medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-432medsovet-7937Research ArticleНЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВАNEUROPSYCHIATRIC DISORDERSОстрые стресс-индуцированные состояния в общей практикеAcute stress-induced disorders in general practicehttps://orcid.org/0000-0002-7465-0677ПизоваН. В.PizovaN. V.

Пизова Наталия Вячеславовна – доктор медицинских наук, профессор кафедры нервных болезней с медицинской генетикой и нейрохирургией.

150000, Ярославль, ул. Революционная, д. 5

Nataliia V. Pizova - Dr. Sci. (Med.), Professor of the Department of Nervous Diseases with Medical Genetics and Neurosurgery, Yaroslavl State Medical University.

5, Revolutsionnaya St., Yaroslavl, 150000

pizova@yandex.ruhttps://orcid.org/0000-0002-0522-675XПизовА. В.PizovA. V.

Пизов Александр Витальевич – кандидат биологических наук, доцент кафедры медицины.

150000, Ярославль, ул. Республиканская, д. 108/1

Aleksandr V. Pizov - Cand. Sci. (Biol.), Associate Professor of the Department of Medicine, Yaroslavl State Pedagogical University named after K.D. Ushinsky.

108/1, Respublikanskaya St., Yaroslavl, 150000

avpizov@yandex.ruЯрославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian FederationЯрославский государственный педагогический университет имени К.Д. УшинскогоРоссияYaroslavl State Pedagogical University named after K.D. UshinskyRussian Federation2023231120230218994Copyright © Пизова Н.В., Пизов А.В., 20232023Пизова Н.В., Пизов А.В.Pizova N.V., Pizov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/7937

Стресс определяет кластер психофизиологических реакций, направленных на активацию ресурсов для решения сложных ситуаций, а также на восстановление и поддержание гомеостаза организма. Стресс – это сочетание физиологических, нейроэндокринных, поведенческих и эмоциональных реакций на новые или угрожающие стимулы, является защитной адаптацией организма в физиологических условиях. По влиянию на организм различают стресс полезный и негативный. Стресс можно разделить на хронический и острый. Интенсивность физиологической реакции на стрессор в высшей степени индивидуальна и зависит от конкретной ситуации. Многие переменные, включая личные качества, стратегии преодоления, социальную поддержку и прошлый опыт, могут изменять физиологическую реакцию на стресс в любой конкретной ситуации и могут объяснять различную реакцию людей, подвергшихся воздействию одного и того же стрессора. Сильный и продолжительный стресс может привести к психологическому и патологическому повреждению организма. Стресс оказывает значительное влияние на различные области мозга, включая гиппокамп, гипоталамус, миндалевидное тело и другие. Депрессия, тревога, когнитивный дефицит и даже психические заболевания, вызванные стрессом, тесно связаны с функциональными и структурными повреждениями соответствующих областей мозга. С повторяющимся ежедневным острым стрессом могут быть связаны различные заболевания, в первую очередь сердечно-сосудистые заболевания, которые влияют на качество жизни и могут сократить продолжительность жизни. Для предотвращения ранних стрессовых реакций, перерастающих в хроническое посттравматическое стрессовое расстройство, особенно у лиц с высоким риском, необходима своевременно начатая терапия. Современные вмешательства для управления стрессом и тревогой включают немедикаментозное и фармакологическое лечение.

Stress defines a cluster of psychophysiological responses aimed at enabling resources to solve difficult situations, as well as restoring and maintaining homeostasis in the body. Stress is a combination of physiological, neuroendocrine, behavioural and emotional responses to new or threatening stimuli and serves as a protective adaptation of the body under physiological conditions. In accordance with the effect on the body, beneficial and negative stress is distinguished. Stress can be divided into “chronic” and “acute”. The intensity of the physiological response to a stressor is highly individual and situationally dependent. Many variables, including personal attributes, coping strategies, social support, and past experiences may modify the physiological stress response in any given situation and can account for the different response of people exposed to the same stressor. Intense and persistent stress can lead to psychological and pathological body injury. Stress has a significant impact on different brain regions, including the hippocampus, hypothalamus, amygdala etc. Depression, anxiety, cognitive deficits, and even stress-induced mental diseases are closely related to functional and structural damage of the related brain regions. Repetitive daily acute stress can be associated with different diseases, first of all cardiovascular diseases, which affect quality of life and can cut short life expectancy. Timely treatment is required to prevent progression of early stress reactions to chronic post-traumatic stress disorder, especially in individuals at high risk. Advanced stress and anxiety management interventions include non-pharmacological and pharmacological treatments.

стресстревогастресс-индуцированные состояниятерапевтические подходыкомбинированные растительные средстваstressanxietystress-induced disorderstherapeutic approachescombined herbal medicinesReferencesVarma P, Junge M, Meaklim H, Jackson ML. Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey. Prog Neuropsychopharmacol Biol Psychiatry. 2021;109:110236. https://doi.org/10.1016/j.pnpbp.2020.110236.Varma P, Junge M, Meaklim H, Jackson ML. Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey. Prog Neuropsychopharmacol Biol Psychiatry. 2021;109:110236. https://doi.org/10.1016/j.pnpbp.2020.110236.Пизова НВ, Пизов АВ. Панические и депрессивные расстройства в клинической практике. Поликлиника. 2020;(6):16–19. Режим доступа: https://www.poliklin.ru/imagearticle/20206/16-19.pdf.Pizova NV, Pizov AV. Panic and depressive disorders in clinical practice. Poliklinika. 2020;(6):16–19. (In Russ.) Available at: https://www.poliklin.ru/imagearticle/20206/16-19.pdf.Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52(12): 1048–1060. https://doi.org/10.1001/archpsyc.1995.03950240066012.Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52(12): 1048–1060. https://doi.org/10.1001/archpsyc.1995.03950240066012.Baxter AJ, Scott KM, Vos T, Whiteford HA. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med. 2013;43(5):897–910. https://doi.org/10.1017/S003329171200147X.Baxter AJ, Scott KM, Vos T, Whiteford HA. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med. 2013;43(5):897–910. https://doi.org/10.1017/S003329171200147X.Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats. Arthritis Rheum. 2007;56(3):871–881. https://doi.org/10.1002/art.22426.Scott A, Cook JL, Hart DA, Walker DC, Duronio V, Khan KM. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats. Arthritis Rheum. 2007;56(3):871–881. https://doi.org/10.1002/art.22426.Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010;35(1):2–16. https://doi.org/10.1016/j.neubiorev.2009.10.002.Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010;35(1):2–16. https://doi.org/10.1016/j.neubiorev.2009.10.002.McEwen BS, Wingfield JC. What is in a name? Integrating homeostasis, allostasis and stress. Horm Behav. 2010;57(2):105–111. https://doi.org/10.1016/j.yhbeh.2009.09.011.McEwen BS, Wingfield JC. What is in a name? Integrating homeostasis, allostasis and stress. Horm Behav. 2010;57(2):105–111. https://doi.org/10.1016/j.yhbeh.2009.09.011.Karatsoreos IN, McEwen BS. Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci. 2011;15(12):576–584. https://doi.org/10.1016/j.tics.2011.10.005.Karatsoreos IN, McEwen BS. Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci. 2011;15(12):576–584. https://doi.org/10.1016/j.tics.2011.10.005.Selye H. Stress and the general adaptation syndrome. Br Med J. 1950;1(4667):1383–1392. https://doi.org/10.1136/bmj.1.4667.1383.Selye H. Stress and the general adaptation syndrome. Br Med J. 1950;1(4667):1383–1392. https://doi.org/10.1136/bmj.1.4667.1383.Vincze J, Vincze-Tiszay G. The physiological aspects of the stress. J Med Biomed Appl Sci. 2020;8(10):529–534. https://doi.org/10.15520/jmbas.v8i10.256.Vincze J, Vincze-Tiszay G. The physiological aspects of the stress. J Med Biomed Appl Sci. 2020;8(10):529–534. https://doi.org/10.15520/jmbas.v8i10.256.Senanayake GB, Arambepola C. Understanding chronic stress: A narrative review of literature. J Coll Community Physicians Sri Lanka. 2019;25(1):30–36. https://doi.org/10.4038/jccpsl.v25i1.8196.Senanayake GB, Arambepola C. Understanding chronic stress: A narrative review of literature. J Coll Community Physicians Sri Lanka. 2019;25(1):30–36. https://doi.org/10.4038/jccpsl.v25i1.8196.Aich P, Potter AA, Griebel PJ. Modern approaches to understanding stress and disease susceptibility: A review with special emphasis on respiratory disease. Int J Gen Med. 2009;2:19–32. https://doi.org/10.2147/ijgm.s4843.Aich P, Potter AA, Griebel PJ. Modern approaches to understanding stress and disease susceptibility: A review with special emphasis on respiratory disease. Int J Gen Med. 2009;2:19–32. https://doi.org/10.2147/ijgm.s4843.Vincze J, Vincze-Tiszay G. Some biophysical aspects of the stress. Int J Recent Innov Med Clin Res. 2020;2(1):37–43. https://doi.org/10.5281/zenodo.3713319.Vincze J, Vincze-Tiszay G. Some biophysical aspects of the stress. Int J Recent Innov Med Clin Res. 2020;2(1):37–43. https://doi.org/10.5281/zenodo.3713319.Bustamante-Sánchez Á, Tornero-Aguilera JF, Fernández-Elías VE, Hormeño-Holgado AJ, Dalamitros AA, Clemente-Suárez VJ. Effect of Stress on Autonomic and Cardiovascular Systems in Military Population: A Systematic Review. Cardiol Res Pract. 2020;2020:7986249. https://doi.org/10.1155/2020/7986249.Bustamante-Sánchez Á, Tornero-Aguilera JF, Fernández-Elías VE, Hormeño-Holgado AJ, Dalamitros AA, Clemente-Suárez VJ. Effect of Stress on Autonomic and Cardiovascular Systems in Military Population: A Systematic Review. Cardiol Res Pract. 2020;2020:7986249. https://doi.org/10.1155/2020/7986249.Sánchez-Molina J, Robles-Pérez JJ, Clemente-Suárez VJ. Assessment of Psychophysiological Response and Specific Fine Motor Skills in Combat Units. J Med Syst. 2018;42(4):67. https://doi.org/10.1007/s10916-018-0922-9.Sánchez-Molina J, Robles-Pérez JJ, Clemente-Suárez VJ. Assessment of Psychophysiological Response and Specific Fine Motor Skills in Combat Units. J Med Syst. 2018;42(4):67. https://doi.org/10.1007/s10916-018-0922-9.Ganzel BL, Morris PA, Wethington E. Allostasis and the human brain: Integrating models of stress from the social and life sciences. Psychol Rev. 2010;117(1):134–174. https://doi.org/10.1037/a0017773.Ganzel BL, Morris PA, Wethington E. Allostasis and the human brain: Integrating models of stress from the social and life sciences. Psychol Rev. 2010;117(1):134–174. https://doi.org/10.1037/a0017773.Bertilsson J, Niehorster DC, Fredriksson P, Dahl M, Granér S, Fredriksson O et al. Towards systematic and objective evaluation of police officer performance in stressful situations. Police Pract Res. 2020;21(6):655–669. https://doi.org/10.1080/15614263.2019.1666006.Bertilsson J, Niehorster DC, Fredriksson P, Dahl M, Granér S, Fredriksson O et al. Towards systematic and objective evaluation of police officer performance in stressful situations. Police Pract Res. 2020;21(6):655–669. https://doi.org/10.1080/15614263.2019.1666006.Phillips-Wren G, Adya M. Decision making under stress: The role of information overload, time pressure, complexity, and uncertainty. J Decis Syst. 2020;29(1):213–225. https://doi.org/10.1080/12460125.2020.1768680.Phillips-Wren G, Adya M. Decision making under stress: The role of information overload, time pressure, complexity, and uncertainty. J Decis Syst. 2020;29(1):213–225. https://doi.org/10.1080/12460125.2020.1768680.Эбзеева ЕЮ, Полякова ОА. Стресс и стресс-индуцированные расстройства. Медицинский совет. 2022;16(2):127–133. https://doi.org/10.21518/2079-701X-2022-16-2-127-133.Ebzeeva EYu, Polyakova OA. Stress and stress-induced disorder. Meditsinskiy Sovet. 2022;16(2):127–133. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-2-127-133.Taverniers J, Smeets T, Van Ruysseveldt J, Syroit J, von Grumbkow J. The risk of being shot at: Stress, cortisol secretion, and their impact on memory and perceived learning during reality-based practice for armed officers. Int J Stress Manag. 2011;(18):113–132. https://doi.org/10.1037/A0023742.Taverniers J, Smeets T, Van Ruysseveldt J, Syroit J, von Grumbkow J. The risk of being shot at: Stress, cortisol secretion, and their impact on memory and perceived learning during reality-based practice for armed officers. Int J Stress Manag. 2011;(18):113–132. https://doi.org/10.1037/A0023742.Kelley DC, Siegel E, Wormwood JB. Understanding Police Performance Under Stress: Insights From the Biopsychosocial Model of Challenge and Threat. Front Psychol. 2019;10:1800. https://doi.org/10.3389/fpsyg.2019.01800.Kelley DC, Siegel E, Wormwood JB. Understanding Police Performance Under Stress: Insights From the Biopsychosocial Model of Challenge and Threat. Front Psychol. 2019;10:1800. https://doi.org/10.3389/fpsyg.2019.01800.Perrin M, Vandeleur CL, Castelao E, Rothen S, Glaus J, Vollenweider P, Preisig M. Determinants of the development of post-traumatic stress disorder, in the general population. Soc Psychiatry Psychiatr Epidemiol. 2014;49(3):447–457. https://doi.org/10.1007/s00127-013-0762-3.Perrin M, Vandeleur CL, Castelao E, Rothen S, Glaus J, Vollenweider P, Preisig M. Determinants of the development of post-traumatic stress disorder, in the general population. Soc Psychiatry Psychiatr Epidemiol. 2014;49(3):447–457. https://doi.org/10.1007/s00127-013-0762-3.Bryant RA. Acute stress disorder as a predictor of posttraumatic stress disorder: a systematic review. J Clin Psychiatry. 2011;72(2):233–239. https://doi.org/10.4088/JCP.09r05072blu.Bryant RA. Acute stress disorder as a predictor of posttraumatic stress disorder: a systematic review. J Clin Psychiatry. 2011;72(2):233–239. https://doi.org/10.4088/JCP.09r05072blu.Cool J, Zappetti D. The Physiology of Stress. In: Zappetti D, Avery J (eds). Medical Student Well-Being. Springer, Cham; 22019, рр. 1–15. https://doi.org/10.1007/978-3-030-16558-1_1.Cool J, Zappetti D. The Physiology of Stress. In: Zappetti D, Avery J (eds). Medical Student Well-Being. Springer, Cham; 22019, рр. 1–15. https://doi.org/10.1007/978-3-030-16558-1_1.Mücke M, Ludyga S, Colledge F, Pühse U, Gerber M. Association of Exercise with Inhibitory Control and Prefrontal Brain Activity Under Acute Psychosocial Stress. Brain Sci. 2020;10(7):439. https://doi.org/10.3390/brainsci10070439.Mücke M, Ludyga S, Colledge F, Pühse U, Gerber M. Association of Exercise with Inhibitory Control and Prefrontal Brain Activity Under Acute Psychosocial Stress. Brain Sci. 2020;10(7):439. https://doi.org/10.3390/brainsci10070439.Andersen JP, Di Nota PM, Beston B, Boychuk EC, Gustafsberg H, Poplawski S, Arpaia J. Reducing Lethal Force Errors by Modulating Police Physiology. J Occup Environ Med. 2018;60(10):867–874. https://doi.org/10.1097/JOM.0000000000001401.Andersen JP, Di Nota PM, Beston B, Boychuk EC, Gustafsberg H, Poplawski S, Arpaia J. Reducing Lethal Force Errors by Modulating Police Physiology. J Occup Environ Med. 2018;60(10):867–874. https://doi.org/10.1097/JOM.0000000000001401.Thayer JF, Hansen AL, Saus-Rose E, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009;37(2):141–153. https://doi.org/10.1007/s12160-009-9101-z.Thayer JF, Hansen AL, Saus-Rose E, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009;37(2):141–153. https://doi.org/10.1007/s12160-009-9101-z.Anderson GS, Di Nota PM, Metz GAS, Andersen JP. The Impact of Acute Stress Physiology on Skilled Motor Performance: Implications for Policing. Front Psychol. 2019;10:2501. https://doi.org/10.3389/fpsyg.2019.02501.Anderson GS, Di Nota PM, Metz GAS, Andersen JP. The Impact of Acute Stress Physiology on Skilled Motor Performance: Implications for Policing. Front Psychol. 2019;10:2501. https://doi.org/10.3389/fpsyg.2019.02501.Thompson AG, Swain DP, Branch JD, Spina RJ, Grieco CR. Autonomic response to tactical pistol performance measured by heart rate variability. J Strength Cond Res. 2015;29(4):926–933. https://doi.org/10.1519/JSC.0000000000000615.Thompson AG, Swain DP, Branch JD, Spina RJ, Grieco CR. Autonomic response to tactical pistol performance measured by heart rate variability. J Strength Cond Res. 2015;29(4):926–933. https://doi.org/10.1519/JSC.0000000000000615.McEwen BS, Bowles NP, Gray JD, Hill MN, Hunter RG, Karatsoreos IN, Nasca C. Mechanisms of stress in the brain. Nat Neurosci. 2015;18(10):1353–1363. https://doi.org/10.1038/nn.4086.McEwen BS, Bowles NP, Gray JD, Hill MN, Hunter RG, Karatsoreos IN, Nasca C. Mechanisms of stress in the brain. Nat Neurosci. 2015;18(10):1353–1363. https://doi.org/10.1038/nn.4086.Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22(3):238–249. https://doi.org/10.1038/nm.4050.Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22(3):238–249. https://doi.org/10.1038/nm.4050.Murrough JW, Abdallah CG, Mathew SJ. Targeting glutamate signaling in depression: progress and prospects. Nat Rev Drug Discov. 2017;16(7):472–486. https://doi.org/10.1038/nrd.2017.16.Murrough JW, Abdallah CG, Mathew SJ. Targeting glutamate signaling in depression: progress and prospects. Nat Rev Drug Discov. 2017;16(7):472–486. https://doi.org/10.1038/nrd.2017.16.Algamal M, Saltiel N, Pearson AJ, Ager B, Burca I, Mouzon B et al. Impact of Repetitive Mild Traumatic Brain Injury on Behavioral and Hippocampal Deficits in a Mouse Model of Chronic Stress. J Neurotrauma. 2019;36(17):2590–2607. https://doi.org/10.1089/neu.2018.6314.Algamal M, Saltiel N, Pearson AJ, Ager B, Burca I, Mouzon B et al. Impact of Repetitive Mild Traumatic Brain Injury on Behavioral and Hippocampal Deficits in a Mouse Model of Chronic Stress. J Neurotrauma. 2019;36(17):2590–2607. https://doi.org/10.1089/neu.2018.6314.Huang RR, Hu W, Yin YY, Wang YC, Li WP, Li WZ. Chronic restraint stress promotes learning and memory impairment due to enhanced neuronal endoplasmic reticulum stress in the frontal cortex and hippocampus in male mice. Int J Mol Med. 2015;35(2):553–559. https://doi.org/10.3892/ijmm.2014.2026.Huang RR, Hu W, Yin YY, Wang YC, Li WP, Li WZ. Chronic restraint stress promotes learning and memory impairment due to enhanced neuronal endoplasmic reticulum stress in the frontal cortex and hippocampus in male mice. Int J Mol Med. 2015;35(2):553–559. https://doi.org/10.3892/ijmm.2014.2026.Musey PI Jr, Schultebraucks K, Chang BP. Stressing Out About the Heart: A Narrative Review of the Role of Psychological Stress in Acute Cardiovascular Events. Acad Emerg Med. 2020;27(1):71–79. https://doi.org/10.1111/acem.13882.Musey PI Jr, Schultebraucks K, Chang BP. Stressing Out About the Heart: A Narrative Review of the Role of Psychological Stress in Acute Cardiovascular Events. Acad Emerg Med. 2020;27(1):71–79. https://doi.org/10.1111/acem.13882.Austin AW, Wissmann T, von Kanel R. Stress and hemostasis: an update. Semin Thromb Hemost. 2013;39(8):902–912. https://doi.org/10.1055/s-0033-1357487.Austin AW, Wissmann T, von Kanel R. Stress and hemostasis: an update. Semin Thromb Hemost. 2013;39(8):902–912. https://doi.org/10.1055/s-0033-1357487.von Känel R. Acute mental stress and hemostasis: When physiology becomes vascular harm. Thromb Res. 2015;135(Suppl 1):S52–S55. https://doi.org/10.1016/S0049-3848(15)50444-1.von Känel R. Acute mental stress and hemostasis: When physiology becomes vascular harm. Thromb Res. 2015;135(Suppl 1):S52–S55. https://doi.org/10.1016/S0049-3848(15)50444-1.Orr E, Arbel T, Levy M, Sela Y, Weissberger O, Liran O, Lewis J. Virtual reality in the management of stress and anxiety disorders: A retrospective analysis of 61 people treated in the metaverse. Heliyon. 2023;9(7):e17870. https://doi.org/10.1016/j.heliyon.2023.e17870.Orr E, Arbel T, Levy M, Sela Y, Weissberger O, Liran O, Lewis J. Virtual reality in the management of stress and anxiety disorders: A retrospective analysis of 61 people treated in the metaverse. Heliyon. 2023;9(7):e17870. https://doi.org/10.1016/j.heliyon.2023.e17870.Шишкова ВН. Простые и эффективные решения в коррекции тревоги и стресса. Медицинский совет. 2023;17(3):161–167. https://doi.org/10.21518/ms2023-023.Shishkova VN. Simple and effective solutions in the correction of anxiety and stress. Meditsinskiy Sovet. 2023;17(3):161–167. (In Russ.) https://doi.org/10.21518/ms2023-023.Кабакова ТИ, Андреева НА, Попова ЕА. Результаты социологического опроса потребителей седативных препаратов безрецептурного отпуска. Фундаментальные исследования. 2011;(11-1):202–207. Режим доступа: https://elibrary.ru/oigmlx.Kabakova TI, Andreeva NA, Popova EA. The results of sociological survey of consumers of OTC sedative medicines. Fundamental Research. 2011;(11-1): 202–207. (In Russ.) Available at: https://elibrary.ru/oigmlx.Конарева ИН. Влияние седативных препаратов растительного происхождения на эмоциональную сферу человека. Ученые записки Таврического национального университета им. В.И. Вернадского. Серия «Биология, химия». 2009;22(2):67–71. Режим доступа: https://cyberleninka.ru/article/n/vliyanie-sedativnyh-preparatov-rastitelnogo-proishozhdeniya-na-emotsionalnuyu-sferu-cheloveka?ysclid=loy2zbrph2337232891.Konareva IN. Influence of sedative vegetable preparations on emotional sphere of the person. Uchenye zapiski Tavricheskogo Natsionalnogo Universiteta im. V.I. Vernadskogo. Series “Biologiya, Khimiya”. 2009;22(2):67–71. (In Russ.) Available at: https://cyberleninka.ru/article/n/vliyanie-sedativnyh-preparatov-rastitelnogo-proishozhdeniya-na-emotsionalnuyu-sferu-cheloveka?ysclid=loy2zbrph2337232891.Mineo L, Concerto C, Patel D, Mayorga T, Paula M, Chusid E et al. Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans. Neuropsychobiology. 2017;75(1):46–51. https://doi.org/10.1159/000480053.Mineo L, Concerto C, Patel D, Mayorga T, Paula M, Chusid E et al. Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans. Neuropsychobiology. 2017;75(1):46–51. https://doi.org/10.1159/000480053.Морохина СЛ, Аляутдин РН, Каперко ДА, Шубникова ЕВ, Снегирева ИИ, Смирнова ЮА. Нежелательные реакции при применении препаратов валерианы и корвалола: анализ спонтанных сообщений. Безопасность и риск фармакотерапии. 2018;6(4):162–173. https://doi.org/10.30895/2312-7821-2018-6-4-162-173.Morokhina SL, Alyautdin RN, Kaperko DA, Shubnikova EV, Snegireva II, Smirnova YuA. Adverse Reactions of Drugs Containing Valeriana and Corvalol: Analysis of Spontaneous Reporting. Safety and Risk of Pharmacotherapy. 2018;6(4): 162–173. (In Russ.) https://doi.org/10.30895/2312-7821-2018-6-4-162-173.Patočka J, Jakl J. Biomedically relevant chemical constituents of Valeriana officinalis. J Appl Biomed. 2010;8(1):11–18. https://doi.org/10.2478/v10136-009-0002-z.Patočka J, Jakl J. Biomedically relevant chemical constituents of Valeriana officinalis. J Appl Biomed. 2010;8(1):11–18. https://doi.org/10.2478/v10136-009-0002-z.Кароматов ИД, Рахматова ДИ. Валериана лекарственная и перспективы применения в неврологической и общеврачебной практике (литературный обзор). Биология и интегративная медицина. 2016;(1):91–108. Режим доступа: https://cyberleninka.ru/article/n/valeriana-lekarstvennaya-i-perspektivy-primeneniya-v-nevrologicheskoy-i-obschevrachebnoy-praktike-literaturnyy-obzor?ysclid=loy5gh57ft443838497.Karomatov ID, Rahmatova DI. Valerian medicinal – a prospects of the using in neurological and GP (literary review). Biologiya i Integrativnaya Meditsina. 2016;(1):91–108. (In Russ.) Available at: https://cyberleninka.ru/article/n/valeriana-lekarstvennaya-i-perspektivy-primeneniya-v-nevrologicheskoy-i-obschevrachebnoy-praktike-literaturnyy-obzor?ysclid=loy5gh57ft443838497.Khatkar S, Lather A, Khatkar A. Valerenic and acetoxyvalerenic acid. In: Belwal T, Nabavi SM, Nabavi SF, Dehpour AR, Shirooie S (eds). Naturally Occurring Chemicals Against Alzheimer’s Disease. Elsevier Inc.; 2021. Р. 117– 125. https://doi.org/10.1016/B978-0-12-819212-2.00045-1.Khatkar S, Lather A, Khatkar A. Valerenic and acetoxyvalerenic acid. In: Belwal T, Nabavi SM, Nabavi SF, Dehpour AR, Shirooie S (eds). Naturally Occurring Chemicals Against Alzheimer’s Disease. Elsevier Inc.; 2021. Р. 117– 125. https://doi.org/10.1016/B978-0-12-819212-2.00045-1.Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res. 2005;138(2):191–197. https://doi.org/10.1016/j.molbrainres.2005.04.009.Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res. 2005;138(2):191–197. https://doi.org/10.1016/j.molbrainres.2005.04.009.Корабельникова ЕА, Данилов АБ. Применение препаратов лекарственных трав для лечения инсомнии. Медицинский алфавит. 2019;2(19):11–18. https://doi.org/10.33667/2078-5631-2019-2-19(394)-11-18Korabelnikova EA, Danilov AB. Use of drugs of medicinal herbs for insomnia treatment. Medical Alphabet. 2019;2(19):11–18. (In Russ.) https://doi.org/10.33667/2078-5631-2019-2-19(394)-11-18.Пояркова НМ, Чулкова ВВ, Сапарклычева СЕ. Мята перечная (Mentha piperitaL.) – важнейшее эфирномасличное растение. Вестник биотехнологии. 2020;(1):12. Режим доступа: https://bio.urgau.ru/ru/1-22-2020/12-01-2020.Poyarkova NM, Chulkova VV, Saparklycheva SE. Peppermint (MénthapiperítaL.) – themostimportantzphyrnomaslichnyplant. Bulletin of Biotechnology. 2020;(1):12. (In Russ.) Available at: https://bio.urgau.ru/ru/1-22-2020/12-01-2020.Соловьева НА, Юсупова МЗ. Применение эфиромасличной продукции в медицине на примере подсолнечника однолетнего и мяты перечной. В: Богатырев СА (ред.). Безопасность и качество товаров: материалы XIV Международной научно-практической конференции. Саратов, 16 июля 2020 г. Саратов: Саратовский государственный аграрный университет им. Н.И. Вавилова; 2020. 242 с. Режим доступа: https://elibrary.ru/nyukoo.Соловьева НА, Юсупова МЗ. Применение эфиромасличной продукции в медицине на примере подсолнечника однолетнего и мяты перечной. В: Богатырев СА (ред.). Безопасность и качество товаров: материалы XIV Международной научно-практической конференции. Саратов, 16 июля 2020 г. Саратов: Саратовский государственный аграрный университет им. Н.И. Вавилова; 2020. 242 с. Режим доступа: https://elibrary.ru/nyukoo.Хажжар Ф, Потанина ОГ. Обоснованность выбора состава комбинированного растительного лекарственного средства седативного действия. В: Гуленков АС, Борисенко ЕВ. 90 лет – от растения до лекарственного препарата: достижения и перспективы: сборник материалов юбилейной международной научной конференции. Москва, 10–11 июня 2021 г. М.: ФГБУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений»; 2021. 613 с. Режим доступа: https://repository.rudn.ru/ru/records/article/record/78739/.Хажжар Ф, Потанина ОГ. Обоснованность выбора состава комбинированного растительного лекарственного средства седативного действия. В: Гуленков АС, Борисенко ЕВ. 90 лет – от растения до лекарственного препарата: достижения и перспективы: сборник материалов юбилейной международной научной конференции. Москва, 10–11 июня 2021 г. М.: ФГБУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений»; 2021. 613 с. Режим доступа: https://repository.rudn.ru/ru/records/article/record/78739/.Девликамова ФИ, Хайбуллина ДХ, Максимов ЮН, Кадырова ЛР. Тревожные расстройства в общеклинической практике. Медицинский совет. 2023;17(6):95–102. https://doi.org/10.21518/ms2023-094.Devlikamova FI, Khaibullina DH, Maksimov YuN, Kadyrova LR. Anxiety disorders in general clinical practice. Meditsinskiy Sovet. 2023;17(6):95–102. (In Russ.) https://doi.org/10.21518/ms2023-094.Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011;25(4):540–543. https://doi.org/10.1002/ptr.3292.Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011;25(4):540–543. https://doi.org/10.1002/ptr.3292.Морозова МА, Пельтихина ОВ, Морозов АМ. Применение фитотерапевтических средств в лечении заболеваний сердечно-сосудистой системы. Синергия наук. 2018;(S24):51–59. Режим доступа: https://elibrary.ru/xtakfn.Morozova MA, Peltykhina OV, Morozov AM. Application of phytotherapeutic medicines in the treatment of diseases of the cardiovascular system. Sinergiya Nauk. 2018;(S24):51–59. (In Russ.) Available at: https://elibrary.ru/xtakfn.

The authors declare that there are no conflicts of interest present.