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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-396</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7935</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE</subject></subj-group></article-categories><title-group><article-title>Новый взгляд на коррекцию психоэмоциональных факторов риска у пациентов с сердечно-сосудистыми заболеваниями в среднем и молодом возрасте</article-title><trans-title-group xml:lang="en"><trans-title>New insight into the management of psychoemotional risk factors in patients with cardiovascular diseases in middle and young age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1042-4275</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шишкова</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shishkova</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шишкова Вероника Николаевна – доктор медицинских наук, ведущий научный сотрудник, руководитель отдела профилактики когнитивных и психоэмоциональных нарушений.</p><p>101000, Москва, Петроверигский переулок, д. 10</p></bio><bio xml:lang="en"><p>Veronika N. Shishkova - Dr. Sci. (Med.), Leading Researcher, Head of the Department of Prevention of Cognitive and Psychoemotional Disorders, National Medical Research Center for Therapy and Preventive Medicine.</p><p>10, Bldg. 3, Petroverigsky Lane, Moscow, 101990</p></bio><email xlink:type="simple">veronika-1306@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр терапии и профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>21</issue><fpage>175</fpage><lpage>183</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шишкова В.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шишкова В.Н.</copyright-holder><copyright-holder xml:lang="en">Shishkova V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7935">https://www.med-sovet.pro/jour/article/view/7935</self-uri><abstract><p>Расстройства аффективного спектра, такие как депрессия и тревожные расстройства, являются важными психоэмоциональными факторами риска развития и осложненного течения многих распространенных хронических неинфекционных заболеваний, в т. ч. сердечно-сосудистых: артериальной гипертензии, ишемической болезни сердца, хронической сердечной недостаточности, фибрилляции предсердий, острого коронарного синдрома и др. Особенностью данной коморбидности является значимое влияние психоэмоциональных факторов на мотивацию и приверженность пациентов к здоровому образу жизни, а также различным вариантам медикаментозного лечения, что влечет за собой увеличение рисков осложнений и, как следствие, возрастание расходов системы здравоохранения. Актуальность вопросов скрининга и коррекции психоэмоциональных нарушений в практике врачей-интернистов обусловлена множеством причин. С одной стороны, высокой частотой встречаемости данных расстройств у пациентов с сердечно-сосудистыми заболеваниями, в т. ч. в молодом и среднем возрасте, которая связана с ухудшением качества жизни и увеличением риска развития осложнений и неблагоприятных исходов в будущем. С другой стороны, недостаточным уровнем осведомленности врачей о новых возможностях коррекции психоэмоционального состояния таких пациентов. В настоящем обзоре представлены данные по эффективности и безопасности терапии психоэмоциональных нарушений у пациентов с различными ССЗ препаратом, содержащим в качестве активного вещества D,L-гопантеновую кислоту (рац-гопантеновую кислоту), обладающим широким спектром клинических эффектов, включающих положительное воздействие не только на психоэмоциональную сферу, но и на когнитивные функции, относящийся к классу ноотранквилизаторов. Обсуждаются перспективы назначения препарата D,L-гопантеновой кислоты пациентам молодого и среднего возраста с ССЗ, что позволяет снизить лекарственную нагрузку на пациента, обеспечивает высокие показатели качества жизни пациентов как на стационарном, так и на последующих этапах лечения. Ключевым моментом является возможность длительного применения препарата, содержащего D,L-гопантеновую кислоту, без риска развития привыкания, синдрома отмены или гиперстимуляции, что является важным клиническим аспектом лекарственной терапии для пациентов с ССЗ, особенно в молодом и среднем возрасте.</p></abstract><trans-abstract xml:lang="en"><p>Affective spectrum disorders, such as depression and anxiety disorders, are important psychoemotional risk factors for the development and complicated course of many common chronic non-communicable diseases, including cardiovascular ones: arterial hypertension, coronary heart disease, chronic heart failure, atrial fibrillation, acute coronary syndrome, etc. A feature of this comorbidity is the significant impact of psychoemotional factors on the motivation and adherence of patients to a healthy lifestyle, as well as various drug treatment options, which involves an increased risk of complications and, as a consequence, increased healthcare costs. The topicality of the issues of screening and management of psychoemotional disorders in the internist practice arises from a variety of reasons. On the one hand, it is a high incidence of these disorders in patients with cardiovascular diseases, including young and middle-aged ones, which is associated with a deterioration in the quality of life and an increased risk of complications and adverse outcomes in the future. On the other hand, it is caused by insufficient level of awareness among doctors about new possibilities for the management of the psychoemotional state of such patients. This review presents data on the effectiveness and safety of therapy of psychoemotional disorders in patients with various CVDs with a drug containing D,L-hopanthenic acid (rat-hopanthenic acid) as an active substance of the nootranquilizer class, which has a wide range of clinical effects, including a beneficial effect not only on psychoemotional sphere, but also on cognitive functions. The prospects for prescribing a D,L-hopantenic acid drug to young and middle-aged patients with CVD, which reduces the drug burden on the patient and provides high quality of life for patients both in hospital and at subsequent stages of treatment, are discussed. The key point is availability of an option for prolonged use of D,L-hopanthenic acid drug without any risk of addiction, withdrawal syndrome or hyperstimulation, which is an important clinical aspect of drug therapy for patients with CVD, especially in young and middle age.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>D</kwd><kwd>L-гопантеновая кислота</kwd><kwd>рац-гопантеновая кислота</kwd><kwd>психоэмоциональные нарушения</kwd><kwd>тревога</kwd><kwd>тревожные расстройства</kwd><kwd>депрессия</kwd><kwd>хронические неинфекционные заболевания</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>D</kwd><kwd>L-hopanthenic acid</kwd><kwd>rat-hopanthenic acid</kwd><kwd>psychoemotional disorders</kwd><kwd>anxiety</kwd><kwd>anxiety disorders</kwd><kwd>depression</kwd><kwd>chronic non-communicable diseases</kwd><kwd>cardiovascular diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–1858. https://doi.org/10.1016/S0140-6736(19)31047-5.15.</mixed-citation><mixed-citation xml:lang="en">GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–1858. https://doi.org/10.1016/S0140-6736(19)31047-5.15.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина ОМ, Концевая АВ, Калинина АМ, Авдеев СН, Агальцов МВ, Александрова ЛМ и др. Профилактика хронических неинфекционных заболеваний в Российской Федерации. Национальное руководство 2022. Кардиоваскулярная терапия и профилактика. 2022;21(4):3235. https://doi.org/10.15829/1728-8800-2022-3235.</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Kontseva AV, Kalinina AM, Avdeev SN, Agaltsov MV, Alexandrova LM et al. 2022 Prevention of chronic non-communicable diseases in the Russian Federation. National guidelines. Cardiovascular Therapy and Prevention (Russian Federation). 2022;21(4):3235. (In Russ.) https://doi.org/10.15829/1728-8800-2022-3235.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Психоэмоциональное состояние пациентов с хроническими неинфекционными заболеваниями: важные аспекты терапии. Медицинский совет. 2023;(13):256–262. https://doi.org/10.21518/ms2023-230.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Psycho-emotional state of patients with chronic non-communicable diseases: important aspects of therapy. Meditsinskiy Sovet. 2023;(13):256–262. (In Russ.) https://doi.org/10.21518/ms2023-230.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина ОМ, Шишкова ВН, Котова МБ. Психоэмоциональные факторы риска хронических неинфекционных заболеваний в амбулаторной практике. Методические рекомендации для терапевтов. Кардиоваскулярная терапия и профилактика. 2022;21(10):97–117. https://doi.org/10.15829/1728-8800-2022-3438.</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Shishkova VN, Kotova MB. Psychoemotional risk factors for non-communicable diseases in outpatient practice. Methodological recommendations for therapists. Cardiovascular Therapy and Prevention (Russian Federation). 2022;21(10):97–117. (In Russ.) https://doi.org/10.15829/1728-8800-2022-3438.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Albus C, Waller C, Fritzsche K, Gunold H, Haass M, Hamann B et al. Significance of psychosocial factors in cardiology: update 2018: Position paper of the German Cardiac Society. Clin Res Cardiol. 2019;108(11):1175–1196. https://doi.org/10.1007/s00392-019-01488-w.</mixed-citation><mixed-citation xml:lang="en">Albus C, Waller C, Fritzsche K, Gunold H, Haass M, Hamann B et al. Significance of psychosocial factors in cardiology: update 2018: Position paper of the German Cardiac Society. Clin Res Cardiol. 2019;108(11):1175–1196. https://doi.org/10.1007/s00392-019-01488-w.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Когнитивные и эмоциональные нарушения у пациентов с хронической сердечной недостаточностью: перспективы выявления и коррекции. Неврология, нейропсихиатрия, психосоматика. 2022;14(3):87–93. https://doi.org/10.14412/2074-2711-2022-3-87-93.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Cognitive and emotional disorders in patients with chronic heart failure: prospects for detection and correction. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(3):87–93. (In Russ.) https://doi.org/10.14412/2074-2711-2022-3-87-93.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ronaldson A, de la Torre JA, Prina M, Armstrong D, Das-Munshi J, Hatch S et al. Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: A prospective analysis using data from the UK Biobank. Lancet Reg Health Eur. 2021;8:100149. https://doi.org/j.lanepe.2021.100149.</mixed-citation><mixed-citation xml:lang="en">Ronaldson A, de la Torre JA, Prina M, Armstrong D, Das-Munshi J, Hatch S et al. Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: A prospective analysis using data from the UK Biobank. Lancet Reg Health Eur. 2021;8:100149. https://doi.org/j.lanepe.2021.100149.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Чазов ЕИ, Оганов РГ, Погосова ГВ, Шальнова СА, Сказин НВ, Ромасенко ЛВ. Клинико-эпидемиологическая программа изучения депрессии в кардиологической практике у больных артериальной гипертонией и ишемической болезнью сердца (КООРДИНАТА): результаты терапевтической части многоцентрового исследования. Сердце: журнал для практикующих врачей. 2007;33(1):44–48.</mixed-citation><mixed-citation xml:lang="en">Chazov EI, Oganov RG, Pogosova GV, Shalnova SA, Skazin NV, Romasenko LV. Clinical and epidemiological program for studying depression in cardiological practice in patients with arterial hypertension and coronary heart disease (COORDINATE): results of the therapeutic part of a multicenter study. Serdtse: Zhurnal dlya Praktikuyushchikh Vrachey. 2007;33(1):44–48. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Celano CM, Millstein RA, Bedoya CA, Healy BC, Roest AM, Huffman JC. Association between anxiety and mortality in patients with coronary artery disease: a meta-analysis. Am Heart J. 2015;170(6):1105–1115. https://doi.org/10.1016/j.ahj.2015.09.013.</mixed-citation><mixed-citation xml:lang="en">Celano CM, Millstein RA, Bedoya CA, Healy BC, Roest AM, Huffman JC. Association between anxiety and mortality in patients with coronary artery disease: a meta-analysis. Am Heart J. 2015;170(6):1105–1115. https://doi.org/10.1016/j.ahj.2015.09.013.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН, Устарбекова ДБ, Шишков ВА, Имамгаязова КЭ, Капустина ЛА. Психоэмоциональные нарушения у пациентов с хронической сердечной недостаточностью. Терапия. 2022;1(8):44–49. https://doi.org/10.18565/therapy.2022.1.44-49.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN, Ustarbekova DB, Shishkov VA, Imamgayazova KE, Kapustina LA. Psycho-emotional disorders in chronic heart failure patients. Therapy. 2022;1(8):44–49. (In Russ.) https://doi.org/10.18565/therapy.2022.1.44-49.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tully PJ, Cosh SM, Baumeister H. The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease. J Psychosom Res. 2014;77(6):439–448. https://doi.org/10.1016/j.jpsychores.2014.10.001.</mixed-citation><mixed-citation xml:lang="en">Tully PJ, Cosh SM, Baumeister H. The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease. J Psychosom Res. 2014;77(6):439–448. https://doi.org/10.1016/j.jpsychores.2014.10.001.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J. 2020;41(17):1687–1696. https://doi.org/10.1093/eurheartj/ehy913.</mixed-citation><mixed-citation xml:lang="en">Vaccarino V, Badimon L, Bremner JD, Cenko E, Cubedo J, Dorobantu M et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J. 2020;41(17):1687–1696. https://doi.org/10.1093/eurheartj/ehy913.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1. 9 Million Women and Men. PLoS ONE. 2016;11(4):e0153838. https://doi.org/10.1371/journal.pone.0153838.</mixed-citation><mixed-citation xml:lang="en">Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1. 9 Million Women and Men. PLoS ONE. 2016;11(4):e0153838. https://doi.org/10.1371/journal.pone.0153838.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Crawshaw J, Auyeung V, Norton S, Weinman J. Identifying psychosocial predictors of medication non-adherence following acute coronary syndrome: a systematic review and meta-analysis. J Psychosom Res. 2016;90:10–32. https://doi.org/10.1016/j.jpsychores.2016.09.003.</mixed-citation><mixed-citation xml:lang="en">Crawshaw J, Auyeung V, Norton S, Weinman J. Identifying psychosocial predictors of medication non-adherence following acute coronary syndrome: a systematic review and meta-analysis. J Psychosom Res. 2016;90:10–32. https://doi.org/10.1016/j.jpsychores.2016.09.003.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kessing D, Denollet J, Widdershoven J, Kupper N. Psychological determinants of heart failure self-care: systematic review and meta-analysis. Psychosom Med. 2016;78(4):412–431. https://doi.org/10.1097/PSY.0000000000000270.</mixed-citation><mixed-citation xml:lang="en">Kessing D, Denollet J, Widdershoven J, Kupper N. Psychological determinants of heart failure self-care: systematic review and meta-analysis. Psychosom Med. 2016;78(4):412–431. https://doi.org/10.1097/PSY.0000000000000270.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН, Драницына БГ, Драпкина ОМ. Алгоритмы ведения пациентов с тревогой в практике терапевта. Кардиоваскулярная терапия и профилактика. 2023;22(2):3526. https://doi.org/ 10.15829/1728-8800-2023-3526.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN, Dranitsyna YuG, Drapkina OM. Algorithms for the management of patients with anxiety in the internist’s practice. Cardiovascular Therapy and Prevention (Russian Federation). 2023;22(2):3526. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3526.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pogosova N, Saner H, Pedersen SS, Cupples ME, McGee H, Höfer S et al. Psychosocial aspects in cardiac rehabilitation: from theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol. 2015;22(10):1290–1306. https://doi.org/10.1177/2047487314543075.</mixed-citation><mixed-citation xml:lang="en">Pogosova N, Saner H, Pedersen SS, Cupples ME, McGee H, Höfer S et al. Psychosocial aspects in cardiac rehabilitation: from theory to practice. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation of the European Society of Cardiology. Eur J Prev Cardiol. 2015;22(10):1290–1306. https://doi.org/10.1177/2047487314543075.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Peters A, McEwen BS. Stress habituation, body shape and cardiovascular mortality. Neurosci Biobehav Rev. 2015;56:139–150. https://doi.org/10.1016/j.neubiorev.2015.07.001.</mixed-citation><mixed-citation xml:lang="en">Peters A, McEwen BS. Stress habituation, body shape and cardiovascular mortality. Neurosci Biobehav Rev. 2015;56:139–150. https://doi.org/10.1016/j.neubiorev.2015.07.001.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Александровский ЮА, Незнанов НГ (ред.). Психиатрия. Национальное руководство. М.: ГЭОТАР-Медиа; 2020. 1008 с.</mixed-citation><mixed-citation xml:lang="en">Александровский ЮА, Незнанов НГ (ред.). Психиатрия. Национальное руководство. М.: ГЭОТАР-Медиа; 2020. 1008 с.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Простые и эффективные решения в коррекции тревоги и стресса. Медицинский совет. 2023;17(3):161–167. https://doi.org/10.21518/ms2023-023.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Simple and effective solutions in the correction of anxiety and stress. Meditsinskiy Sovet. 2023;17(3):161–167. (In Russ.) https://doi.org/10.21518/ms2023-023.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Стратегия ведения и профилактики психоэмоциональных нарушений в практике терапевта. Медицинский совет. 2023;17(6):76–82. https://doi.org/10.21518/ms2023-077.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Strategy for the management and prevention of psychoemotional disorders in the GP’s practice. Meditsinskiy Sovet. 2023;17(6):76–82. (In Russ.) https://doi.org/10.21518/ms2023-077.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН, Драпкина ОМ. Схема «алгоритм ведения пациентов с психоэмоциональными нарушениями». Патент RU 137449, 06.07.2023. Режим доступа: https://gnicpm.ru/wp-content/uploads/2023/07/137449.eod_.pdf.</mixed-citation><mixed-citation xml:lang="en">Шишкова ВН, Драпкина ОМ. Схема «алгоритм ведения пациентов с психоэмоциональными нарушениями». Патент RU 137449, 06.07.2023. Режим доступа: https://gnicpm.ru/wp-content/uploads/2023/07/137449.eod_.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Boehm JK, Kubzansky LD. The heart’s content: The association between positive psychological well-being and cardiovascular health. Psychol Bull. 2012;138(4):655–691. https://doi.org/10.1037/a0027448.</mixed-citation><mixed-citation xml:lang="en">Boehm JK, Kubzansky LD. The heart’s content: The association between positive psychological well-being and cardiovascular health. Psychol Bull. 2012;138(4):655–691. https://doi.org/10.1037/a0027448.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Müller-Riemenschneider F, Meinhard C, Damm K, Vauth C, Bockelbrink A, Greiner W, Willich SN. Effectiveness of nonpharmacological secondary prevention of coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2010;17(6):688–700. https://doi.org/10.1097/HJR.0b013e32833a1c95.</mixed-citation><mixed-citation xml:lang="en">Müller-Riemenschneider F, Meinhard C, Damm K, Vauth C, Bockelbrink A, Greiner W, Willich SN. Effectiveness of nonpharmacological secondary prevention of coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2010;17(6):688–700. https://doi.org/10.1097/HJR.0b013e32833a1c95.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Orth-Gomer K, Schneiderman N, Wang HX, Walldin C, Blom M, Jernberg T. Stress reduction prolongs life in women with coronary disease: the Stockholm Women’s Intervention Trial for Coronary Heart Disease (SWITCHD). Circ Cardiovasc Qual Outcomes. 2009;2(1):25–32. https://doi.org/10.1161/CIRCOUTCOMES.108.812859.</mixed-citation><mixed-citation xml:lang="en">Orth-Gomer K, Schneiderman N, Wang HX, Walldin C, Blom M, Jernberg T. Stress reduction prolongs life in women with coronary disease: the Stockholm Women’s Intervention Trial for Coronary Heart Disease (SWITCHD). Circ Cardiovasc Qual Outcomes. 2009;2(1):25–32. https://doi.org/10.1161/CIRCOUTCOMES.108.812859.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svardsudd K. Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). Arch Intern Med. 2011;171(2):134–140. https://doi.org/10.1001/archinternmed.2010.510.</mixed-citation><mixed-citation xml:lang="en">Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svardsudd K. Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). Arch Intern Med. 2011;171(2):134–140. https://doi.org/10.1001/archinternmed.2010.510.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Virgili M. Mindfulness-based interventions reduce psychological distress in working adults: A meta-analysis of intervention studies. Mindfulness. 2015;6(2):326–337. https://doi.org/10.1007/s12671-013-0264-0.</mixed-citation><mixed-citation xml:lang="en">Virgili M. Mindfulness-based interventions reduce psychological distress in working adults: A meta-analysis of intervention studies. Mindfulness. 2015;6(2):326–337. https://doi.org/10.1007/s12671-013-0264-0.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Dehdari T, Heidarnia A, Ramezankhani A, Sadeghian A, Ghofranipour F. Effects of progressive muscular relaxation training on quality of life in anxious patients after coronary artery bypass graft surgery. Indian J Med Res. 2009;129(5):603–608. Available at: https://pubmed.ncbi.nlm.nih.gov/19675392.</mixed-citation><mixed-citation xml:lang="en">Dehdari T, Heidarnia A, Ramezankhani A, Sadeghian A, Ghofranipour F. Effects of progressive muscular relaxation training on quality of life in anxious patients after coronary artery bypass graft surgery. Indian J Med Res. 2009;129(5):603–608. Available at: https://pubmed.ncbi.nlm.nih.gov/19675392.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shi L, Zhang D, Wang L, Zhuang J, Cook R, Chen L. Meditation and blood pressure. J Hypertens. 2017;35(4):696–706. https://doi.org/10.1097/HJH.0000000000001217.</mixed-citation><mixed-citation xml:lang="en">Shi L, Zhang D, Wang L, Zhuang J, Cook R, Chen L. Meditation and blood pressure. J Hypertens. 2017;35(4):696–706. https://doi.org/10.1097/HJH.0000000000001217.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Blumenthal JA, Sherwood A, Smith PJ, Watkins L, Mabe S, Kraus WE et al. Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial. Circulation. 2016;133(14):1341–1350. https://doi.org/10.1161/CIRCULATIONAHA.115.018926.</mixed-citation><mixed-citation xml:lang="en">Blumenthal JA, Sherwood A, Smith PJ, Watkins L, Mabe S, Kraus WE et al. Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial. Circulation. 2016;133(14):1341–1350. https://doi.org/10.1161/CIRCULATIONAHA.115.018926.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P et al. Psychological interventions for coronary heart disease: Cochrane systematic review and meta-analysis. Eur J Prev Cardiol. 2018;25(3):247–259. https://doi.org/10.1177/2047487317739978.</mixed-citation><mixed-citation xml:lang="en">Richards SH, Anderson L, Jenkinson CE, Whalley B, Rees K, Davies P et al. Psychological interventions for coronary heart disease: Cochrane systematic review and meta-analysis. Eur J Prev Cardiol. 2018;25(3):247–259. https://doi.org/10.1177/2047487317739978.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">He W, Zhou Y, Ma J, Wei B, Fu Y. Effect of antidepressants on death in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2020;25(6):919–926. https://doi.org/10.1007/s10741-019-09850-w.</mixed-citation><mixed-citation xml:lang="en">He W, Zhou Y, Ma J, Wei B, Fu Y. Effect of antidepressants on death in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2020;25(6):919–926. https://doi.org/10.1007/s10741-019-09850-w.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Honkola J, Hookana E, Malinen S, Kaikkonen KS, Junttila MJ, Isohanni M. Psychotropic medications and the risk of sudden cardiac death during an acute coronary event. Eur Heart J. 2012;33(6):745–751. https://doi.org/10.1093/eurheartj/ehr368.</mixed-citation><mixed-citation xml:lang="en">Honkola J, Hookana E, Malinen S, Kaikkonen KS, Junttila MJ, Isohanni M. Psychotropic medications and the risk of sudden cardiac death during an acute coronary event. Eur Heart J. 2012;33(6):745–751. https://doi.org/10.1093/eurheartj/ehr368.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Воронина ТА, Литвинова СА. Фармакологические эффекты и клиническое применение препаратов Пантогам и Пантогам актив. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(8):132–139. https://doi.org/10.17116/jnevro201711781132-139.</mixed-citation><mixed-citation xml:lang="en">Voronina TA, Litvinova SA. Pharmacological effects and clinical application of pantogam and pantogam active. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017;117(8):132–139. (In Russ.) https://doi.org/10.17116/jnevro201711781132-139.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Остроумова ОД, Голобородова ИВ, Фомина ВМ, Бондарец ОВ. Тревожно-депрессивные расстройства в кардиологической практике: возможности применения D,L-гопантеновой кислоты. Consilium Medicum. 2018;20(12):23–29. https://doi.org/10.26442/20751753.2018.12.000032.</mixed-citation><mixed-citation xml:lang="en">Ostroumova OD, Goloborodova IV, Fomina VM, Bondarets OV. Anxiety and depressive disorders in cardiology practice. Possibilities of using. Consilium Medicum. 2018;20(12):23–29. (In Russ.) https://doi.org/10.26442/20751753.2018.12.000032.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов АП, Струтынский АВ, Ойноткинова ОШ, Баранова АА, Тришина ВВ, Голубев ЮЮ, Кружалов АН. Возможности терапии тревожно-депрессивных расстройств у больных с хронической сердечной недостаточностью. Кардиология. 2016;24(9):572–578.</mixed-citation><mixed-citation xml:lang="en">Baranov AP, Strutynsky AV, Oynotkinova OS, Baranova AA, Trishina VV, Golubev YuYu, Kruzhalov AN. Possibilities of therapy of anxiety-depressive disorders in patients with chronic heart failure. Kardiologiya. 2016;24(9):572–578. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Медведев ВЭ, Зверев КВ, Епифанов АВ, Ларцева ОА, Зуйкова НЛ, Фролова ВИ. Возможности ноотропной терапии пограничных психических расстройств у пациентов, перенесших острый коронарный синдром, в условиях кардиологического стационара. Архивь внутренней медицины. 2013;9(1):40–48. https://doi.org/10.20514/2226-6704-2013-0-1-40-48.</mixed-citation><mixed-citation xml:lang="en">Medvedev VE, Zverev KV, Epifanov AV, Lartseva OA, Zuikova NL, Frolova VI Possibilities of nootropic therapy of borderline mental disorders in patients with acute coronary syndrome in a cardiological hospital. Russian Archive of Internal Medicine. 2013;9(1):40–48. (In Russ.) https://doi.org/10.20514/2226-6704-2013-0-1-40-48.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Медведев ВЭ, Албантова КА. Пантогам актив при лечении невротических, связанных со стрессом и соматоформных расстройств у больных кардиологического стационара. Психические расстройства в общей медицине. 2009;(2):40–43.</mixed-citation><mixed-citation xml:lang="en">Medvedev VE, Albantova KA. Pantogam is an asset in the treatment of neurotic, stress-related and somatoform disorders in patients of a cardiological hospital. Mental Disorders in General Medicine. 2009;(2):40–43. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Медведев ВЭ, Епифанов АВ. Терапия невротических, связанных со стрессом, и соматоформных расстройств у пациентов с гипертонической болезнью. Российский психиатрический журнал. 2011;(1):55–61. Режим доступа: https://cyberleninka.ru/article/n/terapiya-nevroticheskih-svyazannyh-so-stressom-i-somatoformnyh-rasstroystv-u-patsientov-s-gipertonicheskoy-boleznyu?ysclid=lmjai3optd863221237.</mixed-citation><mixed-citation xml:lang="en">Medvedev VE, Epifanov AV. Therapy of neurotic, stress-related, and somatoform disorders in hypertension patients. Rossijskij Psihiatriceskij Zurnal. 2011;(1):55–61. (In Russ.) Available at: https://cyberleninka.ru/article/n/terapiya-nevroticheskih-svyazannyh-so-stressom-i-somatoformnyh-rasstroystv-u-patsientov-s-gipertonicheskoy-boleznyu?ysclid=lmjai3optd863221237.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Камчатнов ПР. Коррекция когнитивных и эмоциональных расстройств у больных артериальной гипертонией. РМЖ. Медицинское обозрение. 2019;3(7):28–29. Режим доступа: https://www.rmj.ru/articles/kardiologiya/Korrekciya_kognitivnyh_i_emocionalynyh_rasstroystv_u_bolynyh_arterialynoy_gipertoniey/.</mixed-citation><mixed-citation xml:lang="en">Kamchatnov PR. Correction of cognitive and emotional disorders in patients with arterial hypertension. RMJ. Medical Review. 2019;3(7):28–29. (In Russ.) Available at: https://www.rmj.ru/articles/kardiologiya/Korrekciya_kognitivnyh_i_emocionalynyh_rasstroystv_u_bolynyh_arterialynoy_gipertoniey/.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Смулевич АБ, Волель БА, Терновая ЕС, Никитина ЮМ. Применение препарата пантогам актив (D-, L-гопантеновая кислота) в терапии когнитивных и тревожных расстройств у пациентов с артериальной гипертензией. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;115(12):40–49. https://doi.org/10.17116/jnevro201511511240-49.</mixed-citation><mixed-citation xml:lang="en">Smulevich AB, Volel’ BA, Ternovaia ES, Nikitina YuM. Pantogam active (D-, L-hopantenic acid) in the treatment of cognitive and anxiety disorders in patients with arterial hypertension. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2015;115(12):40–49. (In Russ.) https://doi.org/10.17116/jnevro201511511240-49.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Гехт АБ, Канаева ЛС, Аведисова АС, Марачев МП, Захарова КВ, Дашкина ГК, Куликова ЕВ. Возможности применения рац-гопантеновой кислоты в комплексном лечении тревожно-депрессивных расстройств у больных с хронической ишемией головного мозга. Журнал неврологии и психиатрии им. С.С. Корсакова. 2016;116(11):45–57. https://doi.org/10.17116/jnevro201611611145-57.</mixed-citation><mixed-citation xml:lang="en">Geht AB, Kanaeva LS, Avedisova AS, Marachev MP, Zakharova KV, Dashkina GK, Kulikova EV. Possible applications of rac-hopantenic acid in the treatment of anxiety and depressive disorders in patients with chronic cerebral ischemia. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2016;116(11):45–57. (In Russ.) https://doi.org/10.17116/jnevro201611611145-57.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН, Зотова ЛИ. Применение D-, L-гопантеновой кислоты в терапии когнитивных и тревожных расстройств у женщин с хронической ишемией головного мозга и климактерическим синдромом. РМЖ. 2015;(24):1470–1475. Режим доступа: https://www.rmj.ru/articles/nevrologiya/Primenenie_D-_L-gopantenovoy_kisloty_v_terapiikognitivnyh_i_trevoghnyh_rasstroystv_u_ghenschins_hronicheskoy_ishemiey_golovnogo_mozgai_klimaktericheskim_sindromom/?ysclid=lmjas70gpn378613852.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN, Zotova LI. The use of D-, L-hopanthenic acid in the treatment of cognitive and anxiety disorders in women with chronic cerebral ischemia and menopausal syndrome. RMJ. 2015;(24):1470–1475. (In Russ.) Available at: https://www.rmj.ru/articles/nevrologiya/Primenenie_D-_L-gopantenovoy_kisloty_v_terapiikognitivnyh_i_trevoghnyh_rasstroystv_u_ghenschins_hronicheskoy_ishemiey_golovnogo_mozgai_klimaktericheskim_sindromom/?ysclid=lmjas70gpn378613852.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Канаева ЛС, Вазагаева ТИ, Ястребова ВВ. Перспективы применения препарата Пантогам актив у больных с астеническими расстройствами. Психиатрия и психофармакотерапия. 2009;11(6):34–39.</mixed-citation><mixed-citation xml:lang="en">Kanaeva LS, Vazagaeva TI, Yastrebova VV. Prospects for the use of Pantogam active in patients with asthenic disorders. Psikhiatriya i Psikhofarmakoterapiya. 2009;11(6):34–39. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Значение артериальной гипертензии в развитии поражения головного мозга – от легких когнитивных нарушений к деменции. Системные гипертензии. 2014;11(1):45–51. Режим доступа: https://www.syst-hypertension.ru/jour/article/view/336.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Place of arterial hypertension in brain lesion development – from minor cognitive disorders to dementia. Systemic Hypertension. 2014;11(1):45–51. (In Russ.) Available at: https://www.syst-hypertension.ru/jour/article/view/336.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН, Адашева ТВ. Современный взгляд на механизмы развития когнитивных нарушений у пациентов с сердечно-сосудистыми заболеваниями и возможность их коррекции. Нервные болезни. 2021;(2):41–46. https://doi.org/10.24412/2226-0757-2021-12317.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN, Adasheva TV. Modern view on the mechanisms of cognitive impairment development in patients with cardiovascular diseases and the possibility of their correction. Nervous Diseases. 2021;(2):41–46. (In Russ.) https://doi.org/10.24412/2226-0757-2021-12317.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова ВН. Когнитивные расстройства у пациентов с цереброваскулярными заболеваниями в терапевтической практике: алгоритмы диагностики и ведения. Медицинский совет. 2022;16(23):33–40. https://doi.org/10.21518/2079-701X-2022-16-23-33-40.</mixed-citation><mixed-citation xml:lang="en">Shishkova VN. Cognitive disorders in patients with cerebrovascular diseases in therapeutic practice: diagnostic and management algorithms. Meditsinskiy Sovet. 2022;16(23):33–40. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-23-33-40.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
