medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-143medsovet-8265Research ArticleИНФЕКЦИИ В ОТОРИНОЛАРИНГОЛОГИИINFECTIONS IN OTORHINOLARYNGOLOGYОсобенности антибактериальной терапии при остром синуситеAntibacterial therapy in patients with acute sinusitishttps://orcid.org/0000-0002-5778-629XКочетковП. А.KochetkovP. A.

Кочетков Петр Александрович, д.м.н., профессор, кафедра болезней уха, горла и носа 

119991, Москва, ул. Большая Пироговская, д. 6, стр. 1

Petr A. Kochetkov, Dr. Sci. (Med.), Professor, Chair of Otorhinolaryngology (ENT)

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia

kochetkov_p_a@staff.sechenov.ruhttps://orcid.org/0000-0003-4755-0205ЩенниковаЕ. С.ShchennikovaE. S.

Щенникова Екатерина Сергеевна, врач-оториноларинголог отделения оториноларингологии Университетской клинической больницы 

119991, Москва, ул. Большая Пироговская, д. 6, стр. 1

Ekaterina S. Shchennikova, Otorhinolaryngologist, Department of Otorhinolaryngology, University Clinical Hospital

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia

shchennikova_e_s@staff.sechenov.ruhttps://orcid.org/0009-0001-4926-8986ШабановаЗ. ОShabanovaZ. O.

Шабанова Зумруд Омаровна, студент факультета Института клинической медицины 

119991, Москва, ул. Большая Пироговская, д. 6, стр. 1

Zumrud O. Shabanova, Student at the Institute of Clinical Medicine

6, Bldg. 1, Bolshaya Pirogovskaya St., Moscow, 119991, Russia

zumrud.shabanova2000@gmail.comПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation202418052024078690Copyright © Кочетков П.А., Щенникова Е.С., Шабанова З.О., 20242024Кочетков П.А., Щенникова Е.С., Шабанова З.О.Kochetkov P.A., Shchennikova E.S., Shabanova Z.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8265

В практике ЛОР-врача одним из самых часто встречающихся заболеваний является острый синусит. Данная патология на территории Российской Федерации наблюдается у 6–15% пациентов и составляет около 10 млн случаев в год. Заболеваемость острым синуситом растет осенью и ранней весной и снижается в летнее время года. Чаще всего острый синусит вызывают вирусы, но также может возникать из-за бактериальной инфекции, аллергии или травм. Проявлениями острого синусита являются отек слизистой оболочки полости носа, затруднение дыхания и выделение слизи. Как правило, продолжительность острого воспаления околоносовых пазух составляет в среднем 4 нед. При отсутствии лечения воспалительный процесс с пазух может распространиться на близлежащие ткани и органы – в область глазницы, уха или головного мозга, вследствие чего развиваются серьезные и опасные для жизни осложнения. За последние 10 лет устойчивость патогенной флоры к антимикробным препаратам сильно возросла в связи с необоснованностью и иррациональностью их приема. Целью данного обзора является подробный анализ эффективности и безопасности антибактериальных средств в контексте терапии острого синусита. В статье рассматриваются вопросы этиологии, патогенеза, характера течения острого синусита. Приведены особенности применения наиболее часто используемых лекарственных препаратов, пристальное внимание уделяется сравнительной оценке и терапевтической эффективности антибактериальных препаратов, а также определению оптимальных схем применения в рамках современных клинических протоколов. Представлено описание клинического случая острого синусита и схема терапии препаратом Цефиксим ЭКСПРЕСС.

The prevalence of the acute sinusitis in ENT practice is very high. The current prevalence in Russian Federation is roughly estimated at 6 to 15%, and accounts for about 10 million cases a year. The incidence of acute sinusitis increases in autumn and early spring and decreases in the summer. Most cases of acute sinusitis are of a viral etiology, but it can also arise from bacterial infection, allergies, or injuries. The disease is characterized by swelling of the nasal mucous membrane, nasal blockage and discharge. Typically, the duration of acute inflammation of the paranasal sinuses averages about 4 weeks. In case of the inappropriate treatment, the inflammatory process can spread to adjacent anatomical structures – to the orbit, ear, or brain, resulting in serious, sometimes life-threatening complications. Over the last 10 years, the resistance of pathogenic flora to antimicrobial agents has greatly increased due to the unjustifiability and irrationality of their use. The purpose of this review was to analyze the effectiveness and safety of the antibiotic therapy for acute rhinosinusitis. The paper discusses the etiology, pathogenesis, and characteristics of the acute sinusitis. It presents the features of the most used drugs, with special attention to the comparative assessment of their therapeutic effectiveness compared to other antibiotics, as well as determining the optimal schemes for their use within the framework of modern clinical protocols. A description of a clinical case of acute sinusitis and a treatment regimen with Cefixime EXPRESS is presented.

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The authors declare that there are no conflicts of interest present.