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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-151</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8188</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROPSYCHIATRIC DISORDERS</subject></subj-group></article-categories><title-group><article-title>Ассоциация между мочеполовыми инфекциями матери и риском развития синдрома дефицита внимания с гиперактивностью и расстройств аутистического спектра у детей по данным систематического обзора</article-title><trans-title-group xml:lang="en"><trans-title>Association between maternal genitourinary infections and the risk of attention deficit hyperactivity disorder and autism spectrum disorder in children according to a systematic review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-4220-0315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исаева Полина Сергеевна, студент педиатрического факультета</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Polina S. Isaeva, Student of the Pediatric Faculty</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><email xlink:type="simple">coronoidea.1448@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-2837-8154</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муршудли</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Murshudli</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муршудли Минара Рашадовна, студент педиатрического факультета</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Minara R. Murshudli, Student of the Pediatric Faculty</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><email xlink:type="simple">mmurshudli@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-6579-8299</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Струкова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Strukova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Струкова Алина Викторовна, студент Института клинической медицины</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 1</p></bio><bio xml:lang="en"><p>Alina V. Strukova, Student of the Institute of Clinical Medicine</p><p>8, Bldg. 1, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">al.stk1984@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7453-0230</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Забродин</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zabrodin</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Забродин Никита Александрович, студент факультета клинической психологии</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 1</p></bio><bio xml:lang="en"><p>Nikita A. Zabrodin, Student of the Faculty of Clinical Psychology</p><p>8, Bldg. 1, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">zabrodin.2001@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2228-6316</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петелин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petelin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петелин Дмитрий Сергеевич, к.м.н., врач-психотерапевт клиника нервных болезней им. А.Я. Кожевникова, ассистент кафедры психиатрии и психосоматики</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 1</p></bio><bio xml:lang="en"><p>Dmitry S. Petelin, Cand. Sci. (Med.), Psychotherapist of the Kozhevnikov Clinic of Nervous Diseases, Assistant at the Department of Psychiatry and Psychosomatics</p><p>8, Bldg. 1, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">petelinhome1@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>02</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>3</issue><fpage>80</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Исаева П.С., Муршудли М.Р., Струкова А.В., Забродин Н.А., Петелин Д.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Исаева П.С., Муршудли М.Р., Струкова А.В., Забродин Н.А., Петелин Д.С.</copyright-holder><copyright-holder xml:lang="en">Isaeva P.S., Murshudli M.R., Strukova A.V., Zabrodin N.A., Petelin D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8188">https://www.med-sovet.pro/jour/article/view/8188</self-uri><abstract><sec><title>Введение</title><p>Введение. Расстройства аутистического спектра и синдром дефицита внимания с гиперактивностью относятся к числу наиболее значимых и широко распространенных психических расстройств, манифестирующих в детском и подростковом возрасте. Их этиология и патогенез изучены недостаточно, и, скорее всего, к их формированию приводит комплекс факторов. В числе прочего накапливаются данные о роли различных вредностей и заболеваний матери, которые повышают риск формирования нейропсихических расстройств у потомства. В их числе – мочеполовые инфекции, вклад которых в развитие расстройств аутистического спектра и синдрома дефицита внимания с гиперактивностью до сих пор систематически не изучался.</p></sec><sec><title>Цель</title><p>Цель. Установить вклад материнских мочеполовых инфекций в формирование у детей расстройств аутистического спектра и синдрома дефицита внимания с гиперактивностью.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Был проведен электронный поиск в базах данных Scopus и PubMed для получения соответствующей литературы до августа 2022 г. Стратегия поиска включала комбинацию ключевых слов и MESH-терминов: «урогенитальные инфекции», «аутизм», «расстройства аутистического спектра», «синдром дефицита внимания с гиперактивностью» и «материнские инфекции».</p></sec><sec><title>Результаты</title><p>Результаты. В доступной литературе было идентифицировано 10 работ на данную тематику: 6 посвящены расстройствам аутистического спектра и 4 – синдрому дефицита внимания с гиперактивностью. Во всех включенных в анализ работах по синдрому дефицита внимания с гиперактивностью была выявлена ассоциация между мочеполовыми инфекциями и нейропсихическим расстройствам. При расстройствах аутистического спектра полученные данные были более противоречивыми. Гетерогенность доступных сведений (разный дизайн, различные определения и подходы к диагностике мочеполовых инфекций) не позволила провести метаанализ.</p></sec><sec><title>Заключение</title><p>Заключение. Мочеполовые инфекции играют патогенетическую роль в формировании синдрома дефицита внимания с гиперактивностью, в то время как их влияние на развитие расстройств аутистического спектра представляется менее однозначным. Необходимо продолжить работу в этой области с более унифицированным дизайном для формирования практических рекомендаций по превенции нейропсихических расстройств.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Autism spectrum disorders and attention deficit hyperactivity disorder are among the most significant and widespread mental disorders that manifest in childhood and adolescence. Their etiology and pathogenesis have not been studied enough and most likely a complex of factors leads to their formation. Among other things, data are accumulating on the role of various hazards and diseases of the mother, which increase the risk of neuropsychiatric disorders in offspring. These include genitourinary infections, whose contribution to the development of autism spectrum disorders and attention deficit hyperactivity disorder has not yet been systematically studied.</p></sec><sec><title>Aim</title><p>Aim. To establish the contribution of maternal genitourinary infections to the formation of autism spectrum disorders and attention deficit hyperactivity disorder in children.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. An electronic search was conducted in the Scopus and Pubmed databases to obtain relevant literature by August 2022. The search strategy included a combination of keywords and MESH terms: urogenital infections, and autism, and autism spectrum disorders, and attention deficit hyperactivity disorder, and maternal infections.</p></sec><sec><title>Results</title><p>Results. On this topic 10 papers have been identified in the available literature – 6 on autism spectrum disorders and 4 on attention deficit hyperactivity disorder. In all the papers on attention deficit hyperactivity disorder included in the analysis, an association between genitourinary infections and neuropsychiatric disorders was revealed. In the case of autism spectrum disorders, the data obtained were more contradictory. The heterogeneity of the available data (different designs, different deficits and approaches to the diagnosis of genitourinary infections) did not allow for a meta-analysis.</p></sec><sec><title>Conclusions</title><p>Conclusions. Genitourinary infections play a pathogenetic role in the formation of attention deficit hyperactivity disorder, while the effect of genitourinary infections on the development of autism spectrum disorders seems less unambiguous. It is necessary to continue work in this area with a more unified design to form practical recommendations for the prevention of neuropsychiatric disorders.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>урогенитальные инфекции</kwd><kwd>материнские инфекции</kwd><kwd>синдром дефицита внимания с гиперактивностью</kwd><kwd>расстройства аутистического спектра</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urogenital infections</kwd><kwd>maternal infections</kwd><kwd>attention deficit hyperactivity disorder</kwd><kwd>autism spectrum disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Эйдемиллер Э Г, Городнова МЮ, Тарабанов АЭ (ред.). 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