References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/ms2024-073.

medsovet-8296

Research Article

ПРИКЛАДНЫЕ АСПЕКТЫ ЭНДОКРИНОЛОГИИ И КАРДИОЛОГИИ

APPLIED ASPECTS OF ENDOCRINOLOGY AND CARDIOLOGY

Ассоциация между кишечной микробиотой и дисфункцией щитовидной железы

Association between gut microbiota and thyroid dysfunction

https://orcid.org/0000-0001-9403-265X

Тульский

А. А.

Tulsky

A. A.

Тульский Андрей Алексеевич, аспирант кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Andrey A. Tulsky, Posgraduate Student of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

andrey.a.tulsky@gmail.com

https://orcid.org/0000-0002-7893-145X

Мыринова

О. А.

Myrinova

O. A.

Мыринова Ольга Александровна, аспирант кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Olga A. Myrinova, Postgraduate Student of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

olala.morozova@mail.ru

https://orcid.org/0000-0001-7658-7053

Щетинина

А. О.

Shchetinina

A. O.

Щетинина Анна Олеговна, к.м.н., ассистент кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Anna O. Shchetinina, Cand. Sci. (Med.), Assistant of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

shchetinina_a_o@staff.sechenov.ru

https://orcid.org/0000-0002-0202-1257

Мартиросян

Н. С.

Martirosian

N. S.

Мартиросян Нарине Степановна, к.м.н., доцент кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Narine S. Martirosian, Cand. Sci. (Med.), Associate Professor of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

martirosyan_n_s@staff.sechenov.ru

https://orcid.org/0000-0001-7025-8427

Гончарова

Е. В.

Goncharova

E. V.

Гончарова Екатерина Валерьевна, к.м.н., доцент кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Ekaterina V. Goncharova, Cand. Sci. (Med.), Associate Professor of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

goncharova_e_v_2@staff.sechenov.ru

https://orcid.org/0000-0001-7923-4894

Кузина

И. А.

Kuzina

I. A.

Кузина Ирина Александровна, ассистент кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Irina A. Kuzina, Assistant at the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

kuzina_i_a@staff.sechenov.ru

https://orcid.org/0000-0001-8007-9721

Тельнова

М. Э.

Telnova

M. E.

Тельнова Милена Эдуардовна, к.м.н., доцент кафедры эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Milena E. Telnova, Cand. Sci. (Med.), Associate Professor of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

telnova_m_e@staff.sechenov.ru

https://orcid.org/0000-0001-6000-8002

Валеева

Ф. В.

Valeeva

F. V.

Валеева Фарида Вадутовна, д.м.н., профессор, заведующая кафедрой эндокринологии

420012, Казань, ул. Бутлерова, д. 49

Farida V. Valeeva, Dr. Sci. (Med.), Professor, Head of the Department of Endocrinology

49, Butlerov St., Kazan, 420012

val-farida@yandex.ru

https://orcid.org/0000-0001-9390-1200

Петунина

Н. А.

Petunina

N. A.

Петунина Нина Александровна, чл.- корр. РАН, д.м.н., профессор, заведующая кафедрой эндокринологии

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Nina A. Petunina, Corr. Member RAS, Dr. Sci. (Med.), Professor, Head of the Department of Endocrinology

8, Bldg. 2, Trubetskaya St., Moscow, 119991

petunina_n_a@staff.sechenov.ru

Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation

Казанский государственный медицинский университетРоссияKazan State Medical UniversityRussian Federation

2024

20052024

06240249

2024

Тульский А.А., Мыринова О.А., Щетинина А.О., Мартиросян Н.С., Гончарова Е.В., Кузина И.А., Тельнова М.Э., Валеева Ф.В., Петунина Н.А.

Tulsky A.A., Myrinova O.A., Shchetinina A.O., Martirosian N.S., Goncharova E.V., Kuzina I.A., Telnova M.E., Valeeva F.V., Petunina N.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/8296

Статья посвящена современным представлениям о потенциальной роли микробиоты в развитии патологии щитовидной железы. Кишечная микробиота играет одну из главных ролей как в формировании и поддержании здоровья человека, так и в патогенезе широкого спектра заболеваний. Имеются данные о взаимосвязи кишечной микробиоты и иммунной системы, риска развития ряда злокачественных и аутоиммунных заболеваний. В статье рассмотрены функции кишечной микробиоты, факторы, определяющие ее состав. Исследования показали наличие связи между кишечной микробиотой и щитовидной железой, что легло в основу формирования теории оси «кишечник – щитовидная железа». Показано, что кишечная микробиота принимает участие в метаболизме тиреоидных гормонов и обеспечивает их энтерогепатическую циркуляцию. Предполагается, что одним из связующих звеньев между щитовидной железой и микроорганизмами желудочно-кишечного тракта является иммунная система. Представлены результаты исследований, посвященных изучению таксономического состава кишечной микробиоты у пациентов с аутоиммунным тиреоидитом и болезнью Грейвса. Предполагается, что состав кишечной микробиоты может влиять на потребность в левотироксине натрия, особенно у пациентов с субклиническим гипотиреозом. При этом прием левотироксина при гипотиреозе и в меньшей степени непосредственно манифестный гипотиреоз в исходе аутоиммунного тиреоидита ассоциированы с синдромом избыточного бактериального роста, несмотря на достижение эутиреоза, и могут оказывать влияние на состав микробиоты. Несмотря на то что аутоиммунные заболевания щитовидной железы довольно распространены в общей популяции, работ, посвященной данной проблематике, проведено немного. Необходимы более надежные фундаментальные и клинические исследования для выявления конкретных взаимосвязей и механизмов развития патологии щитовидной железы в зависимости от изменения состава кишечной микробиоты, а также оценки потенциальной возможности ее использования с терапевтической целью.

The article is devoted to modern researches about the potential role of gut microbiota in the development of thyroid pathology. Gut microbiota plays a major role both in the formation and maintenance of human health and in the pathogenesis of a wide range of diseases. There is evidence of the relationship between the gut microbiota and the immune system, the risk of developing several malignant and autoimmune diseases. The article discusses the functions of the gut microbiota and the factors that determine its composition. Studies have shown a connection between the gut microbiota and the thyroid gland, which formed the basis for the formation of the theory of the gut-thyroid axis. It has been shown that the gut microbiota takes part in the metabolism of thyroid hormones and ensures their enterohepatic circulation. It is assumed that one of the links between the thyroid gland and gastrointestinal microorganisms is the immune system. The results of studies examining the taxonomic composition of the gut microbiota in patients with autoimmune thyroiditis and Graves’ disease are presented. It is hypothesized that the composition of the gut microbiota may influence the requirement for levothyroxine, especially in patients with subclinical hypothyroidism. On the other hand, levothyroxine, to a lesser extent, directly hypothyroidism as a result of autoimmune thyroiditis are associated with bacterial overgrowth syndrome despite the achievement of euthyroidism, and may affect the composition of the microbiota. Even though autoimmune thyroid diseases are quite common in the general population, little work has been done on this issue. More reliable basic and clinical researches are needed to identify specific relationships and mechanisms of development of thyroid pathology depending on changes in the composition of the gut microbiota, as well as to assess the potential for therapeutic use.

кишечная микробиотааутоиммунный тиреоидитболезнь Грейвсагипотиреозтиреотоксикоз

gut microbiotaautoimmune thyroiditisGraves’ diseasehypothyroidismthyrotoxicosis

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The authors declare that there are no conflicts of interest present.