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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-144</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8272</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОМОРБИДНЫЕ СОСТОЯНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMORBID CONDITIONS</subject></subj-group></article-categories><title-group><article-title>Фенотипы сердечной недостаточности и клинико-лабораторные особенности пациентов с СД 2-го типа в практике эндокринолога и кардиолога стационарного звена</article-title><trans-title-group xml:lang="en"><trans-title>Heart failure phenotypes and clinical and laboratory features of patients with type 2 diabetes in inpatient endocrinology and cardiology practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6385-540X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Demidova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демидова Татьяна Юльевна, д.м.н., профессор, заведующая кафедрой эндокринологии лечебного факультета</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Tatiana Yu. Demidova, Dr. Sci. (Med.), Professor, Head of Chair for Endocrinology</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><email xlink:type="simple">t.y.demidova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Измайлова</surname><given-names>М. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Izmaylova</surname><given-names>M. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Измайлова Марьям Ярагиевна, ассистент кафедры эндокринологии лечебного факультета</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Maryam Ya. Izmaylova, Assistant of the Department of Endocrinology of the Medical Faculty</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>6</issue><fpage>81</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Демидова Т.Ю., Измайлова М.Я., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Демидова Т.Ю., Измайлова М.Я.</copyright-holder><copyright-holder xml:lang="en">Demidova T.Y., Izmaylova M.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8272">https://www.med-sovet.pro/jour/article/view/8272</self-uri><abstract><sec><title>Введение</title><p>Введение. СД 2-го типа является общепризнанным фактором риска развития не только атеросклеротических сердечно-сосудистых заболеваний, микрососудистых осложнений, но и хронической сердечной недостаточности.</p></sec><sec><title>Цель</title><p>Цель. Оценить распространенность фенотипов ХСН и клинико-лабораторные особенности пациентов с СД 2-го типа, находящихся на стационарном лечении в эндокринологическом и кардиологическом отделениях.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Всего в анализ было включено 107 пациентов с СД2 и ХСН. Всем пациентам проводилось обследование согласно стандартам и порядку оказания медицинской помощи.</p></sec><sec><title>Результаты</title><p>Результаты. Средний возраст составил 69,7 ± 9,12 года, возраст дебюта СД 2-го типа равнялся 58,9 ± 10 годам, длительность СД – 6,5 [4; 17] года. При анализе основных метаболических параметров средний показатель HbA1c соответствовал 8,18 ± 1,72%, ИМТ – 32 [29; 38] кг/м2. У преобладающего количества больных с СД 2-го типа наблюдался фенотип ХСН с сохранной ФВ, доля которых составила 68,22%; 19,63% имели ХСН с умеренно сниженной ФВ и 12,15% – ФВ менее 40%.</p></sec><sec><title>Выводы</title><p>Выводы. Популяция пациентов с СД 2-го типа и ХСН, независимо от профильности отделения, характеризовалась отсутствием целевой компенсации СД 2-го типа, ИР, ожирением и высокой распространенностью АГ и дислипидемии. В отделении эндокринологии достоверно чаще пациенты имели рестриктивный фенотип СН и характеризовались умеренным повышением NTproBNP со сниженной рСКФ, были женского пола, более возрастной категории, с более длительным СД и более высоким уровнем HbA1c. Все это диктует высокую необходимость интеграции ингибиторов НГЛТ 2-го типа в схемы ведения пациентов. В отделении кардиологии наблюдалась высокая частота дилатационного фенотипа ХСН с низкой ФВ и ИБС на фоне значительно повышенных значений NTproBNP, достоверно чаще у мужского пола, среднего возраста, с короткой продолжительностью СД. Таким пациентам, согласно стандартам медицинской помощи, требуется квадротерапия, одним из обязательных компонентов которой будут ингибиторы НГЛТ 2-го типа.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Type 2 diabetes is a generally recognized risk factor for the development of not only ASCVD, microvascular complications, but also CHF.</p></sec><sec><title>Aim</title><p>Aim. To evaluate the prevalence of CHF phenotypes and clinical and laboratory characteristics of patients with type 2 diabetes who are hospitalized in the endocrinology and cardiology departments.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A total of 107 patients with T2DM was included in the analysis. All patients were examined in accordance with the standards and procedures for providing medical care, followed by evaluation of clinical, laboratory and instrumental indicators.</p></sec><sec><title>Results</title><p>Results. The average age of these patients was 69.7 ± 9.12 years, the age of onset of type 2 diabetes was 58.9 ± 10 years, the duration of diabetes was 6.5 [4; 17] years. When analyzing the main metabolic parameters, the average HbA1c was 8.18 ± 1.72%, BMI 32 [29; 38] kg/m2. The predominant number of patients with type 2 diabetes had a CHF phenotype with preserved ejection fraction, the proportion of which was 68.22%, 19.63% had HF with mildly reduced ejection fraction and 12.15% – heart failure with reduced ejection fraction (HFrEF).</p></sec><sec><title>Conclusions</title><p>Conclusions. The population of patients with type 2 diabetes and CHF, regardless of the specialty of the department, was characterized by a lack of targeted compensation for type 2 diabetes, IR, obesity and a high prevalence of hypertension and dyslipidemia. In the endocrinology department, patients significantly more often had a restrictive phenotype of HF and was characterized by a moderate increase in NTproBNP, with a reduced eGFR, were female, of an older age category, with longer duration of diabetes and higher HbA1c levels. All this dictates the high need for integrating SGLT2 inhibitors into patient management regimens. In the cardiology department, a high frequency of the dilated phenotype of CHF with low EF and ischemic heart disease was observed against the background of significantly increased NTproBNP values, significantly more often in males, middle age, with a short duration of diabetes. According to the standards of medical care, such patients require quadruple therapy, one of the mandatory components of which will be iSGLT 2 type.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>фенотипы</kwd><kwd>гипергликемия</kwd><kwd>высокий риск сердечно-сосудистых заболеваний</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>cardiovascular diseases</kwd><kwd>phenotypes</kwd><kwd>hyperglycemia</kwd><kwd>high risk of cardiovascular diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. 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