medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-292medsovet-8497Research ArticleНЕВРОЛОГИЯNEUROLOGYИнсомния - фактор, отягчающий течение сердечно-сосудистых заболеваний: современное понимание проблемы и пути решенияInsomnia is an factor aggravaging the course of cardiovascular diseases: modern understanding of the problem and ways of solutionhttps://orcid.org/0000-0001-6762-8845ЕсинР. Г.EsinR. G.

Есин Радий Германович - д.м.н., профессор кафедры неврологии, KГMA - филиал РМАНПО; профессор кафедры неврологии с курсами психиатрии, клинической психологии и медицинской генетики, КФУ.

420012, Казань, ул. Муштари, д. 11; 420008, Казань, ул. Кремлевская, д. 18, корп. 1

Radiy G. Esin - Dr. Sci. (Med.), Professor, Department of Neurology of the Kazan State Medical Academy - a branch of the Russian Medical Academy of Continuing Professional Education; Professor of the Department of Neurology with Courses in Psychiatry, Clinical Psychology and Medical Genetics, Kazan (Volga Region) Federal University.

11, Mushtari St., Kazan, 420012; 18, Bldg. 1, Kremlevskaya St., Kazan, 420008

radyesin@mail.ruhttps://orcid.org/0000-0003-4244-4446ЕсинО. Р.EsinO. R.

Есин Олег Радиевич - к.м.н., доцент кафедры прикладной и экспериментальной лингвистики и кафедры неврологии с курсами психиатрии, клинической психологии и медицинской генетики.

420008, Казань, ул. Кремлевская, д. 18, корп. 1

Oleg R. Esin - Cand. Sci. (Med.), Associate Professor of the Department of Applied and Experimental Linguistics and the Department of Neurology with courses in Psychiatry, Clinical Psychology and Medical Genetics, Kazan (Volga Region) Federal University.

18, Bldg. 1, Kremlevskaya St., Kazan, 420008

oleg_mdi@mail.ruhttps://orcid.org/0009-0000-6527-596XЭркиноваД. Э.ErkinovaD. E.

Эркинова Дилноза Эркин Кизи - студент лечебного факультета Института фундаментальной медицины и биологии.

420008, Казань, ул. Кремлевская, д. 18, корп. 1

Dilnoza E. Erkinova - Student of the Faculty of Medicine, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University.

18, Bldg. 1, Kremlevskaya St., Kazan, 420008

erkinova-dilya@mail.ruКазанский (Приволжский) федеральный университет Минобрнауки России; Казанская государственная медицинская академия - филиал Российской медицинской академии непрерывного профессионального образованияРоссияKazan (Volga Region) Federal University; Kazan State Medical Academy - a branch of the Russian Medical Academy of Continuing Professional EducationRussian FederationКазанский (Приволжский) федеральный университет Минобрнауки РоссииРоссияKazan (Volga Region) Federal UniversityRussian Federation2024010920240138591Copyright © Есин Р.Г., Есин О.Р., Эркинова Д.Э., 20242024Есин Р.Г., Есин О.Р., Эркинова Д.Э.Esin R.G., Esin O.R., Erkinova D.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8497

Инсомния является распространенной и серьезной проблемой здравоохранения, ассоциированной со значительным и растущим бременем для здоровья. Около 10% взрослого населения страдает от хронической инсомнии, а 20% страдает от нее периодически. Инсомния ассоциирована с повышенным риском психических (депрессия, когнитивные нарушения), соматических (артериальная гипертония, ишемическая болезнь сердца, аритмии, нарушение метаболизма) и профессиональных проблем. В обзоре рассматриваются современные данные о влиянии инсомнии на течение заболеваний сердечно-сосудистой системы, показано негативное влияние инсомнии на ишемическую болезнь сердца, артериальную гипертонию и нарушения ритма сердца. Высокая распространенность (40-80%) апноэ сна наблюдается у пациентов с сердечно-сосудистыми заболеваниями, в т. ч. с ишемической болезнью сердца, фибрилляцией предсердий, сердечной недостаточностью и артериальной гипертензией, что приводит к неблагоприятным кардиологическим исходам. Негативным фактом является неуклонный (эпидемический) рост сердечно-сосудистых заболеваний среди молодых людей в возрасте от 18 до 50 лет, обусловленный изменением образа жизни и повышением уровня стрессорных факторов. У лиц с инсомнией значительно повышен риск инфаркта миокарда, смертности от сердечно-сосудистых заболеваний, заболеваемости сердечно-сосудистыми заболеваниями и смертности от всех причин по сравнению со здоровыми людьми. Оптимальным препаратом для лечения инсомнии может быть доксиламин, особенно его наиболее легко титруемая форма - раствор в каплях. Препарат имеет высокий уровень безопасности и высокоэффективен при лечении инсомнии. Сопутствующим позитивным эффектом препарата может быть снижение интенсивности вестибулярных симптомов.

Insomnia is a common and serious health problem associated with a significant and growing health burden. About 10% of the adult population suffers from chronic insomnia, and 20% suffer from it periodically. Insomnia is associated with an increased risk of mental (depression, cognitive impairment), somatic (arterial hypertension, coronary heart disease, arrhythmias, metabolic disorders) and occupational problems. The review examines current data on the effect of insomnia on the course of diseases of the cardiovascular system, showing the negative impact of insomnia on coronary heart disease, arterial hypertension and cardiac arrhythmias. A high prevalence (40-80%) of sleep apnea is observed in patients with cardiovascular disease, including coronary artery disease, atrial fibrillation, heart failure and hypertension, leading to adverse cardiac outcomes. A negative fact is the steady (epidemic) increase in cardiovascular diseases among young people aged 18 to 50 years, due to lifestyle changes and an increase in the level of stress factors. Individuals with insomnia have a significantly increased risk of myocardial infarction, cardiovascular mortality, cardiovascular disease morbidity, and all-cause mortality compared with healthy individuals. The optimal drug for the treatment of insomnia may be doxylamine, especially its most easily titrated form - a solution in drops. The drug has a high level of safety and is highly effective in the treatment of insomnia. A concomitant positive effect of the drug may be a decrease in the intensity of vestibular symptoms.

инсомнияишемическая болезнь сердцаартериальная гипертонияаритмиядоксиламинinsomniacoronary heart diseasearterial hypertensionarrhythmiadoxylamineРабота выполнена за счет средств Программы стратегического академического лидерства Казанского (Приволжского) федерального университета (Приоритет-2030).This work was supported by the Kazan Federal University Strategic Academic Leadership Program (PRIORITY-2030).ReferencesGauld C, Lopez R, Geoffroy PA, Morin CM, Guichard K, Giroux E et al. A systematic analysis of ICSD-3 diagnostic criteria and proposal for further structured iteration. Sleep Med Rev. 2021;58:101439. https://doi.org/10.1016/j.smrv.2021.101439.Gauld C, Lopez R, Geoffroy PA, Morin CM, Guichard K, Giroux E et al. A systematic analysis of ICSD-3 diagnostic criteria and proposal for further structured iteration. Sleep Med Rev. 2021;58:101439. https://doi.org/10.1016/j.smrv.2021.101439.Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA et al. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat Genet. 2019;51(3):394-403. https://doi.org/10.1038/s41588-018-0333-3.Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA et al. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat Genet. 2019;51(3):394-403. https://doi.org/10.1038/s41588-018-0333-3.Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;144(3):e56-e67. https://doi.org/10.1161/CIR.0000000000000988.Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;144(3):e56-e67. https://doi.org/10.1161/CIR.0000000000000988.Rissling MB, Gray KE, Ulmer CS, Martin JL, Zaslavsky O, Gray SL et al. Sleep Disturbance, Diabetes, and Cardiovascular Disease in Postmenopausal Veteran Women. Gerontologist. 2016;56(Suppl. 1):S54-66. https://doi.org/10.1093/geront/gnv668.Rissling MB, Gray KE, Ulmer CS, Martin JL, Zaslavsky O, Gray SL et al. Sleep Disturbance, Diabetes, and Cardiovascular Disease in Postmenopausal Veteran Women. Gerontologist. 2016;56(Suppl. 1):S54-66. https://doi.org/10.1093/geront/gnv668.Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 20129;4:687-701. https://doi.org/10.1007/s13311-012-0145-6.Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 20129;4:687-701. https://doi.org/10.1007/s13311-012-0145-6.Sateia MJ. International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014;146(5):1387-1394. https://doi.org/10.1378/chest.14-0970.Sateia MJ. International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014;146(5):1387-1394. https://doi.org/10.1378/chest.14-0970.Kaur H, Spurling BC, Bollu PC. Chronic Insomnia. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK526136.Kaur H, Spurling BC, Bollu PC. Chronic Insomnia. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK526136.Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016;5(4):780-784. https://doi.org/10.4103/2249-4863.201153.Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016;5(4):780-784. https://doi.org/10.4103/2249-4863.201153.Bankier B, Januzzi JL, Littman AB. The high prevalence of multiple psychiatric disorders in stable outpatients with coronary heart disease. Psychosom Med. 2004;66(5):645-650. https://doi.org/10.1097/01.psy.0000138126.90551.62.Bankier B, Januzzi JL, Littman AB. The high prevalence of multiple psychiatric disorders in stable outpatients with coronary heart disease. Psychosom Med. 2004;66(5):645-650. https://doi.org/10.1097/01.psy.0000138126.90551.62.Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep. 2007;30(2):213-218. https://doi.org/10.1093/sleep/30.2.213.Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ. Comorbidity of chronic insomnia with medical problems. Sleep. 2007;30(2):213-218. https://doi.org/10.1093/sleep/30.2.213.Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3(5 Suppl.):S7-S10. Available at: https://pubmed.ncbi.nlm.nih.gov/17824495.Roth T. Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3(5 Suppl.):S7-S10. Available at: https://pubmed.ncbi.nlm.nih.gov/17824495.Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97-1 1 1 . https://doi.org/10.1053/smrv.2002.0186.Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002;6(2):97-1 1 1 . https://doi.org/10.1053/smrv.2002.0186.Bonnet M. Etiology of insomnia. Sleep Medicine. 2006;7(7):544. https://doi.org/10.1016/j.sleep.2006.05.012.Bonnet M. Etiology of insomnia. Sleep Medicine. 2006;7(7):544. https://doi.org/10.1016/j.sleep.2006.05.012.Katz DA, McHorney CA. The relationship between insomnia and health-related quality of life in patients with chronic illness. J Fam Pract. 2002;51(3):229-235. Available at: https://pubmed.ncbi.nlm.nih.gov/11978233.Katz DA, McHorney CA. The relationship between insomnia and health-related quality of life in patients with chronic illness. J Fam Pract. 2002;51(3):229-235. Available at: https://pubmed.ncbi.nlm.nih.gov/11978233.Ali E, Shaikh A, Yasmin F, Sughra F, Sheikh A, Owais R et al. Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data. PLoS ONE. 2023;18(9):e0291859. https://doi.org/10.1371/journal.pone.0291859.Ali E, Shaikh A, Yasmin F, Sughra F, Sheikh A, Owais R et al. Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data. PLoS ONE. 2023;18(9):e0291859. https://doi.org/10.1371/journal.pone.0291859.Lechat B, Appleton S, Melaku YA, Hansen K, McEvoy RD, Adams R et al. Comorbid insomnia and sleep apnoea is associated with all-cause mortality. Eur Respir J. 2022;60(1):2101958. https://doi.org/10.1183/13993003.01958-2021.Lechat B, Appleton S, Melaku YA, Hansen K, McEvoy RD, Adams R et al. Comorbid insomnia and sleep apnoea is associated with all-cause mortality. Eur Respir J. 2022;60(1):2101958. https://doi.org/10.1183/13993003.01958-2021.Siebmanns S, Johansson L, Sandberg J, Johansson P, Brostrom A. Experiences and Management of Incidents That Influence Sleep in Patients With Cardiovascular Disease and Insomnia. J Cardiovasc Nurs. 2020;35(4):364-374 . https://doi.org/10.1097/JCN.0000000000000626.Siebmanns S, Johansson L, Sandberg J, Johansson P, Brostrom A. Experiences and Management of Incidents That Influence Sleep in Patients With Cardiovascular Disease and Insomnia. J Cardiovasc Nurs. 2020;35(4):364-374 . https://doi.org/10.1097/JCN.0000000000000626.Pengo MF, Javaheri S, Sanchez-de-la-Torre M, Schwarz EI. What cardiologists should know about sleep. Eur Heart J. 2022;43(31):2911-2913. https://doi.org/10.1093/eurheartj/ehac349.Pengo MF, Javaheri S, Sanchez-de-la-Torre M, Schwarz EI. What cardiologists should know about sleep. Eur Heart J. 2022;43(31):2911-2913. https://doi.org/10.1093/eurheartj/ehac349.Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014;370(24):2265-2275. https://doi.org/10.1056/NEJMoa1306187.Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014;370(24):2265-2275. https://doi.org/10.1056/NEJMoa1306187.Andersson C, Vasan RS. Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. 2018;15(4):230-240. https://doi.org/10.1038/nrcardio.2017.154.Andersson C, Vasan RS. Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. 2018;15(4):230-240. https://doi.org/10.1038/nrcardio.2017.154.Suka M, Yoshida K, Sugimori H. Persistent insomnia is a predictor of hypertension in Japanese male workers. J Occup Health. 2003;45(6):344-350. https://doi.org/10.1539/joh.45.344.Suka M, Yoshida K, Sugimori H. Persistent insomnia is a predictor of hypertension in Japanese male workers. J Occup Health. 2003;45(6):344-350. https://doi.org/10.1539/joh.45.344.Coryell VT, Ziegelstein RC, Hirt K, Quain A, Marine JE, Smith MT. Clinical correlates of insomnia in patients with acute coronary syndrome. Int Heart J. 2013;54(5):258-265. https://doi.org/10.1536/ihj.54.Coryell VT, Ziegelstein RC, Hirt K, Quain A, Marine JE, Smith MT. Clinical correlates of insomnia in patients with acute coronary syndrome. Int Heart J. 2013;54(5):258-265. https://doi.org/10.1536/ihj.54.Laugsand LE, Strand LB, Platou C, Vatten LJ, Janszky I. Insomnia and the risk of incident heart failure: a population study. Eur Heart J. 2014;35(21):1382-1393. https://doi.org/10.1093/eurheartj/eht019.Laugsand LE, Strand LB, Platou C, Vatten LJ, Janszky I. Insomnia and the risk of incident heart failure: a population study. Eur Heart J. 2014;35(21):1382-1393. https://doi.org/10.1093/eurheartj/eht019.Bertisch SM, Pollock BD, Mittleman MA, Buysse DJ, Bazzano LA, Gottlieb DJ, Redline S. Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study. Sleep. 2018;41(6):zsy047. https://doi.org/10.1093/sleep/zsy047.Bertisch SM, Pollock BD, Mittleman MA, Buysse DJ, Bazzano LA, Gottlieb DJ, Redline S. Insomnia with objective short sleep duration and risk of incident cardiovascular disease and all-cause mortality: Sleep Heart Health Study. Sleep. 2018;41(6):zsy047. https://doi.org/10.1093/sleep/zsy047.Morin CM, Belleville G, Belanger L, Ivers H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep. 2011;34(5):601-608. https://doi.org/10.1093/sleep/34.5.601.Morin CM, Belleville G, Belanger L, Ivers H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep. 2011;34(5):601-608. https://doi.org/10.1093/sleep/34.5.601.Ali E, Shaikh A, Yasmin F, Sughra F, Sheikh A, Owais R et al. Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data. PLoS ONE. 2023;18(9):e0291859.. https://doi.org/10.1371/journal.pone.0291859.Ali E, Shaikh A, Yasmin F, Sughra F, Sheikh A, Owais R et al. Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data. PLoS ONE. 2023;18(9):e0291859.. https://doi.org/10.1371/journal.pone.0291859.Huang BH, Duncan MJ, Cistulli PA, Nassar N, Hamer M, Stamatakis E. Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk. Br J Sports Med. 2022;56(13):718-724. https://doi.org/10.1136/bjsports-2021-104046.Huang BH, Duncan MJ, Cistulli PA, Nassar N, Hamer M, Stamatakis E. Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk. Br J Sports Med. 2022;56(13):718-724. https://doi.org/10.1136/bjsports-2021-104046.Yan B, Yang J, Zhao B, Fan Y, Wang W, Ma X. Objective Sleep Efficiency Predicts Cardiovascular Disease in a Community Population: The Sleep Heart Health Study. J Am Heart Assoc. 2021;10(7):e016201. https://doi.org/10.1161/jaha.120.016201.Yan B, Yang J, Zhao B, Fan Y, Wang W, Ma X. Objective Sleep Efficiency Predicts Cardiovascular Disease in a Community Population: The Sleep Heart Health Study. J Am Heart Assoc. 2021;10(7):e016201. https://doi.org/10.1161/jaha.120.016201.Sofi F, Cesari F, Casini A, Macchi C, Abbate R, Gensini GF. Insomnia and risk of cardiovascular disease: a meta-analysis. Eur J Prev Cardiol. 2014;21(1):57-64. https://doi.org/10.1177/2047487312460020.Sofi F, Cesari F, Casini A, Macchi C, Abbate R, Gensini GF. Insomnia and risk of cardiovascular disease: a meta-analysis. Eur J Prev Cardiol. 2014;21(1):57-64. https://doi.org/10.1177/2047487312460020.He Q, Zhang P, Li G, Dai H, Shi J. The association between insomnia symptoms and risk of cardiocerebral vascular events: A meta-analysis of prospective cohort studies. Eur J Prev Cardiol. 2017;24(10):1071-1082. https://doi.org/10.1177/2047487317702043.He Q, Zhang P, Li G, Dai H, Shi J. The association between insomnia symptoms and risk of cardiocerebral vascular events: A meta-analysis of prospective cohort studies. Eur J Prev Cardiol. 2017;24(10):1071-1082. https://doi.org/10.1177/2047487317702043.Hu S, Lan T, Wang Y, Ren L. Individual Insomnia Symptom and Increased Hazard Risk of Cardiocerebral Vascular Diseases: A Meta-Analysis. Front Psychiatry. 2021;12:654719. https://doi.org/10.3389/fpsyt.2021.654719.Hu S, Lan T, Wang Y, Ren L. Individual Insomnia Symptom and Increased Hazard Risk of Cardiocerebral Vascular Diseases: A Meta-Analysis. Front Psychiatry. 2021;12:654719. https://doi.org/10.3389/fpsyt.2021.654719.Kanno Y, Yoshihisa A, Watanabe S, Takiguchi M, Yokokawa T, Sato A et al. Prognostic Significance of Insomnia in Heart Failure. Circ J. 2016;80(7):1571-1577. https://doi.org/10.1253/circj.CJ-16-0205.Kanno Y, Yoshihisa A, Watanabe S, Takiguchi M, Yokokawa T, Sato A et al. Prognostic Significance of Insomnia in Heart Failure. Circ J. 2016;80(7):1571-1577. https://doi.org/10.1253/circj.CJ-16-0205.Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ. Melatonin and cardiovascular disease: myth or reality? Rev Esp Cardiol (Engl Ed). 2012;65(3):215-218. https://doi.org/10.1016/j.recesp.2011.10.009.Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ. Melatonin and cardiovascular disease: myth or reality? Rev Esp Cardiol (Engl Ed). 2012;65(3):215-218. https://doi.org/10.1016/j.recesp.2011.10.009.Krell SB, Kapur VK. Insomnia complaints in patients evaluated for obstructive sleep apnea. Sleep Breath. 2o05;9(3):1o4-11O. https://doi.org/10.1007/s11325-005-0026-x.Krell SB, Kapur VK. Insomnia complaints in patients evaluated for obstructive sleep apnea. Sleep Breath. 2o05;9(3):1o4-11O. https://doi.org/10.1007/s11325-005-0026-x.Chung KF. Insomnia subtypes and their relationships to daytime sleepiness in patients with obstructive sleep apnea. Respiration. 2005;72(5):460-465. https://doi.org/10.1159/000087668.Chung KF. Insomnia subtypes and their relationships to daytime sleepiness in patients with obstructive sleep apnea. Respiration. 2005;72(5):460-465. https://doi.org/10.1159/000087668.Grandner MA, Alfonso-Miller P, Fernandez-Mendoza J, Shetty S, Shenoy S, Combs D. Sleep: important considerations for the prevention of cardiovascular disease. Curr Opin Cardiol. 2016;31(5):551-565. https://doi.org/10.1097/HCO.0000000000000324.Grandner MA, Alfonso-Miller P, Fernandez-Mendoza J, Shetty S, Shenoy S, Combs D. Sleep: important considerations for the prevention of cardiovascular disease. Curr Opin Cardiol. 2016;31(5):551-565. https://doi.org/10.1097/HCO.0000000000000324.Vgontzas AN, Liao D, Pejovic S, Calhoun S, Karataraki M, Bixler EO. Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study. Diabetes Care. 2009;32(11):1980-1985. https://doi.org/10.2337/dc09-0284.Vgontzas AN, Liao D, Pejovic S, Calhoun S, Karataraki M, Bixler EO. Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study. Diabetes Care. 2009;32(11):1980-1985. https://doi.org/10.2337/dc09-0284.Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015;66:143-172. https://doi.org/10.1146/annurev-psych-010213-115205.Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015;66:143-172. https://doi.org/10.1146/annurev-psych-010213-115205.King CR, Knutson KL, Rathouz PJ, Sidney S, Liu K, Lauderdale DS. Short sleep duration and incident coronary artery calcification. JAMA. 2008;300(24):2859-2866. https://doi.org/10.1001/jama.2008.867.King CR, Knutson KL, Rathouz PJ, Sidney S, Liu K, Lauderdale DS. Short sleep duration and incident coronary artery calcification. JAMA. 2008;300(24):2859-2866. https://doi.org/10.1001/jama.2008.867.Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004;43(4):678-683. https://doi.org/10.1016/j.jacc.2003.07.050.Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004;43(4):678-683. https://doi.org/10.1016/j.jacc.2003.07.050.Maniaci A, Di Luca M, Lechien JR, Iannella G, Grillo C, Grillo CM et al. Lateral pharyngoplasty vs. traditional uvulopalatopharyngoplasty for patients with OSA: systematic review and meta-analysis. Sleep Breath. 2022;26(4):1539-1550. https://doi.org/10.1007/s11325-021-02520-y.Maniaci A, Di Luca M, Lechien JR, Iannella G, Grillo C, Grillo CM et al. Lateral pharyngoplasty vs. traditional uvulopalatopharyngoplasty for patients with OSA: systematic review and meta-analysis. Sleep Breath. 2022;26(4):1539-1550. https://doi.org/10.1007/s11325-021-02520-y.Bhatt P, Patel V, Motwani J, Choubey U, Mahmood R, Gupta V, Jain R. Insomnia and Cardiovascular Health: Exploring the Link Between Sleep Disorders and Cardiac Arrhythmias. Curr Cardiol Rep. 2023;25(10):1211-1221. https://doi.org/10.1007/s11886-023-01939-x.Bhatt P, Patel V, Motwani J, Choubey U, Mahmood R, Gupta V, Jain R. Insomnia and Cardiovascular Health: Exploring the Link Between Sleep Disorders and Cardiac Arrhythmias. Curr Cardiol Rep. 2023;25(10):1211-1221. https://doi.org/10.1007/s11886-023-01939-x.Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129(8):837-847. https://doi.org/10.1161/CIRCULATIONAHA.113.005119.Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129(8):837-847. https://doi.org/10.1161/CIRCULATIONAHA.113.005119.Krijthe BP, Kunst A, Benjamin EJ, Lip GY, Franco OH, Hofman A et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J. 2013;34(35):2746-2751. https://doi.org/10.1093/eurheartj/eht280.Krijthe BP, Kunst A, Benjamin EJ, Lip GY, Franco OH, Hofman A et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J. 2013;34(35):2746-2751. https://doi.org/10.1093/eurheartj/eht280.Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P et al. American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association. Circulation. 2018;137(20):e623-e644. https://doi.org/10.1161/CIR.0000000000000568.Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P et al. American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association. Circulation. 2018;137(20):e623-e644. https://doi.org/10.1161/CIR.0000000000000568.Hald EM, Løchen ML, Mathiesen EB, Wilsgaard T, Njølstad I, Brækkan SK, Hansen JB. Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study. Res Pract Thromb Haemost. 2020;4(6):1004–1012. https://doi.org/10.1002/rth2.12351.Hald EM, L0chen ML, Mathiesen EB, Wilsgaard T, Nj0lstad I, Br^kkan SK, Hansen JB. Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Troms0 study. Res Pract Thromb Haemost. 2020;4(6):1004-1012. https://doi.org/10.1002/rth2.12351.Sum-Ping O, Geng Y-J. Impact of sleep on cardiovascular health: a narrative review. Heart and Mind. 2022;6(3):120-126. https://doi.org/10.4103/hm.hm_29_22.Sum-Ping O, Geng Y-J. Impact of sleep on cardiovascular health: a narrative review. Heart and Mind. 2022;6(3):120-126. https://doi.org/10.4103/hm.hm_29_22.Zhang L, Li G, Bao Y, Liu M. Role of sleep disorders in patients with cardiovascular disease: A systematic review. Int J Cardiol Cardiovasc Risk Prev. 2024;21:200257. https://doi.org/10.1016/j.ijcrp.2024.200257.Zhang L, Li G, Bao Y, Liu M. Role of sleep disorders in patients with cardiovascular disease: A systematic review. Int J Cardiol Cardiovasc Risk Prev. 2024;21:200257. https://doi.org/10.1016/j.ijcrp.2024.200257.Полуэктов МГ, Пчелина ПВ. Хроническая инсомния: современная модель «трех П» и основанные на ней методы лечения. Журнал неврологии и психиатрии им. С.С. Корсакова. 2015;115(12):141-147. https://doi.org/10.17116/jnevro2015115112141-147.Poluektov MG, Pchelina PV. Chronic insomnia: treatment methods based on the current «3P» model of insomnia. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2015;115(12):141-147. (In Russ.) https://doi.org/10.17116/jnevro2015115112141-147.Shaha DP. Insomnia Management: A Review and Update. J Fam Pract. 2023;72(6 Suppl.):S31-S36. https://doi.org/10.12788/jfp.0620.Shaha DP. Insomnia Management: A Review and Update. J Fam Pract. 2023;72(6 Suppl.):S31-S36. https://doi.org/10.12788/jfp.0620.Курушина ОВ, Барулин АЕ, Багирова ДЯ. Современные подходы к лечению инсомнии в общетерапевтической практике. Медицинский совет. 2019;(6):20-26. https://doi.org/10.21518/2079-701X-2019-6-20-26.Kurushina OV, Barulin AE, Bagirova DY. Modern approaches to the management of insomnia in general therapeutic practice. Meditsinskiy Sovet. 2019;(6):20-26. (In Russ.) https://doi.org/10.21518/2079-701X-2019-6-20-26.Koren G, Clark S, Hankins GD, Caritis SN, Umans JG, Miodovnik M et al. Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. BMC Pregnancy Childbirth. 2016;16(1):371. https://doi.org/10.1186/s12884-016-1172-9Koren G, Clark S, Hankins GD, Caritis SN, Umans JG, Miodovnik M et al. Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. BMC Pregnancy Childbirth. 2016;16(1):371. https://doi.org/10.1186/s12884-016-1172-9Бурчаков ДИ, Тардов МВ. Инсомния в практике терапевта: роль доксиламина. Медицинский совет. 2020;(2):45-53. https://doi.org/10.21518/2079-701X-2020-2-45-53.Burchakov DI, Tardov MV. Insomnia in general practice: the role of doxylamine. Meditsinskiy Sovet. 2020;(2):45-53. (In Russ.) https://doi.org/10.21518/2079-701X-2020-2-45-53.Мельников АЮ, Лаврик СЮ, Бикбулатова ЛФ, Рагинене ИГ, Иванова ЯА, Захаров АВ. Эффективность препарата реслип (доксиламин) при острой инсомнии: многоцентровое открытое сравнительное рандомизированное исследование. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(4-2):56-59. https://doi.org/10.17116/jnevro20171174256-59.Melnikov AYu, Lavrik SIu, Bikbulatova LF, Raginene IG, Ivanova YaA, Zakharov AV. Effectiveness of reslip (doxylamine) in short-term insomnia: multicenter comparative randomized study. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2017;117(4-2):56-59. (In Russ.) https://doi.org/10.17116/jnevro20171174256-59.Стрыгин КН. Роль центральных блокаторов гистаминовых рецепторов в лечении инсомнии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2018;118(4-2):73-82. https://doi.org/10.17116/jnevro20181184273.Strigin KN. The role of central histamine receptor blockers in the treatment of insomnia. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2018;118(4-2):73-82. (In Russ.) https://doi.org/10.17116/jnevro20181184273.Романов ДВ, Юзбашян ПГ. Острая инсомния: опыт применения доксиламина. Медицинский еовет. 2020;(21):267-273. https://doi.org/10.21518/2079-701X-2020-21-267-273.Romanov DV, Iuzbashian PG. Acute insomnia: experience of treatment with doxylamine. Meditsinskiy Sovet. 2020;(21):267-273. (In Russ.) https://doi.org/10.21518/2079-701X-2020-21-267-273.Brott NR, Reddivari AKR. Doxylamine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK551646.Brott NR, Reddivari AKR. Doxylamine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK551646.Gomez Perez S, Hassel I, Giesel B, Schweimer MT, Iwanowitsch A. Retrospective post-authorisation safety study investigating the relationship of first-generation antihistamines with sedative effect and the risk of falls in older patients. Pharmazie. 2020;75(12):666-670. https://doi.org/10.1691/ph.2020.0784.Gomez Perez S, Hassel I, Giesel B, Schweimer MT, Iwanowitsch A. Retrospective post-authorisation safety study investigating the relationship of first-generation antihistamines with sedative effect and the risk of falls in older patients. Pharmazie. 2020;75(12):666-670. https://doi.org/10.1691/ph.2020.0784.Gomez Perez S, Hassel I, Torben Schweimer M, Gilbert S, Iwanowitsch A. Post-authorisation safety study on doxylamine and fall risk - a patient survey in German pharmacies. SelfCare. 2024;14(1):9-20. Available at: https://selfcarejournal.com/article/post-authorisation-safety-study-on-doxylamine-and-fall-risk-a-patient-survey-in-german-pharmacies.Gomez Perez S, Hassel I, Torben Schweimer M, Gilbert S, Iwanowitsch A. Post-authorisation safety study on doxylamine and fall risk - a patient survey in German pharmacies. SelfCare. 2024;14(1):9-20. Available at: https://selfcarejournal.com/article/post-authorisation-safety-study-on-doxylamine-and-fall-risk-a-patient-survey-in-german-pharmacies.

The authors declare that there are no conflicts of interest present.