medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-115medsovet-7503Research ArticleАЛЛЕРГИЯALLERGYКомплексный подход к лечению аллергического ринитаAn integrated approach to the treatment of allergic rhinitishttps://orcid.org/0000-0002-5778-629XКочетковП. А.KochetkovP. A.

Кочетков Петр Александрович, д.м.н., профессор, кафедра болезней уха, горла и носа 

 119991, Россия, Москва, ул. Большая Пироговская, д. 6, стр. 1 

Petr A. Kochetkov, Dr. Sci. (Med.), Professor, Head of the Department of ENT Diseases

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia 

adenotom@yandex.ruhttps://orcid.org/0000-0001-7414-1293СвистушкинВ. М.SvistushkinV. M.

Свистушкин Валерий Михайлович, д.м.н., профессор, заведующий кафедрой болезней уха, горла и носа 

119991, Россия, Москва, ул. Большая Пироговская, д. 6, стр. 1 

Valery M. Svistushkin, Dr. Sci. (Med.), Professor, Head of the Department of ENT Diseases

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia 

svvm3@yandex.ruhttps://orcid.org/0000-0003-4755-0205ЩенниковаЕ. С.ShchennikovaE. S.

Щенникова Екатерина Сергеевна, врач-оториноларинголог отделения оториноларингологии Университетской клинической больницы № 1 

 119991, Россия, Москва, ул. Большая Пироговская, д. 6, стр. 1 

Ekaterina S. Shchennikova, Otorhinolaryngologist, Department of Otorhinolaryngology, University Clinical Hospital No. 1 

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia 

katt-she@yandex.ruПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation2023060520230796101Copyright © Кочетков П.А., Свистушкин В.М., Щенникова Е.С., 20232023Кочетков П.А., Свистушкин В.М., Щенникова Е.С.Kochetkov P.A., Svistushkin V.M., Shchennikova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7503

Введение. Аллергический ринит – IgE-опосредованное воспаление, которое широко распространено как во взрослой, так и в детской популяции. При контакте аллергена со слизистой оболочкой возникают приступы чихания, выделения из носа, затруднение носового дыхания, зуд в носу, что существенно влияет на качество жизни пациентов и может приводить к развитию сопутствующей патологии верхних и нижних отделов дыхательных путей. Основной целью лечения является сокращение или устранение симптомов аллергического ринита, предупреждение обострений и профилактика развития осложнений. Оптимальная терапия должна поддерживать привычный для пациента образ жизни. Интраназальные глюкокортикостероиды в сочетании с антилейкотриеновым препаратом монтелукаст (Экталуст) обладают высокой эффективностью и профилем безопасности, а также удобным режимом дозирования.Цель. Провести обзор доступной литературы по эффективности применения блокатора антилейкотриеновых рецепторов – монтелукаста (Экталуста) в комплексном лечении аллергического ринита.Материалы и методы. Поиск данных для обзора проводился в базе данных РИНЦ и MEDLINE с использованием ключевых слов.Результаты и обсуждение. Пациенты с аллергическим ринитом, получавшие комбинированную терапию интраназальными глюкокортикостероидами в сочетании с монтелукастом отметили лучший результат в оценке качества жизни и уменьшения клинических проявлений, по сравнению с пациентами, получавшими монотерапию.Выводы. Основываясь на доступных в литературе данных проведенных исследований, можно заключить, что применение монтелукаста (Экталуста) в сочетании с интраназальными глюкокортикостероидами улучшает качество жизни пациентов путем уменьшения клинических проявлений аллергического ринита, в особенности в сочетании с бронхиальной астмой.

Introduction. Аllergic rhinitis is characterized by IgE-mediated inflammation and widely distributed in both adult and pediatric populations. The contact between allergen and mucous membrane is followed by sneezing, rhinorrhea, nasal blockage. It may affect the quality of life and result in upper and lower airway diseases. The treatment aims to reduce or eliminate symptoms, prevent exacerbations and complications. The optimal treatment should maintain a habitual way of patient’s life. Intranasal corticosteroids in combination with selective antagonist of the leukotriene receptor drug – montelukast (Ektalust) have high efficiency and optimal dosing regimen.Aim. The study was to conduct a literature search for effectiveness of selective antagonist of the leukotriene receptor – montelukast (Ektalust) in treatment of allergic rhinitis.Materials and methods. The search was executed using RSCI and MEDLINE by keywords.Results and discussion. Patients with allergic rhinitis who received combination therapy with intranal glucocorticosteroids in combination with montelukast noted a better result in assessing the quality of life and reducing clinical manifestations, compared with patients who received monotherapy.Conclusions. Based on the available data it can be concluded that montelukast (Ektalust) in combination with intranasal corticosteroids may improve quality of life due to reduction of symptoms of allergic rhinitis, especially in conjunction with asthma.

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The authors declare that there are no conflicts of interest present.