medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-085medsovet-8228Research ArticleУРОЛОГИЯ/НЕФРОЛОГИЯUROLOGY/NEPHROLOGYФармакологическое действие эпоэтина бета при лечении анемии у пациентов с заболеваниями почекPharmacological action of epoetin beta in the treatment of anemia in patients with kidney diseaseshttps://orcid.org/0000-0002-2062-0421ШормановИ. С.ShormanovI. S.

Шорманов Игорь Сергеевич, д.м.н., профессор, заведующий кафедрой урологии с нефрологией

150000, Ярославль, ул. Революционная, д. 5

Igor S. Shormanov, Dr. Sci. (Med.), Professor, Head of the Department of Urology with Nephrology

5, Revolutsionnaya St., Yaroslavl, 150000

i-s-shormanov@yandex.ruhttps://orcid.org/0000-0003-2464-572XЖигаловС. А.ZhigalovS. A.

Жигалов Сергей Алексеевич, к.м.н., ассистент кафедры урологии с нефрологией

150000, Ярославль, ул. Революционная, д. 5

Sergei A. Zhigalov, Cand. Sci. (Med.), Assistant of the Department of Urology with Nephrology

5, Revolutsionnaya St., Yaroslavl, 150000

sergey.zhigalow@gmail.comhttps://orcid.org/0000-0001-5612-3227СоловьёвА. C.SolovievA. S.

Соловьев Андрей Сергеевич, к.м.н., доцент кафедры урологии с нефрологией

150000, Ярославль, ул. Революционная, д. 5

Andrey S. Soloviev, Cand. Sci. (Med.), Associate Professor of the Department of Urology with Nephrology

5, Revolutsionnaya St., Yaroslavl, 150000

a-s-soloviev89@yandex.ruhttps://orcid.org/0009-0004-5741-261XБажинаО. В.BazhinaО. V.

Бажина Ольга Викторовна, к.м.н., доцент кафедры урологии с нефрологией

150000, Ярославль, ул. Революционная, д. 5

Olga V. Bazhina, Cand. Sci. (Med.), Associate Professor of the Department of Urology with Nephrology

5, Revolutsionnaya St., Yaroslavl, 150000

mascot212@mail.ruЯрославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian Federation20241005202405117122Copyright © Шорманов И.С., Жигалов С.А., Соловьёв А.C., Бажина О.В., 20242024Шорманов И.С., Жигалов С.А., Соловьёв А.C., Бажина О.В.Shormanov I.S., Zhigalov S.A., Soloviev A.S., Bazhina О.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8228

Хроническая болезнь почек является одной из наиболее быстрорастущих причин смертности во всем мире. Анемия, осложняющая хроническую болезнь почек, не только ухудшает качество жизни пациентов, но и является независимым фактором риска неблагоприятных сердечно-сосудистых исходов. Внедрение в клиническую практику рекомбинантного человеческого эритропоэтина значительно изменило методы лечения анемии у пациентов с хронической болезнью почек. Достижение целевых цифр уровня гемоглобина с помощью рекомбинантного человеческого эритропоэтина значительно улучшает качество жизни и снижает смертность у пациентов. Эпоэтин бета наряду с другими эритропоэтинами является одним из стимулирующих эритропоэз средств, доступных в настоящее время на отечественном фармацевтическом рынке. Различные исследования показали, что введение эпоэтина бета пациентам, находящимся на заместительной почечной терапии, 1 раз в неделю так же эффективно, как и трехкратное введение эпоэтина альфа в эквивалентных недельных дозах для достижения целевых показателей уровня гемоглобина. С одной стороны, это повышает приверженность пациентов к лечению. С другой стороны, снижение частоты назначения терапии рекомбинантного человеческого эритропоэтина сокращает время и затраты на лечение почечной анемии, что в конечном счете позволяет лучше адаптировать терапию к потребностям пациентов. Доказанная эффективность и профиль безопасности эпоэтина бета в сочетании с повышенным удобством менее частого введения делают эпоэтин бета безопасным и эффективным вариантом терапии, который может помочь большему числу пациентов с хронической болезнью почек достичь целевых значений уровня гемоглобина.

Chronic kidney disease is becoming one of the leading causes of death globally. Anemia, a common complication in chronic kidney disease, not only diminishes patients’ life quality but also increases the risk of heart-related problems. The use of recombinant human erythropoietin has revolutionized the treatment of anemia in chronic kidney disease patients. By reaching the desired levels of hemoglobin with recombinant human erythropoietin, patients experience significant improvements in life quality and a decrease in death rates. Epoetin beta is among the various erythropoiesis stimulating agents available in the market. Research indicates that weekly doses of epoetin beta are as effective as three weekly doses of epoietin alpha for reaching hemoglobin goals in patients undergoing renal replacement therapy. This not only enhances patients’ adherence to the treatment but also cuts down on the time and costs associated with managing renal anemia, thus allowing for a therapy that is more tailored to patient needs. On the one hand, this improves patients’ adherence to the treatment. On the other hand, the time and cost burden in the management of renal anemia is decreased due to reduction in recombinant human erythropoietin prescribing rates, which eventually makes it possible to better tailor therapy to the patients’ needs. The proven efficacy and safety profile of epoetin beta combined with the increased convenience of less frequent dosing, make epoetin beta a safe and effective treatment option that can help more patients with chronic kidney disease to reach their target hemoglobin levels.

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The authors declare that there are no conflicts of interest present.