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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-427</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-7945</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE</subject></subj-group></article-categories><title-group><article-title>Клинические проявления и вероятные предикторы формирования постковидного синдрома в неврологической практике</article-title><trans-title-group xml:lang="en"><trans-title>Clinical manifestations and possible predictors of the formation of post-COVID syndrome in neurological practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-9984-2147</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перетечикова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Peretechikova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Перетечикова Анна Владимировна - аспирант кафедры нервных болезней и нейрохирургии.</p><p>119991, Москва, ул. Россолимо, д. 11, корп. 1</p></bio><bio xml:lang="en"><p>Anna V. Peretechikova - Postgraduate Student of the Department of Nervous Diseases and Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University).</p><p>11, Bldg. 1, Rossolimo St., Moscow, 119991</p></bio><email xlink:type="simple">a.peretechikova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7330-633X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воскресенская</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Voskresenskaya</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воскресенская Ольга Николаевна – доктор медицинских наук, профессор кафедры нервных болезней и нейрохирургии.</p><p>119991, Москва, ул. Россолимо, д. 11, корп. 1</p></bio><bio xml:lang="en"><p>Olga N. Voskresenskaya - Dr. Sci. (Med.), Professor of the Department of Nervous Diseases and Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University).</p><p>11, Bldg. 1, Rossolimo St., Moscow, 119991</p></bio><email xlink:type="simple">vos-olga@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>21</issue><fpage>168</fpage><lpage>173</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Перетечикова А.В., Воскресенская О.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Перетечикова А.В., Воскресенская О.Н.</copyright-holder><copyright-holder xml:lang="en">Peretechikova A.V., Voskresenskaya O.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/7945">https://www.med-sovet.pro/jour/article/view/7945</self-uri><abstract><sec><title>Введение</title><p>Введение. Изучение клинической картины и прогностических факторов развития постковидного синдрома (ПКС) остается актуальной задачей для врачей различных специальностей.</p></sec><sec><title>Цель</title><p>Цель. Изучить клинические проявления и вероятные предикторы формирования ПКС в неврологической практике.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включено 34 пациента в возрасте от 18 до 65 лет, проходящих лечение в Клинике нервных болезней им. А.Я. Кожевникова по поводу основного заболевания: головные боли напряжения (ГБН), мигрень (М), скелетно-мышечные боли (СМБ), переболевшие документально подтвержденной коронавирусной инфекцией (КИ, COVID-19). Основную группу (ОГ) составили 21 пациент (средний возраст 47,95 ± 12,21 лет), дополнительно к проявлениям основного заболевания предъявляющие жалобы на нарушение памяти, снижение концентрации внимания и работоспособности, быструю утомляемость, тревогу и внутреннее напряжение, пониженный фон настроения и нежелание что-либо делать, головную боль, возникшие впервые во время, сразу по окончании или в течение 2 мес. после перенесенной КИ, что соответствовало критериям ПКС. В группу сравнения (ГС) включено 13 пациентов (средний возраст 38 ± 12 лет), которые предъявляли жалобы только в рамках их основных заболеваний и не отмечали каких-либо особенностей в их течении в связи с перенесенной КИ. Дополнительно к основным методам исследования применялось анкетирование: утомляемости (шкала MFI-20), тревоги (шкала Спилбергера – Ханина), депрессии (шкала Бека), когнитивных нарушений (MOCA-тест), нарушения концентрации внимания (тест Мюнстерберга), симптомов центральной сенситизации (CSI), качества жизни (SF-36).</p></sec><sec><title>Результаты</title><p>Результаты. Клинические проявления ПКС заключались в легких или субъективных когнитивных нарушениях (КН) без изменения концентрации внимания и астеническом симптомокомплексе. Пациенты ОГ были более старшего возраста, имели среднетяжелое и тяжелое течение острого периода КИ и риски сердечно-сосудистой патологии, статистически достоверно отличались от ГС более высокими баллами по шкалам: депрессии Бека, Спилбергера – Ханина, CSI, MFI-20 – и более низким баллом по шкале MOCA.</p></sec><sec><title>Выводы</title><p>Выводы. В качестве возможных предикторов формирования ПКС могут выступать: возраст старше 40 лет, среднетяжелое и тяжелое течение КИ, наличие рисков сердечно-сосудистой патологии, депрессия и повышенная личностная тревожность, более высокие показатели центральной сенситизации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Studying clinical manifistations and prognostic factors for the development of post-covid syndrome (PCS) remains an actual task for doctors of various specialties.</p></sec><sec><title>Aim</title><p>Aim. To study the clinical manifestations and probable predictors of the formation of PCS in neurological practice.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 34 patients aged 18 to 65 years undergoing treatment at the A.Ya. Kozhevnikov Clinic of Nervous Diseases for the underlying disease: tension headaches (GBN), migraine (M), musculoskeletal pain (SMB), who had a documented coronavirus infection (CI) COVID-19. The main group (OG) consisted of 21 patients (average age 47.95 ± 12.21 years), in addition to the manifestations of the underlying disease, complaining of memory impairment, decreased concentration and performance, fatigue, anxiety and internal tension, low mood background and unwillingness to do anything, headache that occurred for the first time during, immediately after the end or within 2 months after the transferred CI, which met the criteria of the PCC. The comparison group (GS) included 13 patients (average age 38 ± 12 years) who complained only about their underlying diseases and did not note any peculiarities in their course due to the transferred CI. In addition to the main research methods, questionnaires were used: fatigue (MFI-20 scale), anxiety (Spielberger – Khanin scale), depression (Beck scale), cognitive impairment (MOCA test), impaired concentration (Munsterberg test), symptoms of central sensitization (CSI), quality of life (SF-36).</p></sec><sec><title>Results</title><p>Results. Clinical manifestations of PKS consisted in mild or subjective cognitive impairment (CN) without a change in concentration and asthenic symptom complex. OG patients were older, had moderate and severe acute period of CI and risks of cardiovascular pathology, statistically significantly differed from HS with higher scores on the scales: Beck depression, Spielberger – Khanin, CSI, MFI-20 and a lower score on the MOCA scale.</p></sec><sec><title>Conclusions</title><p>Conclusions. Possible predictors of the formation of PKS can be: age over 40 years, moderate and severe course of CI, the presence of risks of cardiovascular pathology, depression and increased personal anxiety, higher rates of central sensitization.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>постковидный синдром</kwd><kwd>факторы риска</kwd><kwd>когнитивные нарушения</kwd><kwd>усталость</kwd><kwd>астения</kwd><kwd>тревога</kwd><kwd>депрессия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>post-COVID syndrome</kwd><kwd>risk factors</kwd><kwd>cognitive impairment</kwd><kwd>fatigue</kwd><kwd>asthenia</kwd><kwd>anxiety</kwd><kwd>depression</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Almasri M, Alqaisi R, Al-Shagahin M, Al-Kubaisy W, Aljarajreh A; Al-Shagahin H. 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