medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2023-457medsovet-8029Research ArticleГИНЕКОЛОГИЯGYNECOLOGYОбоснование к экзогенному восполнению дефицита магния у женщин, планирующих беременность: опыт примененияJustification for exogenous replacement of magnesium deficiency in women planning pregnancy: experienc of using the drughttps://orcid.org/0000-0003-2977-9065МежевитиноваЕ. А.MezhevitinovaE. A.

Межевитинова Елена Анатольевна - д.м.н., врач акушер-гинеколог, ведущий научный сотрудник научно-поликлинического отделения.

117997, Москва, ул. Академика Опарина, д. 4

Elena A. Mezhevitinova - Dr. Sci. (Med.), Obstetrician-Gynecologist, Leading Researcher of the Scientific and Polyclinic Department.

4, Academician Oparin St., Moscow, 117997

e_mezhevitinova@oparina4.ruhttps://orcid.org/0000-0002-0179-7635ЮроваМ. В.IurovaM. A.

Юрова Мария Владимировна - к.м.н., врач акушер-гинеколог, научный сотрудник научно-поликлинического отделения, НМИЦАГП имени академика В.И. Кулакова; Первый МГМУ имени И.М. Сеченова (Сеченовский Университет).

117997, Москва, ул. Академика Опарина, д. 4; 119991, Москва, ул. Трубецкая, д. 8, стр. 2

Mariia V. Iurova - Cand. Sci. (Med.), Obstetrician-Gynecologist, Researcher of the Scientific and Polyclinic Department, Kulakov NMRC of Obstetrics, Gynecology and Perinatology; Sechenov FMSMU (Sechenov University)

4, Academician Oparin St., Moscow, 117997; 8, Bldg. 2, Trubetskaya St., Moscow, 119991

m_yurova@oparina4.ruhttps://orcid.org/0000-0002-8243-5272АбакароваП. Р.AbakarovaP. R.

Абакарова Патимат Рапиевна - к.м.н., врач акушер-гинеколог, старший научный сотрудник научно-поликлинического отделения, НМИЦАГП имени академика В.И. Кулакова.

117997, Москва, ул. Академика Опарина, д. 4

Patimat R. Abakarova - Cand. Sci. (Med.), Obstetrician-Gynecologist, Senior Researcher of the Scientific and Polyclinic Department.

4, Academician Oparin St., Moscow, 117997

p_abakarova@oparina4.ruhttps://orcid.org/0000-0002-4201-1360КепшаМ. А.KepshaM. A.

Кепша Мария Александровна, аспирант научно-поликлинического отделения, НМИЦАГП имени академика В.И. Кулакова.

117997, Москва, ул. Академика Опарина, д. 4

Maria A. Kepsha - Postgraduate Student, of the Scientific and Polyclinic Department.

4, Academician Oparin St., Moscow, 117997

infino-creative@mail.ruНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова; Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияKulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology; Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202321012024023282293Copyright © Межевитинова Е.А., Юрова М.В., Абакарова П.Р., Кепша М.А., 20242024Межевитинова Е.А., Юрова М.В., Абакарова П.Р., Кепша М.А.Mezhevitinova E.A., Iurova M.A., Abakarova P.R., Kepsha M.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8029Введение

Введение. Во время беременности увеличивается потребность организма в большинстве микронутриентов, в связи с чем обоснованы своевременное выявление и адекватная коррекция дефицитных состояний, начиная с этапа прегравидарной подготовки.

Цель

Цель. Представить данные литературы о роли магния в гомеостазе и собственный опыт эффективности применения препарата магния.

Материалы и методы

Материалы и методы. Проведен обзор литературы за 2018–2023 гг. в базах PubMed (the National Library of Medicine), The Cochrane Library, а также в базах данных научного цитирования (Scopus, Web of Science). Также представлен опыт собственного применения препарата, содержащего магния лактата дигидрат (470 мг) + пиридоксина гидрохлорид (5 мг).

Результаты и обсуждение

Результаты и обсуждение. Поступление магния в организм человека с пищей является недостаточным. Экзогенное восполнение магния клинически обоснованно при изолированном или связанном с другими состояниями установленном дефиците, в первую очередь при интенсивной эмоциональной и физической нагрузке, депривации сна, а также при эмоциональной лабильности, ощущениях учащенного сердцебиения, фасцикуляции мышц, элиминации магния, обусловленной ятрогенным воздействием или повышенным запросом, например гестационно обусловленным. Регулярное применение препарата «Магне В6®» продемонстрировало свою эффективность при лечении симптомов психологического ежедневного стресса (утомляемость, раздражительность, ухудшение качества сна) у женщин, планирующих беременность.

Заключение

Заключение. Полученные результаты представляются важными с позиции снижения рисков клинического прогрессирования соматических проявлений, а также снижения рисков потенциальных гестационных осложнений и улучшения качества жизни у женщин детородного возраста, активно планирующих реализацию репродуктивной функции.

Introduction

Introduction. During pregnancy, the body’s need for most micronutrients increases, and therefore timely detection and adequate correction of deficient conditions are justified, starting from the stage of pre-gravidar preparation.

Objective

Objective. The purpose of the study is to present literature data on the role of magnesium in homeostasis and own experience of the effectiveness of the use of magnesium preparation.

Materials and methods

Materials and methods. A review of the literature for 2021–2023 in the databases was conducted in the databases PubMed (the National Library of Medicine), The Cochrane Library, as well as in scientific citation databases (Scopus, Web of Science) The experience of own application of the preparation containing magnesium lactate dihydrate (470 mg) is also presented + pyridoxine hydrochloride (5 mg).

Result and discussion

Result and discussion. The intake of magnesium into the human body with food is insufficient. Exogenous magnesium replenishment is clinically justified in isolated or associated with other conditions of established deficiency, primarily with intense emotional and physical exertion, sleep deprivation, as well as with emotional lability, palpitations, muscle fasciculations, with magnesium elimination due to iatrogenic exposure or increased demand, for example, gestational-conditioned. Regular use of Magne B6® has demonstrated its effectiveness in the treatment of symptoms of psychological daily stress (fatigue, irritability, deterioration of sleep quality) in women planning pregnancy.

Conclusions

Conclusions. The results obtained appear to be important in terms of reducing the risks of clinical progression of somatic symptoms and potential gestational complications, as well as improving the quality of life of childbearing age women who are actively planning to implement their reproductive function.

гипомагниемиямагнийокислительный стресспрегравидарная подготовкарепродукцияhypomagnesemiamagnesiumoxidative stresspregravidar preparationreproductionReferencesTerry J. The other electrolytes: magnesium, calcium, and phosphorus. J Intraven Nurs. 1991;14(3):167–176. Available at: https://pubmed.ncbi.nlm.nih.gov/2033479/.Terry J. The other electrolytes: magnesium, calcium, and phosphorus. J Intraven Nurs. 1991;14(3):167–176. Available at: https://pubmed.ncbi.nlm.nih.gov/2033479/.Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(1):i3-i14. https://doi.org/10.1093/ndtplus/sfr163.Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(1):i3-i14. https://doi.org/10.1093/ndtplus/sfr163.Romani AM. Magnesium in health and disease. Met Ions Life Sci. 2013;(13):49–79. https://doi.org/10.1007/978-94-007-7500-8_3.Romani AM. Magnesium in health and disease. Met Ions Life Sci. 2013;(13):49–79. https://doi.org/10.1007/978-94-007-7500-8_3.Mathew AA, Panonnummal R. ‘Magnesium’-the master cation-as a drug-possibilities and evidences. Biometals. 2021;34(5):955–986. https://doi.org/10.1007/s10534-021-00328-7.Mathew AA, Panonnummal R. ‘Magnesium’-the master cation-as a drug-possibilities and evidences. Biometals. 2021;34(5):955–986. https://doi.org/10.1007/s10534-021-00328-7.Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020;12(12):3672. https://doi.org/10.3390/nu12123672.Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020;12(12):3672. https://doi.org/10.3390/nu12123672.Workeneh BT, Uppal NN, Jhaveri KD, Rondon-Berrios H. Hypomagnesemia in the Cancer Patient. Kidney360. 2020;2(1):154–166. https://doi.org/10.34067/KID.0005622020.Workeneh BT, Uppal NN, Jhaveri KD, Rondon-Berrios H. Hypomagnesemia in the Cancer Patient. Kidney360. 2020;2(1):154–166. https://doi.org/10.34067/KID.0005622020.Tutel’ian VA. Norms of physiological requirements in energy and nutrients in various groups of population in Russian Federation. Vopr Pitan. 2009;78(1):4–15. Available at: https://pubmed.ncbi.nlm.nih.gov/19348278/.Tutel’ian VA. Norms of physiological requirements in energy and nutrients in various groups of population in Russian Federation. Vopr Pitan. 2009;78(1):4–15. Available at: https://pubmed.ncbi.nlm.nih.gov/19348278/.DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. https://doi.org/10.1136/openhrt-2017-000668.DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. https://doi.org/10.1136/openhrt-2017-000668.Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, Ong WK, Paley S, Subhraveti P, Karp PD. The MetaCyc database of metabolic pathways and enzymes – a 2019 update. Nucleic Acids Res. 2020;48(D1):D445–D453. https://doi.org/10.1093/nar/gkz862.Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, Ong WK, Paley S, Subhraveti P, Karp PD. The MetaCyc database of metabolic pathways and enzymes – a 2019 update. Nucleic Acids Res. 2020;48(D1):D445–D453. https://doi.org/10.1093/nar/gkz862.Al Alawi AM, Al Badi A, Al Huraizi A, Falhammar H. Magnesium: the recent research and developments. Adv Food Nutr Res. 2021;(96):193–218. https://doi.org/10.1016/bs.afnr.2021.01.001.Al Alawi AM, Al Badi A, Al Huraizi A, Falhammar H. Magnesium: the recent research and developments. Adv Food Nutr Res. 2021;(96):193–218. https://doi.org/10.1016/bs.afnr.2021.01.001.Bairoch A. The ENZYME database in 2000. Nucleic Acids Res. 2000;28(1):304–305. https://doi.org/10.1093/nar/28.1.304.Bairoch A. The ENZYME database in 2000. Nucleic Acids Res. 2000;28(1):304–305. https://doi.org/10.1093/nar/28.1.304.Apell HJ, Hitzler T, Schreiber G. Modulation of the Na,K-ATPase by Magnesium Ions. Biochemistry. 2017;56(7):1005–1016. https://doi.org/10.1021/acs.biochem.6b01243.Apell HJ, Hitzler T, Schreiber G. Modulation of the Na,K-ATPase by Magnesium Ions. Biochemistry. 2017;56(7):1005–1016. https://doi.org/10.1021/acs.biochem.6b01243.Marín R, Abad C, Rojas D, Chiarello DI, Rangel H, Teppa-Garran A et al. Magnesium salts in pregnancy. J Trace Elements Minerals. 2023;4. https://doi.org/10.1016/j.jtemin.2023.100071.Marín R, Abad C, Rojas D, Chiarello DI, Rangel H, Teppa-Garran A et al. Magnesium salts in pregnancy. J Trace Elements Minerals. 2023;4. https://doi.org/10.1016/j.jtemin.2023.100071.rude RK, Gruber HE, Wei LY, Frausto A, Mills BG. Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int. 2003;72(1):32–41. https://doi.org/10.1007/s00223-001-1091-1.rude RK, Gruber HE, Wei LY, Frausto A, Mills BG. Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int. 2003;72(1):32–41. https://doi.org/10.1007/s00223-001-1091-1.rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009;28(2):131–141. https://doi.org/10.1080/07315724.2009.10719764.rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009;28(2):131–141. https://doi.org/10.1080/07315724.2009.10719764.Harvey AJ. Mitochondria in early development: linking the microenvironment, metabolism and the epigenome. Reproduction. 2019;157(5):R159–R179. https://doi.org/10.1530/REP-18-0431.Harvey AJ. Mitochondria in early development: linking the microenvironment, metabolism and the epigenome. Reproduction. 2019;157(5):R159–R179. https://doi.org/10.1530/REP-18-0431.Liu M, Jeong EM, Liu H, Xie A, So EY, Shi G et al. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI Insight. 2019;4(1):е123182. https://doi.org/10.1172/jci.insight.123182.Liu M, Jeong EM, Liu H, Xie A, So EY, Shi G et al. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI Insight. 2019;4(1):е123182. https://doi.org/10.1172/jci.insight.123182.Watanabe M, Nakamura K, Kato M, Okada T, Iesaki T. Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart. J Pharmacol Sci. 2022;148(2):238–247. https://doi.org/10.1016/j.jphs.2021.12.002.Watanabe M, Nakamura K, Kato M, Okada T, Iesaki T. Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart. J Pharmacol Sci. 2022;148(2):238–247. https://doi.org/10.1016/j.jphs.2021.12.002.Selye H. Stress and the general adaptation syndrome. Br Med J. 1950;1(4667):1383–1392. https://doi.org/10.1136/bmj.1.4667.1383.Selye H. Stress and the general adaptation syndrome. Br Med J. 1950;1(4667):1383–1392. https://doi.org/10.1136/bmj.1.4667.1383.Clark MS, Bond MJ, Hecker JR. Environmental stress, psychological stress and allostatic load. Psychol Health Med. 2007;12(1):18–30. https://doi.org/10.1080/13548500500429338.Clark MS, Bond MJ, Hecker JR. Environmental stress, psychological stress and allostatic load. Psychol Health Med. 2007;12(1):18–30. https://doi.org/10.1080/13548500500429338.Cuciureanu M, Vink R. Magnesium and stress. In: Vink R, Nechifor M (ed.). Magnesium in the Central Nervous System. Adelaide, Australia: University of Adelaide Press; 2011. Available at: https://www.adelaide.edu.au/press/ua/media/251/uap-magnesium-ebook.pdf.Cuciureanu M, Vink R. Magnesium and stress. In: Vink R, Nechifor M (ed.). Magnesium in the Central Nervous System. Adelaide, Australia: University of Adelaide Press; 2011. Available at: https://www.adelaide.edu.au/press/ua/media/251/uap-magnesium-ebook.pdf.Whyte KF, Addis GJ, Whitesmith R, Reid JL. Adrenergic control of plasma magnesium in man. Clin Sci (Lond). 1987;72(1):135–138. https://doi.org/10.1042/cs0720135.Whyte KF, Addis GJ, Whitesmith R, Reid JL. Adrenergic control of plasma magnesium in man. Clin Sci (Lond). 1987;72(1):135–138. https://doi.org/10.1042/cs0720135.Cernak I, Savic V, Kotur J, Prokic V, Kuljic B, Grbovic D, Veljovic M. Alterations in magnesium and oxidative status during chronic emotional stress. Magnes Res. 2000;13(1):29–36. Available at: https://pubmed.ncbi.nlm.nih.gov/10761188/.Cernak I, Savic V, Kotur J, Prokic V, Kuljic B, Grbovic D, Veljovic M. Alterations in magnesium and oxidative status during chronic emotional stress. Magnes Res. 2000;13(1):29–36. Available at: https://pubmed.ncbi.nlm.nih.gov/10761188/.Tanabe K, Osada N, Suzuki N, Nakayama M, Yokoyama Y, Yamamoto А et al. Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. Clin Cardiol. 1997;20(3):265–268. https://doi.org/10.1002/Clc.4960200315.Tanabe K, Osada N, Suzuki N, Nakayama M, Yokoyama Y, Yamamoto А et al. Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. Clin Cardiol. 1997;20(3):265–268. https://doi.org/10.1002/Clc.4960200315.Grases G, Pérez-Castelló JA, Sanchis P, Casero A, Perelló J, Isern B et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes. Res. 2006;19(2):102–106. Available at: https://pubmed.ncbi.nlm.nih.gov/16955721/.Grases G, Pérez-Castelló JA, Sanchis P, Casero A, Perelló J, Isern B et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes. Res. 2006;19(2):102–106. Available at: https://pubmed.ncbi.nlm.nih.gov/16955721/.Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223–227. https://doi.org/10.1002/clc.4960270411.Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223–227. https://doi.org/10.1002/clc.4960270411.Mocci F, Canalis P, Tomasi PA, Casu F, Pettinato S. The effect of noise on serum and urinary magnesium and catecholamines in humans. Occup Med (Lond). 2001;51(1):56–61. https://doi.org/10.1093/occmed/51.1.56.Mocci F, Canalis P, Tomasi PA, Casu F, Pettinato S. The effect of noise on serum and urinary magnesium and catecholamines in humans. Occup Med (Lond). 2001;51(1):56–61. https://doi.org/10.1093/occmed/51.1.56.Ising H, Dienel D, Günther T, Markert B. Health effects of traffic noise. Int Arch Occup Environ Health. 1980;47(2):179–190. https://doi.org/10.1007/BF00716376.Ising H, Dienel D, Günther T, Markert B. Health effects of traffic noise. Int Arch Occup Environ Health. 1980;47(2):179–190. https://doi.org/10.1007/BF00716376.Joborn H, Akerström G, Ljunghall S. Effects of exogenous catecholamines and exercise on plasma magnesium concentrations. Clin Endocrinol (Oxf). 1985;23(3):219–226. https://doi.org/10.1111/j.1365-2265.1985.tb00217.x.Joborn H, Akerström G, Ljunghall S. Effects of exogenous catecholamines and exercise on plasma magnesium concentrations. Clin Endocrinol (Oxf). 1985;23(3):219–226. https://doi.org/10.1111/j.1365-2265.1985.tb00217.x.Акарачкова ЕС, Шавловская ОА. Роль дефицита магния в формировании клинических проявлений стресса у женщин. Проблемы женского здоровья. 2013;3(8):52–59. Режим доступа: https://www.elibrary.ru/rdremb.Akarachkova ES, Shavlovskaya OA. The role of magnesium deficiency in the formation of clinical manifestation of stress in women. Problems of Women Health. 2013;3(8):52–59. (In Russ.) Available at: https://www.elibrary.ru/rdremb.Nielsen FH, Johnson LK, Zeng H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res. 2010;23(4):158–168. https://doi.org/10.1684/mrh.2010.0220.Nielsen FH, Johnson LK, Zeng H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res. 2010;23(4):158–168. https://doi.org/10.1684/mrh.2010.0220.Sales CH, Nascimento AD, Queiroz Medeiros AC, Costa Lima K, Pedrosa LFC, Colli C. There is chronic latent magnesium deficiency in apparently healthy university students. Nutr Hosp. 2014;30(1):200–204. https://doi.org/10.3305/nh.2014.30.1.7510.Sales CH, Nascimento AD, Queiroz Medeiros AC, Costa Lima K, Pedrosa LFC, Colli C. There is chronic latent magnesium deficiency in apparently healthy university students. Nutr Hosp. 2014;30(1):200–204. https://doi.org/10.3305/nh.2014.30.1.7510.Eby GA, Eby KL. Magnesium for treatment-resistant depression: A review and hypothesis. Med Hypotheses. 2010;74(4):649–660. https://doi.org/10.1016/j.mehy.2009.10.051.Eby GA, Eby KL. Magnesium for treatment-resistant depression: A review and hypothesis. Med Hypotheses. 2010;74(4):649–660. https://doi.org/10.1016/j.mehy.2009.10.051.Forsyth AK, Williams PG, Deane FP. Nutrition status of primary care patients with depression and anxiety. Aust J Prim Health. 2012;18(2):172–176. https://doi.org/10.1071/PY11023.Forsyth AK, Williams PG, Deane FP. Nutrition status of primary care patients with depression and anxiety. Aust J Prim Health. 2012;18(2):172–176. https://doi.org/10.1071/PY11023.Pochwat B, Sowa-Kucma M, Kotarska K, Misztak P, Nowak G, Szewczyk B. Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway. Psychopharmacology. 2015;232(2):355–367. https://doi.org/10.1007/s00213-014-3671-6.Pochwat B, Sowa-Kucma M, Kotarska K, Misztak P, Nowak G, Szewczyk B. Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway. Psychopharmacology. 2015;232(2):355–367. https://doi.org/10.1007/s00213-014-3671-6.Parrettini S, Caroli A, Torlone E. Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: focus on Obesity and Gestational Diabetes. Front Endocrinol (Lausanne). 2020;11:611929. https://doi.org/10.3389/fendo.2020.611929.Parrettini S, Caroli A, Torlone E. Nutrition and Metabolic Adaptations in Physiological and Complicated Pregnancy: focus on Obesity and Gestational Diabetes. Front Endocrinol (Lausanne). 2020;11:611929. https://doi.org/10.3389/fendo.2020.611929.Ochoa-Bernal MA, Fazleabas AT. Physiologic events of embryo implantation and decidualization in human and non-human primates. Int J Mol Sci. 2020;21(6):1973. https://doi.org/10.3390/ijms21061973.Ochoa-Bernal MA, Fazleabas AT. Physiologic events of embryo implantation and decidualization in human and non-human primates. Int J Mol Sci. 2020;21(6):1973. https://doi.org/10.3390/ijms21061973.Sanchez-Aranguren L, Nadeem S. Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders. Mol Cell Biochem. 2021;476(11):4003–4018. https://doi.org/10.1007/s11010-021-04215-0.Sanchez-Aranguren L, Nadeem S. Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders. Mol Cell Biochem. 2021;476(11):4003–4018. https://doi.org/10.1007/s11010-021-04215-0.Rytkönen KT, Heinosalo T, Mahmoudian M, Ma X, Perheentupa A, Elo LL et al. Transcriptomic responses to hypoxia in endometrial and decidual stromal cells. Reproduction. 2020;160(1):39–51. 10.1530/REP-19-0615.Rytkönen KT, Heinosalo T, Mahmoudian M, Ma X, Perheentupa A, Elo LL et al. Transcriptomic responses to hypoxia in endometrial and decidual stromal cells. Reproduction. 2020;160(1):39–51. 10.1530/REP-19-0615.Cindrova-Davies T, van Patot MT, Gardner L, Jauniaux E, Burton GJ, Charnock-Jones DS. Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development. Mol Hum Reprod. 2015;21(3):296–308. https://doi.org/10.1093/molehr/gau105.Cindrova-Davies T, van Patot MT, Gardner L, Jauniaux E, Burton GJ, Charnock-Jones DS. Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development. Mol Hum Reprod. 2015;21(3):296–308. https://doi.org/10.1093/molehr/gau105.Lu J, Wang Z, Cao J, Chen Y, Dong Y. A novel and compact review on the role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2018;16(1):80. https://doi.org/10.1186/s12958-018-0391-5.Lu J, Wang Z, Cao J, Chen Y, Dong Y. A novel and compact review on the role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2018;16(1):80. https://doi.org/10.1186/s12958-018-0391-5.Pilchova I, Klacanova K, Tatarkova Z, Kaplan P, Racay P. The Involvement of Mg(2+) in Regulation of Cellular and Mitochondrial Functions. Oxid Med Cell Longev. 2017;2017:6797460. https://doi.org/10.1155/2017/6797460.Pilchova I, Klacanova K, Tatarkova Z, Kaplan P, Racay P. The Involvement of Mg(2+) in Regulation of Cellular and Mitochondrial Functions. Oxid Med Cell Longev. 2017;2017:6797460. https://doi.org/10.1155/2017/6797460.Zheltova AA, Kharitonova MV, Iezhitsa IN, Spasov AA. Magnesium deficiency and oxidative stress: an update. Biomedicine (Taipei). 2016;6(4):20. https://doi.org/10.7603/s40681-016-0020-6.Zheltova AA, Kharitonova MV, Iezhitsa IN, Spasov AA. Magnesium deficiency and oxidative stress: an update. Biomedicine (Taipei). 2016;6(4):20. https://doi.org/10.7603/s40681-016-0020-6.Fanni D, Gerosa C, Nurchi VM, Manchia M, Saba L, Coghe F et al. The role of magnesium in pregnancy and in fetal programming of adult diseases. Biol Trace Elem Res. 2021;199(10):3647–3657. https://doi.org/10.1007/s12011-020-02513-0.Fanni D, Gerosa C, Nurchi VM, Manchia M, Saba L, Coghe F et al. The role of magnesium in pregnancy and in fetal programming of adult diseases. Biol Trace Elem Res. 2021;199(10):3647–3657. https://doi.org/10.1007/s12011-020-02513-0.Bottomley C, Bourne T. Management strategies for hyperemesis. Best Pract Res Clin Obstet Gynaecol. 2009;23(4):549–564. https://doi.org/10.1016/j.bpobgyn.2008.12.012.Bottomley C, Bourne T. Management strategies for hyperemesis. Best Pract Res Clin Obstet Gynaecol. 2009;23(4):549–564. https://doi.org/10.1016/j.bpobgyn.2008.12.012.Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res. 2010;23(4):S194-S198. https://doi.org/10.1684/mrh.2010.0213.Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res. 2010;23(4):S194-S198. https://doi.org/10.1684/mrh.2010.0213.Witkowski M, Hubert J, Mazur A. Methods of assessment of magnesium status in humans: a systematic review. Magnes Res. 2011;24(4):163–180. https://doi.org/10.1684/mrh.2011.0292.Witkowski M, Hubert J, Mazur A. Methods of assessment of magnesium status in humans: a systematic review. Magnes Res. 2011;24(4):163–180. https://doi.org/10.1684/mrh.2011.0292.Pham P-CT, Pham P-AT, Pham SV, Pham P-TT, Pham P-MT, Pham P-TT. Hypomagnesemia: а clinical perspective. Int J Nephrol Renovasc Dis. 2014;7:219–230. https://doi.org/10.2147/IJNRD.S42054.Pham P-CT, Pham P-AT, Pham SV, Pham P-TT, Pham P-MT, Pham P-TT. Hypomagnesemia: а clinical perspective. Int J Nephrol Renovasc Dis. 2014;7:219–230. https://doi.org/10.2147/IJNRD.S42054.Kostov K, Halacheva L. Role of magnesium deficiency in promoting atherosclerosis, endothelial dysfunction, and arterial stiffening as risk factors for hypertension. Int J Mol Sci. 2018;19(6):1724. https://doi.org/10.3390/ijms19061724.Kostov K, Halacheva L. Role of magnesium deficiency in promoting atherosclerosis, endothelial dysfunction, and arterial stiffening as risk factors for hypertension. Int J Mol Sci. 2018;19(6):1724. https://doi.org/10.3390/ijms19061724.Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients. 2021;13(4):1136. https://doi.org/10.3390/nu13041136.Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients. 2021;13(4):1136. https://doi.org/10.3390/nu13041136.Zogović D, Pesić V, Dmitrasinović G, Dajak M, Plećas B, Batinić B et al. Pituitary-gonadal, pituitary-adrenocortical hormonal and IL-6 levels following long-term magnesium supplementation in male students. J Med Biochem. 2014;33(3):291–298. https://doi.org/10.2478/jomb-2014-0016.Zogović D, Pesić V, Dmitrasinović G, Dajak M, Plećas B, Batinić B et al. Pituitary-gonadal, pituitary-adrenocortical hormonal and IL-6 levels following long-term magnesium supplementation in male students. J Med Biochem. 2014;33(3):291–298. https://doi.org/10.2478/jomb-2014-0016.Wienecke E, Nolden C. Long-term HRV analysis shows stress reduction by magnesium intake. MMW Fortschr Med. 2016;158(6):12–16. https://doi.org/10.1007/s15006-016-9054-7.Wienecke E, Nolden C. Long-term HRV analysis shows stress reduction by magnesium intake. MMW Fortschr Med. 2016;158(6):12–16. https://doi.org/10.1007/s15006-016-9054-7.Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. https://doi.org/10.1371/journal.pone.0208454.Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, Hellhammer J et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. https://doi.org/10.1371/journal.pone.0208454.Hermes Sales C, Azevedo Nascimento D, Queiroz Medeiros AC, Costa Lima K, Campos Pedrosa LF, Colli C. There is chronic latent magnesium deficiency in apparently healthy university students. Nutr Hosp. 2014;30(1):200–204. https://doi.org/10.3305/nh.2014.30.1.7510.Hermes Sales C, Azevedo Nascimento D, Queiroz Medeiros AC, Costa Lima K, Campos Pedrosa LF, Colli C. There is chronic latent magnesium deficiency in apparently healthy university students. Nutr Hosp. 2014;30(1):200–204. https://doi.org/10.3305/nh.2014.30.1.7510.Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. https://doi.org/10.3390/nu9050429.Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. https://doi.org/10.3390/nu9050429.Yuan J, Yu Y, Zhu T, Lin X, Jing X, Zhang J. Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials. Biol Trace Elem Res. 2022;200(8):3572–3581. https://doi.org/10.1007/s12011-021-02976-9.Yuan J, Yu Y, Zhu T, Lin X, Jing X, Zhang J. Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials. Biol Trace Elem Res. 2022;200(8):3572–3581. https://doi.org/10.1007/s12011-021-02976-9.Cosaro E, Bonafini S, Montagnana M, Danese E, Trettene MS, Minuz P et al. Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of metabolic syndrome. Nutr Metab Cardiovasc Dis. 2014;24(11):1213–1220. https://doi.org/10.1016/j.numecd.2014.05.010.Cosaro E, Bonafini S, Montagnana M, Danese E, Trettene MS, Minuz P et al. Effects of magnesium supplements on blood pressure, endothelial function and metabolic parameters in healthy young men with a family history of metabolic syndrome. Nutr Metab Cardiovasc Dis. 2014;24(11):1213–1220. https://doi.org/10.1016/j.numecd.2014.05.010.Rangel H, Abad C, Chiarello DI, Rojas D, Proverbio F, Marín R. Can magnesium gluconate be used as an alternative therapy for preeclampsia? Physiol Mini Rev. 2022;15(4):39–46. Available at: https://sedici.unlp.edu.ar/bitstream/handle/10915/140990/Documento_completo.pdf?sequence=1.Rangel H, Abad C, Chiarello DI, Rojas D, Proverbio F, Marín R. Can magnesium gluconate be used as an alternative therapy for preeclampsia? Physiol Mini Rev. 2022;15(4):39–46. Available at: https://sedici.unlp.edu.ar/bitstream/handle/10915/140990/Documento_completo.pdf?sequence=1.

The authors declare that there are no conflicts of interest present.