medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-279medsovet-7817Research ArticleНЕОНАТОЛОГИЯNEONATOLOGYВспомогательные репродуктивные технологии и детское сердцеAssisted reproductive technologies and the children’s hearthttps://orcid.org/0000-0002-3081-9477ПавлюковаЕ. Н.PavlyukovaE. N.

Павлюкова Елена Николаевна, доктор медицинских наук, профессор, заведующий отделением атеросклероза и хронической ишемической болезни сердца

634012, Томск, ул. Киевская, д. 111А

Elena N. Pavlyukova, Dr. Sci. (Med.), Professor, Head of the Department of Atherosclerosis and Chronic Coronary Heart Disease

111A, Kievskaya St., Tomsk, 634012

pavluk@cardio-tomsk.ruhttps://orcid.org/0000-0002-5550-5925КолосоваМ. В.KolosovaM. V.

Колосова Марина Владимировна, доктор медицинских наук, профессор кафедры детских болезней

634002, Томск, Московский тракт, д. 2

Marina V. Kolosova, Dr. Sci. (Med.), Professor of the Department of Children’s Diseases

2, Moskovsky Trakt, Tomsk, 634002

kolosova_mv@inbox.ruhttps://orcid.org/0000-0003-0335-9126АлексееваЕ. О.AlekseevaE. О.

Алексеева Евгения Олеговна, врач-педиатр, Клиники ООО «Абовомед»; соискатель, Научно- исследовательский институт кардиологии – филиал Томского национального исследовательского медицинского центра Российской академии наук

634012, Томск, ул. Киевская, д. 111А,

634062, Томск, ул. Бирюкова, д. 12

Evgeniya O. Alekseeva, Pediatrician, Clinics of Abovomed LLC; Applicant, Research Institute of Cardiology – branch of Tomsk National Research Medical Center of RAS

12, Biryukova St., Tomsk, 634062,

111A, Kievskaya St., Tomsk, 634012

alexeeva_777@mail.ruhttps://orcid.org/0000-0002-7011-4316КарповР. С.KarpovR. S.

Карпов Ростислав Сергеевич, академик РАН, доктор медицинских наук, профессор, научный руководитель

634012, Томск, ул. Киевская, д. 111А

Rostislav S. Karpov, Acad. RAS, Dr. Sci. (Med.), Professor, Scientific Supervisor

111A, Kievskaya St., Tomsk, 634012

karpov@cardio-tomsk.ruНаучно-исследовательский институт кардиологии – филиал Томского национального исследовательского медицинского центра Российской академии наукРоссияResearch Institute of Cardiology – branch of Tomsk National Research Medical Center of RASRussian FederationСибирский государственный медицинский университетРоссияSiberian State Medical UniversityRussian FederationНаучно-исследовательский институт кардиологии – филиал Томского национального исследовательского медицинского центра Российской академии наук;РоссияResearch Institute of Cardiology – branch of Tomsk National Research Medical Center of RAS; Clinics of Abovomed LLCRussian Federation202330102023017Педиатрия1122Copyright © Павлюкова Е.Н., Колосова М.В., Алексеева Е.О., Карпов Р.С., 20232023Павлюкова Е.Н., Колосова М.В., Алексеева Е.О., Карпов Р.С.Pavlyukova E.N., Kolosova M.V., Alekseeva E.О., Karpov R.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7817

Активное применение вспомогательных репродуктивных технологий (ВРТ) помогло добиться весьма внушительных результатов, что позволяет рассматривать данный метод как один из эффективных подходов к лечению бесплодия. К настоящему моменту во всем мире с помощью ВРТ рождено более 8 млн детей. В то же время ВРТ являются важным фактором риска, поскольку долгосрочные последствия для морфологии и функции детского сердца могут предрасполагать к преждевременной сердечно-сосудистой заболеваемости и смертности. Данные факты требуют пересмотра традиционных представлений о долгосрочной безопасности их применения, формировании специальных регистров. Создание регистров применения ВРТ оптимизирует процесс длительного наблюдения за детьми, рожденными при их применении. Представленный в обзоре анализ экспериментальных и клинических исследований создает теоретическую базу для понимания тонких механизмов формирования постнатального здоровья у детей, рожденных преждевременно и в процессе применения вспогательных репродуктивных технологий. Настоящий обзор литературы позволит врачам различных специальностей (эмбриологам, репродуктологам – акушерам-гинекологам, неонатологам, педиатрам, терапевтам, кардиологам) и производителям питательных сред для культивирования существенно расширить традиционные представления о влиянии ВРТ на здоровье сердечно-сосудистой системы в детском возрасте, поскольку даже небольшие изменения условий культивирования и состава питательной среды для эмбриона, особенности течения беременности могут иметь существенные отсроченные эффекты для здоровья детей, рожденных при применении ВРТ. Следовательно, очевидна важность наблюдения за детьми данной клинической группы с целью дальнейшего выяснения возможных долгосрочных последствий для здоровья, более глубокого понимания фундаментальных закономерностей постнатального развития и ранней диагностики субклинических нарушений сердечно-сосудистой системы.

The active use of assisted reproductive technologies has allowed us to achieve very impressive results, which allows us to consider this method as one of the effective approaches to infertility treatment. More than eight million children have been born worldwide with the help of assisted reproduction to date. At the same time, assisted reproductive technologies are an important risk factor, since long-term consequences for the morphology and function of the child’s heart can predispose to premature cardiovascular morbidity and mortality. These facts require a revision of traditional ideas about the long-term safety of their use, the formation of special registers. The creation of registers of the use of assisted reproductive technologies optimizes the process of long-term monitoring of children born with their use. The analysis of experimental and clinical studies presented in the review creates a theoretical basis for understanding the subtle mechanisms of the formation of postnatal health in children born prematurely and in the process of using inflammatory reproductive technologies. This review of the literature will allow doctors of various specialties (embryologists, reproductologists – obstetricians-gynecologists, neonatologists, pediatricians, therapists, cardiologists) and producers of culture media to significantly expand traditional ideas about the impact of assisted reproductive technologies on the health of the cardiovascular system in childhood, since even small changes in the conditions of cultivation and the composition of the culture medium for the embryo, the peculiarities of the course of pregnancy can have significant delayed effects on the health of children, born with the use of assisted reproductive technologies. Therefore, it is obvious the importance of monitoring children of this clinical group in order to further clarify possible long-term health consequences, a deeper understanding of the fundamental patterns of postnatal development and early diagnosis of subclinical disorders of the cardiovascular system.

вспомогательные репродуктивные технологииинтранатальный онтогенезпостнатальный онтогенездетское сердцемеханика детского сердцаремоделирование детского сердцаreproductive technologiesintranatal ontogenesispostnatal ontogenesischildren’s heartmechanics of children’s heartremodeling of children’s heartReferencesElad D, Jaffa AJ, Grisaru D. Biomechanics of Early Life in the Female Reproductive Tract. Physiology (Bethesda). 2020;35(2):134–143. https://doi.org/10.1152/physiol.00028.2019.Elad D, Jaffa AJ, Grisaru D. Biomechanics of Early Life in the Female Reproductive Tract. Physiology (Bethesda). 2020;35(2):134–143. https://doi.org/10.1152/physiol.00028.2019.Morshed-Behbahani B, Lamyian M, Joulaei H, Rashidi BH, Montazeri A. Infertility policy analysis: a comparative study of selected lower middlemiddle- and high-income countries. Global Health. 2020;16(1):104. https://doi.org/10.1186/s12992-020-00617-9.Morshed-Behbahani B, Lamyian M, Joulaei H, Rashidi BH, Montazeri A. Infertility policy analysis: a comparative study of selected lower middlemiddle- and high-income countries. Global Health. 2020;16(1):104. https://doi.org/10.1186/s12992-020-00617-9.Zaat T, Zagers M, Mol F, Goddijn M, van Wely M, Mastenbroek S. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2021;2(2):CD011184. https://doi.org/10.1002/14651858.CD011184.pub3.Zaat T, Zagers M, Mol F, Goddijn M, van Wely M, Mastenbroek S. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2021;2(2):CD011184. https://doi.org/10.1002/14651858.CD011184.pub3.Thoma M, Fledderjohann J, Cox C, Kantum Adageba R. Biological and Social Aspects of Human Infertility: A Global Perspective. Oxford Research Encyclopedia of Global Public Health. 2021. https://doi.org/10.1093/acrefore/9780190632366.013.184.Thoma M, Fledderjohann J, Cox C, Kantum Adageba R. Biological and Social Aspects of Human Infertility: A Global Perspective. Oxford Research Encyclopedia of Global Public Health. 2021. https://doi.org/10.1093/acrefore/9780190632366.013.184.Zandstra H, Brentjens LBPM, Spauwen B, Touwslager RNH, Bons JAP, Mulder AL et al. Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Hum Reprod. 2018;33(9):1645–1656. https://doi.org/10.1093/humrep/dey246.Zandstra H, Brentjens LBPM, Spauwen B, Touwslager RNH, Bons JAP, Mulder AL et al. Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Hum Reprod. 2018;33(9):1645–1656. https://doi.org/10.1093/humrep/dey246.Кириенко КВ, Апрышко ВП, Яковенко СА. Вспомогательный хетчинг (обзор литературы). Проблемы репродукции. 2019;25(4):89–101. https://doi.org/10.17116/repro20192504189.Kirienko KV, Apryshko VP, Yakovenko SA. Assisted hatching (literature review). Russian Journal of Human Reproduction. 2019;25(4):89–101. (In Russ.) https://doi.org/10.17116/repro20192504189.Vrooman LA, Bartolomei MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2017;68:72–84. https://doi.org/10.1016/j.reprotox.2016.07.015.Vrooman LA, Bartolomei MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2017;68:72–84. https://doi.org/10.1016/j.reprotox.2016.07.015.Kaser DJ, Ginsburg ES, Carrell DT, Racowsky C. Chapter 31 – Assisted Reproduction. In: Strauss JF, Barbieri RL (eds.). Yen and Jaffe’s Reproductive Endocrinology. 8th ed. Elsevier; 2019, pp. 779–822.e16. https://doi.org/10.1016/B978-0-323-47912-7.00031-7.Kaser DJ, Ginsburg ES, Carrell DT, Racowsky C. Chapter 31 – Assisted Reproduction. In: Strauss JF, Barbieri RL (eds.). Yen and Jaffe’s Reproductive Endocrinology. 8th ed. Elsevier; 2019, pp. 779–822.e16. https://doi.org/10.1016/B978-0-323-47912-7.00031-7.Berntsen S, Söderström-Anttila V, Wennerholm UB, Laivuori H, Loft A, Oldereid NB et al. The health of children conceived by ART: ‘the chicken or the egg?’. Hum Reprod Update. 2019;25(2):137–158. https://doi.org/10.1093/humupd/dmz001.Berntsen S, Söderström-Anttila V, Wennerholm UB, Laivuori H, Loft A, Oldereid NB et al. The health of children conceived by ART: ‘the chicken or the egg?’. Hum Reprod Update. 2019;25(2):137–158. https://doi.org/10.1093/humupd/dmz001.Von Wolff M, Haaf T. In Vitro Fertilization Technology and Child Health. Dtsch Arztebl Int. 2020;117(3):23–30. https://doi.org/10.3238/arztebl.2020.0023.Von Wolff M, Haaf T. In Vitro Fertilization Technology and Child Health. Dtsch Arztebl Int. 2020;117(3):23–30. https://doi.org/10.3238/arztebl.2020.0023.Hann M, Roberts SA, D’Souza SW, Clayton P, Macklon N, Brison DR. The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study. BMC Med. 2018;16(1):224. https://doi.org/10.1186/s12916-018-1203-7.Hann M, Roberts SA, D’Souza SW, Clayton P, Macklon N, Brison DR. The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study. BMC Med. 2018;16(1):224. https://doi.org/10.1186/s12916-018-1203-7.Valenzuela-Alcaraz B, Cruz-Lemini M, Rodríguez-López M, Goncé A, García-Otero L, Ayuso H et al. Fetal cardiac remodeling in twin pregnancy conceived by assisted reproductive technology. Ultrasound Obstet Gynecol. 2018;51(1):94–100. https://doi.org/10.1002/uog.17527.Valenzuela-Alcaraz B, Cruz-Lemini M, Rodríguez-López M, Goncé A, García-Otero L, Ayuso H et al. Fetal cardiac remodeling in twin pregnancy conceived by assisted reproductive technology. Ultrasound Obstet Gynecol. 2018;51(1):94–100. https://doi.org/10.1002/uog.17527.Yang M, Fan XB, Wu JN, Wang JM. Association of assisted reproductive technology and multiple pregnancies with the risks of birth defects and stillbirth: A retrospective cohort study. Sci Rep. 2018;8(1):8296. https://doi.org/10.1038/s41598-018-26567-2.Yang M, Fan XB, Wu JN, Wang JM. Association of assisted reproductive technology and multiple pregnancies with the risks of birth defects and stillbirth: A retrospective cohort study. Sci Rep. 2018;8(1):8296. https://doi.org/10.1038/s41598-018-26567-2.Belva F, Bonduelle M, Provyn S, Painter RC, Tournaye H, Roelants M, De Schepper J. Metabolic Syndrome and Its Components in Young Adults Conceived by ICSI. Int J Endocrinol. 2018:8170518. https://doi.org/10.1155/2018/8170518.Belva F, Bonduelle M, Provyn S, Painter RC, Tournaye H, Roelants M, De Schepper J. Metabolic Syndrome and Its Components in Young Adults Conceived by ICSI. Int J Endocrinol. 2018:8170518. https://doi.org/10.1155/2018/8170518.Zegers-Hochschild F, Crosby JA, Musri C, Borges de Souza MDC, Martinez AG, Amaral Silva A et al. Assisted reproductive technologies in Latin America: the Latin American Registry, 2019. Reprod Biomed Online. 2022;45(2):235–245. https://doi.org/10.1016/j.rbmo.2022.02.026Zegers-Hochschild F, Crosby JA, Musri C, Borges de Souza MDC, Martinez AG, Amaral Silva A et al. Assisted reproductive technologies in Latin America: the Latin American Registry, 2019. Reprod Biomed Online. 2022;45(2):235–245. https://doi.org/10.1016/j.rbmo.2022.02.026Brake E, Ferguson L (eds.). Philosophical Foundations of Children’s and Family Law (Philosophical Foundations of Law). Oxford University Press; 2018. 368 р.Brake E, Ferguson L (eds.). Philosophical Foundations of Children’s and Family Law (Philosophical Foundations of Law). Oxford University Press; 2018. 368 р.Pomeroy KO, Comizzoli P, Rushing JS, Lersten IL, Nel-Themaat L. The ART of cryopreservation and its changing landscape. Fertil Steril. 2022;117(3):469–476. https://doi.org/10.1016/j.fertnstert.2022.01.018.Pomeroy KO, Comizzoli P, Rushing JS, Lersten IL, Nel-Themaat L. The ART of cryopreservation and its changing landscape. Fertil Steril. 2022;117(3):469–476. https://doi.org/10.1016/j.fertnstert.2022.01.018.Inhorn MC, Birenbaum-Carmeli D. Assisted Reproductive Technologies and Culture Change. Annu Rev Anthropol. 2008;37(1):177–196. https://doi.org/10.1146/annurev.anthro.37.081407.085230.Inhorn MC, Birenbaum-Carmeli D. Assisted Reproductive Technologies and Culture Change. Annu Rev Anthropol. 2008;37(1):177–196. https://doi.org/10.1146/annurev.anthro.37.081407.085230.Taebi M, Bahrami R, Bagheri-Lankarani N, Shahriari M. Ethical Challenges of Embryo Donation in Embryo Donors and Recipients. Iran J Nurs Midwifery Res. 2018;23(1):36–39. https://doi.org/10.4103/ijnmr.IJNMR_162_16.Taebi M, Bahrami R, Bagheri-Lankarani N, Shahriari M. Ethical Challenges of Embryo Donation in Embryo Donors and Recipients. Iran J Nurs Midwifery Res. 2018;23(1):36–39. https://doi.org/10.4103/ijnmr.IJNMR_162_16.Roy MC, Dupras C, Ravitsky V. The epigenetic effects of assisted reproductive technologies: ethical considerations. J Dev Orig Health Dis. 2017;8(4):436–442. https://doi.org/10.1017/S2040174417000344.Roy MC, Dupras C, Ravitsky V. The epigenetic effects of assisted reproductive technologies: ethical considerations. J Dev Orig Health Dis. 2017;8(4):436–442. https://doi.org/10.1017/S2040174417000344.Pooley JA, Malina A. The development of the family within the context of the assisted reproductive technology process: a socio-ecological model of understanding the IVF process in Poland. Polskie Forum Psychologiczne. 2017;22(4):672–680. https://doi.org/10.14656/PFP20170409.Pooley JA, Malina A. The development of the family within the context of the assisted reproductive technology process: a socio-ecological model of understanding the IVF process in Poland. Polskie Forum Psychologiczne. 2017;22(4):672–680. https://doi.org/10.14656/PFP20170409.Hwang SS, Dukhovny D, Gopal D, Cabral H, Missmer S, Diop H et al. Health of Infants After ART-Treated, Subfertile, and Fertile Deliveries. Pediatrics. 2018;142(2):e20174069. https://doi.org/10.1542/peds.2017-4069.Hwang SS, Dukhovny D, Gopal D, Cabral H, Missmer S, Diop H et al. Health of Infants After ART-Treated, Subfertile, and Fertile Deliveries. Pediatrics. 2018;142(2):e20174069. https://doi.org/10.1542/peds.2017-4069.Rimoldi SF, Sartori C, Rexhaj E, Cerny D, Von Arx R, Soria R et al. Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications. Swiss Med Wkly. 2014;144:w13973. https://doi.org/10.4414/smw.2014.13973.Rimoldi SF, Sartori C, Rexhaj E, Cerny D, Von Arx R, Soria R et al. Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications. Swiss Med Wkly. 2014;144:w13973. https://doi.org/10.4414/smw.2014.13973.Goss KN, Haraldsdottir K, Beshish AG, Barton GP, Watson AM, Palta M et al. Association Between Preterm Birth and Arrested Cardiac Growth in Adolescents and Young Adults. JAMA Cardiol. 2020;5(8):910–919. https://doi.org/10.1001/jamacardio.2020.1511.Goss KN, Haraldsdottir K, Beshish AG, Barton GP, Watson AM, Palta M et al. Association Between Preterm Birth and Arrested Cardiac Growth in Adolescents and Young Adults. JAMA Cardiol. 2020;5(8):910–919. https://doi.org/10.1001/jamacardio.2020.1511.Meister TA, Soria R, Ajalbert G, Frobert A, Giraud MN, Cook S et al. Abstract 20248: Assisted Reproductive Technologies Induce Left Ventricular Hypertrophy and Systolic Dysfunction in Mice. Circulation. 2017;136(Suppl. 1):20248. Available at: https://www.ahajournals.org/doi/10.1161/circ.136.suppl_1.20248.Meister TA, Soria R, Ajalbert G, Frobert A, Giraud MN, Cook S et al. Abstract 20248: Assisted Reproductive Technologies Induce Left Ventricular Hypertrophy and Systolic Dysfunction in Mice. Circulation. 2017;136(Suppl. 1):20248. Available at: https://www.ahajournals.org/doi/10.1161/circ.136.suppl_1.20248.Maalouf WE, Mincheva MN, Campbell BK, Hardy IC. Effects of assisted reproductive technologies on human sex ratio at birth. Fertil Steril. 2014;101(5):1321–1325. https://doi.org/10.1016/j.fertnstert.2014.01.041.Maalouf WE, Mincheva MN, Campbell BK, Hardy IC. Effects of assisted reproductive technologies on human sex ratio at birth. Fertil Steril. 2014;101(5):1321–1325. https://doi.org/10.1016/j.fertnstert.2014.01.041.Laguna-Barraza R, Bermejo-Álvarez P, Ramos-Ibeas P, de Frutos C, LópezCardona AP, Calle A et al. Sex-specific embryonic origin of postnatal phenotypic variability. Reprod Fertil Dev. 2012;25(1):38–47. https://doi.org/ 10.1071/RD12262.Laguna-Barraza R, Bermejo-Álvarez P, Ramos-Ibeas P, de Frutos C, LópezCardona AP, Calle A et al. Sex-specific embryonic origin of postnatal phenotypic variability. Reprod Fertil Dev. 2012;25(1):38–47. https://doi.org/ 10.1071/RD12262.Bodke VV, Burdette JE. Advancements in Microfluidic Systems for the Study of Female Reproductive Biology. Endocrinology. 2021;162(10):bqab078. https://doi.org/10.1210/endocr/bqab078.Bodke VV, Burdette JE. Advancements in Microfluidic Systems for the Study of Female Reproductive Biology. Endocrinology. 2021;162(10):bqab078. https://doi.org/10.1210/endocr/bqab078.Smith GD, Takayama S. Application of microfluidic technologies to human assisted reproduction. Mol Hum Reprod. 2017;23(4):257–268. https://doi.org/10.1093/molehr/gaw076.Smith GD, Takayama S. Application of microfluidic technologies to human assisted reproduction. Mol Hum Reprod. 2017;23(4):257–268. https://doi.org/10.1093/molehr/gaw076.Yanez LZ, Camarillo DB. Microfluidic analysis of oocyte and embryo biomechanical properties to improve outcomes in assisted reproductive technologies. Mol Hum Reprod. 2017;23(4):235–247. https://doi.org/10.1093/molehr/gaw071.Yanez LZ, Camarillo DB. Microfluidic analysis of oocyte and embryo biomechanical properties to improve outcomes in assisted reproductive technologies. Mol Hum Reprod. 2017;23(4):235–247. https://doi.org/10.1093/molehr/gaw071.Alias AB, Huang HY, Yao DJ. A Review on Microfluidics: An Aid to Assisted Reproductive Technology. Molecules. 2021;26(14):4354. https://doi.org/10.3390/molecules26144354.Alias AB, Huang HY, Yao DJ. A Review on Microfluidics: An Aid to Assisted Reproductive Technology. Molecules. 2021;26(14):4354. https://doi.org/10.3390/molecules26144354.Matsuzaki S. Mechanobiology of the female reproductive system. Reprod Med Biol. 2021;20(4):371–401. https://doi.org/10.1002/rmb2.12404.Matsuzaki S. Mechanobiology of the female reproductive system. Reprod Med Biol. 2021;20(4):371–401. https://doi.org/10.1002/rmb2.12404.Hickman DL, Beebe DJ, Rodriguez-Zas SL, Wheeler MB. Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. Comp Med. 2002;52(2):122–126. Available at: https://www.ingentaconnect.com/content/aalas/cm/2002/00000052/00000002/art00006;jsessionid=215xw1r5jt4b0.x-ic-live-02#.Hickman DL, Beebe DJ, Rodriguez-Zas SL, Wheeler MB. Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. Comp Med. 2002;52(2):122–126. Available at: https://www.ingentaconnect.com/content/aalas/cm/2002/00000052/00000002/art00006;jsessionid=215xw1r5jt4b0.x-ic-live-02#.Heo YS, Cabrera LM, Bormann CL, Shah CT, Takayama S, Smith GD. Dynamic microfunnel culture enhances mouse embryo development and pregnancy rates. Hum Reprod. 2010;25(3):613–622. https://doi.org/10.1093/humrep/dep449.Heo YS, Cabrera LM, Bormann CL, Shah CT, Takayama S, Smith GD. Dynamic microfunnel culture enhances mouse embryo development and pregnancy rates. Hum Reprod. 2010;25(3):613–622. https://doi.org/10.1093/humrep/dep449.Foo JY, Lim CS. Biofluid mechanics of the human reproductive process: modelling of the complex interaction and pathway to the oocytes. Zygote. 2008;16(4):343–354. https://doi.org/10.1017/S0967199408004899.Foo JY, Lim CS. Biofluid mechanics of the human reproductive process: modelling of the complex interaction and pathway to the oocytes. Zygote. 2008;16(4):343–354. https://doi.org/10.1017/S0967199408004899.Inoue T, Yamashita Y, Tsujimoto Y, Yamamoto S, Taguchi S, Hirao K et al. The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection. Clin Exp Reprod Med. 2017;44(3):126–131. https://doi.org/10.5653/cerm.2017.44.3.126.Inoue T, Yamashita Y, Tsujimoto Y, Yamamoto S, Taguchi S, Hirao K et al. The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection. Clin Exp Reprod Med. 2017;44(3):126–131. https://doi.org/10.5653/cerm.2017.44.3.126.Ottolini CS, Kitchen J, Xanthopoulou L, Gordon T, Summers MC, Handyside AH. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro. Sci Rep. 2017;7(1):9744. https://doi.org/10.1038/s41598-017-09693-1.Ottolini CS, Kitchen J, Xanthopoulou L, Gordon T, Summers MC, Handyside AH. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro. Sci Rep. 2017;7(1):9744. https://doi.org/10.1038/s41598-017-09693-1.Boulet SL, Kawwass JF, Crawford S, Davies MJ, Kissin DM. Preterm Birth and Small Size for Gestational Age in Singleton, In Vitro Fertilization Births Using Donor Oocytes. Am J Epidemiol. 2018;187(8):1642–1650. https://doi.org/10.1093/aje/kwy051.Boulet SL, Kawwass JF, Crawford S, Davies MJ, Kissin DM. Preterm Birth and Small Size for Gestational Age in Singleton, In Vitro Fertilization Births Using Donor Oocytes. Am J Epidemiol. 2018;187(8):1642–1650. https://doi.org/10.1093/aje/kwy051.Schoolcraft WB. Importance of embryo transfer technique in maximizing assisted reproductive outcomes. Fertil Steril. 2016;105(4):855–860. https://doi.org/10.1016/j.fertnstert.2016.02.022.Schoolcraft WB. Importance of embryo transfer technique in maximizing assisted reproductive outcomes. Fertil Steril. 2016;105(4):855–860. https://doi.org/10.1016/j.fertnstert.2016.02.022.Aygün EG, Dilek TUK. Do embryo transfer catheters affect pregnancy success? J Surg Med. 2021;5(2):132–134. https://doi.org/10.28982/josam.823728.Aygün EG, Dilek TUK. Do embryo transfer catheters affect pregnancy success? J Surg Med. 2021;5(2):132–134. https://doi.org/10.28982/josam.823728.Tanaka A, Suzuki K, Nagayoshi M, Tanaka A, Takemoto Y, Watanabe S et al. Ninety babies born after round spermatid injection into oocytes: survey of their development from fertilization to 2 years of age. Fertil Steril. 2018;110(3):443–451. https://doi.org/10.1016/j.fertnstert.2018.04.033.Tanaka A, Suzuki K, Nagayoshi M, Tanaka A, Takemoto Y, Watanabe S et al. Ninety babies born after round spermatid injection into oocytes: survey of their development from fertilization to 2 years of age. Fertil Steril. 2018;110(3):443–451. https://doi.org/10.1016/j.fertnstert.2018.04.033.Kondapalli LA, Perales-Puchalt A. Low birth weight: is it related to assisted reproductive technology or underlying infertility? Fertil Steril. 2013;99(2):303–310. https://doi.org/10.1016/j.fertnstert.2012.12.035.Kondapalli LA, Perales-Puchalt A. Low birth weight: is it related to assisted reproductive technology or underlying infertility? Fertil Steril. 2013;99(2):303–310. https://doi.org/10.1016/j.fertnstert.2012.12.035.Meister TA, Rexhaj E, Rimoldi SF, Scherrer U, Sartori C. Fetal programming and vascular dysfunction. Artery Research. 2017;21(C):69–77. https://doi.org/10.1016/j.artres.2017.11.005.Meister TA, Rexhaj E, Rimoldi SF, Scherrer U, Sartori C. Fetal programming and vascular dysfunction. Artery Research. 2017;21(C):69–77. https://doi.org/10.1016/j.artres.2017.11.005.Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M. Epigenetic changes and assisted reproductive technologies. Epigenetics. 2020;15(1-2):12–25. https://doi.org/10.1080/15592294.2019.1646572.Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M. Epigenetic changes and assisted reproductive technologies. Epigenetics. 2020;15(1-2):12–25. https://doi.org/10.1080/15592294.2019.1646572.Scherrer U, Rexhaj E, Allemann Y, Sartori C, Rimoldi SF. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur Heart J. 2015;36(25):1583–1589. https://doi.org/10.1093/eurheartj/ehv145.Scherrer U, Rexhaj E, Allemann Y, Sartori C, Rimoldi SF. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur Heart J. 2015;36(25):1583–1589. https://doi.org/10.1093/eurheartj/ehv145.Belfort MB, Qureshi F, Litt J, Enlow MB, De Vivo I, Gregory K, Tiemeier H. Telomere length shortening in hospitalized preterm infants: A pilot study. PLoS ONE. 2021;16(1):e0243468. https://doi.org/10.1371/journal.pone.0243468.Belfort MB, Qureshi F, Litt J, Enlow MB, De Vivo I, Gregory K, Tiemeier H. Telomere length shortening in hospitalized preterm infants: A pilot study. PLoS ONE. 2021;16(1):e0243468. https://doi.org/10.1371/journal.pone.0243468.Casavant SG, Cong X, Moore J, Starkweather A. Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review. Early Hum Dev. 2019;131:63–74. https://doi.org/10.1016/j.earlhumdev.2019.03.003.Casavant SG, Cong X, Moore J, Starkweather A. Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review. Early Hum Dev. 2019;131:63–74. https://doi.org/10.1016/j.earlhumdev.2019.03.003.Feuer S, Rinaudo P. From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel). 2016;4(3):51. https://doi.org/10.3390/healthcare4030051.Feuer S, Rinaudo P. From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel). 2016;4(3):51. https://doi.org/10.3390/healthcare4030051.Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil Steril. 2016;106(3):629–639.e10. https://doi.org/10.1016/j.fertnstert.2016.05.006.Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil Steril. 2016;106(3):629–639.e10. https://doi.org/10.1016/j.fertnstert.2016.05.006.Canovas S, Ross PJ, Kelsey G, Coy P. DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies). Bioessays. 2017;39(11):1700106. https://doi.org/10.1002/bies.201700106.Canovas S, Ross PJ, Kelsey G, Coy P. DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies). Bioessays. 2017;39(11):1700106. https://doi.org/10.1002/bies.201700106.Whitelaw N, Bhattacharya S, Hoad G, Horgan GW, Hamilton M, Haggarty P. Epigenetic status in the offspring of spontaneous and assisted conception. Hum Reprod. 2014;29(7):1452–1458. https://doi.org/10.1093/humrep/deu094.Whitelaw N, Bhattacharya S, Hoad G, Horgan GW, Hamilton M, Haggarty P. Epigenetic status in the offspring of spontaneous and assisted conception. Hum Reprod. 2014;29(7):1452–1458. https://doi.org/10.1093/humrep/deu094.Ramos-Ibeas P, Heras S, Gómez-Redondo I, Planells B, FernándezGonzález R, Pericuesta E et al. Embryo responses to stress induced by assisted reproductive technologies. Mol Reprod Dev. 2019;86(10):1292–1306. https://doi.org/10.1002/mrd.23119.Ramos-Ibeas P, Heras S, Gómez-Redondo I, Planells B, FernándezGonzález R, Pericuesta E et al. Embryo responses to stress induced by assisted reproductive technologies. Mol Reprod Dev. 2019;86(10):1292–1306. https://doi.org/10.1002/mrd.23119.Forton K, Motoji Y, Pezzuto B, Caravita S, Delbaere A, Naeije R, Faoro V. Decreased pulmonary vascular distensibility in adolescents conceived by in vitro fertilization. Hum Reprod. 2019;34(9):1799–1808. https://doi.org/10.1093/humrep/dez113.Forton K, Motoji Y, Pezzuto B, Caravita S, Delbaere A, Naeije R, Faoro V. Decreased pulmonary vascular distensibility in adolescents conceived by in vitro fertilization. Hum Reprod. 2019;34(9):1799–1808. https://doi.org/10.1093/humrep/dez113.Lan KC, Lin YC, Chang YC, Lin HJ, Tsai YR, Kang HY. Limited relationships between reactive oxygen species levels in culture media and zygote and embryo development. J Assist Reprod Genet. 2019;36(2):325–334. https://doi.org/10.1007/s10815-018-1363-6.Lan KC, Lin YC, Chang YC, Lin HJ, Tsai YR, Kang HY. Limited relationships between reactive oxygen species levels in culture media and zygote and embryo development. J Assist Reprod Genet. 2019;36(2):325–334. https://doi.org/10.1007/s10815-018-1363-6.Ghosh J, Coutifaris C, Sapienza C, Mainigi M. Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clin Epigenetics. 2017;9:14. https://doi.org/10.1186/s13148-017-0318-6.Ghosh J, Coutifaris C, Sapienza C, Mainigi M. Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clin Epigenetics. 2017;9:14. https://doi.org/10.1186/s13148-017-0318-6.Gardner DK, Kelley RL. Impact of the IVF laboratory environment on human preimplantation embryo phenotype. J Dev Orig Health Dis. 2017;8(4):418–435. https://doi.org/10.1017/S2040174417000368.Gardner DK, Kelley RL. Impact of the IVF laboratory environment on human preimplantation embryo phenotype. J Dev Orig Health Dis. 2017;8(4):418–435. https://doi.org/10.1017/S2040174417000368.Agarwal A, Maldonado Rosas I, Anagnostopoulou C, Cannarella R, Boitrelle F, Munoz LV et al. Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment. Antioxidants (Basel). 2022;11(3):477. https://doi.org/10.3390/antiox11030477.Agarwal A, Maldonado Rosas I, Anagnostopoulou C, Cannarella R, Boitrelle F, Munoz LV et al. Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment. Antioxidants (Basel). 2022;11(3):477. https://doi.org/10.3390/antiox11030477.Gardner DK, Hamilton R, McCallie B, Schoolcraft WB, Katz-Jaffe MG. Human and mouse embryonic development, metabolism and gene expression are altered by an ammonium gradient in vitro. Reproduction. 2013;146(1):49–61. https://doi.org/10.1530/REP-12-0348.Gardner DK, Hamilton R, McCallie B, Schoolcraft WB, Katz-Jaffe MG. Human and mouse embryonic development, metabolism and gene expression are altered by an ammonium gradient in vitro. Reproduction. 2013;146(1):49–61. https://doi.org/10.1530/REP-12-0348.Eskild A, Monkerud L, Tanbo T. Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Hum Reprod. 2013;28(12):3207–3214. https://doi.org/10.1093/humrep/det376.Eskild A, Monkerud L, Tanbo T. Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Hum Reprod. 2013;28(12):3207–3214. https://doi.org/10.1093/humrep/det376.Li R, Pedersen KS, Liu Y, Pedersen HS, Lægdsmand M, Rickelt LF et al. Effect of red light on the development and quality of mammalian embryos. J Assist Reprod Genet. 2014;31(7):795–801. https://doi.org/10.1007/s10815-014-0247-7.Li R, Pedersen KS, Liu Y, Pedersen HS, Lægdsmand M, Rickelt LF et al. Effect of red light on the development and quality of mammalian embryos. J Assist Reprod Genet. 2014;31(7):795–801. https://doi.org/10.1007/s10815-014-0247-7.Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3–12. https://doi.org/10.1016/j.bpobgyn.2018.04.003.Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3–12. https://doi.org/10.1016/j.bpobgyn.2018.04.003.Scala M, Berg J, Keszler M, Abubakar K. Premature Infants Conceived with Assisted Reproductive Technology: An Analysis of Infant Morbidity, Compared with Infants Conceived Naturally. Am J Perinatol. 2019;36(3):258–261. https://doi.org/10.1055/s-0038-1667288.Scala M, Berg J, Keszler M, Abubakar K. Premature Infants Conceived with Assisted Reproductive Technology: An Analysis of Infant Morbidity, Compared with Infants Conceived Naturally. Am J Perinatol. 2019;36(3):258–261. https://doi.org/10.1055/s-0038-1667288.Bavineni M, Wassenaar TM, Agnihotri K, Ussery DW, Lüscher TF, Mehta JL. Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood. Eur Heart J. 2019;40(14):1107–1112. https://doi.org/10.1093/eurheartj/ehz025.Bavineni M, Wassenaar TM, Agnihotri K, Ussery DW, Lüscher TF, Mehta JL. Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood. Eur Heart J. 2019;40(14):1107–1112. https://doi.org/10.1093/eurheartj/ehz025.Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565–579. https://doi.org/10.1016/j.cell.2014.03.032.Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565–579. https://doi.org/10.1016/j.cell.2014.03.032.El-Khuffash A, McNamara PJ. Hemodynamic Assessment and Monitoring of Premature Infants. Clin Perinatol. 2017;44(2):377–393. https://doi.org/10.1016/j.clp.2017.02.001.El-Khuffash A, McNamara PJ. Hemodynamic Assessment and Monitoring of Premature Infants. Clin Perinatol. 2017;44(2):377–393. https://doi.org/10.1016/j.clp.2017.02.001.Fruchter E, Beck-Fruchter R, Hourvitz A, Weiser M, Goldberg S, Fenchel D, Lerner-Geva L. Health and functioning of adolescents conceived by assisted reproductive technology. Fertil Steril. 2017;107(3):774–780. https://doi.org/10.1016/j.fertnstert.2016.12.001.Fruchter E, Beck-Fruchter R, Hourvitz A, Weiser M, Goldberg S, Fenchel D, Lerner-Geva L. Health and functioning of adolescents conceived by assisted reproductive technology. Fertil Steril. 2017;107(3):774–780. https://doi.org/10.1016/j.fertnstert.2016.12.001.Cui L, Zhou W, Xi B, Ma J, Hu J, Fang M et al. Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology. Diabetologia. 2020;63(10):2150–2157. https://doi.org/10.1007/s00125-020-05241-1.Cui L, Zhou W, Xi B, Ma J, Hu J, Fang M et al. Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology. Diabetologia. 2020;63(10):2150–2157. https://doi.org/10.1007/s00125-020-05241-1.Guo XY, Liu XM, Jin L, Wang TT, Ullah K, Sheng JZ, Huang HF. Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertil Steril. 2017;107(3):622–631.e5. https://doi.org/10.1016/j.fertnstert.2016.12.007.Guo XY, Liu XM, Jin L, Wang TT, Ullah K, Sheng JZ, Huang HF. Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertil Steril. 2017;107(3):622–631.e5. https://doi.org/10.1016/j.fertnstert.2016.12.007.Yeung EH, Druschel C. Cardiometabolic health of children conceived by assisted reproductive technologies. Fertil Steril. 2013;99(2):318–326. https://doi.org/10.1016/j.fertnstert.2012.12.015.Yeung EH, Druschel C. Cardiometabolic health of children conceived by assisted reproductive technologies. Fertil Steril. 2013;99(2):318–326. https://doi.org/10.1016/j.fertnstert.2012.12.015.Valenzuela-Alcaraz B, Serafini A, Sepulveda-Martínez A, Casals G, Rodríguez-López M, Garcia-Otero L et al. Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study. BJOG. 2019;126(2):291–298. https://doi.org/10.1111/1471-0528.15246.Valenzuela-Alcaraz B, Serafini A, Sepulveda-Martínez A, Casals G, Rodríguez-López M, Garcia-Otero L et al. Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study. BJOG. 2019;126(2):291–298. https://doi.org/10.1111/1471-0528.15246.Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125(15):1890–1896. https://doi.org/10.1161/CIRCULATIONAHA.111.071183.Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125(15):1890–1896. https://doi.org/10.1161/CIRCULATIONAHA.111.071183.Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil Steril. 2010;94(5):1693–1699. https://doi.org/10.1016/j.fertnstert.2009.09.049.Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil Steril. 2010;94(5):1693–1699. https://doi.org/10.1016/j.fertnstert.2009.09.049.Qin N, Zhou Z, Zhao W, Zou K, Shi W, Yu C et al. Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer. Front Cell Dev Biol. 2021;9:637781. https://doi.org/10.3389/fcell.2021.637781.Qin N, Zhou Z, Zhao W, Zou K, Shi W, Yu C et al. Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer. Front Cell Dev Biol. 2021;9:637781. https://doi.org/10.3389/fcell.2021.637781.Kosteria I, Tsangaris GT, Gkourogianni A, Anagnostopoulos A, Papadopoulou A, Papassotiriou I et al. Proteomics of Children Born After Intracytoplasmic Sperm Injection Reveal Indices of an Adverse Cardiometabolic Profile. J Endocr Soc. 2017;1(4):288–301. https://doi.org/10.1210/js.2016-1052.Kosteria I, Tsangaris GT, Gkourogianni A, Anagnostopoulos A, Papadopoulou A, Papassotiriou I et al. Proteomics of Children Born After Intracytoplasmic Sperm Injection Reveal Indices of an Adverse Cardiometabolic Profile. J Endocr Soc. 2017;1(4):288–301. https://doi.org/10.1210/js.2016-1052.Meister TA, Rimoldi SF, Soria R, von Arx R, Messerli FH, Sartori C et al. Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence. J Am Coll Cardiol. 2018;72(11):1267–1274. https://doi.org/10.1016/j.jacc.2018.06.060.Meister TA, Rimoldi SF, Soria R, von Arx R, Messerli FH, Sartori C et al. Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence. J Am Coll Cardiol. 2018;72(11):1267–1274. https://doi.org/10.1016/j.jacc.2018.06.060.Zhu Y, Fu Y, Tang M, Yan H, Zhang F, Hu X et al. Risk of Higher Blood Pressure in 3 to 6 Years Old Singleton Born From OHSS Patients Undergone With Fresh IVF/ICSI. Front Endocrinol (Lausanne). 2022;13:817555. https://doi.org/10.3389/fendo.2022.817555.Zhu Y, Fu Y, Tang M, Yan H, Zhang F, Hu X et al. Risk of Higher Blood Pressure in 3 to 6 Years Old Singleton Born From OHSS Patients Undergone With Fresh IVF/ICSI. Front Endocrinol (Lausanne). 2022;13:817555. https://doi.org/10.3389/fendo.2022.817555.Belva F, Roelants M, De Schepper J, Roseboom TJ, Bonduelle M, Devroey P, Painter RC. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27(10):3100–3108. https://doi.org/10.1093/humrep/des259.Belva F, Roelants M, De Schepper J, Roseboom TJ, Bonduelle M, Devroey P, Painter RC. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27(10):3100–3108. https://doi.org/10.1093/humrep/des259.Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab. 2007;92(9):3417–3423. https://doi.org/10.1210/jc.2006-2896.Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab. 2007;92(9):3417–3423. https://doi.org/10.1210/jc.2006-2896.Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93(5):1682–1688. https://doi.org/10.1210/jc.2007-2432.Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93(5):1682–1688. https://doi.org/10.1210/jc.2007-2432.Seggers J, Haadsma ML, La Bastide-Van Gemert S, Heineman MJ, Middelburg KJ, Roseboom TJ et al. Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis. Hum Reprod. 2014;29(3):502–509. https://doi.org/10.1093/humrep/det396.Seggers J, Haadsma ML, La Bastide-Van Gemert S, Heineman MJ, Middelburg KJ, Roseboom TJ et al. Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis. Hum Reprod. 2014;29(3):502–509. https://doi.org/10.1093/humrep/det396.Bonduelle M, Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod. 2005;20(2):413–419. https://doi.org/10.1093/humrep/deh592.Bonduelle M, Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod. 2005;20(2):413–419. https://doi.org/10.1093/humrep/deh592.Koivurova S, Hartikainen AL, Sovio U, Gissler M, Hemminki E, Järvelin MR. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod. 2003;18(11):2328–2336. https://doi.org/10.1093/humrep/deg445.Koivurova S, Hartikainen AL, Sovio U, Gissler M, Hemminki E, Järvelin MR. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod. 2003;18(11):2328–2336. https://doi.org/10.1093/humrep/deg445.Belva F, Painter R, Bonduelle M, Roelants M, Devroey P, De Schepper J. Are ICSI adolescents at risk for increased adiposity? Hum Reprod. 2012;27(1):257–264. https://doi.org/10.1093/humrep/der375.Belva F, Painter R, Bonduelle M, Roelants M, Devroey P, De Schepper J. Are ICSI adolescents at risk for increased adiposity? Hum Reprod. 2012;27(1):257–264. https://doi.org/10.1093/humrep/der375.Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, KanakaGantenbein C. Euthyroid hyperthyrotropinemia in children born after in vitro fertilization. J Clin Endocrinol Metab. 2009;94(4):1338–1341. https://doi.org/10.1210/jc.2008-1624.Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, KanakaGantenbein C. Euthyroid hyperthyrotropinemia in children born after in vitro fertilization. J Clin Endocrinol Metab. 2009;94(4):1338–1341. https://doi.org/10.1210/jc.2008-1624.Green MP, Mouat F, Miles HL, Hopkins SA, Derraik JG, Hofman PL et al. Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children. Fertil Steril. 2013;99(7):1898–904. https://doi.org/10.1016/j.fertnstert.2013.02.009.Green MP, Mouat F, Miles HL, Hopkins SA, Derraik JG, Hofman PL et al. Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children. Fertil Steril. 2013;99(7):1898–904. https://doi.org/10.1016/j.fertnstert.2013.02.009.Wikstrand MH, Niklasson A, Strömland K, Hellström A. Abnormal vessel morphology in boys born after intracytoplasmic sperm injection. Acta Paediatr. 2008;97(11):1512–1517. https://doi.org/10.1111/j.1651-2227.2008.00959.x.Wikstrand MH, Niklasson A, Strömland K, Hellström A. Abnormal vessel morphology in boys born after intracytoplasmic sperm injection. Acta Paediatr. 2008;97(11):1512–1517. https://doi.org/10.1111/j.1651-2227.2008.00959.x.Rizzo G, Pietrolucci ME, Mappa I, Bitsadze V, Khizroeva J, Makatsariya A, D’Antonio F. Fetal Cardiac Remodeling Is Affected by the Type of Embryo Transfer in Pregnancies Conceived by in vitro Fertilization: A Prospective Cohort Study. Fetal Diagn Ther. 2020;47(10):772–778. https://doi.org/10.1159/000508987.Rizzo G, Pietrolucci ME, Mappa I, Bitsadze V, Khizroeva J, Makatsariya A, D’Antonio F. Fetal Cardiac Remodeling Is Affected by the Type of Embryo Transfer in Pregnancies Conceived by in vitro Fertilization: A Prospective Cohort Study. Fetal Diagn Ther. 2020;47(10):772–778. https://doi.org/10.1159/000508987.Aye CYL, Lewandowski AJ, Lamata P, Upton R, Davis E, Ohuma EO et al. Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. Pediatr Res. 2017;82(1):36–46. https://doi.org/10.1038/pr.2017.96.Aye CYL, Lewandowski AJ, Lamata P, Upton R, Davis E, Ohuma EO et al. Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. Pediatr Res. 2017;82(1):36–46. https://doi.org/10.1038/pr.2017.96.Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Curr Opin Obstet Gynecol. 2019;31(3):183–187. https://doi.org/10.1097/GCO.0000000000000535.Reig A, Seli E. The association between assisted reproductive technologies and low birth weight. Curr Opin Obstet Gynecol. 2019;31(3):183–187. https://doi.org/10.1097/GCO.0000000000000535.Järvisalo MJ, Jartti L, Näntö-Salonen K, Irjala K, Rönnemaa T, Hartiala JJ et al. Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation. 2001;104(24):2943–2947. https://doi.org/10.1161/hc4901.100522.Järvisalo MJ, Jartti L, Näntö-Salonen K, Irjala K, Rönnemaa T, Hartiala JJ et al. Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation. 2001;104(24):2943–2947. https://doi.org/10.1161/hc4901.100522.Segers P, Rietzschel ER, Chirinos JA. How to Measure Arterial Stiffness in Humans. Arterioscler Thromb Vasc Biol. 2020;40(5):1034–1043. https://doi.org/10.1161/ATVBAHA.119.313132.Segers P, Rietzschel ER, Chirinos JA. How to Measure Arterial Stiffness in Humans. Arterioscler Thromb Vasc Biol. 2020;40(5):1034–1043. https://doi.org/10.1161/ATVBAHA.119.313132.Olson M, Chambers M, Shaibi G. Pediatric Markers of Adult Cardiovascular Disease. Curr Pediatr Rev. 2017;13(4):255–259. https://doi.org/10.2174/1573396314666180117092010.Olson M, Chambers M, Shaibi G. Pediatric Markers of Adult Cardiovascular Disease. Curr Pediatr Rev. 2017;13(4):255–259. https://doi.org/10.2174/1573396314666180117092010.Cox DJ, Bai W, Price AN, Edwards AD, Rueckert D, Groves AM. Ventricular remodeling in preterm infants: computational cardiac magnetic resonance atlasing shows significant early remodeling of the left ventricle. Pediatr Res. 2019;85(6):807–815. https://doi.org/10.1038/s41390-018-0171-0.Cox DJ, Bai W, Price AN, Edwards AD, Rueckert D, Groves AM. Ventricular remodeling in preterm infants: computational cardiac magnetic resonance atlasing shows significant early remodeling of the left ventricle. Pediatr Res. 2019;85(6):807–815. https://doi.org/10.1038/s41390-018-0171-0.Кулида ЛВ, Малышева МВ, Перетятко ЛП, Сарыева ОП, Проценко ЕВ. Патоморфология гипоксически-ишемических повреждений миокарда у новорожденных 22–27 недель гестации. Архив патологии. 2021;83(4):29–34. https://doi.org/10.17116/patol20218304129.Kulida LV, Malysheva MV, Peretiatko LP, Saryeva OP, Protsenko EV. Morphopathology of myocardial hypoxic-ischemic injuries in newborns at 22–27 weeks’ gestation. Arkhiv Patologii. 2021;83(4):29–34. (In Russ.) https://doi.org/10.17116/patol20218304129.Liu H, Zhang Y, Gu HT, Feng QL, Liu JY, Zhou J, Yan F. Association between assisted reproductive technology and cardiac alteration at age 5 years. JAMA Pediatr. 2015;169(6):603–605. https://doi.org/10.1001/jamapediatrics.2015.0214.Liu H, Zhang Y, Gu HT, Feng QL, Liu JY, Zhou J, Yan F. Association between assisted reproductive technology and cardiac alteration at age 5 years. JAMA Pediatr. 2015;169(6):603–605. https://doi.org/10.1001/jamapediatrics.2015.0214.Zhou J, Liu H, Gu HT, Cui YG, Zhao NN, Chen J et al. Association of cardiac development with assisted reproductive technology in childhood: a prospective single-blind pilot study. Cell Physiol Biochem. 2014;34(3):988–1000. https://doi.org/10.1159/000366315.Zhou J, Liu H, Gu HT, Cui YG, Zhao NN, Chen J et al. Association of cardiac development with assisted reproductive technology in childhood: a prospective single-blind pilot study. Cell Physiol Biochem. 2014;34(3):988–1000. https://doi.org/10.1159/000366315.Xu GF, Zhang JY, Pan HT, Tian S, Liu ME, Yu TT et al. Cardiovascular dysfunction in offspring of ovarian-hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis. J Clin Endocrinol Metab. 2014;99(12):E2494–2503. https://doi.org/10.1210/jc.2014-2349.Xu GF, Zhang JY, Pan HT, Tian S, Liu ME, Yu TT et al. Cardiovascular dysfunction in offspring of ovarian-hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis. J Clin Endocrinol Metab. 2014;99(12):E2494–2503. https://doi.org/10.1210/jc.2014-2349.Sitzberger C, Oberhoffer-Fritz R, Freiberger A, Engelhard J, Felberbaum R, Wacker-Gußmann A. Cardiovascular risks of children conceived by assisted reproductive technologies: a systematic review. Gynäkologische Endokrinologie. 2021;19(Suppl. 1):1–7. https://doi.org/10.1007/s10304-021-00386-7.Sitzberger C, Oberhoffer-Fritz R, Freiberger A, Engelhard J, Felberbaum R, Wacker-Gußmann A. Cardiovascular risks of children conceived by assisted reproductive technologies: a systematic review. Gynäkologische Endokrinologie. 2021;19(Suppl. 1):1–7. https://doi.org/10.1007/s10304-021-00386-7.Gao Q, Pan HT, Lin XH, Zhang JY, Jiang Y, Tian S et al. Altered protein expression profiles in umbilical veins: insights into vascular dysfunctions of the children born after in vitro fertilization. Biol Reprod. 2014;91(3):71. https://doi.org/10.1095/biolreprod.114.120659.Gao Q, Pan HT, Lin XH, Zhang JY, Jiang Y, Tian S et al. Altered protein expression profiles in umbilical veins: insights into vascular dysfunctions of the children born after in vitro fertilization. Biol Reprod. 2014;91(3):71. https://doi.org/10.1095/biolreprod.114.120659.Valenzuela-Alcaraz B, Crispi F, Cruz-Lemini M, Bijnens B, García-Otero L, Sitges M et al. Differential effect of assisted reproductive technology and small-for-gestational age on fetal cardiac remodeling. Ultrasound Obstet Gynecol. 2017;50(1):63–70. https://doi.org/10.1002/uog.16217.Valenzuela-Alcaraz B, Crispi F, Cruz-Lemini M, Bijnens B, García-Otero L, Sitges M et al. Differential effect of assisted reproductive technology and small-for-gestational age on fetal cardiac remodeling. Ultrasound Obstet Gynecol. 2017;50(1):63–70. https://doi.org/10.1002/uog.16217.Valenzuela-Alcaraz B, Cruz-Lemini M, Rodríguez-López M, Goncé A, García-Otero L, Ayuso H et al. Fetal cardiac remodeling in twin pregnancy conceived by assisted reproductive technology. Ultrasound Obstet Gynecol. 2018;51(1):94–100. https://doi.org/10.1002/uog.17527.Valenzuela-Alcaraz B, Cruz-Lemini M, Rodríguez-López M, Goncé A, García-Otero L, Ayuso H et al. Fetal cardiac remodeling in twin pregnancy conceived by assisted reproductive technology. Ultrasound Obstet Gynecol. 2018;51(1):94–100. https://doi.org/10.1002/uog.17527.Boutet ML, Casals G, Valenzuela-Alcaraz B, García-Otero L, Crovetto F, Cívico MS et al. Cardiac remodeling in fetuses conceived by ARTs: fresh versus frozen embryo transfer. Hum Reprod. 2021;36(10):2697–2708. https://doi.org/10.1093/humrep/deab159.Boutet ML, Casals G, Valenzuela-Alcaraz B, García-Otero L, Crovetto F, Cívico MS et al. Cardiac remodeling in fetuses conceived by ARTs: fresh versus frozen embryo transfer. Hum Reprod. 2021;36(10):2697–2708. https://doi.org/10.1093/humrep/deab159.Mizrak I, Asserhøj LL, Lund MAV, Kielstrup LR, Greisen G, Clausen TD et al. Cardiovascular function in 8- to 9-year-old singletons born after ART with frozen and fresh embryo transfer. Hum Reprod. 2022;37(3):600–611. https://doi.org/10.1093/humrep/deab284.Mizrak I, Asserhøj LL, Lund MAV, Kielstrup LR, Greisen G, Clausen TD et al. Cardiovascular function in 8- to 9-year-old singletons born after ART with frozen and fresh embryo transfer. Hum Reprod. 2022;37(3):600–611. https://doi.org/10.1093/humrep/deab284.Cui L, Zhao M, Zhang Z, Zhou W, Lv J, Hu J et al. Assessment of Cardiovascular Health of Children Ages 6 to 10 Years Conceived by Assisted Reproductive Technology. JAMA Netw Open. 2021;4(11):e2132602. https://doi.org/10.1001/jamanetworkopen.2021.32602.Cui L, Zhao M, Zhang Z, Zhou W, Lv J, Hu J et al. Assessment of Cardiovascular Health of Children Ages 6 to 10 Years Conceived by Assisted Reproductive Technology. JAMA Netw Open. 2021;4(11):e2132602. https://doi.org/10.1001/jamanetworkopen.2021.32602.Mohlkert LA, Hallberg J, Broberg O, Rydberg A, Halvorsen CP, Liuba P et al. The Preterm Heart in Childhood: Left Ventricular Structure, Geometry, and Function Assessed by Echocardiography in 6-Year-Old Survivors of Periviable Births. J Am Heart Assoc. 2018;7(2):e007742. https://doi.org/10.1161/JAHA.117.007742.Mohlkert LA, Hallberg J, Broberg O, Rydberg A, Halvorsen CP, Liuba P et al. The Preterm Heart in Childhood: Left Ventricular Structure, Geometry, and Function Assessed by Echocardiography in 6-Year-Old Survivors of Periviable Births. J Am Heart Assoc. 2018;7(2):e007742. https://doi.org/10.1161/JAHA.117.007742.Rodríguez-López M, Cruz-Lemini M, Valenzuela-Alcaraz B, Garcia-Otero L, Sitges M, Bijnens B et al. Descriptive analysis of different phenotypes of cardiac remodeling in fetal growth restriction. Ultrasound Obstet Gynecol. 2017;50(2):207–214. https://doi.org/10.1002/uog.17365.Rodríguez-López M, Cruz-Lemini M, Valenzuela-Alcaraz B, Garcia-Otero L, Sitges M, Bijnens B et al. Descriptive analysis of different phenotypes of cardiac remodeling in fetal growth restriction. Ultrasound Obstet Gynecol. 2017;50(2):207–214. https://doi.org/10.1002/uog.17365.Masoumy EP, Sawyer AA, Sharma S, Patel JA, Gordon PMK, Regnault TRH et al. The lifelong impact of fetal growth restriction on cardiac development. Pediatr Res. 2018;84(4):537–544. https://doi.org/10.1038/s41390-018-0069-x.Masoumy EP, Sawyer AA, Sharma S, Patel JA, Gordon PMK, Regnault TRH et al. The lifelong impact of fetal growth restriction on cardiac development. Pediatr Res. 2018;84(4):537–544. https://doi.org/10.1038/s41390-018-0069-x.Graham E, Bergmann O. Dating the Heart: Exploring Cardiomyocyte Renewal in Humans. Physiology (Bethesda). 2017;32(1):33–41. https://doi.org/10.1152/physiol.00015.2016.Graham E, Bergmann O. Dating the Heart: Exploring Cardiomyocyte Renewal in Humans. Physiology (Bethesda). 2017;32(1):33–41. https://doi.org/10.1152/physiol.00015.2016.

The authors declare that there are no conflicts of interest present.