Введение

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/ms2024-230

medsovet-8479

Research Article

РЕВМАТОЛОГИЯ

RHEUMATOLOGY

Применение тофацитиниба при псориатическом артрите (обзор литературы)

Use of tofacitinib in psoriatic arthritis (literature review)

https://orcid.org/0000-0002-0475-8391

Шафиева

И. А.

Shafieva

I. A.

Шафиева Ирина Алексеевна, к.м.н., врач-ревматолог высшей квалификационной категории, заведующая отделением эндокринологии и остеопороза

443079, Самара, проспект Карла Маркса, д. 165б

Irina A. Shafieva, Cand. Sci. (Med.), Rheumatologist of the Highest Qualification Category, Head of the Department of Endocrinology and Osteoporosis

165b, Karl Marks St., Samara, 443079

ifabtdf@yandex.ru

https://orcid.org/0000-0003-0027-1786

Булгакова

С. В.

Bulgakova

S. V.

Булгакова Светлана Викторовна, д.м.н., доцент, заведующая кафедрой эндокринологии и гериатрии; главный внештатный специалист по гериатрии

443099, Самара, ул. Чапаевская, д. 89

443010, Самара, ул. Ленинская, д. 73

Svetlana V. Bulgakova, Dr. Sci. (Med.), Associate Professor, Head of the Department of Endocrinology and Geriatrics; Chief Freelance Specialist in Geriatrics

89, Chapaevskaya St., Samara, 443099

73, Lenin St., Samara, 443010

osteoporosis@gmail.com

https://orcid.org/0000-0003-4114-5233

Курмаев

Д. П.

Kurmaev

D. P.

Курмаев Дмитрий Петрович, к.м.н., ассистент кафедры эндокринологии и гериатрии

443099, Самара, ул. Чапаевская, д. 89

Dmitriy P. Kurmaev, Cand. Sci. (Med.), Assistant, Department of Endocrinology and Geriatrics

89, Chapaevskaya St., Samara, 443099

geriatry@mail.ru

https://orcid.org/0000-0003-0097-7252

Тренева

Е. В.

Treneva

E. V.

Тренева Екатерина Вячеславовна, к.м.н., доцент кафедры эндокринологии и гериатрии

443099, Самара, ул. Чапаевская, д. 89

Ekaterina V. Treneva, Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics

89, Chapaevskaya St., Samara, 443099

geriatry@mail.ru

Клиники Самарского государственного медицинского университетаРоссияClinics of the Samara State Medical UniversityRussian Federation

Самарский государственный медицинский университет; Министерство здравоохранения Самарской областиРоссияSamara State Medical University; Ministry of Health of the Samara RegionRussian Federation

Самарский государственный медицинский университетРоссияSamara State Medical UniversityRussian Federation

2024

15082024

012

114–122

2024

Шафиева И.А., Булгакова С.В., Курмаев Д.П., Тренева Е.В.

Shafieva I.A., Bulgakova S.V., Kurmaev D.P., Treneva E.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/8479

Введение

Введение. Псориатический артрит (ПсА) – хроническое системное иммуноопосредованное воспалительное заболевание опорно-двигательного аппарата, представляет собой сложную воспалительную артропатию с гетерогенным спектром проявлений. Стойкое воспаление может привести к разрушению суставов и инвалидизации, которые можно предотвратить при ранней диагностике и лечении. Несмотря на обширный терапевтический арсенал, контроль заболевания у значительной части пациентов является неоптимальным. Представляет интерес оценка эффективности ингибитора янус-киназ (JAK-киназ) тофацитиниба при лечении псориаза и ПсА.

Цель

Цель. Оценить возможности применения тофацитиниба при лечении псориаза и псориатического артрита.

Материалы и методы

Материалы и методы. Выполнен поиск литературы по данной тематике в базах электронных научных медицинских библиотек PubMed, PubMed Central, Scopus, eLibrary.Ru (до 29 февраля 2024 г.). Наша обзорная научная статья основана на ранее проведенных исследованиях и не содержит каких-либо исследований с участием животных или людей, проведенных кем-либо из авторов нашей статьи.

Результаты

Результаты. Рандомизированные контролируемые исследования продемонстрировали высокую эффективность тофацитиниба при лечении ПсА. Тофацитиниб является современным эффективным лекарственным препаратом для лечения псориаза и ПсА с хорошим профилем эффективности и приемлемым профилем безопасности. Дальнейшие долгосрочные расширенные исследования и клинические данные помогут расширить роль тофацитиниба в лечении этих заболеваний.

Заключение

Заключение. Литературные данные свидетельствуют о высокой эффективности тофацитиниба при лечении псориаза и псориатического артрита. Применение тофацитиниба является многообещающим в лечении пациентов с ПсА, особенно пациентов, отягощенных остаточными явлениями заболевания и болью.

Introduction

Introduction. Psoriatic arthritis (PsA) is a chronic systemic immune-mediated inflammatory disease of the musculoskeletal system, and is a complex inflammatory arthropathy with a heterogeneous spectrum of manifestations. Persistent inflammation can lead to joint destruction and disability, which can be prevented with early diagnosis and treatment. Despite the extensive therapeutic arsenal, disease control in a significant proportion of patients is suboptimal. It is of interest to evaluate the effectiveness of the janus kinase inhibitor (JAK kinase) tofacitinib in the treatment of psoriasis and PsA.

Aim

Aim. Evaluate the possibilities of using tofacitinib in the treatment of psoriasis and psoriatic arthritis.

Materials and methods

Materials and methods. We searched for literature on this topic in the databases of the electronic scientific medical libraries PubMed, PubMed Central, Scopus, eLibrary.Ru (until February 29, 2024). Our review scientific article is based on previously conducted research and does not contain any studies involving animals or humans conducted by any of the authors of our article. Results. Randomized controlled trials have demonstrated the high efficacy of tofacitinib in the treatment of PsA. Tofacitinib is a modern effective drug for the treatment of psoriasis and PsA, with a good efficacy profile and an acceptable safety profile. Further long-term expanded research and clinical data will help expand the role of tofacitinib in the treatment of these diseases

Conclusion

Conclusion. The literature data indicate the high efficacy of tofacitinib in the treatment of psoriasis and psoriatic arthritis. The use of tofacitinib is promising in the treatment of patients with PsA, especially patients burdened with residual disease phenomena and pain.

ингибиторы янус-киназыингибиторы JAKпсориатический артритспондилоартриттофацитинибпсориаз

janus kinase inhibitorsJAK inhibitorspsoriatic arthritisspondyloarthritistofacitinibpsoriasis

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The authors declare that there are no conflicts of interest present.