medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-040medsovet-8181Research ArticleПРЕГРАВИДАРНАЯ ПОДГОТОВКА И БЕРЕМЕННОСТЬPREGRAVID PREPARATION AND PREGNANCYДефицит железа у беременной: влияние на нервно-психическое развитие у потомстваIron deficiency in pregnant women: effect on offspring neuropsychic developmenthttps://orcid.org/0000-0001-6711-1563СоловьеваА. В.SolovyevaA. V.

Соловьева Алина Викторовна, д.м.н., доцент кафедры акушерства и гинекологии с курсом перинатологии

117198, Москва, ул. Миклухо-Маклая, д. 8

Alina V. Solovyeva, Dr. Sci. (Med.), Associate Professor of the Department of Obstetrics and Gynecology with Perinatology Module

8, Miklukho-Maklai St., Moscow, 117198

av_soloveva@mail.ruhttps://orcid.org/0000-0002-1434-0386АлейниковаЕ. Ю.AleynikovaE. Yu.

Алейникова Екатерина Юрьевна, аспирант кафедры акушерства и гинекологии с курсом перинатологии

117198, Москва, ул. Миклухо-Маклая, д. 8

Ekaterina Yu. Aleynikova, Postgraduate Student of the Department of Obstetrics and Gynecology with Perinatology Module

8, Miklukho-Maklai St., Moscow, 117198

ketall@mail.ruhttps://orcid.org/0009-0005-3745-0042СпицынаМ. А.SpitsynaM. A.

Спицына Мария Александровна, аспирант кафедры акушерства и гинекологии с курсом перинатологии

117198, Москва, ул. Миклухо-Маклая, д. 8

Maria A. Spitsyna, Postgraduate Student of the Department of Obstetrics and Gynecology with Perinatology Module

8, Miklukho-Maklai St., Moscow, 117198

lotyreva31@gmail.comhttps://orcid.org/0000-0003-1362-2979ГуленковаК. А.GulenkovaK. A.

Гуленкова Кристина Артуровна, клинический ординатор кафедры акушерства и гинекологии с курсом перинатологии

117198, Москва, ул. Миклухо-Маклая, д. 8

Kristina A. Gulenkova, Clinical Resident of the Department of Obstetrics and Gynecology with Perinatology Module

8, Miklukho-Maklai St., Moscow, 117198

oneil98@mail.ruhttps://orcid.org/0009-0004-2401-632XДжафароваА. М.JafarovaA. M.

Джафарова Аян Маис-кызы, клинический ординатор кафедры акушерства и гинекологии с курсом перинатологии

117198, Москва, ул. Миклухо-Маклая, д. 8

Ayan M. Jafarova, Clinical Resident of the Department of Obstetrics and Gynecology with Perinatology Module

8, Miklukho-Maklai St., Moscow, 117198

dzhafarova_ayana@mail.ruМедицинский институт Российского университета дружбы народов имени Патриса ЛумумбыРоссияInstitute of Medicine of Peoples’ Friendship University of Russia named after Patrice LumumbaRussian Federation202401052024049297Copyright © Соловьева А.В., Алейникова Е.Ю., Спицына М.А., Гуленкова К.А., Джафарова А.М., 20242024Соловьева А.В., Алейникова Е.Ю., Спицына М.А., Гуленкова К.А., Джафарова А.М.Solovyeva A.V., Aleynikova E.Y., Spitsyna M.A., Gulenkova K.A., Jafarova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8181

Все больше данных указывает на то, что неблагоприятные факторы во внутриутробном и раннем возрасте у детей могут оказывать длительное воздействие на физиологическое и психическое здоровье не только в детстве, но и во взрослом возрасте. Дефицит микроэлементов, и в частности дефицит железа, – один из наиболее значимых факторов. Цель работы – на основании литературных данных определить влияние дефицита железа у беременной на нервно-психическое развитие младенцев, а также определить когорту беременных, нуждающихся в назначении добавок железа. Поиск проводился в MEDLINE (от PubMed), EMBASE (от OVID), Cochrane Library и ClinicalTrials.gov с 2010 г. до декабря 2023 г. без языковых ограничений. Были извлечены и систематизированы данные, связанные с уровнем железа у беременных и перинатальных исходов. Первичные исходы включали дефицит железа, сывороточный ферритин менее 15 мкг/л у беременных женщин, перинатальные исходы, развитие детей в младенчестве. Показатели сывороточного ферритина в пуповинной крови у новорожденных в сравнении с показателями сывороточного ферритина матерей. Добавки железа, влияние на перинатальные исходы. Ежедневный пероральный прием добавок железа во время беременности у женщин без железодефицитной анемии (ЖДА) и дефицита железа (ДЖ) снижает частоту железодефицитной анемии к сроку родов у женщины, уменьшает частоту дефицита железа у доношенных новорожденных и заболеваемость младенцев с низкой массой тела при рождении. Добавки железа во время беременности и в послеродовом периоде – стратегия своевременного восполнения ДЖ и предотвращения ЖДА – снижают церебральный дефицит железа у плода и новорожденного. Отсутствие побочных эффектов, высокая биодоступность, усиленная аскорбиновой кислотой, делают возможным применение SunActive®Fe Боноферлат в качестве ежедневной добавки беременным и кормящим женщинам согласно рекомендации ВОЗ.

Increasing evidence indicates that adversities in utero and early childhood can have long-lasting effects on physiological and mental health not only in childhood but also in adulthood. Micronutrient deficiency, and in particular iron deficiency, is one of the most significant factors. Based on literature data, to determine the effect of iron deficiency in pregnant women on the neuropsychological development of infants, as well as to determine a cohort of pregnant women who need iron supplements. The search was conducted in MEDLINE (from PubMed), EMBASE (from OVID), Cochrane Library and ClinicalTrials.gov from 2010 to December 2023 without language restrictions. Data were extracted. Primary outcomes included iron deficiency, serum ferritin less than 15 μg/L in pregnant women, perinatal outcomes, and development of children in infancy. The data of serum ferritin in umbilical cord blood in newborns were compared with the serum ferritin of mothers. Data on iron supplementation and its effect on perinatal outcomes were assessed. Daily oral iron supplementation during pregnancy in women without IDA or ID reduces the incidence of iron deficiency anemia at the woman’s due date, reduces the incidence of iron deficiency in fullterm neonates, and reduces the incidence of morbidity in low-birth-weight infants. Iron supplementation during pregnancy and the postpartum period is a strategy for timely replenishment of ID and prevention of IDA to reduce cerebral iron deficiency in the fetus and newborn. The absence of side effects and high bioavailability, enhanced by ascorbic acid, allow us to recommend SunActive®Fe Bonoferlat as a daily supplement for pregnant and lactating women, according to WHO recommendations.

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The authors declare that there are no conflicts of interest present.