medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-168medsovet-8324Research ArticleФУНКЦИОНАЛЬНЫЕ ЗАБОЛЕВАНИЯ ОРГАНОВ ЖКТFUNCTIONAL GASTROINTESTINAL DISEASESПотенциальная роль короткоцепочечных жирных кислот в формировании синдрома раздраженного кишечника у лиц с избыточной массой тела и ожирениемPotential role of short-chain fatty acids in irritable bowel syndrome in overweight and obese individualshttps://orcid.org/0000-0002-0238-4664ФедоринМ. М.FedorinM. M.

Федорин Максим Михайлович, ассистент кафедры факультетской терапии и гастроэнтерологии,  

644099, Омск, ул. Ленина, д. 12

Maksim M. Fedorin, Assistant of the Department of Faculty Therapy and Gastroenterology,

12, Lenin St., Omsk, 644099

mail.maxim.f@gmail.comhttps://orcid.org/0000-0002-6581-7017ЛивзанМ. А.LivzanM. A.

Ливзан Мария Анатольевна, член-корр. РАН, д.м.н., профессор, ректор, заведующий кафедрой факультетской терапии и гастроэнтерологии,

644099, Омск, ул. Ленина, д. 12

Maria A. Livzan, Corr. Member RAS, Dr. Sci. (Med.), Professor, Rector, Head of the Department of Faculty Therapy and Gastroenterology,

12, Lenin St., Omsk, 644099

mlivzan@yandex.ruhttps://orcid.org/0000-0001-9370-4768ГаусО. В.GausO. V.

Гаус Ольга Владимировна, к.м.н., доцент кафедры факультетской терапии и гастроэнтерологии,

644099, Омск, ул. Ленина, д. 12

Olga V. Gaus, Cand. Sci. (Med.), Associate Professor of the Department of Faculty Therapy and Gastroenterology, 

12, Lenin St., Omsk, 644099

gaus_olga@bk.ruhttps://orcid.org/0009-0000-2815-750XПашковаЕ. В.PashkovaE. V.

Пашкова Евгения Вячеславовна, студент лечебного факультета,

644099, Омск, ул. Ленина, д. 12

Eugenia V. Pashkova, Student of Medical Faculty, 

12, Lenin St., Omsk, 644099

pashkova.evgeni@gmail.comОмский государственный медицинский университетРоссияOmsk State Medical UniversityRussian FederationОмский государственный медицинский университетРоссияOmsk State Medical UniversityRussian Federation202405062024082027Copyright © Федорин М.М., Ливзан М.А., Гаус О.В., Пашкова Е.В., 20242024Федорин М.М., Ливзан М.А., Гаус О.В., Пашкова Е.В.Fedorin M.M., Livzan M.A., Gaus O.V., Pashkova E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8324

Растущая распространенность функциональных заболеваний толстой кишки у пациентов с ожирением диктует потребность в изучении механизмов влияния кишечной микробиоты на формирование симптомов синдрома раздраженного кишечника в условиях метаболической активности жировой ткани. Одним из ключевых механизмов влияния кишечного микробиоценоза на возникновение и особенности течения синдрома раздраженного кишечника является количественное и качественное изменение пула синтезируемых короткоцепочечных жирных кислот, оказывающих разнонаправленное влияние на моторную функцию толстой кишки. Вопрос влияния отдельных короткоцепочечных жирных кислот на выраженность абдоминальной боли и особенности моторных нарушений толстой кишки остается предметом дискуссии. Отдельного внимания заслуживает изучение механизмов влияния короткоцепочечных жирных кислот на формирование и прогрессирование ожирения. Повышение концентрации короткоцепочечных жирных кислот в сыворотке крови и кале больных ожирением может как являться следствием изменений состава микрофлоры кишечника, связанных с особыми пищевыми привычками и образом жизни, так и оказывать самостоятельное влияние на формирование ожирения у отдельных лиц вследствие уже сформированных нарушений состава кишечной микрофлоры. В связи с наличием характерных особенностей течения синдрома раздраженного кишечника, ассоциированного с избыточной массой тела и ожирением, изучение состава кишечной микробиоты и синтезируемых ею короткоцепочечных жирных кислот у данной когорты больных синдромом раздраженного кишечника представляет особый интерес. Настоящая публикация подготовлена с целью описания и систематизации возможных механизмов влияния короткоцепочечных жирных кислот на формирование абдоминальной боли и нарушение моторной функции толстой кишки у больных синдромом раздраженного кишечника с избыточной массой тела и ожирением. Поиск литературы проводился в системах Embase, PubMed и Google Scholar по ключевым словам «синдром раздраженного кишечника», «ожирение», «короткоцепочечные жирные кислоты», «кишечная микробиота».

Due to increasing prevalence of functional diseases of the colon in obese patients, the mechanisms by which the intestinal microbiota affects the development of symptoms of irritable bowel syndrome (IBS) in the setting of metabolic activity of adipose tissue should be investigated. The quantitative and qualitative changes in the pool of synthesized short-chain fatty acids, which have a multidirectional impact on the colonic motility is one of the key mechanisms by which the intestinal microbiota affects the occurrence and features of the course of irritable bowel syndrome. But as regards the issue of whether individual short-chain fatty acids have an impact on the severity of abdominal pain and characteristics of colonic motility dysfunction, it remains a subject of discussions. The study of the mechanisms of impact of short-chain fatty acids on the development and progression of obesity deserves special attention. Increased serum and faecal short-chain fatty acid levels in obese patients can either be a result of changes in the intestinal microflora composition associated with special eating habits and lifestyle, or have an independent effect on the development of obesity in individuals due to intestinal microflora composition disorders that have been already developed. Due to special features of the course of irritable bowel syndrome associated with overweight and obesity, studying the intestinal microbiota composition and the short-chain fatty acids produced by it in this cohort of IBS patients is of particular interest. This publication has been prepared to describe and systematize the possible mechanisms of impact of short-chain fatty acids on the development of abdominal pain and impaired colonic motility in IBS patients with overweight and obesity. The literature search was conducted in the databases Embase, PubMed and Google Scholar using the keywords “irritable bowel syndrome”, “obesity”, “short-chain fatty acids”, “gut microbiota”.

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The authors declare that there are no conflicts of interest present.