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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-394</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7864</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ БИЛИАРНОЙ СИСТЕМЫ И ПЕЧЕНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISEASES OF THE BILIARY SYSTEM AND LIVER</subject></subj-group></article-categories><title-group><article-title>Применение фитокомпонентов в комплексной терапии хронического некалькулезного холецистита</article-title><trans-title-group xml:lang="en"><trans-title>The role of phytocomponents in the complex therapy of chronic non-calculous cholecystitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2164-3537</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скворцов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skvortsov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скворцов Всеволод Владимирович - доктор медицинских наук, профессор  кафедры внутренних болезней.</p><p>400131, Волгоград, площадь Павших Борцов, д. 1</p></bio><bio xml:lang="en"><p>Vsevolod V. Skvortsov - Dr. Sci. (Med.), Professor of the Department of Internal Diseases, Volgograd State Medical University.</p><p>1, Pavshikh Bortsov Square, Volgograd, 400131</p></bio><email xlink:type="simple">vskvortsov1@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6433-9068</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малякина</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malyakina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Малякина Эллина Альбертовна - ординатор  2-го года.</p><p>119991, Москва, Абрикосовский переулок, д. 2</p></bio><bio xml:lang="en"><p>Ellina A. Malyakina - 2nd year Resident, Petrovsky  National  Research  Centre  of  Surgery.</p><p>2, Abrikosovky Lane, Moscow, 119435</p></bio><email xlink:type="simple">golieva133@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1128-2678</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малякин</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Malyakin</surname><given-names>G. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Малякин Георгий Ильич - ординатор  2-го года.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Georgiy I. Malyakin - 2nd year  Resident,  Sechenov  First Moscow State  Medical University (Sechenov  University).</p><p>8, Bldg. 2, Trubetskaya  St., Moscow, 119991</p></bio><email xlink:type="simple">malyakin_g_i@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский научный центр хирургии имени академика Б.В. Петровского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrovsky National  Research Centre of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>04</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>18</issue><fpage>97</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Скворцов В.В., Малякина Э.А., Малякин Г.И., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Скворцов В.В., Малякина Э.А., Малякин Г.И.</copyright-holder><copyright-holder xml:lang="en">Skvortsov V.V., Malyakina E.A., Malyakin G.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7864">https://www.med-sovet.pro/jour/article/view/7864</self-uri><abstract><p>Некалькулезный холецистит – это форма  холецистита, обусловленная  дисфункцией или гипокинезом  желчного пузыря. Полиэтиологичность и множественность механизмов  патогенеза  данного заболевания требует различных подходов к его коррекции. В этой ситуации фитопрепараты, содержащие  компоненты природного происхождения, заслуживают особенного внимания в комплексе с основной терапией. Куркумин оказывает защитное действие  против холестаза  через  фарнезоидный X-рецептор, что приводит к восстановлению гомеостаза  желчных кислот и противодействию воспалительным реакциям  и, как следствие, к снижению холестаза. Несколько исследований  показали, что куркумин обладает  способностью сокращать желчный пузырь. Несмотря на наличие большого количества разнообразных полезных свойств, широкое применение  куркумина в медицинской  практике до последнего  времени  ограничивалось  его низкой биодоступностью. Были синтезированы  формы с повышенной биодоступностью, например  кавакуркумин. Использование  экстракта листьев артишока в гастроэнтерологии  основано  на его сильном антидиспептическом  действии, опосредованном желчегонной активностью. В исследованиях  показано, что желчегонный эффект артишока был более  выраженным, чем у эталонного препарата.  В литературе  не  встречается  прямое  действие  фитокомпонентов  ромашки  на  состояние  желчного пузыря и функцию желчеоттока, однако  возможно  опосредованное действие  на его работу. Данные свойства  делают экстракт цветков ромашки хорошим дополнением  к комплексной  терапии. Таким образом, комплекс из указанных синергичных компонентов может применяться у лиц, страдающих хроническими заболеваниями желчевыводящих путей, при функциональных расстройствах, в период лечения в составе комплексной терапии, с целью профилактики обострений и продления ремиссии, а также у здоровых лиц для профилактики этих заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>Non-calculous  cholecystitis is a form of cholecystitis caused  by dysfunction  or hypokinesis of the gallbladder. The polyetiology and multiplicity of the pathogenesis of this disease  requires  different  approaches to its correction. In this situation, phytopreparations containing components of origin provide special  attention in combination with the main therapy. Curcumin has a strong protective  effect against  cholestasis through farnesoid X receptors, resulting  in a release of bile acid homeostasis and counteracting inflammatory  inflammation and as a manifestation of cholestasis. Several studies  show that  curcumin requires a contraction of the gallbladder. Despite the presence of many useful properties,  the widespread use of curcumin in medical practice was limited by its limited bioavailability. Forms with increased bioavailability have been synthesized, such as kavacarcumin. The use of artichoke leaf extract  in gastroenterology is based on its strong antidyspeptic effect, mediated by choleretic activity. As study  show, the  choleretic effect  of the  artichoke  was  more  pronounced than  that  of the  reference drug. In the  description,  there  is no direct effect  of chamomile  phytocomponents on the  state  of bile compatibility  and the  function of bile outflow, however, an indirect effect on its work is possible. The results  make chamomile  flower extract  a good addition to therapy. Thus, due to the occurrence  of synergistic components, the complex is found in individuals, in patients with chronic diseases  of the biliary tract, with functional  disorders, the period of treatment in long-term complex therapy, with the prevention  of exacerbation and prolongation of remission, as well as in healthy individuals for the prevention of these  diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дисфункция желчного пузыря</kwd><kwd>фитопрепараты</kwd><kwd>куркумин</kwd><kwd>экстракт листьев артишока</kwd><kwd>экстракт цветков ромашки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dysfunction  of the gallbladder</kwd><kwd>phytopreparations</kwd><kwd>curcumin</kwd><kwd>artichoke  leaf extract</kwd><kwd>chamomile  flower extract</kwd><kwd>chronic non-calculous cholecystitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barkat MA, Goyal A, Barkat HA, Salauddin M, Pottoo FH, Anwer ET. 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