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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-102</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7469</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Псориаз и сердечно-сосудистая коморбидность – взаимоотягощающая связь</article-title><trans-title-group xml:lang="en"><trans-title>Psoriasis and cardiovascular comorbidity – a mutually aggravating relationship</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4401-3722</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалева</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovaleva</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ковалева Юлия Сергеевна - доктор медицинских наук, доцент, заведующая кафедрой дерматовенерологии, косметологии и иммунологии, Алтайский государственный медицинский университет</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Julia S. Kovaleva - Dr. Sci. (Med.), Associate Professor, Head of the Department of Dermatovenerology.</p><p>40, Lenin Ave., Barnaul, Altai Krai, 656038</p></bio><email xlink:type="simple">julia_jsk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4093-9170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ведлер</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vedler</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ведлер Анна Андреевна - ассистент кафедры дерматовенерологии, косметологии и иммунологии.</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Anna A. Vedler - Assistant of the Department of Dermatovenerology.</p><p>40, Lenin Ave., Barnaul, Altai Krai, 656038</p></bio><email xlink:type="simple">vedler013@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Алтайский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Altai State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>18</day><month>08</month><year>2023</year></pub-date><volume>0</volume><issue>13</issue><fpage>24</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковалева Ю.С., Ведлер А.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ковалева Ю.С., Ведлер А.А.</copyright-holder><copyright-holder xml:lang="en">Kovaleva Y.S., Vedler A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7469">https://www.med-sovet.pro/jour/article/view/7469</self-uri><abstract><sec><title>Введение</title><p>Введение. Системный псориатический процесс поражает не только кожу, но и другие системы органов, в т. ч. сердечно-сосудистую. Иммунопатологическое воспаление, возникающее в коже и суставных тканях, является центральным связующим звеном в патологии сердечно-сосудистой системы при псориазе.</p></sec><sec><title>Цель</title><p>Цель. Выявить заболевания сердечно-сосудистой системы и факторы их развития у больных псориазом и оценить их выраженность в зависимости от степени тяжести дерматоза.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование было включено 406 больных псориазом в возрасте от 18 до 74 лет, которые были разделены на три подгруппы в зависимости от степени тяжести течения. Оценка состояния сердечно-сосудистой системы была проведена с помощью методов: анкетно-опросного, клинического, физикального, лабораторного и статистического. Группу сравнения составили 200 человек.</p></sec><sec><title>Результаты</title><p>Результаты. У 53,9% больных псориаз протекал на фоне сердечно-сосудистой коморбидности. Более 90% пациентов со средней и тяжелой степенью тяжести псориаза более трех факторов риска заболеваний ССС. Больные более подвержены развитию артериальной гипертензии, гиперхолестеринемии, ожирения, абдоминальному ожирению, стрессу и курению. Сердечно-сосудистый риск тем выше, чем тяжелее протекает псориаз.</p></sec><sec><title>Выводы</title><p>Выводы. Наличие немодифицируемых и модифицируемых факторов риска развития сердечно-сосудистых заболеваний является отягощающим для течения псориаза, а значит, и выше риск развития нежелательных смертельных событий. Больные псориазом нуждаются в дополнительных профилактических мероприятиях, направленных на предупреждение развития кардиоваскулярной патологии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The systemic psoriatic process affects not only the skin, but also other organ systems, including the cardiovascular system. Immunopathological inflammation that occurs in the skin and articular tissues is a central link in the pathology of the cardiovascular system in psoriasis.</p></sec><sec><title>Objective</title><p>Objective. Identify diseases of the cardiovascular system and factors of their development in patients with psoriasis and to assess their severity depending on the severity of dermatosis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 406 patients with psoriasis aged 18 to 74 years, who were divided into three subgroups depending on the severity of the course. Assessment of the state of the cardiovascular system was carried out using the following methods: uestionnaire, clinical, physical, laboratory and statistical. The comparison group consisted of 200 people.</p></sec><sec><title>Results</title><p>Results. In 53.9% of patients, psoriasis occurred against the background of cardiovascular comorbidity. More than 90% of patients with moderate to severe psoriasis have more than three risk factors for CCC diseases. Patients are more susceptible to the development of hypertension, hypercholesterolemia, obesity, abdominal obesity, stress and smoking. The higher the cardiovascular risk, the more severe psoriasis is.</p></sec><sec><title>Conclusions</title><p>Conclusions. The presence of unmodified and modifiable risk factors for the development of cardiovascular diseases is aggravating for the course of psoriasis, which means that the risk of undesirable fatal events is higher. Patients with psoriasis need additional preventive measures aimed at preventing the development of cardiovascular pathology.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>гиперхолестеринемия</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>сахарный диабет</kwd><kwd>инсулинорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psoriasis</kwd><kwd>comorbidity</kwd><kwd>cardiovascular diseases</kwd><kwd>diabetes mellitus</kwd><kwd>insulin resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Асхаков М.С., Чеботарев В.В. Псориаз: современное представление о дерматозе. Медицинский вестник Северного Кавказа. 2017;12(2):225–229. https://doi.org/10.14300/mnnc.2017.12065.</mixed-citation><mixed-citation xml:lang="en">Askhakov M.S., Chebotaryov V.V. Psoriasis: the modern idea of dermatosis. 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