>Заключение</title><p>Заключение. Преморбидные психосоциальные стрессоры являются маркерами тяжести течения хронической боли и аффективного дистресса. В то же время преморбидные психосоциальные стрессоры можно считать модифицируемым фактором, устранив которые можно предотвратить развитие хронической боли и связанного с ней аффективного дистресса.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. It is now recognized that stress plays an important role in the occurrence and exacerbation of chronic pain syndromes. Stress has a modulatory effect on the structures of the nervous system depending on the nature, duration and intensity of the stressor which is reflected in the clinical characteristics of pain.</p></sec><sec><title>Aim</title><p>Aim. To study the features of the clinical characteristics of chronic localized pain syndromes depending on the presence of psychosocial stressors at the onset of pain.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 118 patients with chronic localized pain syndromes 38 men (32.2%) and 80 women (67.8%) aged 19 to 66 years (mean age 41 ± 11 years). Depending on the presence of premorbid psychosocial stressors at the onset of pain patients were divided into two groups group I (main), group II (control). The research methods included a general clinical assessment of the pain syndrome characteristics, an assessment of the emotional state, psychosocial indicators and quality of life using special scales and tests. Statistical analysis was carried out using the StatTech v. 2.6.1.</p></sec><sec><title>Results</title><p>Results. Patients of group I experience more than 4-6 episodes of exacerbations per year, the duration of pain is from 8 to 28 days, affecting an average of 4 (3; 6) localizations, using more descriptors (p &lt; 0.001, p = 0.013, p = 0.014, p=0.017, p=0.002 resp.), more likely to suffer from headaches and cervicalgia (p = 0.004 and p &lt; 0.001 resp.), use on average 4 (2; 5) drug group for pain relief (p = 0.004). Among patients with premorbid psychosocial stressors the proportion of women is 6.5 times higher (p &lt; 0.001). A significantly greater number of patients with sleep disorders and anxiety were identified in group I (p &lt; 0.001, p = 0.009 respectively), the total score in assessing fatigue was 24 (19; 39) points which corresponds to moderate fatigue (p = 0.009). The average stress score on the Holmes-Rahe scale was 80 (53; 102) (p &lt; 0.001), the main stressful events are work-related problems. Direct statistically significant relationships between the level of stress and the characteristics of the pain syndrome were established the number of pain localizations, the intensity of pain, the number of descriptors (p &lt; 0.001, p &lt; 0.001, p &lt; 0.001). The life quality index was 2 (2; 4) scores according to the EQ-5D-3L questionnaire which indicates   a decrease in the quality of life (p &lt; 0.001) in group I. It was noted that the chances of stress onset of pain in an active lifestyle are 3.4 times lower (p = 0.012).</p></sec><sec><title>Conclusion</title><p>Conclusion. Premorbid psychosocial stressors are markers of the severity of chronic pain and affective distress. At the same time premorbid psychosocial stressors can be considered a modifiable factor. If it is assessed and recognized in time, the development of chronic pain and associated affective distress can be eliminated and potentially prevented.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая боль</kwd><kwd>болевой синдром</kwd><kwd>психосоциальные стрессоры</kwd><kwd>дистресс</kwd><kwd>соматические факторы</kwd><kwd>психологические факторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic pain</kwd><kwd>pain syndrome</kwd><kwd>psychosocial stressors</kwd><kwd>distress</kwd><kwd>somatic factors</kwd><kwd>psychological factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Elzahaf R.A., Tashani O.A., Unsworth B.A., Johnson M.I. The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9: a systematic review without meta-analysis. 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