medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-017medsovet-8127Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESСовременные реалии коррекции нарушений кожного барьера при различных заболеванияхModern realities of correction of skin barrier disorders in various diseaseshttps://orcid.org/0000-0001-5723-6573ЖуковаО. В.ZhukovaO. V.

Жукова Ольга Валентиновна - д.м.н., профессор, заведующая кафедрой дерматовенерологии, аллергологии и косметологии медицинского института, РУДН им. Патриса Лумумбы; главный врач, МНПЦДК.

117198, Москва, ул. Миклухо-Маклая, д. 6; 119071, Москва, Ленинский проспект, д. 17

Olga V. Zhukova - Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia; Chief Medical Officer, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology.

6, Miklukho-Maklaya St., Moscow, 117198; 17, Leninskiy Ave., Moscow, 119071

klinderma@inbox.ruhttps://orcid.org/0000-0001-9643-0440ТерещенкоГ. П.TereshchenkoG. P.

Терещенко Галина Павловна - к.м.н., к.м.н., доцент кафедры дерматовенерологии, аллергологии и косметологии медицинского института, РУДН им. Патриса Лумумбы; врач-дерматовенеролог, аллерголог-иммунолог, МНПЦДК.

117198, Москва, ул. Миклухо-Маклая, д. 6; 119071, Москва, Ленинский проспект, д. 17

Galina P. Tereshchenko - Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia; Dermatologist, Allergologist-Immunologist, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology.

6, Miklukho-Maklaya St., Moscow, 117198; 17, Leninskiy Ave., Moscow, 119071

gala_ter@mail.ruhttps://orcid.org/0000-0002-0767-8821КасихинаЕ. И.KasikhinaE. I.

Касихина Елена Игоревна - к.м.н., доцент кафедры дерматовенерологии, аллергологии и косметологии медицинского института, РУДН им. Патриса Лумумбы; врач-дерматовенеролог, МНПЦДК.

117198, Москва, ул. Миклухо-Маклая, д. 6; 119071, Москва, Ленинский проспект, д. 17

Elena I. Kasikhina - Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia; Dermatologist, Allergologist-Immunologist, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology.

6, Miklukho-Maklaya St., Moscow, 117198; 17, Leninskiy Ave., Moscow, 119071

kasprof@bk.ruhttps://orcid.org/0000-0003-3386-1467ОстрецоваМ. Н.OstretsovaM. N.

Острецова Мария Николаевна - к.м.н., доцент кафедры дерматовенерологии, аллергологии и косметологии медицинского института.

117198, Москва, ул. Миклухо-Маклая, д. 6

Maria N. Ostretsova - Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia.

6, Miklukho-Maklaya St., Moscow, 117198

ostretsova-mn@rudn.ruhttps://orcid.org/0000-0002-0909-482XНемерА. А.M.NemerA. A.M.

Немер Алаа А.М. - ассистент кафедры общей патологии и патологической физиологии имени В.А. Фролова.

117198, Москва, ул. Миклухо-Маклая, д. 6

Alaa A.M. Nemer - Teaching Assistant, Department of General Pathology and Pathological Physiology named after V.A. Frolov, Peoples’ Friendship University of Russia.

6, Miklukho-Maklaya St., Moscow, 117198

dr.alaa.nemer@gmail.comМосковский научно-практический центр дерматовенерологии и косметологии; Российский университет дружбы народов имени Патриса ЛумумбыРоссияMoscow Scientific and Practical Center of Dermatovenereology and Cosmetology; Peoples’ Friendship University of RussiaRussian FederationРоссийский университет дружбы народов имени Патриса ЛумумбыРоссияPeoples’ Friendship University of RussiaRussian Federation202407032024021927Copyright © Жукова О.В., Терещенко Г.П., Касихина Е.И., Острецова М.Н., Немер А.А., 20242024Жукова О.В., Терещенко Г.П., Касихина Е.И., Острецова М.Н., Немер А.А.Zhukova O.V., Tereshchenko G.P., Kasikhina E.I., Ostretsova M.N., Nemer A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8127

Ксероз кожи является распространенным симптомом, свидетельствующим о нарушениях барьерной функции кожи. Такие заболевания, как атопический дерматит (АтД) и ихтиоз, связаны с генетическими мутациями генов эпидермальной дифференцировки, при других заболеваниях (контактные дерматиты, экзема) нарушения эпидермального барьера возникают в результате воспалительного процесса в коже, механического или химического повреждения, значительно влияя на течение патологического процесса. В статье освещены современные данные о значении основного структурного белка рогового слоя филаггрина (FLG) и роли его дефицита не только при дерматологических заболеваниях, но и в формировании гиперреактивности. Основными способами коррекции нарушений кожного барьера является применение эмолентов, которые относятся к методам базисной терапии при АтД и рекомендуются к применению в комплексной терапии других патологических состояний, сопровождающихся явлениями ксероза. На сегодняшний день разработан инновационный метод, позволяющий не только замещать дефицит FLG, но и активировать собственные ресурсы и стимулировать синтез белка в коже. В связи с этим представляет интерес уникальное средство дерматокосметики Адмера, относящееся к категории «эмоленты плюс» за счет сочетания в себе всех необходимых свойств эмолента и наличия модулятора синтеза FLG филагринола. Филагринол представляет собой запатентованный комплекс активных веществ, которые активируют ферменты, участвующие в дефосфорилировании предшественника FLG профилаггрина, и увеличивают концентрацию в клетках зернистого слоя гликопротеина, богатого гистидином, участвующим в формировании цитоскелета рогового слоя. В статье представлен обзор клинических исследований по эффективности крема Адмера и приводится собственный клинический опыт его применения у пациентов с АтД и экземой кистей.

Skin xerosis is a common symptom that indicates of impaired skin barrier function. Such diseases as atopic dermatitis (AD) and ichthyosis are associated with genetic mutations of epidermal differentiation genes, while in other diseases (contact dermatitis, eczema) epidermal barrier disorders occur as a result of inflammatory process in the skin, mechanical or chemical damage, significantly affecting the course of the pathological process. The article highlights modern data on the importance of the main structural protein of the stratum corneum filaggrin (FLG) and the role of its deficiency not only in dermatologic diseases, but also in the development of hyperresponsiveness. The main methods of correction of skin barrier disorders are emollients, which belong to the methods of basic therapy in AD and are recommended for the complex therapy of other pathological conditions accompanied by xerosis. At the present time, an innovative method has been developed, that allows not only to replace FLG deficiency, but also to activate and stimulate protein synthesis in the skin. In this regard, a unique dermatocosmetics product “Admera”, which belongs to the category of “emollients plus” due to the combination of all the necessary properties of the emollient and the presence of FLG synthesis modulator filagrinol, is of interest. Filagrinol is a proprietary complex of active ingredients that activate enzymes involved in dephosphorylation of the FLG predecessor profilaggrin and increase the concentration in the stratum granulosum сells of a histidine-rich glycoprotein, involved in the formation of the stratum corneum cytoskeleton. The article presents a review of clinical studies on the efficacy of Admera cream and presents our own clinical experience of its use in patients with AD and hand eczema.

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The authors declare that there are no conflicts of interest present.