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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-468</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE</subject></subj-group></article-categories><title-group><article-title>Экспериментальное исследование интерстициального воздействия полупроводникового лазера с длиной волны 445 нм на биологическую модель</article-title><trans-title-group xml:lang="en"><trans-title>Experimental study of the interstitial effect of a semiconductor laser with a wavelength of 445 nm on a biological model</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0937-5370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Никита Игоревич - аспирант научно-исследовательского отдела патологии верхних дыхательных путей.</p><p>190013, Санкт-Петербург, ул. Бронницкая, д. 9</p></bio><bio xml:lang="en"><p>Nikita I. Ivanov - Postgraduate Student of the Department for Development and Implementation of New High-Tech Treatment Methods.</p><p>9, Bronnitskaya St., St Petersburg, 190013</p></bio><email xlink:type="simple">Chicago_96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2316-6279</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Захарова Галина Порфирьевна - д.м.н., ведущий научный сотрудник научно-исследовательского отдела патологии верхних дыхательных.</p><p>190013, Санкт-Петербург, ул. Бронницкая, д. 9</p></bio><bio xml:lang="en"><p>Galina P. Zakharova - Dr. Sci. (Med.), Leading Researcher of the Department for Development and Implementation of New High-Tech Treatment Methods.</p><p>9, Bronnitskaya St., St Petersburg, 190013</p></bio><email xlink:type="simple">GalinaZaharovaLOR@yandex.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8168-2343</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабалин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabalin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабалин Владимир Владимирович - д.б.н., старший научный сотрудник научно-исследовательского отдела патологии верхних дыхательных путей.</p><p>190013, Санкт-Петербург, ул. Бронницкая, д. 9</p></bio><bio xml:lang="en"><p>Vladimir V. Shabalin - Dr. Sci. (Biol.), Leading Researcher of the Department for Development and Implementation of New High-Tech Treatment Methods.</p><p>9, Bronnitskaya St., St Petersburg, 190013</p></bio><email xlink:type="simple">vvshabalin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7811-9835</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гайдуков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaidukov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гайдуков Станислав Сергеевич - научный сотрудник научно-исследовательского отдела патологии верхних дыхательных путей.</p><p>190013, Санкт-Петербург, ул. Бронницкая, д. 9</p></bio><bio xml:lang="en"><p>Stanislav S. Gaidukov - Researcher of the Department for Development and Implementation of New High-Tech Treatment Methods.</p><p>9, Bronnitskaya St., St Petersburg, 190013</p></bio><email xlink:type="simple">s.gajdukov@niilor.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Research Institute of Ear, Throat, Nose and Speech</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2024</year></pub-date><volume>0</volume><issue>23</issue><fpage>369</fpage><lpage>374</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванов Н.И., Захарова Г.П., Шабалин В.В., Гайдуков С.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Иванов Н.И., Захарова Г.П., Шабалин В.В., Гайдуков С.С.</copyright-holder><copyright-holder xml:lang="en">Ivanov N.I., Zakharova G.P., Shabalin V.V., Gaidukov S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8039">https://www.med-sovet.pro/jour/article/view/8039</self-uri><abstract><sec><title>Введение</title><p>Введение. В настоящем исследовании представлены результаты интерстициального воздействия полупроводникового лазера с длиной волны 445 нм на биологические образцы ткани при различной мощности импульсной волны в постоянном режиме при контактном способе.</p></sec><sec><title>Цель</title><p>Цель. Изучить интерстициальное воздействие полупроводникового лазера с длиной волны 445 нм на экспериментальных образцах ткани в постоянном режиме при различной мощности.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В качестве экспериментального образца нами использовалась биологическая ткань с развитой сосудистой структурой в виде свиной печени. Источником лазерного излучения служил полупроводниковый лазер с длиной волны 445 нм, с диапазоном мощности от 0,5 до 4 вт. При работе с биологическими образцами ткани мы оценивали их наружные и внутренние изменения после воздействия лазера. Время экспозиции при интерстициальном воздействии составляло 1 мм/с при глубине погружения лазерного волокна в ткань на 20 мм. Результаты воздействия лазера оценивали по макро-и микроскопической картине экспериментальных образцов с использованием гистологического исследования и морфометрии зон деструкции и коагуляционного некроза, на поперечном разрезе ткани.</p></sec><sec><title>Результаты</title><p>Результаты. Экспериментальное исследование свидетельствует, что интерстициальное применение лазера оказывает выраженное коагуляционное, сочетающееся с режущим воздействие на экспериментальные ткани. Оптимальное сочетание коагуляционного и режущего эффекта воздействия сопровождается визуальной сократимостью ткани без избыточной карбонизации при мощности 3,0 Вт.</p></sec><sec><title>Заключение</title><p>Заключение. Применение интерстициального воздействия полупроводникового лазера с длиной волны 445 нм на экспериментальных образцах ткани в постоянном режиме при различной мощности обнаружило преобладание коагуляционного эффекта в сочетании с режущим при выраженном сокращении объема ткани. Эксперименты показали, что мощность 3 Вт является оптимальной мощностью лазерного воздействия при интерстициальном способе, при которой наступает выраженное сокращение объема исследуемого препарата без избыточной карбонизации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. This study presents the results of interstitial exposure of a semiconductor laser with a wavelength of 445 nm to biological tissue samples at different pulsed wave power in a constant mode, with a contact method.</p></sec><sec><title>Aim</title><p>Aim. To study the interstitial effect of a semiconductor laser with a wavelength of 445 nm on experimental tissue samples in a constant mode at different power.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. As an experimental sample, we used biological tissue with a developed vascular structure in the form of pig liver. The source of laser radiation was a semiconductor laser with a wavelength of 445 nm, with a power range from 0.5 to 4 watts. When working with biological tissue samples, we evaluated their external and internal changes after laser exposure. The exposure time during interstitial exposure was 1 mm/sec with a 20 mm immersion depth of the laser fiber into the fabric. The results of the macro and microscopic picture were evaluated using histological examination and morphometry of the zones of destruction and coagulation necrosis, on a transverse section of the tissue.</p></sec><sec><title>Results</title><p>Results. The results of an experimental study indicate that interstitial laser exposure has a pronounced coagulation effect combined with a cutting effect. The optimal combination of coagulation and cutting effect of exposure, accompanied by visual contractility of the tissue, without excessive carbonation at a power of 3.0 watts.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of interstitial exposure of a semiconductor laser with a wavelength of 445 nm on experimental tissue samples in a constant mode at different power showed the predominance of the coagulation effect in combination with the cutting effect with a pronounced reduction in tissue volume. Experiments have shown that the power of 3 W is the optimal power of laser exposure in the interstitial method, in which there is a pronounced reduction in the volume of the studied drug without excessive carbonation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>биологическая ткань</kwd><kwd>свиная печень</kwd><kwd>коагуляционное воздействие</kwd><kwd>режущий эффект</kwd><kwd>избыточная карбонизация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>experimental study</kwd><kwd>biological tissue</kwd><kwd>pig liver</kwd><kwd>coagulation effect</kwd><kwd>cutting effect</kwd><kwd>excess carbonation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пискунов ГЗ. Физиология и патофизиология носа и околоносовых пазух. Российская ринология. 2017;25(3):51–57. https://doi.org/10.17116/rosrino201725351-57.</mixed-citation><mixed-citation xml:lang="en">Piskunov GZ. 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