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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-17-8-9</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-766</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Новости</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>News. Findings and events</subject></subj-group></article-categories><title-group><article-title>ХОБЛ: роль инфекционных обострений и их профилактики</article-title><trans-title-group xml:lang="en"><trans-title>COPD: Role and prevention of infectious exacerbatons</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапорова</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shaporova</surname><given-names>N. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марченко</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchenko</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яблонская</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yablonskayа</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Saint Petersburg State Medical University named after I.P. Pavlov, Russia’s Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>17</issue><fpage>8</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шапорова Н.Л., Марченко В.Н., Яблонская В.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Шапорова Н.Л., Марченко В.Н., Яблонская В.Н.</copyright-holder><copyright-holder xml:lang="en">Shaporova N.L., Marchenko V.N., Yablonskayа V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/766">https://www.med-sovet.pro/jour/article/view/766</self-uri><abstract><p>На ежегодной конференции Европейского общества медицинской онкологии - 2014, прошедшей осенью в Мадриде, были представлены новые данные по терапии местнораспространенного или метастазирующего рака молочной железы, а также прогрессирующего, рефрактерного к радиоактивному йоду дифференцированного рака щитовидной железы.</p></abstract><trans-abstract xml:lang="en"><p>The article is a detailed review of current views on the incidence, causes and role of exacerbations in the progression of COPD, and the role of bacterial infection in exacerbations of the disease. Primary and secondary preventive actions are described. Antibacterial treatment approaches in patients with acute exacerbations of COPD are analyzed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ХОБЛ</kwd><kwd>обострение ХОБЛ</kwd><kwd>антибактериальная терапия</kwd><kwd>COPD</kwd><kwd>COPD exacerbations</kwd><kwd>antibiotic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. The World Health Report 2002. Reducing risks, promoting healthy life. MDI.WHR202.A. The World Health Organization, Geneva, 2002.</mixed-citation><mixed-citation xml:lang="en">WHO. The World Health Report 2002. Reducing risks, promoting healthy life. MDI.WHR202.A. The World Health Organization, Geneva, 2002.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Murray CJ. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C.J. Murray, A.D. Lopez. Lancet, 1997, 349: 1498-1504.</mixed-citation><mixed-citation xml:lang="en">Murray CJ. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C.J. Murray, A.D. Lopez. Lancet, 1997, 349: 1498-1504.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez AD. Chronic obstructive pulmonary disease: current burden and future projections. A.D. Lopez , K. Shibuya, C. Rao et al. Eur Respir J., 2006, 27 (2): 188-207.</mixed-citation><mixed-citation xml:lang="en">Lopez AD. Chronic obstructive pulmonary disease: current burden and future projections. A.D. Lopez , K. Shibuya, C. Rao et al. Eur Respir J., 2006, 27 (2): 188-207.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pauwels RA. Burden and clinical features of chronic obstructive pulmonary disease (COPD). R.A. Pauwels, K.F. Rabe. Lancet, 2004, 364: 613-620.</mixed-citation><mixed-citation xml:lang="en">Pauwels RA. Burden and clinical features of chronic obstructive pulmonary disease (COPD). R.A. Pauwels, K.F. Rabe. Lancet, 2004, 364: 613-620.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Donaldson GC Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. G.C. Donaldson, T.A. Seemungal, A. Bhowmik, J.A. Wedzicha. Thorax, 2002, 57: 847-852.</mixed-citation><mixed-citation xml:lang="en">Donaldson GC Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. G.C. Donaldson, T.A. Seemungal, A. Bhowmik, J.A. Wedzicha. Thorax, 2002, 57: 847-852.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Seemungal T.A. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. T.A. Seemungal, G.C. Donaldson, E.A. Paul et al. Am] Respir Crit Care Med., 1998. 157: 1418-1422.</mixed-citation><mixed-citation xml:lang="en">Seemungal T.A. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. T.A. Seemungal, G.C. Donaldson, E.A. Paul et al. Am] Respir Crit Care Med., 1998. 157: 1418-1422.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M. Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD. M. Miravitlles., C. Murio., T. Guerrero et al. Chest, 2002, 121: 1449-1455.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M. Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD. M. Miravitlles., C. Murio., T. Guerrero et al. Chest, 2002, 121: 1449-1455.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gunen H. Factors affecting survival of hospitalized patients with COPD. H. Gunen, S.S. Hacievliyagil, F. Kosar et al. Eur Respir]., 2005, 26: 234-241.</mixed-citation><mixed-citation xml:lang="en">Gunen H. Factors affecting survival of hospitalized patients with COPD. H. Gunen, S.S. Hacievliyagil, F. Kosar et al. Eur Respir]., 2005, 26: 234-241.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Soler-Cataluna JJ. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. J.J. Soler-Cataluna, M.A. Martinez-Garcia, P Roman Sanchez et al. Thorax 2005, 60: 925-931.</mixed-citation><mixed-citation xml:lang="en">Soler-Cataluna JJ. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. J.J. Soler-Cataluna, M.A. Martinez-Garcia, P Roman Sanchez et al. Thorax 2005, 60: 925-931.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wedzicha J.A. Exacerbations of chronic obstructive pulmonary disease. J.A. Wedzicha, G.C Donaldson. Respir Care. 2003, 48 (12): 1204-13.</mixed-citation><mixed-citation xml:lang="en">Wedzicha J.A. Exacerbations of chronic obstructive pulmonary disease. J.A. Wedzicha, G.C Donaldson. Respir Care. 2003, 48 (12): 1204-13.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">White AJ. Chronic obstructive pulmonary disease: 6. The aetiology of exacerbation of chronic obstructive pulmonary disease. AJ. White, S. Gompertz., R.A. Stockley. Thorax, 2003, 58: 73-80.</mixed-citation><mixed-citation xml:lang="en">White AJ. Chronic obstructive pulmonary disease: 6. The aetiology of exacerbation of chronic obstructive pulmonary disease. AJ. White, S. Gompertz., R.A. Stockley. Thorax, 2003, 58: 73-80.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gompertz S. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. S. Gompertz, C. O'Brien, D.L. Bayley et al. Eur Respir J., 2001, 17: 1112-1119.</mixed-citation><mixed-citation xml:lang="en">Gompertz S. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. S. Gompertz, C. O'Brien, D.L. Bayley et al. Eur Respir J., 2001, 17: 1112-1119.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cote CG. Impact of COPD Exacerbations on Patient-Centered Outcomes. C.G. Cote, L.J. Dordelly, B.R. Celli. Chest. 2007, 131: 696-704.</mixed-citation><mixed-citation xml:lang="en">Cote CG. Impact of COPD Exacerbations on Patient-Centered Outcomes. C.G. Cote, L.J. Dordelly, B.R. Celli. Chest. 2007, 131: 696-704.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO workshop report. Bethesda, National Heart, Lung and Blood Institute; Update 2007, GOLD website (http://wwwgoldcopd.com).</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO workshop report. Bethesda, National Heart, Lung and Blood Institute; Update 2007, GOLD website (http://wwwgoldcopd.com).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Дворецкий Л.И. Инфекционные обострения ХОБЛ. Л.И. Дворецкий. Лечащий врач, 2007, (3): 80-84.</mixed-citation><mixed-citation xml:lang="en">Дворецкий Л.И. Инфекционные обострения ХОБЛ. Л.И. Дворецкий. Лечащий врач, 2007, (3): 80-84.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen NR. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. N.R. Anthonisen, J. Manfreda, C.P Warren et al. Ann Intern. Med. 1987, 106: 196-204.</mixed-citation><mixed-citation xml:lang="en">Anthonisen NR. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. N.R. Anthonisen, J. Manfreda, C.P Warren et al. Ann Intern. Med. 1987, 106: 196-204.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wedzicha JA. Exacerbations of chronic obstructive pulmonary disease. J.A. Wedzicha, G.C. Donaldson. Respir Care. 2003, 48(12): 1204-1213.</mixed-citation><mixed-citation xml:lang="en">Wedzicha JA. Exacerbations of chronic obstructive pulmonary disease. J.A. Wedzicha, G.C. Donaldson. Respir Care. 2003, 48(12): 1204-1213.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Monso E. Risk factors for lower airway bacterial colonization in chronic bronchitis. E. Monso, A. Rosell, G. Bonet et al. Eur Respir J, 1999, 13: 338-342.</mixed-citation><mixed-citation xml:lang="en">Monso E. Risk factors for lower airway bacterial colonization in chronic bronchitis. E. Monso, A. Rosell, G. Bonet et al. Eur Respir J, 1999, 13: 338-342.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Soler N. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. N. Soler, S. Ewig, A. Torres et al. Eur Respir J, 1999, 14: 1015-1022.</mixed-citation><mixed-citation xml:lang="en">Soler N. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. N. Soler, S. Ewig, A. Torres et al. Eur Respir J, 1999, 14: 1015-1022.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Patel IS. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. I.S. Patel, T.A. Seemungal, M. Wilks et al. Thorax 2002, 57: 759-764.</mixed-citation><mixed-citation xml:lang="en">Patel IS. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. I.S. Patel, T.A. Seemungal, M. Wilks et al. Thorax 2002, 57: 759-764.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">White AJ. The aetiology of exacerbations of chronic obstructive pulmonary disease. A.J. White, S. Gompertz, R.A. Stockle. Thorax, 2003, 58: 73-80.</mixed-citation><mixed-citation xml:lang="en">White AJ. The aetiology of exacerbations of chronic obstructive pulmonary disease. A.J. White, S. Gompertz, R.A. Stockle. Thorax, 2003, 58: 73-80.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Monso E. Bacterial infection in chronic obstructive pulmonary disease: a study of stable and exacerbated outpatients using the protected specimen brush. E. Monso, J. Ruiz, J. Manterola et al. AmJ Respir Crit Care Med, 1995, 152: 1316-1320.</mixed-citation><mixed-citation xml:lang="en">Monso E. Bacterial infection in chronic obstructive pulmonary disease: a study of stable and exacerbated outpatients using the protected specimen brush. E. Monso, J. Ruiz, J. Manterola et al. AmJ Respir Crit Care Med, 1995, 152: 1316-1320.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lieberman D. Serological evidence of Mycoplasma pneumoniae infection in acute exacerbation of COPD. D. Lieberman,. Lieberman D, M. Ben-Yaakov et al. Diagn Microbiol Infect Dis, 2002, 44 (1): 1-6.</mixed-citation><mixed-citation xml:lang="en">Lieberman D. Serological evidence of Mycoplasma pneumoniae infection in acute exacerbation of COPD. D. Lieberman,. Lieberman D, M. Ben-Yaakov et al. Diagn Microbiol Infect Dis, 2002, 44 (1): 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lieberman D. Infectious etiologies in acute exacerbation of COPD. D. Lieberman, D. Lieberman, M. Ben-Yaakov et al. Diagn Microbiol Infect Dis 2001, 40: 95-102.</mixed-citation><mixed-citation xml:lang="en">Lieberman D. Infectious etiologies in acute exacerbation of COPD. D. Lieberman, D. Lieberman, M. Ben-Yaakov et al. Diagn Microbiol Infect Dis 2001, 40: 95-102.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Soler N. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. N. Soler., A. Torres, S. Ewig et al. Am J Respir Crit Care Med, 1998, 157: 1498-1505.</mixed-citation><mixed-citation xml:lang="en">Soler N. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. N. Soler., A. Torres, S. Ewig et al. Am J Respir Crit Care Med, 1998, 157: 1498-1505.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Eller J. Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. J. Eller, A. Ede, T. Schaberg et al. Chest 1998, 113: 1542-1548.</mixed-citation><mixed-citation xml:lang="en">Eller J. Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. J. Eller, A. Ede, T. Schaberg et al. Chest 1998, 113: 1542-1548.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Papi A, Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations. A. Papi, C.M. Bellettato, F. Braccioni et al. Am J Respir Crit Care Med 2006, 173: 1114-1121.</mixed-citation><mixed-citation xml:lang="en">Papi A, Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations. A. Papi, C.M. Bellettato, F. Braccioni et al. Am J Respir Crit Care Med 2006, 173: 1114-1121.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D. Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebocontrolled, randomised trial. D. Tashkin, R. Kanner, W. Bailey et al. Lancet 2001, 357 (9268): 1571-1575.</mixed-citation><mixed-citation xml:lang="en">Tashkin D. Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebocontrolled, randomised trial. D. Tashkin, R. Kanner, W. Bailey et al. Lancet 2001, 357 (9268): 1571-1575.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Casaburi R. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group. R. Casaburi, D.D. Jr Briggs., J.F. Donohue et al. Chest. 2000, 118: 1294-1302.</mixed-citation><mixed-citation xml:lang="en">Casaburi R. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group. R. Casaburi, D.D. Jr Briggs., J.F. Donohue et al. Chest. 2000, 118: 1294-1302.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Vincken W. On behalf of the Dutch/Belgian Tiotropium Study Group. Improved health outcomes in patients with COPD during 1-yr's treatment with tiotropium. W. Vincken, J.A. van Noord, A.PM. Greefhorst et al. Eur Respir J, 2002, 19: 209-216.</mixed-citation><mixed-citation xml:lang="en">Vincken W. On behalf of the Dutch/Belgian Tiotropium Study Group. Improved health outcomes in patients with COPD during 1-yr's treatment with tiotropium. W. Vincken, J.A. van Noord, A.PM. Greefhorst et al. Eur Respir J, 2002, 19: 209-216.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Barr RG. Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis. R.G. Barr, J. Bourbeau, C.A Camargo, FS.F Ram. Thorax 2006, 61: 854-862.</mixed-citation><mixed-citation xml:lang="en">Barr RG. Tiotropium for stable chronic obstructive pulmonary disease: a meta-analysis. R.G. Barr, J. Bourbeau, C.A Camargo, FS.F Ram. Thorax 2006, 61: 854-862.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Alsaeedi A. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. A. Alsaeedi, D.D. Sin, F.A. McAlister. Am J Med 2002, 113(1): 59-65.</mixed-citation><mixed-citation xml:lang="en">Alsaeedi A. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. A. Alsaeedi, D.D. Sin, F.A. McAlister. Am J Med 2002, 113(1): 59-65.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gartlehner Effecacy and safety of inhaled corticosteroids in patients with COPD a systematic review and meta analysis of health outcomes. Gartlehner et al. AnnFam Med 2006, 4: 253-262.</mixed-citation><mixed-citation xml:lang="en">Gartlehner Effecacy and safety of inhaled corticosteroids in patients with COPD a systematic review and meta analysis of health outcomes. Gartlehner et al. AnnFam Med 2006, 4: 253-262.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wongsurakiat P Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. P Wongsurakiat, K.N. Maranetra, C. Wasi et al. Chest 2004, 125 (6): 2011-2020.</mixed-citation><mixed-citation xml:lang="en">Wongsurakiat P Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. P Wongsurakiat, K.N. Maranetra, C. Wasi et al. Chest 2004, 125 (6): 2011-2020.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Alfageme R. Clinical efficiacy of anti-pneumococcal vaccination in patients with COPD. R Alfageme, R Vazquez, N. Reyes, et al. Thorax, 2006, 61: 189-195.</mixed-citation><mixed-citation xml:lang="en">Alfageme R. Clinical efficiacy of anti-pneumococcal vaccination in patients with COPD. R Alfageme, R Vazquez, N. Reyes, et al. Thorax, 2006, 61: 189-195.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Decramer M. Chronic obstructive pulmonary disease. Seminar. M Decramer et al. Lancet, 2012, 379: 1341-1351.</mixed-citation><mixed-citation xml:lang="en">Decramer M. Chronic obstructive pulmonary disease. Seminar. M Decramer et al. Lancet, 2012, 379: 1341-1351.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Woodhead M. Guidelines for the management of adult lower respiratory tract infections-full version. M. Woodhead et al. Clin Microbiol Infect, 2011, 17 (6): 1-59.</mixed-citation><mixed-citation xml:lang="en">Woodhead M. Guidelines for the management of adult lower respiratory tract infections-full version. M. Woodhead et al. Clin Microbiol Infect, 2011, 17 (6): 1-59.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов РС. Динамика резистентности Streptococcus pneumonia к антибиотикам в России за период 1999-2009 года (результаты многоцентрового проспективного исследования ПеГАС). Козлов РС. и соавт. Клин, микробиол. антимикроб. химиотер., 2010, 4: 329-341.</mixed-citation><mixed-citation xml:lang="en">Козлов РС. Динамика резистентности Streptococcus pneumonia к антибиотикам в России за период 1999-2009 года (результаты многоцентрового проспективного исследования ПеГАС). Козлов РС. и соавт. Клин, микробиол. антимикроб. химиотер., 2010, 4: 329-341.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
