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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-016</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ КОЖИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Проблема терапии акне и розацеа у женщин репродуктивного возраста</article-title><trans-title-group xml:lang="en"><trans-title>The problem of treating acne and rosacea in women of reproductive age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5896-7455</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мильдзихова</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Mildzikhova</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мильдзихова Дзерасса Руслановна - младший научный сотрудник, косметолог, дерматолог.</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p></bio><bio xml:lang="en"><p>Dzerassa R. Mildzikhova - Junior Researcher, Cosmetologist, Dermatologist, Center for Theoretical Problems of Physico-Chemical Pharmacology RAS.</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029</p></bio><email xlink:type="simple">dzerasska@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2027-5987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сакания</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sakaniya</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сакания Луиза Руслановна - к.м.н., старший научный сотрудник, врач-дерматовенеролог, ЦТП ФХФ РАН; врач-дерматовенеролог, косметолог, трихолог, МНПЦДК.</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30; 127473, Москва, ул. Селезневская, д. 20</p></bio><bio xml:lang="en"><p>Luiza R. Sakaniya - Cand. Sci. (Med.), Senior Researcher, Dermatovenerologist, Center for Theoretical Problems of Physico-Chemical Pharmacology RAS; Dermatovenerologist, Cosmetologist, Trichologist, Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology.</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029; 20, Seleznevskaya St., Moscow, 127473</p></bio><email xlink:type="simple">sakania.luiz@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2758-4002</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Церикидзе</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tserikidze</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Церикидзе Наталья Георгиевна - врач-дерматокосметолог.</p><p>127473, Москва, ул. Селезневская, д. 20</p></bio><bio xml:lang="en"><p>Natalia G. Tserikidze - Dermatocosmetologist, Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology.</p><p>20, Seleznevskaya St., Moscow, 127473</p></bio><email xlink:type="simple">gn998@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-0318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корсунская</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korsunskaya</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корсунская Ирина Марковна - д.м.н., профессор, заведующая лабораторией.</p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p></bio><bio xml:lang="en"><p>Irina M. Korsunskaya - Dr. Sci. (Med.), Professor, Head of Laboratory, Center for Theoretical Problems of Physico-Chemical Pharmacology RAS.</p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029</p></bio><email xlink:type="simple">marykor@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр теоретических проблем физико-химической фармакологии РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Theoretical Problems of Physico-Chemical Pharmacology RAS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Центр теоретических проблем физико-химической фармакологии РАН; Московский научно-практический центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Theoretical Problems of Physico-Chemical Pharmacology RAS; Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Московский научно-практический центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>07</day><month>03</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>54</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мильдзихова Д.Р., Сакания Л.Р., Церикидзе Н.Г., Корсунская И.М., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Мильдзихова Д.Р., Сакания Л.Р., Церикидзе Н.Г., Корсунская И.М.</copyright-holder><copyright-holder xml:lang="en">Mildzikhova D.R., Sakaniya L.R., Tserikidze N.G., Korsunskaya I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8130">https://www.med-sovet.pro/jour/article/view/8130</self-uri><abstract><p>Довольно часто женщины репродуктивного возраста обращаются к специалисту с такими проблемами, как акне и розацеа. Терапия данных заболеваний в этой группе пациенток имеет свои особенности. Так, например, изотретиноин может быть назначен только по ряду показаний и в сочетании с высокоэффективными методами контрацепции ввиду тератогенности препарата. Также стоит отметить, что среди беременных достаточно высока распространенность акне – до 43% по данным различных исследований. В основном симптомы заболевания проявляются во втором и третьем триместре. Выбор терапии для этих пациенток ограничен и включает в основном топические средства. Тактика терапии акне у женщин, планирующих беременность, схожа с таковой у беременных. В зарубежных исследованиях отмечается взаимосвязь розацеа с гормональными и репродуктивными факторами. Так, заболевание часто развивается в пременопаузе, также риск развития розацеа повышен у нерожавших и женщин с поздним возрастом первых и последних родов. В своей практике в качестве топического антибиотика мы часто назначаем 1%-й раствор клиндамицина. Препарат легко наносится и не заметен на коже после применения. Существенным преимуществом раствора перед препаратами других групп является отсутствие развития фотосенсибилизации, что позволяет использовать препарат в периоды повышенной солнечной активности (в частности, в весенне-летний период). Это также важно для пациенток с розацеа, поскольку известно, что ультрафиолетовое излучение является одним из усугубляющих заболевание факторов. Ряд принципов ведения и алгоритм терапии пациенток репродуктивного возраста, страдающих от акне и розацеа, приведенные в данной работе, помогут специалистам подобрать оптимальное и безопасное лечение с учетом репродуктивных планов женщины.</p></abstract><trans-abstract xml:lang="en"><p>Often enough, women of reproductive age make medical appointments for problems such as acne and rosacea. Treatment of these diseases in this group of patients has unique features. For example, isotretinoin can only be administered for some indications and in combination with most effective contraceptive methods due to its teratogenicity. Also worth noting is that acne prevalence rates among pregnant women are quite high – up to 43% according to various studies. In fact, symptoms of the disease develop during the second and third trimesters. The choice of therapy for these patients is limited and mainly includes topical drugs. The acne management strategies in women planning pregnancy are similar to that in pregnant women. Foreign studies show the relationship between rosacea and hormonal and reproductive factors. Thus, the disease often develops in premenopause; the risk of developing rosacea is also increased in nulliparous women and women delivering their first and last child at an older age. In our practice, we often prescribe a 1% clindamycin solution as a topical antibiotic. The drug is easy to apply and is not visible on the skin after its use. Absence of drug-induced photosensitivity is a significant advantage of the solution over drugs from other groups, which allows using the drug during periods of high solar activity (in particular, in spring and summer). This is also important for patients with rosacea, as exposure to ultraviolet light is one of the factors known to aggravate the disease. A number of management strategies and treatment algorithm for patients of reproductive age suffering from acne and rosacea that are provided in this work will help physicians to select the optimal and safe treatment with due account for reproductive life plans.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акне</kwd><kwd>розацеа</kwd><kwd>репродуктивный возраст</kwd><kwd>беременность</kwd><kwd>фотосенсибилизация</kwd><kwd>клиндамицин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acne</kwd><kwd>rosacea</kwd><kwd>reproductive age</kwd><kwd>pregnancy</kwd><kwd>photosensitivity</kwd><kwd>Clindamycin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dréno B, Thiboutot D, Layton AM, Berson D, Perez M, Kang S. Large-scale international study enhances understanding of an emerging acne population: adult females. 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