medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-310medsovet-8528Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESКачество жизни пациентов с дисгидротической экземой: одномоментное исследованиеQuality of life of patients with dyshidrotic eczema: a cross-sectional studyhttps://orcid.org/0000-0003-1655-8992ШачневA. С.ShachnevA. S.

Шачнев Александр Сергеевич, аспирант кафедры дерматовенерологии, аллергологии и косметологии Медицинского института

117198, Москва, ул. Миклухо-Маклая, д. 6

Aleksandr S. Shachnev, Postgraduate Student of the Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine

6, Miklukho-Maklaya St., Moscow, 117198

dr.shachnev@gmail.comhttps://orcid.org/0000-0001-5723-6573ЖуковаО. В.ZhukovaO. V.

Жукова Ольга Валентиновна, д.м.н., профессор, заведующая кафедрой дерматовенерологии, аллергологии и косметологии Медицинского института, Российский университет дружбы народов имени Патриса Лумумбы; главный врач, Московский научно-практический центр дерматовенерологии и косметологии

117198, Москва, ул. Миклухо-Маклая, д. 6,

119071, Москва, Ленинский проспект, д. 17

Olga V. Zhukova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia named after Patrice Lumumba; Chief Medical Officer, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

6, Miklukho-Maklaya St., Moscow, 117198,

17, Leninskiy Ave., Moscow, 119071

klinderma@inbox.ruhttps://orcid.org/0000-0002-0767-8821КасихинаЕ. И.KasikhinaE. I.

Касихина Елена Игоревна, к.м.н., доцент кафедры дерматовенерологии, аллергологии и косметологии Медицинского института, Российский университет дружбы народов имени Патриса Лумумбы; врач-дерматовенеролог, Московский научно-практический центр дерматовенерологии и косметологии

117198, Москва, ул. Миклухо-Маклая, д. 6,

119071, Москва, Ленинский проспект, д. 17

Elena I. Kasikhina, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia named after Patrice Lumumba; Dermatologist, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

6, Miklukho-Maklaya St., Moscow, 117198,

17, Leninskiy Ave., Moscow, 119071

kasprof@bk.ruРоссийский университет дружбы народов имени Патриса ЛумумбыРоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian FederationРоссийский университет дружбы народов имени Патриса Лумумбы; Московский научно-практический центр дерматовенерологии и косметологииРоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Moscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian Federation2024140920240141422Copyright © Шачнев A.С., Жукова О.В., Касихина Е.И., 20242024Шачнев A.С., Жукова О.В., Касихина Е.И.Shachnev A.S., Zhukova O.V., Kasikhina E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8528Введение

Введение. Дисгидротическая экзема (ДЭ) – разновидность истинной экземы, склонная к хроническому рецидивирующему течению, оказывающая негативное влияние на качество жизни пациентов. В отечественной литературе уделяется недостаточное внимание изучению роли и характера течения заболевания на повседневную жизнь больных ДЭ.

Цель

Цель. Изучить влияние ДЭ кистей рук на качество жизни пациентов в зависимости от пола. Дать описание клинических случаев ДЭ и опыта наружной терапии.

Материалы и методы

Материалы и методы. В исследование было включено 105 пациентов с ДЭ в возрасте от 18 до 52 лет, средний возраст составил 31,3 ± 8,1 года. Качество жизни оценивалось с помощью Дерматологического индекса качества жизни (Dermatology Life Quality Index, DLQI). Для клинической оценки тяжести ДЭ использовался Индекс площади поражения и степени тяжести ДЭ (Dyshidrotic Eczema Area and Severity Index, DASI).

Результаты

Результаты. Все пациенты, страдающие ДЭ, отметили негативное влияние кожного процесса на качество жизни. В то же время средний балл DLQI у всех пациентов составил 6,99 ± 4,6, что свидетельствует об умеренном нежелательном влиянии ДЭ на качество жизни без статистически значимых различий по половому признаку. Средний балл индекса DASI составил 12,6 ± 8,8, что свидетельствует о преобладании в выборке легкой степени тяжести ДЭ. У женщин чаще диагностировался процесс средней степени тяжести и индекс DASI составил 13,2 ± 8,5. Исследованием продемонстрировано, что женский пол в большей степени подвержен влиянию симптомов ДЭ на качество жизни вне зависимости от степени тяжести и распространенности процесса на коже, а минимальные изменения на коже могут оказывать негативное влияние на качество жизни. В статье представлены клинические примеры успешной терапии ДЭ с локализацией на коже кистей рук наружным препаратом, содержащим комбинацию 0,05% бетаметазона дипропионата, 0,1% гентамицина сульфата и 1% клотримазола.

Выводы

Выводы. Наружная терапия ДЭ должна осуществляться вне зависимости от степени тяжести, отдавать предпочтение стоит методам терапии, дающим хорошие результаты в кратчайшие сроки с целью уменьшения выраженности симптомов, достижения быстрой и стойкой ремиссии, а также улучшения качества жизни пациентов. Топическая терапия фиксированной комбинацией бетаметазона дипропионата 0,05%, гентамицина сульфата 0,1% и клотримазола 1% оказывает быстрый терапевтический эффект, уменьшает основные симптомы ДЭ и положительно влияет на качество жизни пациентов.

Introduction

Introduction. Dyshidrotic eczema (DE) is a type of true eczema, prone to chronic recurrent course, which has a negative impact on the quality of life of patients. In the domestic literature, insufficient attention is paid to the study of the role and nature of the course of the disease on the daily life of patients with DE.

Aim

Aim. To study the quality of life in patients of DE. Provide a description of a clinical cases of DE and experience with external therapy.

Materials and methods

Materials and methods. 105 patients with DE aged 18 to 52 years were included in the study, the mean age was 31.3 ± 8.1 years. The quality of life was assessed using the Dermatology Life Quality Index (DLQI). The Dyshidrotic Eczema Area and Severity Index (DASI) was used to clinically assess the severity of DE.

Results

Results. All patients suffering from DE noted a negative impact of the skin process on the quality of life. At the same time, the average DLQI score in all patients was 6.99 ± 4.6, which indicates a moderate undesirable effect of DE on the quality of life, without statistically significant differences by gender. The average DASI score was 12.6 ± 8.8, which indicates a predominance of mild DE in the sample. In women, a process of moderate severity was more often diagnosed and the DASI index was 13.2 ± 8.5. The study demonstrated that the female gender is more susceptible to the influence of DE symptoms on the quality of life, regardless of the severity and extent of the skin process, and minimal changes in the skin can have a negative impact on the quality of life. The article presents clinical examples of successful treatment of DE localized on the skin of the hands with an external preparation containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole.

Conclusion

Conclusion. DE is a common condition and affects quality of life. Proper diagnosis is essential for effective and efficient treatment. External therapy with the inclusion of a cream (ointment) containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole gives better results and increases satisfaction with the treatment of patients with DE.

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The authors declare that there are no conflicts of interest present.