medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-267medsovet-8436Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYВлияние дотации холекальциферола на уровень провоспалительных цитокинов у детей с бронхиальной астмойThe effect of cholecalciferol subsidies on the level of pro-inflammatory cytokines in children with bronchial asthmahttps://orcid.org/0000-0002-2056-153XДолбняС. В.DolbnyaS. V.

Долбня Светлана Викторовна, к.м.н., доцент кафедры факультетской педиатрии; врач-пульмонолог

55017, Ставрополь, ул. Мира, д. 310 

55029, Ставрополь, ул. Семашко, д. 3 

Svetlana V. Dolbnya, Cand. Sci. (Med.), Assistant Professor of the Department of Faculty Pediatrics; Pulmonologist

310, Mira St., Stavropol, 355017

3, Semashko St., Stavropol, 355029

svet-lana.dolbnya@yandex.ruhttps://orcid.org/0000-0001-6983-0967ТолкуноваА. А.TolkunovaA. A.

Толкунова Анна Александровна, ассистент факультетской педиатрии; врач-пульмонолог

55017, Ставрополь, ул. Мира, д. 310 

55029, Ставрополь, ул. Семашко, д. 3 

Anna Tolkunova, Assistant of the Department of Faculty Pediatric; Pulmonologist

310, Mira St., Stavropol, 355017

3, Semashko St., Stavropol, 355029

anndiatlova@mail.ruhttps://orcid.org/0000-0003-4200-4598ЗахароваИ. Н.ZakharovaI. N.

Захарова Ирина Николаевна, д.м.н., профессор, заведующая кафедрой педиатрии имени академика Г.Н. Сперанского

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1 

Irina N. Zakharova, Dr. Sci. (Med.), Professor, Head of the Department of Pediatrics named after Academician G.N. Speransky

2/1, Вldg. 1, Barrikadnaya St., Moscow, 125993

zakharova-rmapo@yandex.ruhttps://orcid.org/0009-0007-9505-3349ПонамареваВ. Р.PonamaryovaV. R.

Понамарева Виктория Романовна, студентка педиатрического факультета

55017, Ставрополь, ул. Мира, д. 310 

Viktoriya R. Ponamaryova, Student of the Faculty of Pediatrics

310, Mira St., Stavropol, 355017

viktoriaponamarevaaa@yandex.ruhttps://orcid.org/0000-0001-7248-1614КлимовЛ. Я.KlimovL. Ya.

Климов Леонид Яковлевич, д.м.н., профессор, заведующий кафедрой факультетской педиатрии

55017, Ставрополь, ул. Мира, д. 310 

Leonid Ya. Klimov, Dr. Sci. (Med.), Professor, Head of the Department of Faculty Pediatrics

310, Mira St., Stavropol, 355017

klimov_leo@mail.ruhttps://orcid.org/0000-0002-4069-0566БарычеваЛ. Ю.BarychevaL. Yu.

Барычева Людмила Юрьевна, д.м.н., профессор, заведующая кафедрой иммунологии с курсом дополнительного профессионального образования; врач – аллерголог- иммунолог

55017, Ставрополь, ул. Мира, д. 310 

55029, Ставрополь, ул. Семашко, д. 3 

Liudmila Yu. Barycheva, Dr. Sci. (Med.), Professor, Head of the Department of Immunology with a Course of Additional Professional Education; Allergist-Immunologist

310, Mira St., Stavropol, 355017

3, Semashko St., Stavropol, 355029

for_ludmila@inbox.ruhttps://orcid.org/0009-0009-9178-1634ЗарытовскаяН. В.ZaritovskayaN. V.

Зарытовская Наталья Владимировна, д.м.н., профессор кафедры пропедевтики детских болезней с курсом дополнительного профессионального образования

55017, Ставрополь, ул. Мира, д. 310 

Natalia V. Zaritovskaya, Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Childhood Diseases with a Course of Additional Professional Education

310, Mira St., Stavropol, 355017

leda54@mail.ruhttps://orcid.org/0009-0003-5246-0527КузнецоваВ. В.KuznetsovaV. V.

Кузнецова Вера Валентиновна, ассистент кафедры иммунологии с курсом дополнительного профессионального образования; врач – аллерголог-иммунолог

55017, Ставрополь, ул. Мира, д. 310 

55029, Ставрополь, ул. Семашко, д. 3 

Vera V. Kuznetsova, Assistant of the Department of Immunology with a Course of Additional Professional Education; Allergist-Immunologist

310, Mira St., Stavropol, 355017

3, Semashko St., Stavropol, 355029

kuznetsovavera96@mail.ruhttps://orcid.org/0000-0002-5306-8223ЕнинаЕ. А.EninaE. A.

Енина Елена Александровна, к.м.н., доцент кафедры госпитальной педиатрии; заведующая отделением пульмонологии

55017, Ставрополь, ул. Мира, д. 310 

55029, Ставрополь, ул. Семашко, д. 3 

Elena A. Enina, Cand. Sci. (Med.), Associate Professor, Department of Hospital Pediatrics; Head of the Pulmonology Department

310, Mira St., Stavropol, 355017

3, Semashko St., Stavropol, 355029

enina_ea@rambler.ruСтавропольский государственный медицинский университет; Краевая детская клиническая больницаРоссияStavropol State Medical University; Regional Children’s Clinical HospitalRussian FederationРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian Federation202407082024011119–129Copyright © Долбня С.В., Толкунова А.А., Захарова И.Н., Понамарева В.Р., Климов Л.Я., Барычева Л.Ю., Зарытовская Н.В., Кузнецова В.В., Енина Е.А., 20242024Долбня С.В., Толкунова А.А., Захарова И.Н., Понамарева В.Р., Климов Л.Я., Барычева Л.Ю., Зарытовская Н.В., Кузнецова В.В., Енина Е.А.Dolbnya S.V., Tolkunova A.A., Zakharova I.N., Ponamaryova V.R., Klimov L.Y., Barycheva L.Y., Zaritovskaya N.V., Kuznetsova V.V., Enina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8436Введение

Введение. На сегодняшний день недостаточно исследований, демонстрирующих влияние обеспеченности витамином D на продукцию провоспалительных цитокинов у детей с аллергическими заболеваниями, что явилось предпосылкой для выполнения исследования.

Цель

Цель. Проанализировать динамику показателей интерферона-γ, интерлейкина-17А и 33 у детей с бронхиальной астмой в зависимости от уровня кальцидиола в сыворотке крови до и на фоне дотации препаратами холекальциферола.

Материалы и методы

Материалы и методы. Обследован 71 ребенок в возрасте от 3 лет до 18 лет: 51 пациент с бронхиальной астмой и 20 детей контрольной группы. Всем детям назначался 3-месячный курс холекальциферола в профилактической дозе в соответствии с национальной программой. У обследованных детей двукратно определялись показатели 25(ОН)D, интерферона-γ, интерлейкина-17А и 33.

Результаты и обсуждение

Результаты и обсуждение. Медиана 25(ОН)D у пациентов с бронхиальной астмой не достигала уровня здоровых детей ни до, ни после дотации препаратами холекальциферола в профилактических дозах. Прием витамина D приводил к снижению интерферона-γ у здоровых детей с 3,07 [2,29; 4,81] пг/ мл до 2,18 [1,74; 3,45] пг/ мл (р < 0,05). У пациентов с бронхиальной астмой данных изменений в исходной популяции выявлено не было, однако после дотации холекальциферола уровень интерферона-γ у них был значимо выше, чем у здоровых детей: 3,11 [0,89; 5,0] пг/ мл и 2,18 [1,74; 3,45] пг/ мл соответственно (р < 0,05). При анализе интерлейкина-17А у детей с бронхиальной астмой до дотации холекальциферола медиана цитокина была значимо выше, чем после дотации: 2,03 [0,1; 10,01] пг/ мл и 0,96 [0,1; 12,87] пг/ мл соответственно (р = 0,03). Медиана интерлейкина-17А у детей с бронхиальной астмой значимо выше, чем у здоровых детей как до, так и на фоне дотации холекальциферола. Медиана интерлейкина-33 значимо выше у детей с бронхиальной астмой по сравнению со здоровыми детьми как до, так и на фоне дотации витамином D.

Заключение

Заключение. Выявлено наличие у холекальциферола модулирующего эффекта в отношении интерферона-γ и интерлейкина-17А у пациентов с бронхиальной астмой. Уровни интерлейкина-33 у детей с бронхиальной астмой на фоне приема холекальциферола значимо не изменялись.

Introduction

Introduction. Currently, there are insufficient studies to demonstrate the effect of vitamin D status on the production of proinflammatory cytokines in children with allergic diseases, which precipitated this study.

Aim

Aim. To analyse interferon-γ, interleukin-17A and 33 profiles in children with asthma according to serum calcidiol levels before and during cholecalciferol subsidies.

Materials and methods

Materials and methods. A total of 71 children aged 3 to 18 years were examined: 51 patients with asthma and 20 children in the control group. A 3-month cholecalciferol course at a prophylactic dose specified in the national program was prescribed to all children. 25(OH)D, interferon-γ, interleukin-17A and 33 levels were twice determined in the examined children.

Results and discussion

Results and discussion. Median 25(OH)D levels in patients with asthma did not reach the levels of healthy children either before or after cholecalciferol subsidies at prophylactic doses. Vitamin D intake led to a decrease in interferon-γ levels in healthy children from 3.07 [2.29; 4.81] pg/ml to 2.18 [1.74; 3.45] pg/ml (p < 0.05). In patients with asthma, such changes were not detected in the initial population, however, after cholecalciferol subsidies their interferon-γ levels were significantly higher than those in healthy children: 3.11 [0.89; 5.0] pg/ml and 2.18 [1.74; 3.45] pg/ml, respectively (p < 0.05). Assessment results of interleukin-17A levels in children with asthma showed that the median cytokine levels were significantly higher before the cholecalciferol subsidies than after them: 2.03 [0.1; 10.01] pg/ml and 0.96 [0.1; 12.87] pg/ml, respectively (p = 0.03). The median interleukin-17A levels in children with asthma were significantly higher than in healthy children, both before and during the cholecalciferol subsidies. The median interleukin-33 levels were significantly higher in children with asthma as compared to healthy children, both before and during vitamin D subsidies.

Conclusion

Conclusion. Our results suggest that cholecalciferol has a modulatory effect on interferon-γ and interleukin-17A in patients with asthma. Interleukin-33 levels did not change significantly in children with asthma on cholecalciferol.

бронхиальная астмавитамин Dкальцидиолцитокиныдетиbronchial asthmavitamin DcalcidiolcytokineschildrenReferencesБяловский ЮЮ, Глотов СИ, Ракитина ИС, Ермачкова АН. Патогенетические аспекты фенотипирования бронхиальной астмы. Российский медико-биологический вестник имени академика И.П. Павлова. 2024;32(1):145–158. https://doi.org/10.17816/PAVLOVJ181606.Byalovskiy YuYu, Glotov SI, Rakitina IS, Ermachkova AN. Pathogenetic aspects of bronchial asthma phenotyping. I.P. Pavlov Russian Medical Biological Herald. 2024;32(1):145–158. (In Russ.) https://doi.org/10.17816/PAVLOVJ181606.Лошкова ЕВ, Кондратьева ЕИ, Малиновская МГ, Янкина ГН. Современное представление о витамине D и генетической регуляции воспаления на примере бронхиальной астмы. Вопросы практической педиатрии. 2022;17(3):147–155. https://doi.org/10.20953/1817-7646-2022-3-147-155.Loshkova EV, Kondratyeva EI, Malinovskaya MG, Yankina GN. Current understanding of vitamin D and genetic regulation of inflammation on the example of bronchial asthma. Clinical Practice in Pediatrics. 2022;17(3):147–155. (In Russ.) https://doi.org/10.20953/1817-7646-2022-3-147-155.Ненашева НМ. Т2-бронхиальная астма: характеристика эндотипа и биомаркеры. Пульмонология. 2019;29(2):216–228. https://doi.org/10.18093/0869-0189-2019-29-2-216-228.Nenasheva NM. Т2-high and T2-low bronchial asthma, endotype characteristics and biomarkers. Pulmonologiya. 2019;29(2):216–228. (In Russ.) https://doi.org/10.18093/0869-0189-2019-29-2-216-228.Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–1485. https://doi.org/10.1016/j.cell.2021.02.016.Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–1485. https://doi.org/10.1016/j.cell.2021.02.016.Van der Ploeg EK, Krabbendam L, Vroman H, van Nimwegen M, de Bruijn MJW, de Boer GM et al. Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations. Nat Commun. 2023;14(1):5137. https://doi.org/10.1038/s41467-023-40820-x.Van der Ploeg EK, Krabbendam L, Vroman H, van Nimwegen M, de Bruijn MJW, de Boer GM et al. Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations. Nat Commun. 2023;14(1):5137. https://doi.org/10.1038/s41467-023-40820-x.Ильенкова НА, Степанова ЛВ, Коноплева ОС, Федоров МВ. Роль витамина D в формировании бронхиальной астмы у детей и ее течении. Педиатрия. Журнал имени Г.Н. Сперанского. 2020;99(2):249–255. https://doi.org/10.24110/0031-403X-2020-99-2-249-255.Ilenkova NA, Stepanova LV, Konopleva OS, Fedorov MV. The role of vitamin D in the formation of bronchial asthma in children and its course. Pediatriya – Zhurnal im G.N. Speranskogo. 2020;99(2):249–255. (In Russ.) https://doi.org/10.24110/0031-403X-2020-99-2-249-255.Schröder A, Lunding LP, Zissler UM, Vock C, Webering S, Ehlers JC et al. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33. Allergy. 2022;77(3):856–869. https://doi.org/10.1111/all.15072.Schröder A, Lunding LP, Zissler UM, Vock C, Webering S, Ehlers JC et al. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33. Allergy. 2022;77(3):856–869. https://doi.org/10.1111/all.15072.Van der Ploeg EK, Golebski K, van Nimwegen M, Fergusson JR, Heesters BA, Martinez-Gonzalez I et al. Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases. Sci Immunol. 2021;6(55):eabd3489. https://doi.org/10.1126/sciimmunol.abd3489.Van der Ploeg EK, Golebski K, van Nimwegen M, Fergusson JR, Heesters BA, Martinez-Gonzalez I et al. Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases. Sci Immunol. 2021;6(55):eabd3489. https://doi.org/10.1126/sciimmunol.abd3489.Ketelaar ME, Portelli MA, Dijk FN, Shrine N, Faiz A, Vermeulen CJ et al. Phenotypic and functional translation of IL33 genetics in asthma. J Allergy Clin Immunol. 2021;147(1):144–157. https://doi.org/10.1016/j.jaci.2020.04.051.Ketelaar ME, Portelli MA, Dijk FN, Shrine N, Faiz A, Vermeulen CJ et al. Phenotypic and functional translation of IL33 genetics in asthma. J Allergy Clin Immunol. 2021;147(1):144–157. https://doi.org/10.1016/j.jaci.2020.04.051.Zhao R, Shi Y, Liu N, Li B. Elevated levels of interleukin-33 are associated with asthma: A meta-analysis. Immun Inflamm Dis. 2023;11(4):e842. https://doi.org/10.1002/iid3.842.Zhao R, Shi Y, Liu N, Li B. Elevated levels of interleukin-33 are associated with asthma: A meta-analysis. Immun Inflamm Dis. 2023;11(4):e842. https://doi.org/10.1002/iid3.842.Yang Q, Zheng Y, Dong J, Xu Q, Li S, Li A et al. Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children. J Pediatr (Rio J). 2024;100(1):81–87. https://doi.org/10.1016/j.jped.2023.08.004.Yang Q, Zheng Y, Dong J, Xu Q, Li S, Li A et al. Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children. J Pediatr (Rio J). 2024;100(1):81–87. https://doi.org/10.1016/j.jped.2023.08.004.Ritzmann F, Lunding LP, Bals R, Wegmann M, Beisswenger C. IL-17 cytokines and chronic lung diseases. Cells. 2022;11(14):2132. https://doi.org/10.3390/cells11142132.Ritzmann F, Lunding LP, Bals R, Wegmann M, Beisswenger C. IL-17 cytokines and chronic lung diseases. Cells. 2022;11(14):2132. https://doi.org/10.3390/cells11142132.Liu Z, Niu C, Ying L, Zhang Q, Long M, Fu Z. Exploration of the serum interleukin-17 and interleukin-27 expression levels in children with bronchial asthma and their correlation with indicators of lung function. Genet Test Mol Biomarkers. 2020;24(1):10–16. https://doi.org/10.1089/gtmb.2019.0155.Liu Z, Niu C, Ying L, Zhang Q, Long M, Fu Z. Exploration of the serum interleukin-17 and interleukin-27 expression levels in children with bronchial asthma and their correlation with indicators of lung function. Genet Test Mol Biomarkers. 2020;24(1):10–16. https://doi.org/10.1089/gtmb.2019.0155.Song J, Zhang H, Tong Y, Wang Y, Xiang Q, Dai H et al. Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. Redox Biol. 2023;68:102970. https://doi.org/10.1016/j.redox.2023.102970.Song J, Zhang H, Tong Y, Wang Y, Xiang Q, Dai H et al. Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation. Redox Biol. 2023;68:102970. https://doi.org/10.1016/j.redox.2023.102970.Bosco A. Emerging role for interferons in respiratory viral infections and childhood asthma. Front Immunol. 2023;14:1109001. https://doi.org/10.3389/fimmu.2023.1109001.Bosco A. Emerging role for interferons in respiratory viral infections and childhood asthma. Front Immunol. 2023;14:1109001. https://doi.org/10.3389/fimmu.2023.1109001.Raju A, Luthra G, Shahbaz M, Almatooq H, Foucambert P, Esbrand FD et al. Role of vitamin D deficiency in increased susceptibility to respiratory infections among children: a systematic review. Cureus. 2022;14(9):e29205. https://doi.org/10.7759/cureus.29205.Raju A, Luthra G, Shahbaz M, Almatooq H, Foucambert P, Esbrand FD et al. Role of vitamin D deficiency in increased susceptibility to respiratory infections among children: a systematic review. Cureus. 2022;14(9):e29205. https://doi.org/10.7759/cureus.29205.Kilic A, Halu A, De Marzio M, Maiorino E, Duvall MG, Bruggemann TR et al. Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1. eLife. 2024;12:RP89270. https://doi.org/10.7554/eLife.89270.2.Kilic A, Halu A, De Marzio M, Maiorino E, Duvall MG, Bruggemann TR et al. Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1. eLife. 2024;12:RP89270. https://doi.org/10.7554/eLife.89270.2.Bastyte D, Tamasauskiene L, Golubickaite I, Ugenskiene R, Sitkauskiene B. Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study. BMC Pulm Med. 2023;23(1):245. https://doi.org/10.1186/s12890-023-02531-3.Bastyte D, Tamasauskiene L, Golubickaite I, Ugenskiene R, Sitkauskiene B. Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study. BMC Pulm Med. 2023;23(1):245. https://doi.org/10.1186/s12890-023-02531-3.Bastyte D, Tamasauskiene L, Stakaitiene I, Ugenskiene R, Gradauskiene Sitkauskiene B. The association of vitamin D receptor gene polymorphisms with vitamin D, total IgE, and blood eosinophils in patients with atopy. Biomolecules. 2024;14(2):212. https://doi.org/10.3390/biom14020212.Bastyte D, Tamasauskiene L, Stakaitiene I, Ugenskiene R, Gradauskiene Sitkauskiene B. The association of vitamin D receptor gene polymorphisms with vitamin D, total IgE, and blood eosinophils in patients with atopy. Biomolecules. 2024;14(2):212. https://doi.org/10.3390/biom14020212.Goncalves-Mendes N, Talvas J, Dualé C, Guttmann A, Corbin V, Marceau G et al. Impact of vitamin D supplementation on influenza vaccine response and immune functions in deficient elderly persons: a randomized placebo-controlled trial. Front Immunol. 2019;10:65. https://doi.org/10.3389/fimmu.2019.00065.Goncalves-Mendes N, Talvas J, Dualé C, Guttmann A, Corbin V, Marceau G et al. Impact of vitamin D supplementation on influenza vaccine response and immune functions in deficient elderly persons: a randomized placebo-controlled trial. Front Immunol. 2019;10:65. https://doi.org/10.3389/fimmu.2019.00065.El Abd A, Dasari H, Dodin P, Trottier H, Ducharme FM. The effects of vitamin D supplementation on inflammatory biomarkers in patients with asthma: a systematic review and meta-analysis of randomized controlled trials. Front Immunol. 2024;15:1335968. https://doi.org/10.3389/fimmu.2024.1335968.El Abd A, Dasari H, Dodin P, Trottier H, Ducharme FM. The effects of vitamin D supplementation on inflammatory biomarkers in patients with asthma: a systematic review and meta-analysis of randomized controlled trials. Front Immunol. 2024;15:1335968. https://doi.org/10.3389/fimmu.2024.1335968.Papamichael MM, Itsiopoulos C, Katsardis C, Tsoukalas D, Erbas B. Does BMI modify the association between vitamin D and pulmonary function in children of the mild asthma phenotype? Int J Environ Res Public Health. 2022;19(24):16768. https://doi.org/10.3390/ijerph192416768.Papamichael MM, Itsiopoulos C, Katsardis C, Tsoukalas D, Erbas B. Does BMI modify the association between vitamin D and pulmonary function in children of the mild asthma phenotype? Int J Environ Res Public Health. 2022;19(24):16768. https://doi.org/10.3390/ijerph192416768.Gaudet M, Plesa M, Mogas A, Jalaleddine N, Hamid Q, Al Heialy S. Recent advances in vitamin D implications in chronic respiratory diseases. Respir Res. 2022;23(1):252. https://doi.org/10.1186/s12931-022-02147-x.Gaudet M, Plesa M, Mogas A, Jalaleddine N, Hamid Q, Al Heialy S. Recent advances in vitamin D implications in chronic respiratory diseases. Respir Res. 2022;23(1):252. https://doi.org/10.1186/s12931-022-02147-x.Li Q, Zhou Q, Zhang G, Tian X, Chen Y, Cun Y et al. Long-term effects of vitamin D on exacerbation rate, health care utilization and lung function in children with asthma. Ann Transl Med. 2022;10(20):1094. https://doi.org/10.21037/atm-22-2750.Li Q, Zhou Q, Zhang G, Tian X, Chen Y, Cun Y et al. Long-term effects of vitamin D on exacerbation rate, health care utilization and lung function in children with asthma. Ann Transl Med. 2022;10(20):1094. https://doi.org/10.21037/atm-22-2750.Luo C, Sun Y, Zeng Z, Liu Y, Peng S. Vitamin D supplementation in pregnant women or infants for preventing allergic diseases: a systematic review and meta-analysis of randomized controlled trials. Chin Med J (Engl). 2022;135(3):276–284. https://doi.org/10.1097/CM9.0000000000001951.Luo C, Sun Y, Zeng Z, Liu Y, Peng S. Vitamin D supplementation in pregnant women or infants for preventing allergic diseases: a systematic review and meta-analysis of randomized controlled trials. Chin Med J (Engl). 2022;135(3):276–284. https://doi.org/10.1097/CM9.0000000000001951.Tareke AA, Hadgu AA, Ayana AM, Zerfu TA. Prenatal vitamin D supplementation and child respiratory health: A systematic review and meta-analysis of randomized controlled trials. World Allergy Organ J. 2020;13(12):100486. https://doi.org/10.1016/j.waojou.2020.100486.Tareke AA, Hadgu AA, Ayana AM, Zerfu TA. Prenatal vitamin D supplementation and child respiratory health: A systematic review and meta-analysis of randomized controlled trials. World Allergy Organ J. 2020;13(12):100486. https://doi.org/10.1016/j.waojou.2020.100486.Brustad N, Chawes B. Vitamin D primary prevention of respiratory infections and asthma in early childhood: evidence and mechanisms. J Allergy Clin Immunol Pract. 2024;12(7):1707–1714. https://doi.org/10.1016/j.jaip.2024.02.005.Brustad N, Chawes B. Vitamin D primary prevention of respiratory infections and asthma in early childhood: evidence and mechanisms. J Allergy Clin Immunol Pract. 2024;12(7):1707–1714. https://doi.org/10.1016/j.jaip.2024.02.005.Sharma S, Garg M. Investigating the role of vitamin D in asthma. eLife. 2024;13:e97031. https://doi.org/10.7554/eLife.97031.Sharma S, Garg M. Investigating the role of vitamin D in asthma. eLife. 2024;13:e97031. https://doi.org/10.7554/eLife.97031.Shimizu M, Kato T, Adachi Y, Wada T, Murakami S, Ito Y et al. Maternal dietary vitamin D intake during pregnancy is associated with allergic disease symptoms in children at 3 years old: the Japan environment and children’s study. Int Arch Allergy Immunol. 2023;184(11):1106–1115. https://doi.org/10.1159/000531970.Shimizu M, Kato T, Adachi Y, Wada T, Murakami S, Ito Y et al. Maternal dietary vitamin D intake during pregnancy is associated with allergic disease symptoms in children at 3 years old: the Japan environment and children’s study. Int Arch Allergy Immunol. 2023;184(11):1106–1115. https://doi.org/10.1159/000531970.Abi-Ayad M, Nedjar I, Chabni N. Association between 25-hydroxy vitamin D and lung function (FEV1, FVC, FEV1/FVC) in children and adults with asthma: A systematic review. Lung India. 2023;40(5):449–456. https://doi.org/10.4103/lungindia.lungindia_213_23.Abi-Ayad M, Nedjar I, Chabni N. Association between 25-hydroxy vitamin D and lung function (FEV1, FVC, FEV1/FVC) in children and adults with asthma: A systematic review. Lung India. 2023;40(5):449–456. https://doi.org/10.4103/lungindia.lungindia_213_23.Grant WB. Vitamin D and viral infections: Infectious diseases, autoimmune diseases, and cancers. Adv Food Nutr Res. 2024;109:271–314. https://doi.org/10.1016/bs.afnr.2023.12.007.Grant WB. Vitamin D and viral infections: Infectious diseases, autoimmune diseases, and cancers. Adv Food Nutr Res. 2024;109:271–314. https://doi.org/10.1016/bs.afnr.2023.12.007.Долбня СВ, Дятлова АА, Климов ЛЯ, Кондратьева ЕИ, Захарова ИН, Енина ЕА. Взаимосвязь между обеспеченностью витамином D и уровнем интерферона-γ у детей с хроническими заболеваниями легких. Медицинский совет. 2023;17(12):231–239. https://doi.org/10.21518/ms2023-221.Dolbnya SV, Dyatlova AA, Klimov LY, Kondratyeva EI, Zakharova IN, Enina EA. Relationship between vitamin D sufficiency and interferon-γ levels in children with chronic lung diseases. Meditsinskiy Sovet. 2023;17(12):231–239. (In Russ.) https://doi.org/10.21518/ms2023-221.Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2023;(2):CD011511. https://doi.org/10.1002/14651858.CD011511.pub3.Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2023;(2):CD011511. https://doi.org/10.1002/14651858.CD011511.pub3.Aierken A, Yusufu B, Xu P. Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E. Exp Ther Med. 2020;20(3):2122–2126. https://doi.org/10.3892/etm.2020.8949.Aierken A, Yusufu B, Xu P. Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E. Exp Ther Med. 2020;20(3):2122–2126. https://doi.org/10.3892/etm.2020.8949.Shabana MA, Esawy MM, Ismail NA, Said AM. Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology. 2019;224(6):721–727. https://doi.org/10.1016/j.imbio.2019.09.005.Shabana MA, Esawy MM, Ismail NA, Said AM. Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology. 2019;224(6):721–727. https://doi.org/10.1016/j.imbio.2019.09.005.Боровик ТЭ, Громова ОА, Захарова ИН, Мальцев СВ, Мошетова ЛК, Намазова-Баранова ЛС. и др. Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции: национальная программа. 2-е изд. М.: Педиатръ; 2021. 116 с.Боровик ТЭ, Громова ОА, Захарова ИН, Мальцев СВ, Мошетова ЛК, Намазова-Баранова ЛС. и др. Недостаточность витамина D у детей и подростков Российской Федерации: современные подходы к коррекции: национальная программа. 2-е изд. М.: Педиатръ; 2021. 116 с.Maboshe W, Macdonald HM, Wassall H, Fraser WD, Tang J, Fielding S et al. Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-P roduced IFN-γ: Results From the D-SIRe2 Randomized Controlled Trial. Front Immunol. 2021;12:623087. https://doi.org/10.3389/fimmu.2021.623087.Maboshe W, Macdonald HM, Wassall H, Fraser WD, Tang J, Fielding S et al. Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-P roduced IFN-γ: Results From the D-SIRe2 Randomized Controlled Trial. Front Immunol. 2021;12:623087. https://doi.org/10.3389/fimmu.2021.623087.Xing X, Li A, Tan H, Zhou Y. IFN-γ+ IL-17+ Th17 cells regulate fibrosis through secreting IL-21 in systemic scleroderma. J Cell Mol Med. 2020;24(23):13600–13608. https://doi.org/10.1111/jcmm.15266.Xing X, Li A, Tan H, Zhou Y. IFN-γ+ IL-17+ Th17 cells regulate fibrosis through secreting IL-21 in systemic scleroderma. J Cell Mol Med. 2020;24(23):13600–13608. https://doi.org/10.1111/jcmm.15266.Xie H, Zeng J, Yan X, Shen N, Zheng X, Luo H. Clinical Significance and Properties of IFN-γ+IL-17+ Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection. Digestion. 2022;103(6):438–450. https://doi.org/10.1159/000526924.Xie H, Zeng J, Yan X, Shen N, Zheng X, Luo H. Clinical Significance and Properties of IFN-γ+IL-17+ Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection. Digestion. 2022;103(6):438–450. https://doi.org/10.1159/000526924.Stern DA, Guerra S, Halonen M, Wright AL, Martinez FD. Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood. J Allergy Clin Immunol. 2007;120(4):835–841. https://doi.org/10.1016/j.jaci.2007.05.050.Stern DA, Guerra S, Halonen M, Wright AL, Martinez FD. Low IFN-gamma production in the first year of life as a predictor of wheeze during childhood. J Allergy Clin Immunol. 2007;120(4):835–841. https://doi.org/10.1016/j.jaci.2007.05.050.Tian M, Zhou Y, Jia H, Zhu X, Cui Y. The Clinical Significance of Changes in the Expression Levels of MicroRNA-1 and Inflammatory Factors in the Peripheral Blood of Children with Acute-Stage Asthma. Biomed Res Int. 2018:7632487. https://doi.org/10.1155/2018/7632487.Tian M, Zhou Y, Jia H, Zhu X, Cui Y. The Clinical Significance of Changes in the Expression Levels of MicroRNA-1 and Inflammatory Factors in the Peripheral Blood of Children with Acute-Stage Asthma. Biomed Res Int. 2018:7632487. https://doi.org/10.1155/2018/7632487.Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132(2):297–304.e3. https://doi.org/10.1016/j.jaci.2013.03.037.Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132(2):297–304.e3. https://doi.org/10.1016/j.jaci.2013.03.037.Shabana MA, Esawy MM, Ismail NA, Said AM. Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology. 2019;224(6):721–727. https://doi.org/10.1016/j.imbio.2019.09.005.Shabana MA, Esawy MM, Ismail NA, Said AM. Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Immunobiology. 2019;224(6):721–727. https://doi.org/10.1016/j.imbio.2019.09.005.

The authors declare that there are no conflicts of interest present.