medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-354medsovet-7796Research ArticleРЕПРОДУКТИВНОЕ ЗДОРОВЬЕ И ВРТREPRODUCTIVE HEALTH AND ARTРоль антимюллерова гормона в контексте современных патогенетических подходов к терапии эндометриоза (обзор литературы)The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)https://orcid.org/0000-0001-5109-6725БуралкинаН. А.BuralkinaN. A.

Буралкина Наталья Александровна – доктор медицинских наук, старший научный сотрудник хирургического отделения.

117997, Москва, ул. Академика Опарина, д. 4

Natalya A. Buralkina - Dr. Sci. (Med.), Senior Researcher of the Surgical Department, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.

4, Academician Oparin St., Moscow, 117997

natalyaburalkina@yandex.ruhttps://orcid.org/0009-0008-6645-6648ЧекеневаН. А.ChekenevaN. A.

Чекенева Наталья Александровна - врач – акушер-гинеколог, соискатель.

117997, Москва, ул. Академика Опарина, д. 4

Natalya A. Chekeneva - Obstetrician-Gynecologist, Applicant, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.

4, Academician Oparin St., Moscow, 117997

4ekeneva@gmail.comhttps://orcid.org/0000-0002-1313-7079ПавловичС. В.PavlovichS. V.

Павлович Станислав Владиславович - кандидат медицинских наук, ученый секретарь.

117997, Москва, ул. Академика Опарина, д. 4

Stanislav V. Pavlovich - Cand. Sci. (Med.), Scientific Secretary, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.

4, Academician Oparin St., Moscow, 117997

s_pavlovich@oparina4.ruhttps://orcid.org/0009-0003-7856-2863ЧупрынинВ. Д.ChupryninV. D.

Чупрынин Владимир Дмитриевич - кандидат медицинских наук, заведующий хирургическим отделением.

117997, Москва, ул. Академика Опарина, д. 4

Vladimir D. Chuprynin, Cand. Sci. (Med.), Head of the Surgical Department, Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.

4, Academician Oparin St., Moscow, 117997

v_chuprynin@oparina4.ruhttps://orcid.org/0009-0003-5440-7674ПилюгинаЭ. И.PilyuginaE. I.

Пилюгина Эллина Ивановна - клинический ординатор.

123098, Москва, ул. Живописная, д. 46, стр. 8

Ellina I. Pilyugina - Resident, Clinical Resident, State Scientific Center of the Russian Federation – Federal Medical Biophysical Center named after A.I. Burnazyan.

46, Bldg. 8, Zhivopisnaya St., Moscow, 123098

elya13.11.97@icloud.comНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationСеченовский центр материнства и детства Первого Московского государственного медицинского университета имени И.М. Сеченова (Сеченовского Университета)РоссияSechenov Center for Maternity and Childhood of the Sechenov First Moscow State Medical University (Sechenov University)Russian FederationГосударственный научный центр Российской Федерации – Федеральный медицинский биофизический центр имени А.И. БурназянаРоссияState Scientific Center of the Russian – Federation Federal Medical Biophysical Center named after A.I. BurnazyanRussian Federation2023211020230155864Copyright © Буралкина Н.А., Чекенева Н.А., Павлович С.В., Чупрынин В.Д., Пилюгина Э.И., 20232023Буралкина Н.А., Чекенева Н.А., Павлович С.В., Чупрынин В.Д., Пилюгина Э.И.Buralkina N.A., Chekeneva N.A., Pavlovich S.V., Chuprynin V.D., Pilyugina E.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7796

Антимюллеров гормон (АМГ) хорошо известен как один из ключевых факторов в репродуктивном развитии и формировании половых признаков в эмбриональном периоде у обоих полов. У женщин АМГ вырабатывается гранулезными клетками преантральных и ранних антральных фолликулов яичников и является ключевым биохимическим маркером овариального резерва. В последнее время активно исследуется роль АМГ и его трансмембранного рецептора AMHRII как возможных патогенетических звеньев ряда гинекологических заболеваний. Способность АМГ вызывать регрессию мюллерова протока у мужских эмбрионов позволяет предполагать его ингибирующую роль в ряде доброкачественных и злокачественных гинекологических опухолей, а также эндометриоза. В связи с этим в настоящее время ведется активный научный поиск в данном направлении. В ряде исследований было показано, что АМГ вызывает апоптоз стромальных клеток эндометрия человека и клеток эндометриоза in vitro, а также участвует в развитии процессов аутофагии при эндометриозе. Указанные исследования демонстрируют важную роль АМГ в клеточном апоптозе при эндометриозе и свидетельствуют о его терапевтическом потенциале для широкого спектра гинекологических заболеваний. Также известно, что рецептор AMHRII экспрессируется в клетках эктопического и эутопического эндометрия и может являться мишенью для таргетной терапии. Важно отметить, что AMГ как представитель надсемейства TGF-β обладает высокой аффинностью и специфичностью к рецептору AMHRII, что делает дальнейшее изучение функции АМГ и AMHRII актуальным как для оценки их влияния на процессы фолликулогенеза и репродуктивного старения, так и для разработки новых стратегий таргетной терапии широкого спектра гинекологической заболеваний, в том числе эндометриоза.

Anti-Mullerian hormone (AMH) is well known as one of the key factors in reproductive development and the formation of sexual characteristics in the embryonic period in both sexes. In women, AMH is produced by granulosa cells of the preantral and early antral follicles of the ovaries and is a key biochemical marker of ovarian reserve. Recently, the role of AMH and its transmembrane receptor AMHRII as possible pathogenetic links in a number of gynecological diseases has been actively studied. The ability of AMH to cause regression of the Müllerian duct in male embryos suggests its inhibitory role for a number of benign and malignant gynecological tumors, as well as endometriosis. In this connection, active scientific research in this direction is currently underway. A number of studies have shown that AMH causes apoptosis of human endometrial stromal cells and endometriosis cells in vitro, and is also involved in the development of autophagy processes in endometriosis. The above studies demonstrate the important role of AMH in cell apoptosis in endometriosis, and indicate its therapeutic potential for a wide range of gynecological diseases. It is important to note that AMH, as a representativemember of the TGF-β superfamily, has high affinity and specificity for the AMHRII receptor, which. This fact makes further study of the function of AMH and AMHRII relevant both for assessing their effectinfluence on the processes of folliculogenesis, and reproductive aging processes, and for developing new targeting targeted therapy strategies therapy for a wide range of gynecological diseases, including endometriosis.

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The authors declare that there are no conflicts of interest present.