medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-386medsovet-7838Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYОсобенности постковидного синдрома у детей, перенесших инфекцию в легкой формеCharacteristics of post COVID-19 condition in children after mild COVID-19https://orcid.org/0000-0002-3068-762XЧернявскаяА. С.ChernyavskayaA. S.

Чернявская Анастасия Сергеевна, аспирант кафедры педиатрии и детской ревматологии Клинического института детского здоровья имени Н.Ф. Филатова, Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет); врач-педиатр приемно-диагностического отделения, Национальный медицинский исследовательский центр здоровья детей

119991, Москва, ул. Трубецкая, д. 8, стр. 2,

119296, Москва, Ломоносовский проспект, д. 2, стр. 1

Anastasia S. Chernyavskaya, Postgraduate Student, Department of Pediatrics and Pediatric Rheumatology of the N.F. Filatov Clinical Institute of Child Health, Sechenov First Moscow State Medical University (Sechenov University); Pediatrician of the Admission and Diagnostic Department, National Medical Research Center for Children’s Health

8, Bldg. 2, Trubetskaya St., Moscow, 119991,

2, Bldg. 1, Lomonosovsky Ave., Moscow, 119926

a.chernyawskaya@gmail.comhttps://orcid.org/0000-0002-2367-9920СимоноваО. И.SimonovaO. I.

Симонова Ольга Игоревна, доктор медицинских наук, профессор кафедры педиатрии и детской ревматологии Клинического института детского здоровья имени Н.Ф. Филатова, Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет); заведующая пульмонологическим отделением, Национальный медицинский исследовательский центр здоровья детей; руководитель кабинета муковисцидоза, Морозовская детская городская клиническая больница

119991, Москва, ул. Трубецкая, д. 8, стр. 2,

119296, Москва, Ломоносовский проспект, д. 2, стр. 1,

119049, Москва, 4-й Добрынинский переулок, д. 1/9

Olga I. Simonova, Dr. Sci. (Med.), Professor of the Department of Pediatrics and Pediatric Rheumatology of the N.F. Filatov Clinical Institute of Child Health, Sechenov First Moscow State Medical University (Sechenov University); Head of the Pulmonology Department, National Medical Research Center for Children’s Health; Chief of Cystic Fibrosis Department, Morozovskaya Children’s City Clinical Hospital

8, Bldg. 2, Trubetskaya St., Moscow, 119991,

2, Bldg. 1, Lomonosovsky Ave., Moscow, 119926,

2, Bldg. 1, Lomonosovsky Ave., Moscow, 119926

oisimonova@mail.ruhttps://orcid.org/0000-0003-0503-6371КаширскаяН. Ю.KashirskayaN. Yu.

Каширская Наталия Юрьевна, доктор медицинских наук, профессор, главный научный сотрудник лаборатории генетической эпидемиологии, Медико-генетический научный центр имени академика Н.П. Бочкова; профессор кафедры педиатрии, Московский областной научно-исследовательский клинический институт (МОНИКИ) имени М.Ф. Владимирского

115522, Москва, ул. Москворечье, д. 1,

129110, Москва, ул. Щепкина, д. 61/2, корп. 1

Nataliya Yu. Kashirskaya, Dr. Sci. (Med.), Professor, Chief Research Scientist, Laboratory of Genetic Epidemiology, Research Centre for Medical Genetics; Professor of the Department of Pediatrics, Moscow Regional Research Clinical Institute named after M.F. Vladimirsky

1, Moskvorechye St., Moscow, 115522,

61/2, Bldg. 1, Schepkin St., Moscow, 129110

kashirskayanj@mail.ruПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет); Национальный медицинский исследовательский центр здоровья детейРоссияSechenov First Moscow State Medical University (Sechenov University); 2National Medical Research Center for Children’s HealthRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет); Национальный медицинский исследовательский центр здоровья детей; Морозовская детская городская клиническая больницаРоссияSechenov First Moscow State Medical University (Sechenov University) National Medical Research Center for Children’s Health; Morozovskaya Children’s City Clinical HospitalRussian FederationМедико-генетический научный центр имени академика Н.П. Бочкова; Московский областной научно-исследовательский клинический институт имени М.Ф. ВладимирскогоРоссияResearch Centre for Medical Genetics; Moscow Regional Research Clinical Institute named after M.F. VladimirskyRussian Federation202301112023017Педиатрия187193Copyright © Чернявская А.С., Симонова О.И., Каширская Н.Ю., 20232023Чернявская А.С., Симонова О.И., Каширская Н.Ю.Chernyavskaya A.S., Simonova O.I., Kashirskaya N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7838Введение

Введение. Дети, перенесшие COVID-19, могут длительное время предъявлять жалобы со стороны различных органов и систем, влияющие на качество их жизни.

Цель

Цель. Определить распространенность и характеристики постковидного синдрома у детей, перенесших инфекцию в легкой форме.

Материалы и методы

Материалы и методы. Данное одноцентровое исследование «случай – контроль» включало 206 детей, перенесших COVID-19, и 176 детей, перенесших другие острые респираторные инфекции в легкой форме. Диагноз «COVID-19» был подтвержден путем полимеразной цепной реакции. Пациенты были оценены в среднем через 1 год после перенесенной инфекции. Средний возраст респондентов составил 8,8 года в группе «случаев» и 8,4 года в группе «контроля», девочки составили 55% (114) и 50% (88) соответственно. Использован опросник Международного консорциума по тяжелым острым респираторным и новым инфекционным заболеваниям ISARIC COVID-19 для детей. Оценена распространенность, длительность и характеристика персистирующих симптомов, а также проведен сравнительный анализ указанных симптомов между группами пациентов.

Результаты и обсуждение

Результаты и обсуждение. К наиболее часто встречающимся персистирующим симптомам COVID-19 относились потеря вкуса – 8,7% [ДИ: 5,3%; 13,1%], усталость – 8,7% [ДИ: 4,9%; 13,1%], боль в груди – 4,9% [ДИ: 1,9%; 7,8%], головная боль – 2,4% [ДИ: 1,0%; 4,9%], ощущение покалываний (в ладонях/ступнях) – 2,4% [ДИ: 0,5%; 4,9%]. Дети контрольной группы страдали от схожих симптомов, однако в группе COVID-19 значимо более часто выявлялись усталость/утомляемость и потеря вкуса. В основном статистически значимой разницы между манифестациями различных групп симптомов у пациентов через 1 год после перенесенной COVID-19 и после других острых респираторных инфекций выявлено не было. Распространенность постковидного синдрома в соответствии с определением ВОЗ у пациентов через 1 год после COVID-19 составила 1,5% [ДИ: 0,0%; 3,4%].

Выводы

Выводы. Дети, перенесшие в легкой форме острые респираторные инфекции, в т. ч. COVID-19, в небольшом проценте случаев могут страдать от персистирующих симптомов даже спустя 1 год после инфекции и требовать повышенного внимания клиницистов.

Introduction

Introduction. Post COVID-19 condition in children causes variety of persistent symptoms such as fatigue, post-exertional malaise, cognitive problems, muscle pain and can affect different aspects of patient’s life.

Aim

Aim. The aim of this study was to describe the prevalence and characteristics of persistent symptoms of COVID-19 in non-hospitalized pediatric patients one year after infection.

Material and methods

Material and methods. This is a single center case-control study including children and young people (COVID-19 as cases and other acute respiratory infections as controls). A survey using ISARIC Global COVID-19 paediatric follow-up questionnaire was conducted by a pediatrician in person or via telephone interview one year after infection. Post COVID-19 condition was defined using WHO case definition.

Results and discussion

Results and discussion. 206 cases and 176 controls were analyzed. The mean ages of cases and controls were 8.8 years and 8.4 years accordingly, with 55% and 50% being females. The most frequent persistent symptoms in cases at 1 year were loss of taste – 8.7% [5.3%; 13.1%], fatigue – 8.7% [4.9%; 13.1%], chest pain – 4.9% [1.9%; 7.8%], headache – 2.4% [1.0%; 4.9%], tingling – 2.4% [0.5%; 4.9%]. Controls had similar persistent symptoms, but cases had significantly higher rates of sensory disturbances (taste/smell alterations) and fatigue. There were no statistically significant differences between other groups of symptoms found. Prevalence of post COVID-19 condition in cases group was 1.5% [0.0%; 3.4%].

Conclusion

Conclusion. Prevalence of post COVID-19 condition in children one year after mild infection is low. However, compared to other respiratory infections, COVID-19 may cause persistent taste/smell disturbances and fatigue.

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The authors declare that there are no conflicts of interest present.