medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-146medsovet-8195Research ArticleПРЕГРАВИДАРНАЯ ПОДГОТОВКА И БЕРЕМЕННОСТЬPREGRAVID PREPARATION AND PREGNANCYПрегравидарная подготовка женщин с бактериальным вагинозом и ранней потерей беременности в анамнезеPregravid preparation for women with bacterial vaginosis and a history of early pregnancy lossГерасимоваО. П.GerasimovaO. P.

Герасимова Ольга Павловна, к.м.н., врач

107078, Москва, проспект Академика Сахарова, д. 7

Olga P. Gerasimova, Cand. Sci. (Med.), Physician

7, Akademik Sakharov Ave, Moscow, 107078

detti-mag@mail.ruhttps://orcid.org/0000-0001-6711-1563СоловьеваA. В.SolovyevaA. V.

Соловьева Алина Викторовна, д.м.н., профессор кафедры акушерства и гинекологии с курсом перинатологии, Медицинский институт

117198, Москва, ул. Миклухо-Маклая, д. 6

Alina V. Solovyeva, Dr. Sci. (Med.), Professor of the Department of Obstetrics and Gynecology with a course in Perinatology, Medical Institute

6, Miklukho-Maklai St., Moscow, 117198

av_soloveva@mail.ruhttps://orcid.org/0000-0002-9698-8038ЧегусЛ. А.ChegusL. A.

Чегус Лариса Алексеевна, к.м.н., доцент кафедры акушерства и гинекологии

628011, Ханты-Мансийск, ул. Мира, д. 40

Larisa A. Chegus, Cand. Sci. (Med.), Associate Professor of the Department of Obstetrics and Gynecology

40, Mira St., Khanty-Mansiysk, 628011

lchegus@mail.ruhttps://orcid.org/0000-0002-6779-7566ВинокуроваЕ. А.VinokurovaE. А.

Винокурова Елена Александровна, д.м.н., профессор кафедры акушерства и гинекологии лечебного факультета

625023, Тюмень, ул. Одесская, д. 54

Elena A. Vinokurova, Dr. Sci. (Med.), Professor of the Department of Obstetrics and Gynecology, Faculty of Medicine

54, Odesskaya St., Tyumen, 625023

vinokurovaelena@mail.ruhttps://orcid.org/0000-0002-4288-353XДоронинаО. К.DoroninaO. K.

Доронина Ольга Константиновна, д.м.н., профессор кафедры акушерства и гинекологии с курсом перинатологии, Медицинский институт

117198, Москва, ул. Миклухо-Маклая, д. 6

Olga K. Doronina, Dr. Sci. (Med.), Professor of the Department of Obstetrics and Gynecology with a course in Perinatology, Medical Institute

6, Miklukho-Maklai St., Moscow, 117198

doronina-ok@rudn.ruhttps://orcid.org/0009-0005-3745-0042СпицынаМ. А.SpitsynaM. A.

Спицына Мария Александровна, аспирант кафедры акушерства и гинекологии с курсом перинатологии, Медицинский институт

117198, Москва, ул. Миклухо-Маклая, д. 6

Maria A. Spitsyna, Postgraduate Student of the Department of Obstetrics and Gynecology with a course in Perinatology, Medical Institute

6, Miklukho-Maklai St., Moscow, 117198

lotyreva31@gmail.comhttps://orcid.org/0000-0002-1434-0386АлейниковаЕ. Ю.AleynikovaE. Yu.

Алейникова Екатерина Юрьевна, аспирант кафедры акушерства и гинекологии с курсом перинатологии, Медицинский институт

117198, Москва, ул. Миклухо-Маклая, д. 6

Ekaterina Yu. Aleynikova, Postgraduate Student of the Department of Obstetrics and Gynecology with a course in Perinatology, Medical Institute

6, Miklukho-Maklai St., Moscow, 117198

ketall@mail.ruhttps://orcid.org/0009-0007-1264-2931РуденкоД. Б.RudenkoD. B.

Руденко Дарья Борисовна, врач акушер-гинеколог консультативно-диагностической поликлиники

355041, Ставропольский край, Ставрополь, ул. Ломоносова, д. 44

Daria B. Rudenko, Obstetrician-Gynecologist, Consultative and Diagnostic Outpatient Clinic

44, Lomonosov St., Stavropol, Stavropol Territory, 355041

dariazatona16@gmail.comМногопрофильный медицинский центр «Центравиамед»РоссияMultidisciplinary Medical Center “Tsentraviamed” JSCRussian FederationРоссийский университет дружбы народов имени Патриса ЛумумбыРоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian FederationХанты-Мансийская государственная медицинская академияРоссияKhanty-Mansiysk State Medical AcademyRussian FederationТюменский государственный медицинский университетРоссияTyumen State Medical UniversityRussian FederationСтавропольский краевой клинический перинатальный центрРоссияStavropol Regional Clinical Perinatal CenterRussian Federation20240205202404119125Copyright © Герасимова О.П., Соловьева A.В., Чегус Л.А., Винокурова Е.А., Доронина О.К., Спицына М.А., Алейникова Е.Ю., Руденко Д.Б., 20242024Герасимова О.П., Соловьева A.В., Чегус Л.А., Винокурова Е.А., Доронина О.К., Спицына М.А., Алейникова Е.Ю., Руденко Д.Б.Gerasimova O.P., Solovyeva A.V., Chegus L.A., Vinokurova E.А., Doronina O.K., Spitsyna M.A., Aleynikova E.Y., Rudenko D.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8195Введение

Введение. Согласно статистике, 13–15 беременностей из 100 заканчиваются выкидышем на раннем сроке. Это представляет как медицинскую, так и социальную проблему, поскольку такой исход может быть сопряжен с депрессиями и тревогой матери, что неминуемо отражается на ее активности, работоспособности и включенности в социум. Одной из ключевых задач у женщин, планирующих беременность, является восстановление нормобиоценоза и доминирования пула лактобацилл.

Цель

Цель. Оценить эффективность назначения пробиотиков на этапе прегравидарной подготовки у женщин с ранней потерей беременности в анамнезе и бактериальным вагинозом (БВ).

Материалы и методы

Материалы и методы. На базах 5 медицинских клиник Москвы, Тюмени и Ставрополя мы отобрали 46 пациенток репродуктивного возраста (24–39 лет), обратившихся по поводу потери беременности на раннем сроке, с жалобами на выделения из половых путей с неприятным запахом, зуд, жжение, диспареунию. С целью устранения бактериального вагиноза применялась двухэтапная терапия, направленная на элиминацию повышенного количества анаэробных микроорганизмов и восстановление микробиоценоза влагалища.

Результаты

Результаты. Оценка эффективности комбинированной терапии проводилась через 1 мес. У всех пациенток на фоне терапии отмечалось клиническое улучшение, нормализация показателей микробиоценоза влагалища по данным теста «Фемофлор-16» после окончания лечения. Физиологический микробиоценоз Lactobacillus spp. > 107 был выявлен у 43 (94,5%). У всех пациенток среднее значение рН влагалища после двухэтапной терапии составляло 4,3 ± 0,7. Безопасность терапии Ацилакт Дуо оценивали у всех участниц исследования. Отрицательной динамики не зафиксировано.

Выводы

Выводы. Ацидофильные бактерии + витаминно-минеральный белково-пептидный комплекс Суперлимфлайф (Ацилакт Дуо) быстро восстанавливает оптимальную кислотность влагалища (показатель рН), способствует росту лактобактерий, снижает частоту рецидивов БВ.

Introduction

Introduction. Statistics show that about 13 to 15 in 100 pregnancies end in early miscarriage. This represents both a medical and social issue, as such outcome may be associated with maternal depression and anxiety, which inevitably affects women’s activities, performance efficiency and social inclusion. Restoration of normobiocenosis and lactobacilli pool dominance is one of the key challenges for women planning pregnancy.

Aim

Aim. To evaluate the effectiveness of probiotics at the pregravid preparation stage in women with a history of early pregnancy loss and bacterial vaginosis (BV).

Materials and methods

Materials and methods. We selected 46 patients of reproductive age (24–39 years) who applied for early pregnancy loss, with complaints of vaginal discharge with an unpleasant odour, pruritus, burning, and dyspareunia, using databases of 5 medical clinics in Moscow, Tyumen and Stavropol. To treat bacterial vaginosis, two-stage therapy aimed at eliminating the increased number of anaerobic microorganisms and restoring the vaginal microbiocenosis was used.

Results

Results. The effectiveness of combination therapy was assessed at 1 month. All patients on therapy experienced clinical improvement, normalization of vaginal microbiocenosis parameters based on Femoflor-16 test findings after the end of treatment. Physiological microbiocenosis of Lactobacillus spp. > 107 was detected in 43 (94.5%). In all patients, the average vaginal pH after two-stage therapy was 4.3 ± 0.7. The safety of Acilact Duo therapy was assessed in all study participants. No negative trends were recorded.

Conclusion

Conclusion. Superlimflife (Acilact Duo), acidophilus bacteria + vitamin-mineral protein-peptide complex, quickly restores optimal vaginal acidity (pH), stimulates the growth of lactobacilli, and reduces the incidence of BV relapses.

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The authors declare that there are no conflicts of interest present.