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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2023-499</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8090</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>Ожирение и нарушения менструального цикла у девочек-подростков: есть ли взаимное влияние?</article-title><trans-title-group xml:lang="en"><trans-title>Obesity and abnormal uterine bleeding in adolescent girls: is there a relationship?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4013-0785</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Ирина Леоровна, д.м.н., профессор, заведующая кафедрой детских болезней с клиникой лечебного факультета Института медицинского образования</p><p>97341, Санкт-Петербург, ул. Аккуратова, д. 2 </p></bio><bio xml:lang="en"><p>Irina L. Nikitina, Dr. Sci. (Med.), Professor, Head of the Department of Children’s Diseases with the Clinic of the Medical Faculty of the Institute of Medical Education</p><p>2, Akkuratov St., St Petersburg, 197341</p></bio><email xlink:type="simple">nikitina0901@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0307-5553</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лискина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Liskina</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лискина Анастасия Сергеевна, ассистент кафедры детских болезней с клиникой лечебного факультета Института медицинского образования, научный сотрудник научно-исследовательской лаборатории детской эндокринологии Института эндокринологии</p><p>97341, Санкт-Петербург, ул. Аккуратова, д. 2 </p></bio><bio xml:lang="en"><p>Anastasiya S. Liskina, Assistant of the Department of Children’s Diseases with the Clinic of the Medical Faculty of the Institute of Medical Education, Researcher at the Research Laboratory of Pediatric Endocrinology of the Institute of Endocrinology</p><p>2, Akkuratov St., St Petersburg, 197341</p></bio><email xlink:type="simple">anastoz@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4449-2786</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кельмансон</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kelmanson</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кельмансон Игорь Александрович, д.м.н., профессор кафедры детских болезней с клиникой лечебного факультета Института медицинского образования</p><p>97341, Санкт-Петербург, ул. Аккуратова, д. 2 </p></bio><bio xml:lang="en"><p>Igor A. Kelmanson, Dr. Sci. (Med.), Professor of the Department of Children’s Diseases with the Clinic of the Medical Faculty of the Institute of Medical Education</p><p>2, Akkuratov St., St Petersburg, 197341</p></bio><email xlink:type="simple">iakelmanson@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-9183-2912</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Купцова</surname><given-names>П. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuptsova</surname><given-names>P. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Купцова Полина Николаевна, клинический ординатор детских болезней с клиникой лечебного факультета Института медицинского образования</p><p>97341, Санкт-Петербург, ул. Аккуратова, д. 2 </p></bio><bio xml:lang="en"><p>Polina N. Kuptsova, Clinical Resident of Children’s Diseases with the Clinic of the Medical Faculty of the Institute of Medical Education</p><p>2, Akkuratov St., St Petersburg, 197341</p></bio><email xlink:type="simple">polina.kuptsova.1999@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр имени В.А. Алмазова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>26</day><month>02</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><elocation-id>144–151</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Никитина И.Л., Лискина А.С., Кельмансон И.А., Купцова П.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Никитина И.Л., Лискина А.С., Кельмансон И.А., Купцова П.Н.</copyright-holder><copyright-holder xml:lang="en">Nikitina I.L., Liskina A.S., Kelmanson I.A., Kuptsova P.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8090">https://www.med-sovet.pro/jour/article/view/8090</self-uri><abstract><sec><title>Введение</title><p>Введение. Ожирение носит характер неинфекционной пандемии и является серьезной проблемой во всем мире. По мере увеличения распространенности детского ожирения появляется все больше доказательств связи между ожирением и факторами риска нарушений менструального цикла.</p></sec><sec><title>Цель</title><p>Цель. Изучить влияние немедикаментозной терапии ожирения на характеристику менструального цикла у девочек подросткового возраста.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Группа 1 (40 человек) – с ожирением и нарушением менструального цикла. Группа 2 (40 человек) – с ожирением и регулярным менструальным циклом. Проводилась оценка антропометрических данных, сбор наследственного анамнеза, анамнеза жизни, анализ дневников менструального цикла. Всем девочкам были даны рекомендации, направленные на снижение массы тела, через 12 мес. проведена оценка динамики веса и характера менструального цикла.</p></sec><sec><title>Результаты</title><p>Результаты. Увеличение массы тела на каждый 1 кг, прибавленный за 12 мес., существенно повышает риск возникновения нарушений менструального цикла: отношение шансов 1,45 (95% ДИ: 1,11–1,88), p = 0,005. Увеличение индекса массы тела на 1 единицу за 12 мес. существенно увеличивает риск возникновения нарушений менструального цикла: отношение шансов 1,70 (95% ДИ: 1,28–2,24), p = 0,001, аналогичным образом снижаясь при соответствующем снижении индекса массы тела.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Риск нарушений менструального цикла связан с динамическим изменением массы тела: при нарастании массы тела в течение года шансы нарушений менструального цикла на каждый прибавленный 1 кг возрастают в 1,45 раза, во столько же раз снижаясь при соответствующем снижении массы. При увеличении индекса массы тела на каждую прибавленную единицу за год шансы нарушения менструального цикла возрастают в 1,7 раза, во столько же раз снижаясь при соответствующем снижении индекса массы тела.</p></sec><sec><title>Выводы</title><p>Выводы. Динамические изменения массы тела могут иметь как позитивный, так и негативный эффект на прогноз нарушений менструального цикла, что обуславливает большую важность терапевтических усилий, направленных на снижение массы тела.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Obesity is a non-communicable pandemic and a major problem worldwide. As the prevalence of childhood obesity increases, there is growing evidence of an association between obesity and risk factors for menstrual disorders.</p></sec><sec><title>Aim</title><p>Aim. To study the role of obesity treatment in shaping menstrual disorders in adolescent girls.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Group: with obesity and menstrual cycle disorders. Group 2: obese and regular menstrual cycle. An assessment of anthropometric data, collection of hereditary history, life history, and analysis of data from menstrual cycle diaries were carried out. All girls were given recommendations aimed at reducing body weight, and after 12 months, weight dynamics and the nature of the menstrual cycle were assessed.</p></sec><sec><title>Results</title><p>Results. An increase in body weight for every 1 kilogram added over 12 months significantly increases the risk of menstrual cycle disorders: the odds ratio is 1.45 (95% CI: 1.11–1.88), p = 0.005. An increase in body mass index by 1 unit over 12 months significantly increases the risk of menstrual cycle disorders: the odds ratio is 1.70 (95% CI: 1.28–2.24), p = 0.001, similarly decreasing with a corresponding decrease in body mass index.</p></sec><sec><title>Discussion</title><p>Discussion. The risk of menstrual cycle disorders is associated with a dynamic change in body weight: with an increase in body weight during the year, the chances of menstrual cycle disorders for every 1 kg added increase by 1.45 times, decreasing by the same number of times with a corresponding decrease in weight. With an increase in body mass index for each added unit per year, the chances of menstrual cycle disorders increase by 1.7 times, decreasing by the same number of times with a corresponding decrease in body mass index.</p></sec><sec><title>Conclusions</title><p>Conclusions. Dynamic changes in body weight can have both a positive and a negative effect on the prognosis of menstrual cycle disorders, which determines the great importance of therapeutic efforts aimed at reducing body weight.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>нарушение менструального цикла</kwd><kwd>менструальный цикл</kwd><kwd>индекс массы тела</kwd><kwd>ожирение</kwd><kwd>девочки-подростки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>menstrual cycle disorders</kwd><kwd>menstrual cycle</kwd><kwd>body mass index</kwd><kwd>obesity</kwd><kwd>adolescent girls</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, Flegal KM. Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988–1994 Through 2013–2014. 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