medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-251medsovet-7724Research ArticleРЕВМАТОЛОГИЯRHEUMATOLOGYНекоторые аспекты противовоспалительной терапии остеоартритаSome aspects of anti-inflammatory therapy of osteoarthritishttps://orcid.org/0000-0003-3024-9483ФилатоваЮ. С.FilatovaYu. S.

Филатова Юлия Сергеевна - кандидат медицинских наук, доцент кафедры терапии имени Е.Н. Дормидонтова Института непрерывного профессионального образования, Ярославский ГМУ; врач-ревматолог, ООО «Центр диагностики и профилактики плюс»;

150000, Ярославль, ул. Революционная, д. 5; 150003, Ярославль, проспект Ленина, д. 33

Yulia S. Filatova - Cand. Sci. (Med.), Associate Professor of the Department of Therapy named after E.N. Dormidontov of the Institute of Continuing Professional Education, Yaroslavl SMU; Rheumatologist, “Center for diagnostics and prevention plus” LLC;

5, Revolutsionnaya St., Yaroslavl, 150000; 33, Lenin Ave., Yaroslavl, 150003

y.s.filatova@mail.ruhttps://orcid.org/0000-0002-9347-1551СоловьевИ. Н.SolovyovI. N.

Соловьев Игорь Николаевич - кандидат медицинских наук, доцент кафедры травматологии и ортопедии, Ярославский ГМУ; врач – травматолог-ортопед, ООО «Центр диагностики и профилактики плюс»

150000, Ярославль, ул. Революционная, д. 5; 150003, Ярославль, проспект Ленина, д. 33

Igor N. Solovyov - Cand. Sci. (Med.), Associate Professor of the Department of Traumatology and Orthopedics, Yaroslavl SMU; Orthopedic Traumatologist, “Center for diagnostics and prevention plus” LLC.

5, Revolutsionnaya St., Yaroslavl, 150000; 33, Lenin Ave., Yaroslavl, 150003

giper75@mail.ruЯрославский государственный медицинский университет; ООО «Центр диагностики и профилактики плюс»РоссияYaroslavl State Medical University; “Center for diagnostics and prevention plus” LLCRussian Federation202319082023013157164Copyright © Филатова Ю.С., Соловьев И.Н., 20232023Филатова Ю.С., Соловьев И.Н.Filatova Y.S., Solovyov I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7724

Статья посвящена обсуждению вопросов терапии остеоартрита (ОА) как одного из самых распространенных заболеваний опорно-двигательного аппарата, приводящих к инвалидизации людей трудоспособного возраста. В статье приведены рекомендации ведущих мировых сообществ (EULAR, ARC OARSI) и заключение резолюции консенсуса экспертов РФ по диагностике и лечению остеоартрита 2022 г. Делая акцент на современных концепциях патогенеза, авторы также обращают внимание на боль и механизмы ее формирования при ОА. Отображены данные исследований и метаанализов, демонстрирующие эффективность НПВП при болях, связанных с ОА, приводятся данные эффективности и безопасности нимесулида, а также его дополнительные свой ства, такие как ингибирование пролиферации раковых клеток, нейропротективный и гастропротективный эффекты. В статье приведены заключения консенсусных совещаний 2005 г. и 2014 г., целью которых было обеспечение непрерывной и актуальной оценки клинического профиля и профиля безопасности нимесулида (2005 г.), и ознакомление с современным состоянием патофизиологии и лечения острой боли с особым акцентом на нимесулид (2014 г.). Кроме того, отображены данные безопасности и эффективности нимесулида в терапии ОА в сравнении с такими препаратами, как диклофенак, напроксен и ибупрофен. Одним из малоизученных аспектов терапии боли является предпочтение пациента. Именно поэтому авторы приводят в статье данные исследований эффективности различных форм НПВП и предпочтений пациентов и делают вывод, что наиболее приемлемым с точки зрения эффективности, безопасности, скорости наступления эффекта, а также предпочтений пациентов является нимесулид в виде гранул для приготовления раствора.

In the article, the authors discuss the therapy of OA as one of the common diseases of the musculoskeletal system, which leads to disability of people of working age. Focusing on modern concepts of pathogenesis, the article draws attention to pain and the mechanisms of its formation in OA. The recommendations of the world’s leading communities (EULAR, ARC OARSI) and the conclusions of the consensus resolution of experts of the Russian Federation on the diagnosis and treatment of osteoarthritis 2022 are also given. The article draws attention to some aspects of pain therapy. The data of studies and meta-analyses demonstrating the effectiveness of NSAIDs in pain associated with OA are presented. Among the variety of NSAIDs, the article provides data on the efficacy and safety of nimesulide, as well as its additional properties such as inhibition of cancer cell proliferation, neuroprotective and gastroprotective effects. The conclusions of the consensus meetings of 2005, the purpose of which was to provide a continuous and up-to-date assessment of the clinical profile and safety profile of nimesulide, and 2014, the purpose of which was to familiarize with the current state of pathophysiology and treatment of acute pain with a special focus on nimesulide, are presented. The article also provides data on the safety and efficacy of nimesulide in the treatment of OA in comparison with drugs such as diclofenac, naproxen and ibuprofen. One of the little-studied aspects of pain therapy is the patient’s preference. The article presents data from studies of the effectiveness of various forms of NSAIDs and patient preferences in therapy. The authors of the article conclude that the most acceptable from the point of view of efficacy, safety, the rate of onset of the effect, as well as the preferences of patients is nimesulide in the form of granules for the preparation of a solution.

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The authors declare that there are no conflicts of interest present.