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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-266</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7767</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТРИХОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TRICHOLOGY</subject></subj-group></article-categories><title-group><article-title>Опыт использования линии средств с миноксидилом в терапии стресс-индуцированных нерубцовых форм алопеции</article-title><trans-title-group xml:lang="en"><trans-title>Experience in using minoxidil product line for the treatment of stress-induced non scarring alopecia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4537-401X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катханова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katkhanova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катханова Ольга Алиевна, д.м.н., профессор кафедры пластической реконструктивной хирургии косметологии регенеративной медицины факультета повышения квалификации и  профессиональной переподготовки специалистов, 344022, Ростов-на-Дону, пер. Нахичеванский, д. 29;</p><p>врач-дерматовенеролог, трихолог, 350063, Краснодар, ул. Кубанская Набережная, д. 37/1</p></bio><bio xml:lang="en"><p>Olga A. Katkhanova, Dr. Sci. (Med.), Professor of the Department of Plastic Reconstructive Surgery Cosmetology Regenerative Medicine of the Faculty of Advanced Training and Professional Retraining of Specialists, 29, Nakhichevan Lane, Rostov-onDon, 344022;</p><p>Dermatovenerologist, Trichologist; 37/1, Kubanskaya Embankment St., Krasnodar, 350063</p></bio><email xlink:type="simple">okathanova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Ростовский государственный медицинский университет;&#13;
Клиника «Екатерининская»<country>Россия</country></aff><aff xml:lang="en">Rostov State Medical University;&#13;
Ekaterininskaya Clinic<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2023</year></pub-date><volume>0</volume><issue>14</issue><fpage>89</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Катханова О.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Катханова О.А.</copyright-holder><copyright-holder xml:lang="en">Katkhanova O.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7767">https://www.med-sovet.pro/jour/article/view/7767</self-uri><abstract><sec><title>Введение</title><p>Введение. Длительный стресс может увеличивать секрецию провоспалительных цитокинов, таких как INF-ɣ, что приводит к воспалению и в результате заканчивается апоптозом, старением клеток и нарушением цикличности роста волос. Важно знать, что стрессором может стать собственно соматическая болезнь, в нашем случае потеря волос, провоцирующая развитие реактивного тревожно-депрессивного состояния  (нозогенная реакция), чаще протекающего с  преобладанием тревожных опасений за свое здоровье.</p></sec><sec><title>Цель</title><p>Цель. Изучить эффективность и переносимость обновленной композиции спрея ALERANA® 5% для наружного применения в комбинации с сывороткой БИО активный комплекс для роста волос ALERANA®, содержащих миноксидил, в терапии стрессиндуцированных нерубцовых форм алопеции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Было проведено исследование средств ALERANA®, содержащих миноксидил. Все пациенты (50 человек) прошли комплексное клинико-лабораторное обследование и трихоскопическую диагностику. Признаки психоэмоционального неблагополучия диагностированы у 56%; симптомы вегетативных расстройств (сердцебиение, приливы к лицу, красный дермографизм, гипергидроз) – у 21%; нарушения сна – у 48%; изменение аппетита – у18 %; мышечное напряжение, спазмы – у 12%.</p></sec><sec><title>Результаты</title><p>Результаты. Количество волос достоверно увеличивалось на  фоне применения комплексной терапии. Средний прирост к 3-му месяцу терапии составил 17%. Также отмечалось появление новых волос в теменной и височных зонах и сокращение числа одиночных фолликулярных юнитов. Спрей ALERANA® имеет высокую эффективность, хорошо переносится пациентами и может назначаться как в виде монотерапии, так и в комбинации с системными и местными препаратами.</p></sec><sec><title>Выводы</title><p>Выводы. Выявление психических расстройств у пациентов с хроническими видами выпадения волос, такими как гнездная и андрогенетическая алопеция, представляется важным этапом в обследовании данной группы дерматологических больных. Условие выбора оптимальной терапии для пациента кроется в понимании патогенетических факторов и коррекции возможных причин выпадения волос. Ключом к успешному лечению диффузной алопеции служит комплексный, многофакторный и индивидуальный подход.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Sustained stress can promote the secretion of proinflammatory cytokines, such as INF-ɣ, which leads to inflammation and results in apoptosis, cell senescence, and disruption of hair growth cycles. It is important to know that a somatic disease itself can become a stress factor. In our case it is a hair loss, which provokes a reactive anxiety-depressive state (nosogenic reaction), often affected by predominant anxious fears for one's health.</p></sec><sec><title>Aim</title><p>Aim. To study the efficacy and tolerability of the updated composition of ALERANA® 5% topical spray combined with ALERANA® Serum BIO active complex for hair growth containing minoxidil for the treatment of stress-induced nonscarring alopecia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A study of ALERANA minoxidil products was conducted. All patients (50 people) underwent comprehensive clinical and laboratory examination and trichoscopic diagnosis. Signs of psycho-emotional distress were diagnosed in 56%, symptoms of autonomic disorders (palpitations, hot flushes, red dermographism, hyperhidrosis) in 21%, sleep disorders in 48%, change in appetite in 18%, muscle tension, spasms in 12%.</p></sec><sec><title>Results</title><p>Results. The amount of hair significantly increased during complex therapy. In the first 3 months of therapy, the average gain was 17%. The appearance of new hair in the parietal and temporal areas, as well as a decline in the number of single follicular units were also observed. ALERANA® spray is highly effective, well tolerated by patients and can be prescribed both as a monotherapy as well as in combination with systemic and local drugs.</p></sec><sec><title>Conclusion</title><p>Conclusion. Identification of mental disorders in patients with chronic types of hair loss, such as alopecia areata and androgenetic alopecia, appears to be an important stage during examination of this group of dermatological patients. The condition for the choice of optimal therapy for a patient is rooted in understanding the pathogenetic factors and correction of possible causes of hair loss. The key to successful treatment of diffuse alopecia is a comprehensive, multifactorial and personalized approach. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>стресс</kwd><kwd>алопеция</kwd><kwd>миноксидил</kwd><kwd>наружная терапия</kwd><kwd>андрогены</kwd><kwd>фолликулы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stress</kwd><kwd>alopecia</kwd><kwd>minoxidil</kwd><kwd>local therapy</kwd><kwd>androgens</kwd><kwd>follicles</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева ОВ. Стресс и расстройства адаптации. РМЖ. 2009;(11):789–793. Режим доступа: https://www.rmj.ru/articles/nevrologiya/Stress_i_rasstroystva_adaptacii.</mixed-citation><mixed-citation xml:lang="en">Vorobyeva OV. Stress and adjustment disorders. RMJ. 2009;(11):789–793. (In Russ.) 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