medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-403medsovet-7934Research ArticleЗАБОЛЕВАНИЯ ПЕРИФЕРИЧЕСКОЙ НЕРВНОЙ СИСТЕМЫPERIPHERAL NERVOUS SYSTEM DISEASESРоль нейротропных витаминов группы B в клинической практикеThe role of neurotropic B vitamins in clinical practicehttps://orcid.org/0000-0002-7465-0677ПизоваН. В.PizovaN. V.

Пизова Наталья Вячеславовна – доктор медицинских наук, профессор кафедры нервных болезней с медицинской генетикой и нейрохирургией.

150000, Ярославль, ул. Революционная, д. 5

Nataliia V. Pizova - Dr. Sci. (Med.), Professor of the Department of Nervous Diseases with Medical Genetics and Neurosurgery, Yaroslavl State Medical University.

5, Revolutsionnaya St., Yaroslavl, 150000

pizova@yandex.ruЯрославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian Federation202323112023021116121Copyright © Пизова Н.В., 20232023Пизова Н.В.Pizova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7934

Витамины группы B представляют собой группу из 8 водорастворимых витаминов. Они являются кофакторами для многих ферментов, а также аксонального транспорта, синтеза нейротрансмиттеров и других метаболических процессов. Их функцию можно разделить на катаболический метаболизм, приводящий к выработке энергии, и анаболический метаболизм. Некоторые витамины группы B считаются нейротропными и играют особую важную роль как в центральной, так и в периферической нервной системе. Нейротропные витамины группы В (В1 – тиамин, В6 – пиридоксин и В12 – цианокобаламин) играют роль модуляторов воспаления и боли, они необходимы для правильного функционирования нервной системы. Дефицит этих витаминов рассматривается как этиологический фактор развития различных неврологических расстройств и широкого спектра патологических состояний. В работе подробно рассмотрены витамины В1, В6 и В12 и их влияние на течение невропатий, двигательных нарушений, ноцицептивной и невропатической боли. Освещены вопросы синергического действия этих витаминов. Представлены данные эффективности лечения нейротропными витаминами группы B симптомов невропатии у разных групп пациентов. Рассмотрена  возможность  использования  комплекса  витаминов В1 и В6 в клинической практике при условии непереносимости витамина В12. Представлены сведения о препарате Цитипигам® композитум как содержащем витамины В1 и В6. Описан клинический случай эффективного применения указанного препарата в клинической практике.

B-group vitamins are a collection of 8 water-soluble vitamins. They are cofactors for many enzymes, as well as axonal transport, synthesis of neurotransmitters and other metabolic processes. Their function can be divided into catabolic metabolism, leading to energy production, and anabolic metabolism. Some B vitamins are considered neurotrophic and play a particularly important role in both the central and peripheral nervous systems. Neurotropic B-group vitamins (B1 – thiamine, B6 – pyridoxine and B12 – cyanocobalamin) play the role of modulators for the treatment of inflammation and pain, they are essential for the proper functioning of the nervous system. B vitamin deficiencies have been considered as etiological factors in the development of various neurological disorders and a broad spectrum of pathological states. The work examines in detail vitamins B1, B6 and B12 and their effect on the course of neuropathies, movement disorders, nociceptive and neuropathic pain. The issues of the synergistic action of these vitamins are highlighted. Evidence of neurotropic B vitamin treatment effectiveness of neuropathy symptoms in different groups of patients is presented. The possibility to use vitamin B1 and B6 complex in clinical practice under the condition of individual intolerance of vitamin B12 is discussed. Information about Cytipigam® compositum as a drug containing B1 and B6 is provided. A clinical case report on the effective use of this drug in clinical practice is described.

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The authors declare that there are no conflicts of interest present.