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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-425</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7928</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГОЛОВНАЯ БОЛЬ И ГОЛОВОКРУЖЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEADACHE AND VERTIGO</subject></subj-group></article-categories><title-group><article-title>Современные стратегии лечения приступа мигрени и возможности дифференцированного подхода</article-title><trans-title-group xml:lang="en"><trans-title>Modern strategies for the treatment of migraine attacks and the possibility of a differentiated approach</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3833-532X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табеева</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabeeva</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Табеева Гюзяль Рафкатовна – доктор медицинских наук, профессор кафедры нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского.</p><p>119021, Москва, ул. Россолимо, д. 11, стр. 1</p></bio><bio xml:lang="en"><p>Gyuzal R. Tabeeva - Dr. Sci. (Med.), Professor of the Department of Nervous Diseases and Neurosurgery, Sklifosovsky Institute  of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>11, Bldg. 1, Rossolimo St., Moscow, 119435</p></bio><email xlink:type="simple">grtabeeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5827-9428</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косивцова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosivtsova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косивцова Ольга Владимировна – кандидат медицинских наук, доцент кафедры нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского.</p><p>119021, Москва, ул. Россолимо, д. 11, стр. 1</p></bio><bio xml:lang="en"><p>Olga V. Kosivtsova - Cand. Sci. (Med.), Associate  Professor  of the  Department of Nervous  Diseases  and  Neurosurgery,  Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>11, Bldg. 1, Rossolimo St., Moscow, 119435</p></bio><email xlink:type="simple">o.kosivtsova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)<country>Россия</country></aff><aff xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>21</issue><fpage>54</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Табеева Г.Р., Косивцова О.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Табеева Г.Р., Косивцова О.В.</copyright-holder><copyright-holder xml:lang="en">Tabeeva G.R., Kosivtsova O.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7928">https://www.med-sovet.pro/jour/article/view/7928</self-uri><abstract><p>Стратегии лечения приступов мигрени включают использование  неспецифических  средств (простых и комбинированных анальгетиков, противорвотных  средств)  и специфических  препаратов  (триптанов, производных  эрготамина, гепантов, дитанов), а также методов  нейромодуляции. Несмотря на расширение  спектра специфических  средств, эффективность купирования приступов головной при мигрени остается неудовлетворительной. Выбор средства для лечения приступов мигрени основывается  на их стратификации по степени нарушения функциональной активности пациентов  и при умеренной и тяжелой дезадаптации предполагает назначение специфических антимигренозных средств. Стратифицированный подход имеет ряд преимуществ по основным параметрам  эффективности анальгезии, сопряжен с более низкими затратами на лечение и несет меньший риск злоупотребления  анальгетиками. Мигренозные приступы характеризуются высоким полиморфизмом и наличием множества клинических проявлений, которые во многом определяют тяжесть состояния пациента и требуют подчас самостоятельного лечения. Специфические препараты для лечения приступов мигрени (триптаны) позволяют купировать не только головную боль, но и симптомы тошноты, рвоты, фото- и фонофобии. Выбор средства основывается на индивидуальных характеристиках пациента, профиле мигренозных атак и предполагает учет фармакологических  свойств  лекарственного  средства. Такие  особенности  мигрени, как высокая  скорость нарастания боли  в  приступе, наличие  быстроразвивающейся   тошноты, необходимость  обеспечения   длительного  обезболивания, требуют использования  быстродействующих форм  лекарственных  препаратов.  Преимущества выбора  этих форм  подтверждают результаты исследований  предпочтений  пациентов. Данные клинических исследований  и результаты исследований  реальной  клинической  практики  позволяют  сформулировать  некоторые  подходы  к  дифференцированному выбору лекарственного  средства.</p></abstract><trans-abstract xml:lang="en"><p>Treatment strategies for migraine  attacks  include the use of nonspecific drugs (simple and combined  analgesics, antiemetics) and specific drugs (triptans, ergotamine derivatives, gepants, ditans), as well as neuromodulation methods. Despite the expansion of the  range  of specific drugs, the  effectiveness of relieving  headache attacks  during migraine  remains  unsatisfactory. The choice of drug for the treatment of migraine attacks is based on their stratification according to the degree  of impairment of the  functional  activity of patients and involves  the  prescription  of specific anti-migraine drugs for moderate and severe disability. The stratified  approach  has a number  of advantages in terms  of the  main parameters of analgesic  effectiveness, is associated with lower treatment costs and carries a lower risk of analgesic  abuse. Migraine attacks are characterized by high polymorphism  and the presence of many clinical manifestations, which largely determine the severity of the patient’s disability and sometimes require  independent treatment. Specific drugs for the treatment of migraine  attacks  (triptans) can relieve not only headaches, but also symptoms of nausea, vomiting, photo- and phonophobia. The choice of drug is based on the individual characteristics of the  patient,  the  profile  of migraine  attacks  and  involves  taking  into  account  the  pharmacological properties of the drug. Features  of migraine  such as a high rate  of increase  in pain during an attack, the presence of rapidly developing nausea, and the need to provide long-term pain relief require the use of fast-acting forms of medications. The benefits of choosing  these  forms are supported by patient  preference studies. Clinical trial data and research  results  from actual clinical practice  allow us to formulate  some approaches to differentiated drug selection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>купирование приступов мигрени</kwd><kwd>стратификация приступов мигрени</kwd><kwd>дифференцированный подход</kwd><kwd>специфические  антимигренозные  средства</kwd><kwd>триптаны</kwd><kwd>ризатриптан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>migraine</kwd><kwd>relief of migraine  attacks</kwd><kwd>stratification of migraine  attacks</kwd><kwd>differentiated approach</kwd><kwd>specific anti-migraine drugs</kwd><kwd>triptans</kwd><kwd>rizatriptan</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2016 Headache Collaborators. 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